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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 76903-88-3 with fast shipping

Cas:76903-88-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoyl chloride,3,4-difluoro- 76903-88-3

Cas:76903-88-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3,4-Difluorobenzoyl chloride CAS:76903-88-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

3,4-Difluorobenzoyl chloride CAS:76903-88-3

Cas:76903-88-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzoyl chloride,3,4-difluoro-

Cas:76903-88-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzoyl chloride,3,4-difluoro-

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoyl chloride,3,4-difluoro-

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzoyl chloride,3,4-difluoro- factory

Cas:76903-88-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,4-Difluorobenzoyl chloride cas no. 76903-88-3 98%

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Benzoyl chloride,3,4-difluoro-

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 3,4-Difluorobenzoyl Chloride 5g

Cas:76903-88-3

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzoyl chloride,3,4-difluoro-

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

3,4-Difluorobenzoyl chloride Application:3,4-Difluorobenzoyl chloride

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

3,4-Difluorobenzoyl chloride

Cas:76903-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

3,4-Difluorobenzoic acid
455-86-7

3,4-Difluorobenzoic acid

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide at 70 - 80℃; Substitution;96.3%
With thionyl chloride Heating;88%
With thionyl chloride In benzene Heating;81%
1,2-difluoro-4-(trifluoromethyl)benzene
32137-19-2

1,2-difluoro-4-(trifluoromethyl)benzene

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / conc. sulfuric acid / 2 h / 80 °C
2: thionyl chloride / benzene / 2 h / Heating
View Scheme
1,2-dichloro-4-(trifluoromethyl)benzene
328-84-7

1,2-dichloro-4-(trifluoromethyl)benzene

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KF / various solvent(s) / 24 h / 265 °C / other temperatures, other solvents
2: 86 percent / conc. sulfuric acid / 2 h / 80 °C
3: thionyl chloride / benzene / 2 h / Heating
View Scheme
4-chlorotrichloromethylbenzene
5216-25-1

4-chlorotrichloromethylbenzene

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: chlorosulfuric acid / 1) 120 deg C, 1 h 2) 150 deg C, 2 h
2: 94 percent / SOCl2 / benzene / 8 h / Heating
3: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating
4: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr
5: 93 percent / 10percent NaOH / 1 h
6: 81 percent / SOCl2 / benzene / Heating
View Scheme
4-chloro-3-(chlorosulfonyl)benzoic acid
2494-79-3

4-chloro-3-(chlorosulfonyl)benzoic acid

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 94 percent / SOCl2 / benzene / 8 h / Heating
2: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating
3: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr
4: 93 percent / 10percent NaOH / 1 h
5: 81 percent / SOCl2 / benzene / Heating
View Scheme
3-chlorosulfonyl-4-chlorobenzoyl chloride
62574-66-7

3-chlorosulfonyl-4-chlorobenzoyl chloride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating
2: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr
3: 93 percent / 10percent NaOH / 1 h
4: 81 percent / SOCl2 / benzene / Heating
View Scheme
3,4-difluorobenzoyl fluoride
127269-25-4

3,4-difluorobenzoyl fluoride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / 10percent NaOH / 1 h
2: 81 percent / SOCl2 / benzene / Heating
View Scheme
4-fluoro-3-(fluorosulfonyl)benzoyl fluoride
127986-80-5

4-fluoro-3-(fluorosulfonyl)benzoyl fluoride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr
2: 93 percent / 10percent NaOH / 1 h
3: 81 percent / SOCl2 / benzene / Heating
View Scheme
1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-piperidin-4-amine
1408075-34-2

1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-piperidin-4-amine

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3,4-difluorobenzamide

N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3,4-difluorobenzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 3h;100%
1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride
41994-51-8

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

2-(3,4-difluorobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
1147550-70-6

2-(3,4-difluorobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride; 3,4-difluorobenzoyl chloride With sodium hydroxide In water; acetone for 1h; pH=> 10;
Stage #2:
Stage #3: With hydrogenchloride In water
98.8%
Stage #1: 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride With sodium hydroxide In acetone at 20℃;
Stage #2: 3,4-difluorobenzoyl chloride With sodium hydroxide In acetone at 20℃; pH=> 10;
Stage #3: With hydrogenchloride In water pH=5 - 6;
95%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

acetonitrile
75-05-8

acetonitrile

3-(3,4-difluorophenyl)-3-oxopropanenitrile
71682-97-8

3-(3,4-difluorophenyl)-3-oxopropanenitrile

Conditions
ConditionsYield
Stage #1: acetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 3,4-difluorobenzoyl chloride In tetrahydrofuran at 20℃; for 4h;
97%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

N-butylamine
109-73-9

N-butylamine

2-(3',4'-difluorophenyl)pyridine
387831-85-8

2-(3',4'-difluorophenyl)pyridine

Conditions
ConditionsYield
With dmap; copper(II) ethylacetoacetate; C26H36NP; silver(I) acetate In propan-1-ol at 60℃; for 12h; Reagent/catalyst;96.2%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

glycine
56-40-6

glycine

2-(3,4-difluorobenzamido)acetic acid
315707-69-8

2-(3,4-difluorobenzamido)acetic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 0 - 20℃;96%
With hydrogenchloride; sodium hydroxide In water
trans-4-(4-quinolyloxy)cyclohexylamine

trans-4-(4-quinolyloxy)cyclohexylamine

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

N-[trans-4-(4-quinolyloxy)cyclohexyl]-3,4-difluorobenzamide

N-[trans-4-(4-quinolyloxy)cyclohexyl]-3,4-difluorobenzamide

Conditions
ConditionsYield
With pyridine; triethylamine at 0 - 20℃;96%
berberrubine chloride
15401-69-1

berberrubine chloride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

9-O-(3,4-diflourobenzoyl)berberrubine chloride
1297302-82-9

9-O-(3,4-diflourobenzoyl)berberrubine chloride

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.5h;94%
glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

methyl N-(3,4-difluorobenzoyl)glycinate

methyl N-(3,4-difluorobenzoyl)glycinate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 18 - 25℃; for 2h; Cooling with ice;94%
2-chloroethanamine hydrochloride
870-24-6

2-chloroethanamine hydrochloride

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

N-(2-chloroethyl)-2-(3,4-difluorophenyl)acid amide
1082817-08-0

N-(2-chloroethyl)-2-(3,4-difluorophenyl)acid amide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 3h; Inert atmosphere;93%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

dimedone
126-81-8

dimedone

5,5-dimethyl-3-oxocyclohex-1-en-1-yl 3,4-difluorobenzoate

5,5-dimethyl-3-oxocyclohex-1-en-1-yl 3,4-difluorobenzoate

Conditions
ConditionsYield
With pyridine In 1,2-dichloro-ethane at 20℃; for 12h; Inert atmosphere;93%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

Propargylamine
2450-71-7

Propargylamine

3,4-difluoro-N-(prop-2-ynyl)benzamide
1250231-35-6

3,4-difluoro-N-(prop-2-ynyl)benzamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;92%
With dmap; triethylamine In dichloromethane at 0 - 20℃;
7-hydroxy-4,6-dimethylcoumarin
1484-98-6

7-hydroxy-4,6-dimethylcoumarin

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

4,6-dimethyl-2-oxo-2H-chromen-7-yl-3,4-difluorobenzoate

4,6-dimethyl-2-oxo-2H-chromen-7-yl-3,4-difluorobenzoate

Conditions
ConditionsYield
With potassium carbonate for 0.25h;92%
piperidine-2,6-dione
1121-89-7

piperidine-2,6-dione

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

1-(3,4-difluorobenzoyl)piperidine-2,6-dione

1-(3,4-difluorobenzoyl)piperidine-2,6-dione

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;91.2%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;91%
With dmap; triethylamine In dichloromethane at 0 - 23℃; Inert atmosphere;
With dmap; triethylamine In dichloromethane at 0 - 23℃; Inert atmosphere; Schlenk technique;
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

3-chloro-6-hydroxy-4,7-dimethyl-2H-chromen-2-one

3-chloro-6-hydroxy-4,7-dimethyl-2H-chromen-2-one

3-chloro-4,7-dimethyl-2-oxo-2H-chromen-6-yl 3,4-difluorobenzoate

3-chloro-4,7-dimethyl-2-oxo-2H-chromen-6-yl 3,4-difluorobenzoate

Conditions
ConditionsYield
With potassium carbonate In neat (no solvent) at 20℃; for 0.25h; Milling;91%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

N-(tert-butyl)-3,4-difluorobenzamide
223444-29-9

N-(tert-butyl)-3,4-difluorobenzamide

Conditions
ConditionsYield
90%
2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

potassium thioacyanate
333-20-0

potassium thioacyanate

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

O-(2-methoxyethyl)(3,4-difluorobenzoyl)carbamothioate

O-(2-methoxyethyl)(3,4-difluorobenzoyl)carbamothioate

Conditions
ConditionsYield
Stage #1: potassium thioacyanate; 3,4-difluorobenzoyl chloride In acetone at 55℃; for 1h; Inert atmosphere;
Stage #2: 2-methoxy-ethanol In acetone at 55℃; for 12h;
90%
tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate
247570-24-7

tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

(cis-4-{[1-(3,4-difluoro-phenyl)-methanoyl]-amino}-cyclohexyl)-carbamic acid tert-butyl ester
771553-05-0

(cis-4-{[1-(3,4-difluoro-phenyl)-methanoyl]-amino}-cyclohexyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1h;89%
4-[2-(2-Methyl-piperidin-1-yl)-ethoxy]-3-(2-methyl-2H-pyrazol-3-yl)-phenylamine
887938-43-4

4-[2-(2-Methyl-piperidin-1-yl)-ethoxy]-3-(2-methyl-2H-pyrazol-3-yl)-phenylamine

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

3,4-difluoro-N-[4-[2-(2-methyl-piperidin-1-yl)-ethoxy]-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-benzamide

3,4-difluoro-N-[4-[2-(2-methyl-piperidin-1-yl)-ethoxy]-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;88.2%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methanol
145782-15-6, 145782-16-7

cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methanol

3,4-Difluoro-benzoic acid (2R,4R)-2-biphenyl-4-yl-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester

3,4-Difluoro-benzoic acid (2R,4R)-2-biphenyl-4-yl-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester

Conditions
ConditionsYield
With pyridine at 0℃; for 2.5h;88%
3-aminobenzenemethanol
1877-77-6

3-aminobenzenemethanol

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

3,4-difluoro-N-(3-hydroxymethyl-phenyl)-benzamide
879871-58-6

3,4-difluoro-N-(3-hydroxymethyl-phenyl)-benzamide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane88%
methyl-phenyl-carbamic acid 5-amino-pyridin-2-yl ester
548769-49-9

methyl-phenyl-carbamic acid 5-amino-pyridin-2-yl ester

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

methyl-phenyl-carbamic acid 5-(3,4-difluoro-benzoylamino)-pyridin-2-yl ester
812639-58-0

methyl-phenyl-carbamic acid 5-(3,4-difluoro-benzoylamino)-pyridin-2-yl ester

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 1h;88%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate
565460-55-1

methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

methyl [(2R)-1-(3,4-difluorobenzoyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]-acetate

methyl [(2R)-1-(3,4-difluorobenzoyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]-acetate

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine In tetrahydrofuran88%
With 4-pyrrolidin-1-ylpyridine In tetrahydrofuran88%
C19H23N5O3

C19H23N5O3

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

C26H25F2N5O4

C26H25F2N5O4

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;88%
4-aminopyridine
504-24-5

4-aminopyridine

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

3,4-difluoro-N-(pyridin-4-yl)benzamide

3,4-difluoro-N-(pyridin-4-yl)benzamide

Conditions
ConditionsYield
In tetrahydrofuran at 0℃; Inert atmosphere;88%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole
101337-92-2

2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole

N-(5-chloro-6-fluoro-benzothiazol-2-yl)-3,4-difluoro-benzamide

N-(5-chloro-6-fluoro-benzothiazol-2-yl)-3,4-difluoro-benzamide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 50 - 60℃; for 2h;87.2%
4-oxazol-2-yl-benzoic acid ethyl ester
1139705-32-0

4-oxazol-2-yl-benzoic acid ethyl ester

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

ethyl 4-(5-(3,4-difluorobenzoyl)oxazol-2-yl)benzoate
1492786-00-1

ethyl 4-(5-(3,4-difluorobenzoyl)oxazol-2-yl)benzoate

Conditions
ConditionsYield
Stage #1: 4-oxazol-2-yl-benzoic acid ethyl ester With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex In tetrahydrofuran at 50℃; for 2h; Inert atmosphere; Schlenk technique;
Stage #2: 3,4-difluorobenzoyl chloride With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 25℃; for 1h; Negishi Coupling; Inert atmosphere; Schlenk technique; regioselective reaction;
87%
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

3,4-difluoro-benzaldehyde oxime
238743-29-8

3,4-difluoro-benzaldehyde oxime

(E)-3,4-di-fluorobenzaldehyde O-3,4-difluorobenzoyloxime

(E)-3,4-di-fluorobenzaldehyde O-3,4-difluorobenzoyloxime

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;85%
Stage #1: 3,4-difluorobenzoyl chloride; 3,4-difluoro-benzaldehyde oxime
Stage #2: With triethylamine hydrochloride
85%
1,3-diphenyl-1H-pyrazol-5-amine
5356-71-8

1,3-diphenyl-1H-pyrazol-5-amine

3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

N-(1,3-diphenyl-1H-pyrazol-5-yl)-3,4-difluorobenzamide

N-(1,3-diphenyl-1H-pyrazol-5-yl)-3,4-difluorobenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane84%
Stage #1: 1,3-diphenyl-1H-pyrazol-5-amine With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.25h;
Stage #2: 3,4-difluorobenzoyl chloride In dichloromethane at 20℃;
3,4-difluorobenzoyl chloride
76903-88-3

3,4-difluorobenzoyl chloride

2,3-difluoro-N-[4-(2-trifluoromethyl-imidazo[1,2-a]pyrid-3-yl)-phenyl]-benzamide

2,3-difluoro-N-[4-(2-trifluoromethyl-imidazo[1,2-a]pyrid-3-yl)-phenyl]-benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-nitrophenyl)-2-(trifluoromethyl)imidazo[1,2-a]pyridine With water; tin(ll) chloride In ethanol; dichloromethane Heating / reflux;
Stage #2: 3,4-difluorobenzoyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 4h;
84%

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