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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 2,5-DIFLUORO THIOPHENOL

Cas:77380-28-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 77380-28-0 with competitive price

Cas:77380-28-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzenethiol,2,5-difluoro-

Cas:77380-28-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenethiol,2,5-difluoro-

Cas:77380-28-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenethiol,2,5-difluoro-

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,5-DIFLUORO THIOPHENOL

Cas:77380-28-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Colorless to light yellow liquid Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,5-Difluorobenzenethiol cas no. 77380-28-0 98%

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2,5-difluorobenzenethiolate

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2,5-difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Fandachem Co.,Ltd

FandaChem, a China-based chemical company, specialize in exporting 2,5-DIFLUOROBENZENETHIOL / C6H4F2S cas no 77380-28-0 (Fandachem), Please contact us by email freely. Appearance:white crystalline powder Storage:Store in dry, dark and v

2,5-DIFLUOROBENZENETHIOL / C6H4F2S cas no 77380-28-0 (Fandachem)

Cas:77380-28-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

2,5-DIFLUORO THIOPHENOL

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzenethiol,2,5-difluoro-

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

2,5-Difluoro thiophenol Application:2,5-Difluoro thiophenol

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2,5-DIFLUORO THIOPHENOL CAS No.77380-28-0

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

77380-28-0

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

77380-28-0

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. Prompt reaction, good quality and best service make us reliable and outstanding in this industry.Appearance:Colorless to light yellow l

2,5-Difluoro thiophenol manufacture

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

77380-28-0 Application:intermediate

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Newgreat Chemical Co., Ltd

Wuhan Xinweiye Chemical Co., Ltd. is mainly engaged in the process development and production of customized synthesis and pharmaceutical intermediates. We have professional researchers in organic synthesis, analytical chemistry and production process

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

2,5-Difluoro thiophenolAppearance:liquid Package:EMS, DHL, FEDEX, UPS, TNT Application:Intermediates/Pharmaceutical intermediates Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

2,5-Difluoro thiophenol

Cas:77380-28-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

2,5-difluorobenzenesulfonyl chloride
26120-86-5

2,5-difluorobenzenesulfonyl chloride

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

Conditions
ConditionsYield
With formic acid; 6% Pd/C; triphenylphosphine at 60℃; for 8h;87%
With potassium formate at 200℃; for 7h; neat (no solvent);68%
2,5-Difluoro-benzenesulfonic acid

2,5-Difluoro-benzenesulfonic acid

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

Conditions
ConditionsYield
With 6% Pd/C; iodine; triphenylphosphine; isopropyl alcohol for 10h; Reflux;85%
2,5-difluoroaniline
367-30-6

2,5-difluoroaniline

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

Conditions
ConditionsYield
Yield given. Multistep reaction;
chloropropionic acid
107-94-8

chloropropionic acid

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

3-((2,5-difluorophenyl)thio)propanoic acid
926232-57-7

3-((2,5-difluorophenyl)thio)propanoic acid

Conditions
ConditionsYield
Stage #1: 2,5-Difluorothiophenol With sodium hydroxide In water at 0℃; for 0.0833333h;
Stage #2: chloropropionic acid In water at 70℃;
Stage #3: With hydrogenchloride In water at 0℃;
100%
2-Chloro-5-(trifluoromethylthio)benzaldehyde
83975-70-6

2-Chloro-5-(trifluoromethylthio)benzaldehyde

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde
83975-71-7

5-(Trifluoromethylthio)-2-(2,5-difluorophenylthio)benzaldehyde

Conditions
ConditionsYield
With sodium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 5.5h;75%
2,5-dichloro-benzaldehyde
6361-23-5

2,5-dichloro-benzaldehyde

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

5-Chloro-2-(2,5-difluorophenylthio)benzaldehyde
83975-59-1

5-Chloro-2-(2,5-difluorophenylthio)benzaldehyde

Conditions
ConditionsYield
With sodium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 5.5h;74%
o-iodophenylacetic acid
18698-96-9

o-iodophenylacetic acid

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

<2-(2,5-difluorophenylthio)phenyl>acetic acid
77380-29-1

<2-(2,5-difluorophenylthio)phenyl>acetic acid

Conditions
ConditionsYield
With potassium hydroxide; copper In water for 16h; Heating;64%
2-bromo-5-methoxy-benzaldehyde
7507-86-0

2-bromo-5-methoxy-benzaldehyde

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

A

2-(2,5-difluorophenylthio)-5-hydroxybenzaldehyde
84884-56-0

2-(2,5-difluorophenylthio)-5-hydroxybenzaldehyde

B

2-(2,5-Difluorophenylthio)-5-methoxybenzaldehyde
83975-63-7

2-(2,5-Difluorophenylthio)-5-methoxybenzaldehyde

Conditions
ConditionsYield
With copper In N,N-dimethyl-formamide at 150℃; for 6h;A 2.8 g
B 39%
3-(benzyloxy)cyclobutyl sulfochloridate

3-(benzyloxy)cyclobutyl sulfochloridate

2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

(3-(benzyloxy)cyclobutyl)(2,5-difluorophenyl)sulfane
1080636-88-9

(3-(benzyloxy)cyclobutyl)(2,5-difluorophenyl)sulfane

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 12h;12%
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

1,4-difluorodibenzothiepin
77380-34-8

1,4-difluorodibenzothiepin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / KOH, Cu / H2O / 16 h / Heating
2: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C
3: 94 percent / NaBH4, aq. NaOH / ethanol; benzene / 4 h / Heating
4: 97 percent / HCl, CaCl2 / benzene / Ambient temperature
5: 21 percent / CHCl3 / 8 h / Heating
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

6,9-difluorodibenzothiepin-10(11H)-one
77380-30-4

6,9-difluorodibenzothiepin-10(11H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / KOH, Cu / H2O / 16 h / Heating
2: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

8-chloro-2-fluoro-6H-dibenz-1,4-oxathiepin
84884-57-1

8-chloro-2-fluoro-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
3: 1.75 g / NaH / dimethylformamide / 1) RT, 2 h; 2) 50 deg C, 14 h
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

11-chloro-1,4-difluoro-10,11-dihydrodibenzothiepin
77380-33-7

11-chloro-1,4-difluoro-10,11-dihydrodibenzothiepin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 64 percent / KOH, Cu / H2O / 16 h / Heating
2: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C
3: 94 percent / NaBH4, aq. NaOH / ethanol; benzene / 4 h / Heating
4: 97 percent / HCl, CaCl2 / benzene / Ambient temperature
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

6,9-difluoro-10,11-dihydrodibenzothiepin-10-ol
77380-32-6

6,9-difluoro-10,11-dihydrodibenzothiepin-10-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 64 percent / KOH, Cu / H2O / 16 h / Heating
2: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C
3: 94 percent / NaBH4, aq. NaOH / ethanol; benzene / 4 h / Heating
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

2-fluoro-8-methoxy-6-(1-methyl-4-piperidyl)-6H-dibenz-1,4-oxathiepin
84884-60-6

2-fluoro-8-methoxy-6-(1-methyl-4-piperidyl)-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 39 percent / Cu / dimethylformamide / 6 h / 150 °C
2: 1) Mg / 1) THF, reflux, 1.5 h; 2) THF, reflux, 3 h
3: 1.06 g / NaH / dimethylformamide; tetrahydrofuran / 11 h / 70 °C
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

[5-Chloro-2-(2,5-difluoro-phenylsulfanyl)-phenyl]-(1-methyl-piperidin-4-yl)-methanol
83986-23-6

[5-Chloro-2-(2,5-difluoro-phenylsulfanyl)-phenyl]-(1-methyl-piperidin-4-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

[2-(2,5-Difluoro-phenylsulfanyl)-5-trifluoromethylsulfanyl-phenyl]-(1-methyl-piperidin-4-yl)-methanol
83975-66-0

[2-(2,5-Difluoro-phenylsulfanyl)-5-trifluoromethylsulfanyl-phenyl]-(1-methyl-piperidin-4-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

6,9-difluoro-11-<2-(2,5-difluorophenylthio)phenyl>acetyldibenzothiepin-10-ol
77380-31-5

6,9-difluoro-11-<2-(2,5-difluorophenylthio)phenyl>acetyldibenzothiepin-10-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / KOH, Cu / H2O / 16 h / Heating
2: 0.25 g / polyphosphoric acid / 2.5 h / 120 - 125 °C
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

4-(2-Chloro-7-fluoro-11H-10-oxa-5-thia-dibenzo[a,d]cyclohepten-11-yl)-1-methyl-piperidine; hydrochloride
84884-58-2

4-(2-Chloro-7-fluoro-11H-10-oxa-5-thia-dibenzo[a,d]cyclohepten-11-yl)-1-methyl-piperidine; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
3: 36 percent / NaH / dimethylformamide / 1) RT, 2 h; 2) 50 deg C, 14 h
4: 0.35 g / 1) ethyl chloroformate, 2) KOH / 1) benzene, reflux, 1.5 h; 2) ethanol, 125 deg C, 2 h
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

8-Chloro-2-fluoro-6-(4-piperidyl)-6H-dibenz-1,4-oxathiepin
83975-78-4

8-Chloro-2-fluoro-6-(4-piperidyl)-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
3: 36 percent / NaH / dimethylformamide / 1) RT, 2 h; 2) 50 deg C, 14 h
4: 1) ethyl chloroformate, 2) KOH / 1) benzene, reflux, 1.5 h; 2) ethanol, 125 deg C, 2 h
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

2-fluoro-8-methoxy-6H-dibenz-1,4-oxathiepin
83975-60-4

2-fluoro-8-methoxy-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 39 percent / Cu / dimethylformamide / 6 h / 150 °C
2: 1) Mg / 1) THF, reflux, 1.5 h; 2) THF, reflux, 3 h
3: 61 percent / NaH / dimethylformamide; tetrahydrofuran / 11 h / 70 °C
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

8-Chloro-2-fluoro-6-(1-methyl-4-piperidyl)-6H-dibenz-1,4-oxathiepin
83986-22-5

8-Chloro-2-fluoro-6-(1-methyl-4-piperidyl)-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
3: 36 percent / NaH / dimethylformamide / 1) RT, 2 h; 2) 50 deg C, 14 h
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

1,4-difluoro-11-(4-methylpiperazino)-10,11-dihydrodibenzothiepin
77380-35-9

1,4-difluoro-11-(4-methylpiperazino)-10,11-dihydrodibenzothiepin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / KOH, Cu / H2O / 16 h / Heating
2: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C
3: 94 percent / NaBH4, aq. NaOH / ethanol; benzene / 4 h / Heating
4: 97 percent / HCl, CaCl2 / benzene / Ambient temperature
5: 67 percent / CHCl3 / 8 h / Heating
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

2-(2,5-Difluorophenylthio)-5-methoxy-α-(1-methyl-4-piperidyl)benzyl Alcohol
83975-61-5

2-(2,5-Difluorophenylthio)-5-methoxy-α-(1-methyl-4-piperidyl)benzyl Alcohol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 39 percent / Cu / dimethylformamide / 6 h / 150 °C
2: 1) Mg / 1) THF, reflux, 1.5 h; 2) THF, reflux, 3 h
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

8-Chloro-2-fluoro-6-<1-(2-hydroxyethyl)-4-piperidyl>-6H-dibenz-1,4-oxathiepin
83975-82-0

8-Chloro-2-fluoro-6-<1-(2-hydroxyethyl)-4-piperidyl>-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
3: 36 percent / NaH / dimethylformamide / 1) RT, 2 h; 2) 50 deg C, 14 h
4: 1) ethyl chloroformate, 2) KOH / 1) benzene, reflux, 1.5 h; 2) ethanol, 125 deg C, 2 h
5: 69 percent / K2CO3 / acetone / 6 h / Heating
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

2-Fluoro-8-(trifluoromethylthio)-6-(1-methyl-4-piperidyl)-6H-dibenz-1,4-oxathiepin
83975-65-9

2-Fluoro-8-(trifluoromethylthio)-6-(1-methyl-4-piperidyl)-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg
3: 21 percent / NaH / dimethylformamide / 15 h / 70 °C
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

8-Chloro-6-<1-(2-decanoyloxyethyl)-4-piperidyl>-2-fluoro-6H-dibenz-1,4-oxathiepin
83975-88-6

8-Chloro-6-<1-(2-decanoyloxyethyl)-4-piperidyl>-2-fluoro-6H-dibenz-1,4-oxathiepin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 74 percent / NaOH / hexamethylphosphoric acid triamide / 5.5 h / 100 °C
2: 1) Mg / 1) THF, 2) THF, reflux, 2 h
3: 36 percent / NaH / dimethylformamide / 1) RT, 2 h; 2) 50 deg C, 14 h
4: 1) ethyl chloroformate, 2) KOH / 1) benzene, reflux, 1.5 h; 2) ethanol, 125 deg C, 2 h
5: 69 percent / K2CO3 / acetone / 6 h / Heating
6: 55 percent / xylene / 6 h / Heating
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

6,9-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
1415214-29-7

6,9-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydroxide / water / 0.08 h / 0 °C
1.2: 70 °C
1.3: 0 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
3.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere
3.2: Cooling with ice
4.1: trichlorophosphate / 2 h / 0 - 80 °C
5.1: sodium ethanolate / ethanol / 0 - 70 °C
6.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 60 - 68 °C
6.2: 20 °C / pH 2
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

ethyl 6,9-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylate
1415214-28-6

ethyl 6,9-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 0.08 h / 0 °C
1.2: 70 °C
1.3: 0 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
3.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere
3.2: Cooling with ice
4.1: trichlorophosphate / 2 h / 0 - 80 °C
5.1: sodium ethanolate / ethanol / 0 - 70 °C
View Scheme
2,5-Difluorothiophenol
77380-28-0

2,5-Difluorothiophenol

5,8-difluorothiochroman-4-one
1153968-35-4

5,8-difluorothiochroman-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 0.08 h / 0 °C
1.2: 70 °C
1.3: 0 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
3.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere
3.2: Cooling with ice
View Scheme

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