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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

7-ethylcamptothecin

Cas:78287-27-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance yellowish crystals powder Comply Coupling value 98%min

High purity 7-Ethyl-Camptothecin with high quality and lowest pricre cas:78287-27-1

Cas:78287-27-1

Min.Order:1 Kilogram

FOB Price: $16.0 / 80.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 7-Ethylcamptotrecin supplier in China

Cas:78287-27-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 7-Ethylcamptotrecin

Cas:78287-27-1

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% 7-Ethylcamptothecin 78287-27-1 HACCP Manufacturer

Cas:78287-27-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Ethylcamptothecin

Cas:78287-27-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 7-Ethylcamptothecin

Cas:78287-27-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Supply Factory Price 7-Ethylcamptothecin Powder CAS 78287-27-1

Cas:78287-27-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 78287-27-1 with best quality

Cas:78287-27-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

7-Ethylcamptothecin/ LIDE PHARMA- Factory supply / Best price

Cas:78287-27-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

High purity 7-Ethyl-Camptothecin with high quality and lowest pricre cas:78287-27-1 1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitiv

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,11-diethyl-4-hydroxy-,(4S)- 78287-27-1

Cas:78287-27-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality 7-Ethylcamptothecin CAS 78287-27-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in C

High quality 7-Ethylcamptothecin CAS 78287-27-1

Cas:78287-27-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

7-Ethylcamptothecin

Cas:78287-27-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

7-Ethylcamptothecin cas:78287-27-1

Cas:78287-27-1

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales 7-Ethylcamptothecin CAS 78287-27-1

Cas:78287-27-1

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,11-diethyl-4-hydroxy-,(4S)-

Cas:78287-27-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

7-Ethylcamptothecin

Cas:78287-27-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High purity 7-Ethyl-Camptothecin with high quality and lowest pricre cas:78287-27-1

Cas:78287-27-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

7-ETHYLCAMPTOTHECIN

Cas:78287-27-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Manufacturer/High quality Ethylcamptothecin 78287-27-1

Cas:78287-27-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,11-diethyl-4-hydroxy-,(4S)-

Cas:78287-27-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

7-Ethylcamptothecin

Cas:78287-27-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

7-ethylcamptothecin

Cas:78287-27-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

7-ETHYLCAMPTOTHECIN

Cas:78287-27-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High purity 7-Ethyl-Camptothecin with high quality and lowest pricre cas:78287-27-1

Cas:78287-27-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

7-Ethylcamptothecin

Cas:78287-27-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

High purity 7-Ethyl-Camptothecin with high quality and lowest pricre cas:78287-27-1

Cas:78287-27-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

High purity 7-Ethyl-Camptothecin with high quality and lowest pricre cas:78287-27-1

Cas:78287-27-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

7-Ethyl-Camptothecin

Cas:78287-27-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

propionaldehyde
123-38-6

propionaldehyde

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; acetic acid at -5 - 5℃; for 0.166667h; Temperature;95.4%
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water for 3h; Ambient temperature;77%
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate for 3h; Ambient temperature;77%
tert-amyl hydroperoxide
3425-61-4

tert-amyl hydroperoxide

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; iron(II) sulfate; acetic acid In water at 0℃; for 0.5h;83.3%
Acetic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester
148550-34-9

Acetic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester

A

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

B

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione
152266-85-8

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 2.5h; Heating;A 74%
B 11%
Ethyl boronic acid
4433-63-0

Ethyl boronic acid

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 48h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation;60%
propan-1-ol
71-23-8

propan-1-ol

camptothecin
7689-03-4

camptothecin

A

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

B

7(3-Hydroxy-1-propyl)camptothecin
139080-89-0

7(3-Hydroxy-1-propyl)camptothecin

C

7-(1-Hydroxy-2-propyl)camptothecin
96962-27-5

7-(1-Hydroxy-2-propyl)camptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water for 3h; Ambient temperature;A 40%
B 12%
C 22%
camptothecin
7689-03-4

camptothecin

pentan-3-one
96-22-0

pentan-3-one

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water; acetic acid for 48h; Ambient temperature;22%
propionic acid
802294-64-0

propionic acid

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water for 48h; Ambient temperature;13%
Isobutyric acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester
148550-35-0

Isobutyric acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester

A

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

B

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione
152266-85-8

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 2.5h; Heating;A 10 % Chromat.
B 16 % Chromat.
Benzoic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester
120730-50-9

Benzoic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester

A

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

B

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione
152266-85-8

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 2.5h; Heating;A 38 % Chromat.
B 36 % Chromat.
4-Methoxy-benzoic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester
120730-51-0

4-Methoxy-benzoic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester

A

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

B

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione
152266-85-8

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 2.5h; Heating;A 20 % Chromat.
B 46 % Chromat.
4-Cyano-benzoic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester

4-Cyano-benzoic acid 7-[(S)-1-(2-dimethylamino-ethylcarbamoyl)-1-hydroxy-propyl]-12-ethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-8-ylmethyl ester

A

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

B

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione
152266-85-8

(S)-2-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-2H,4H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 2.5h; Heating;A 42 % Chromat.
B 46 % Chromat.
ferrous(II) sulfate heptahydrate

ferrous(II) sulfate heptahydrate

propionaldehyde
123-38-6

propionaldehyde

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; acetic acid In water
ferrous(II) sulfate heptahydrate

ferrous(II) sulfate heptahydrate

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; propionic acid In water
propan-1-ol
71-23-8

propan-1-ol

ferrous(II) sulfate heptahydrate

ferrous(II) sulfate heptahydrate

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide In water
ferrous(II) sulfate heptahydrate

ferrous(II) sulfate heptahydrate

camptothecin
7689-03-4

camptothecin

pentan-3-one
96-22-0

pentan-3-one

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; acetic acid In water
7-ethyl-18,19-dehydrocamptothecin
955939-02-3

7-ethyl-18,19-dehydrocamptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In 1,4-dioxane; ethanol at 20℃; for 1 - 7h;
acetaldehyde
75-07-0

acetaldehyde

camptothecin
7689-03-4

camptothecin

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

Conditions
ConditionsYield
With ferrous(II) sulfate heptahydrate; sulfuric acid; dihydrogen peroxide In water at 0℃; for 8h;
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

7-ethyl-1,2,6,7-tetrahydro-20-(S)-camptothecin
797762-11-9

7-ethyl-1,2,6,7-tetrahydro-20-(S)-camptothecin

Conditions
ConditionsYield
With hydrogen; N113 In acetic acid at 110℃; under 15001.5 Torr; for 6h; Autoclave;96%
With hydrogen; dimethyl sulfoxide; platinum on carbon In acetic acid at 25 - 65℃; under 3750.38 Torr; for 43.5h;
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

C32H37N3O7

C32H37N3O7

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 20h;92%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

5-fluorouracil-1-acetic acid
56059-30-4

5-fluorouracil-1-acetic acid

C28H23FN4O7

C28H23FN4O7

Conditions
ConditionsYield
Stage #1: 5-fluorouracil-1-acetic acid With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;
Stage #2: 7-ethylcamptothecin at 0 - 20℃; Inert atmosphere;
88%
uracilacetic acid
4113-97-7

uracilacetic acid

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

C28H24N4O7

C28H24N4O7

Conditions
ConditionsYield
Stage #1: uracilacetic acid With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;
Stage #2: 7-ethylcamptothecin at 0 - 20℃; Inert atmosphere;
86.6%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

2-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid
57846-83-0

2-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid

C28H23IN4O7

C28H23IN4O7

Conditions
ConditionsYield
Stage #1: 2-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;
Stage #2: 7-ethylcamptothecin at 0 - 20℃; Inert atmosphere;
86.6%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

isopropylamine
75-31-0

isopropylamine

(S)-2-(12-Ethyl-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-N-isopropyl-butyramide

(S)-2-(12-Ethyl-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-N-isopropyl-butyramide

Conditions
ConditionsYield
for 1.5h; Heating;86%
1-carboxymethyl-5-chlorouracil
95209-81-7

1-carboxymethyl-5-chlorouracil

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

C28H23ClN4O7

C28H23ClN4O7

Conditions
ConditionsYield
Stage #1: 1-carboxymethyl-5-chlorouracil With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;
Stage #2: 7-ethylcamptothecin at 0 - 20℃; Inert atmosphere;
84%
p-nitrobenzotrifluoride
402-54-0

p-nitrobenzotrifluoride

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

7-ethylcamptothecin-20(S)-O-p-triflouoromethylbenzoate

7-ethylcamptothecin-20(S)-O-p-triflouoromethylbenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 2 - 20℃; for 2.25h;82%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

7-ethyl-10-hydroxycamptothecin
86639-52-3, 110714-48-2, 130144-34-2

7-ethyl-10-hydroxycamptothecin

Conditions
ConditionsYield
With dihydrogen peroxide; acetic anhydride; acetic acid at 50℃;80.3%
Multi-step reaction with 2 steps
1: 77.7 percent / 30percent aq. H2O2, acetic acid / 3.5 h / 70 - 80 °C
2: 49.1 percent / 1 N aq. H2SO4 / dioxane / 0.5 h / Irradiation
View Scheme
Multi-step reaction with 2 steps
1: 78 percent / 30percent H2O2 / acetic acid / 3.5 h / 70 - 80 °C
2: 49 percent / 1 N H2SO4 / dioxane / 0.5 h / Irradiation
View Scheme
Stage #1: 7-ethylcamptothecin With hydrogen; acetic acid; platinum(IV) oxide In dimethyl sulfoxide at 50 - 60℃; under 3102.97 Torr; for 10h;
Stage #2: With [bis(acetoxy)iodo]benzene In water at 20℃; for 3h;
Multi-step reaction with 2 steps
1: acetic acid; dihydrogen peroxide / 8 h / 80 °C
2: sulfuric acid; water / 1,4-dioxane; acetonitrile / Inert atmosphere; Irradiation
View Scheme
(5-bromouracil)acetic acid
31385-63-4

(5-bromouracil)acetic acid

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

C28H23BrN4O7

C28H23BrN4O7

Conditions
ConditionsYield
Stage #1: (5-bromouracil)acetic acid With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;
Stage #2: 7-ethylcamptothecin at 0 - 20℃; Inert atmosphere;
80%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

7-Ethylcamptothecin 1-Oxide
86639-51-2

7-Ethylcamptothecin 1-Oxide

Conditions
ConditionsYield
With dihydrogen peroxide In acetic acid at 70 - 80℃; for 3.5h;78%
With dihydrogen peroxide; acetic acid at 70 - 80℃; for 3.5h;77.7%
With dihydrogen peroxide; acetic acid at 80℃; for 8h;72%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

3-nitrobenzoic acid
121-92-6

3-nitrobenzoic acid

7-ethylcamptothecin-20(S)-O-m-nitrobenzoate

7-ethylcamptothecin-20(S)-O-m-nitrobenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 2 - 20℃; for 2.25h;77.1%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

N,N-dimethylethylenediamine
108-00-9

N,N-dimethylethylenediamine

(S)-N-(2-Dimethylamino-ethyl)-2-(12-ethyl-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyramide
120730-44-1

(S)-N-(2-Dimethylamino-ethyl)-2-(12-ethyl-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyramide

Conditions
ConditionsYield
at 50℃; for 1.5h;71%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

propargyl bromide
106-96-7

propargyl bromide

2-propyn-1-yl-7-ethylcamptothecin

2-propyn-1-yl-7-ethylcamptothecin

Conditions
ConditionsYield
Stage #1: 7-ethylcamptothecin With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: propargyl bromide In N,N-dimethyl-formamide Inert atmosphere; Reflux;
70%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

2-Amino-4,11-diethyl-2H,12H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

2-Amino-4,11-diethyl-2H,12H-2,6,12a-triaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With hydrazine hydrate for 2h; Heating;64%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

7-ethyl-14-nitro-camptothecin
1258494-58-4

7-ethyl-14-nitro-camptothecin

Conditions
ConditionsYield
With nitric acid; acetic anhydride at 0℃; for 1h;63.4%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

biotin
58-85-5

biotin

biotin-(20s)-7-ethylcamptothecin

biotin-(20s)-7-ethylcamptothecin

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;57%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

N-(+)-biotinyl-6-aminocaproic acid
72040-64-3

N-(+)-biotinyl-6-aminocaproic acid

6-biotinylaminocaproic acid-(20s)-7-ethylcamptothecin

6-biotinylaminocaproic acid-(20s)-7-ethylcamptothecin

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;56%
C17H20N2O4S2

C17H20N2O4S2

C28H29ClNO2(1+)*I(1-)

C28H29ClNO2(1+)*I(1-)

7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

C69H65ClN5O13S2(1+)*I(1-)

C69H65ClN5O13S2(1+)*I(1-)

Conditions
ConditionsYield
Stage #1: C17H20N2O4S2 With pyridine In tetrahydrofuran for 0.0833333h; Inert atmosphere; Cooling with ice;
Stage #2: With trichloromethyl chloroformate In tetrahydrofuran for 1h;
Stage #3: C28H29ClNO2(1+)*I(1-); 7-ethylcamptothecin With dmap; triethylamine In tetrahydrofuran at 20℃; for 12h; Inert atmosphere; Cooling with ice;
31%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

12-Ethyl-8-methyl-7-propionyl-11H-indolizino[1,2-b]quinolin-9-one
152266-83-6

12-Ethyl-8-methyl-7-propionyl-11H-indolizino[1,2-b]quinolin-9-one

Conditions
ConditionsYield
With sodium azide; 18-crown-6 ether In N,N-dimethyl-formamide at 120℃; for 4h;20%
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

(S)-2-(12-Ethyl-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyric acid hydrazide
1026285-00-6

(S)-2-(12-Ethyl-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyric acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate for 0.5h; Ambient temperature;

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