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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quan

D-Biotin

Cas:58-85-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

It conforms to USP35.We have GMP and DMF Appearance:a white crystalline powder Storage:a cool & dry place protected from light, keep drum close when not in use. Package:25kg/drum Application:used for drug substance Transportation:by sea air or expr

D-Biotin

Cas:58-85-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Best price for D-Biotin powder CAS 58-85-5

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $300.0

Type:Trading Company

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Manufacturer Supply D-Biotin (Vitamin H)

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

D-Biotin

Cas:58-85-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Superiority KONO is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in

High quality D-Biotin 99% with best price

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $620.0 / 650.0

Type:Other

inquiry

Xi'an Quanao Biotech Co., Ltd.

Building Healthy Life Professional Factory We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of content and proportion of extract according to the demand. Appearance:White fine

Fast Shipping Human supplement 99% purity Vitamin B7 / D-biotin / Vitamin H Powder

Cas:58-85-5

Min.Order:2 Kilogram

FOB Price: $77.0 / 589.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Coenzyme Q10/Ubidecarenone[CAS:303-98-0] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & dis

Manufacture D-Biotin Vitamin H stock with GMP

Cas:58-85-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at cool & dr

Shanghai Upbio Tech Co.,Ltd

1,In No Less 8 years exporting experience.clients can 1005received goods. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio specialized in APIs,

Topsale BIOTIN, D-BIOTIN, VITAMIN H 99%

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1, High quality with competitive price: 1)Standard: Enterprise Standard 2)All Purity min 99% 3)We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1)Parcel can be sent out in 24 hours afte

VH/D-Biotin

Cas:58-85-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Asure Biochem CO.,LTD.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support ★.Shortest delivery time Appearance:White powder Storage:Store in dry, cool and ventilated place Package:1kg/carto

D-biotin

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $300.0 / 400.0

Type:Trading Company

inquiry

Leader Biochemical Group

PRODUCT DETAILS

Hot Sales!!!!!!!!!+China Biggest Manufacturer supply D-BIOTIN (Vitamin B7)

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

High Purity Biotin API D-Biotin Powder CAS 58-85-5

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.5

Type:Trading Company

inquiry

Cartoon Ingredients Co., Ltd

Cartoon Ingredients Co.,Ltd.is located in NanJing, the capital of Jiangsu Province.with Convenient traffic As a manufacturer, the company mainly engaged in providing Food ingredients, Herbal extracts, Vitamins, APIs and Fine chemicals &a

D-Biotin

Cas:58-85-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Item Standard Result Appearance White or almost white crystalline powder Conform Identification

D-Biotin High purity Vitamin H CAS:58-85-5

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality biotin supplier in China

Cas:58-85-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Biotin,D-Biotin,Vitamin H CAS NO.58-85-5

Cas:58-85-5

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for D-biotin/VITAMIN H Cas 58-85-5 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:2-8°C Package:1kg/foil bag, 25kg/drum or

Wholesale factory price D-biotin/VITAMIN H Cas 58-85-5 with high quality best purity

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $85.0

Type:Trading Company

inquiry

shanghai Tauto Biotech Co., Ltd

18-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2008 quality management system Leader Supplier of Botanical Reference Materials in China

D-Biotin

Cas:58-85-5

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

Service we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to your requirem

D-Biotin / Vitamin H

Cas:58-85-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White

D-Biotin

Cas:58-85-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

EAST CHEMSOURCES LIMITED

Vitamin H Product name: Vitamin H Specifications and models: 2%,98% Relative molecular weight: 244.31 Molecular formula: C10H16N2O3S CAS#: 58-85-5 Properties: light yellow crystal powder, soluble in water, stable in neutral solution Scope o

Vitamin H

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply d-biotin

Cas:58-85-5

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Food Grade Biotin 58-85-5 HACCP Manufacturer

Cas:58-85-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

Product Name:D-Biotin Appearance:White Powder Assay: 99% Shipping method: Fedex, DHL, TNT, Sea, Air or as you wish Package: Aluminum Foil Bag Hot Market: Europe, America, Asia Usage: Food,Cosmetics,Dietary Supplements,Medicines,Pharmaceuticals

Eastling Supply Top Quality Vitamin H D-Biotin Powder D Biotin 98%

Cas:58-85-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 6.0

Type:Lab/Research institutions

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Vitamin H

Cas:58-85-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Pribolab PTE.LTD

We can offer products of different specifications Appearance:bottle Application:Determination of corresponding toxins

D-Biotin/Vitamin B7

Cas:58-85-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanxi Zorui Biotechnology Co.Ltd.

Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ

Human Supplement 99% Vitamin B7/ D-Biotin/ Vitamin H Powder CAS 58-85-5

Cas:58-85-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

GMP factoryFull experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Rich experience for

D-Biotin / Vitamin H

Cas:58-85-5

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

(2S,3S,4S)-5-(3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid

(2S,3S,4S)-5-(3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

biotin
58-85-5

biotin

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; tin(IV) chloride at 150℃; under 300.03 Torr; for 3.5h; Temperature; Pressure; Reagent/catalyst; Autoclave;97.5%
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione
28092-52-6

(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

potassium thioacetate
10387-40-3

potassium thioacetate

biotin
58-85-5

biotin

Conditions
ConditionsYield
In water at 0 - 60℃; Temperature;97%
5-((3aR,6S,6aS)-1-Benzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid

5-((3aR,6S,6aS)-1-Benzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
With hydrogenchloride; sodium dithionite; water; sodium hydroxide In water at 55 - 90℃; for 0.5h; Reagent/catalyst;95.8%
(3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid
33607-60-2

(3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid With boron tribromide In dichloromethane at -5 - 50℃; for 1.16667h; Inert atmosphere;
Stage #2: With hydrogenchloride In water Temperature; Solvent;
95%
Stage #1: (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid With water; hydrogen bromide In xylene for 20h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12;
Stage #3: With hydrogenchloride; bis(trichloromethyl) carbonate; pyrographite Product distribution / selectivity; more than 3 stages;
92%
Stage #1: (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid With water; hydrogen bromide In xylene for 20h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12;
Stage #3: With hydrogenchloride; bis(trichloromethyl) carbonate; pyrographite Product distribution / selectivity; more than 3 stages;
92%
(3aS,4S,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylpentane nitrile
31099-31-7

(3aS,4S,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylpentane nitrile

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: (3aS,4S,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylpentane nitrile With water; hydrogen bromide In xylene for 20h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12;
Stage #3: With hydrogenchloride; bis(trichloromethyl) carbonate; pyrographite Product distribution / selectivity; more than 3 stages;
95%
With water; hydrogen bromide for 10h; Reflux; Inert atmosphere;80%
Multi-step reaction with 2 steps
1: aq. HBr / toluene / 40 h / Heating
2: 22 g / aq. NaOH / toluene; methoxybenzene / 6 h / 30 °C
View Scheme
5-[(2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl]pentanoic acid hydrobromide

5-[(2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl]pentanoic acid hydrobromide

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

biotin
58-85-5

biotin

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 10h; pH=9-11;93%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

5-[(2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl]pentanoic acid hydrobromide

5-[(2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl]pentanoic acid hydrobromide

biotin
58-85-5

biotin

Conditions
ConditionsYield
With potassium hydroxide at 20℃; for 10h; pH=9-11; Reagent/catalyst;92%
(2S,3S,4S)-5-(3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid

(2S,3S,4S)-5-(3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid

Diethyl carbonate
105-58-8

Diethyl carbonate

biotin
58-85-5

biotin

Conditions
ConditionsYield
With methanetrisulfonic acid at 170℃; under 3000.3 - 4500.45 Torr; Reagent/catalyst; Pressure; Temperature; Autoclave;91.67%
(3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid ethyl ester
292151-19-0

(3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid ethyl ester

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid ethyl ester With water; hydrogen bromide In xylene for 20h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12;
Stage #3: With hydrogenchloride; bis(trichloromethyl) carbonate; pyrographite Product distribution / selectivity; more than 3 stages;
90%
With sulfuric acid; water; acetic acid at 20 - 80℃;82%
With methanesulfonic acid In 1,3,5-trimethyl-benzene74%
Stage #1: (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid ethyl ester With hydrogen bromide for 48h; Substitution; Heating;
Stage #2: With sodium hydroxide; chloroformic acid ethyl ester Substitution;
Stage #3: With hydrogenchloride Hydrolysis;
benzyl (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
179532-60-6

benzyl (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: benzyl (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate With water; hydrogen bromide In xylene for 24h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12;
Stage #3: With hydrogenchloride; trichloromethyl chloroformate; pyrographite Product distribution / selectivity; more than 3 stages;
90%
Stage #1: benzyl (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanoate With water; hydrogen bromide In xylene for 20h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12;
Stage #3: With hydrogenchloride; trichloromethyl chloroformate; pyrographite Product distribution / selectivity; more than 3 stages;
90%
C19H24N2O3S

C19H24N2O3S

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: C19H24N2O3S With palladium on activated charcoal; hydrogen In ethanol at 80 - 85℃; under 11400.8 - 15201 Torr; for 15h;
Stage #2: With sodium hydroxide In water at 25 - 30℃; for 5h; Solvent;
86.9%
<3aS-(3aα,4β,6aα)>-Hexahydro-2-oxo-3-(phenylmethyl)-1H-thieno<3,4-d>imidazole-4-pentanoic acid methyl ester
83541-80-4

<3aS-(3aα,4β,6aα)>-Hexahydro-2-oxo-3-(phenylmethyl)-1H-thieno<3,4-d>imidazole-4-pentanoic acid methyl ester

biotin
58-85-5

biotin

Conditions
ConditionsYield
With hydrogen bromide85%
With hydrogen bromide85%
<3aS-(3aα,4β,6aα)>-Hexahydro-2-oxo-1-(phenylmethyl)-1H-thieno<3,4-d>imidazole-4-pentanoic acid methyl ester
151526-81-7

<3aS-(3aα,4β,6aα)>-Hexahydro-2-oxo-1-(phenylmethyl)-1H-thieno<3,4-d>imidazole-4-pentanoic acid methyl ester

biotin
58-85-5

biotin

Conditions
ConditionsYield
With hydrogen bromide for 2h; Heating;85%
With hydrogen bromide for 2h; Heating;85%
Multi-step reaction with 2 steps
1.1: water; NaOH / methanol / 3 h / 40 °C
2.1: MeSO3H / xylene / 3 h / 135 °C
2.2: 3.06 g / water / 1 h / 10 °C
View Scheme
(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid
324012-42-2

(3aS,6aR)-1,3-Dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylidenepentanoic acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
With formic acid; methanesulfonic acid; palladium on activated charcoal for 15h; Catalytic hydrogenation; Debenzylation; Heating;85%
Multi-step reaction with 2 steps
1: H2 / 10percent Pd/C / propan-2-ol / 18 h / 50 °C / 7500.6 Torr
2: 48percent HBr / 2 h / 100 °C
View Scheme
ethyl 5-iodopentanoate

ethyl 5-iodopentanoate

(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione
28092-52-6

(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: ethyl 5-iodopentanoate With bromine; zinc In tetrahydrofuran; toluene at 40℃; for 1h;
Stage #2: (3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione With palladium 10% on activated carbon In tetrahydrofuran; N,N-dimethyl-formamide; toluene at 28 - 40℃; for 5h; Further stages;
85%
(1-naphthyl)CH2CONH(CH2)2OPO2O-5\-d(GCGAGAAGTTAAGACCTATGCTCGC)-3\-O(CH2)3S-(4-succinimide-1)-(CH2)2O-(p-C6H4)COCH2(biotinate)

(1-naphthyl)CH2CONH(CH2)2OPO2O-5\-d(GCGAGAAGTTAAGACCTATGCTCGC)-3\-O(CH2)3S-(4-succinimide-1)-(CH2)2O-(p-C6H4)COCH2(biotinate)

biotin
58-85-5

biotin

Conditions
ConditionsYield
With 5'-d(CATAGGTCTTAACTT)-3'; sodium cacodylate In water; isopropyl alcohol at 20℃; pH=7.0; UV-irradiation;84%
N,N'-p-methoxybenzylbiotin
1245507-48-5

N,N'-p-methoxybenzylbiotin

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: N,N'-p-methoxybenzylbiotin With hydrogen bromide In toluene for 36h; Reflux;
Stage #2: With bis(trichloromethyl) carbonate; methoxybenzene In water for 2h; pH=10;
83%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(2S,3S,4S)-5-(3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid

(2S,3S,4S)-5-(3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at -10 - -5℃;82.38%

biotin
58-85-5

biotin

Conditions
ConditionsYield
Stage #1: N,N'-dibenzylbiotin methyl ester With hydrogen bromide for 5h; Heating;
Stage #2: With sulfuric acid In methanol for 2h; Heating;
78%
With hydrogen bromide for 5h; Heating;0.041 g
phosgene
75-44-5

phosgene

(2S,3S,4R-3,4-diaminotetrahydrothiophen-2-yl)-pentanoate sodium

(2S,3S,4R-3,4-diaminotetrahydrothiophen-2-yl)-pentanoate sodium

biotin
58-85-5

biotin

Conditions
ConditionsYield
With sodium hydroxide In water; 1,2-dichloro-ethane at 70 - 80℃; for 4h; pH=10 - 12;75.8%
hept-6-ynoic acid
30964-00-2

hept-6-ynoic acid

amine-biotin

amine-biotin

isobutyl chloroformate
543-27-1

isobutyl chloroformate

A

alk-biotin

alk-biotin

B

biotin
58-85-5

biotin

Conditions
ConditionsYield
With 4-methyl-morpholine In dichloromethane; N,N-dimethyl-formamideA n/a
B 62%
phosgene
75-44-5

phosgene

(2S,3S,4R)-cis-5-(3,4-diaminotetrahydro-2-thienyl)valeric acid
22342-46-7

(2S,3S,4R)-cis-5-(3,4-diaminotetrahydro-2-thienyl)valeric acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
With MANDELIC ACID
With (9S)-9-hydroxy-6'-methoxy-1-methyl-cinchonanium hydroxide
With L-arginine
5-[(3aS)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid
76335-62-1

5-[(3aS)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
With ammonia; sodium; xylene
Stage #1: 5-[(3aS)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid With methanesulfonic acid In xylene at 135℃; for 3h;
Stage #2: With water at 10℃; for 1h; Further stages.;
3.06 g
With ammonia; sodium; xylene
phosgene
75-44-5

phosgene

5-[3,4-bis-(2,2,2-trifluoro-acetylamino)-2,5-dihydro-thiophen-2-yl]-pentanoic acid methyl ester
64820-06-0

5-[3,4-bis-(2,2,2-trifluoro-acetylamino)-2,5-dihydro-thiophen-2-yl]-pentanoic acid methyl ester

biotin
58-85-5

biotin

Conditions
ConditionsYield
(i) H2, Pd/C, (ii) K2CO3, H2O, (iii) /BRN= 1098367/; Multistep reaction;
[3-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-propyl]-malonic acid
57671-79-1

[3-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-propyl]-malonic acid

biotin
58-85-5

biotin

Conditions
ConditionsYield
With sodium hydroxide at 180℃; for 0.5h;
5-((3aS)-1,3-diacetyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-pentanoic acid methyl ester
66244-06-2

5-((3aS)-1,3-diacetyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-pentanoic acid methyl ester

biotin
58-85-5

biotin

Conditions
ConditionsYield
With sodium hydroxide In methanol; water
Sodium; 5-((3aR,6S,6aS)-1-benzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoate

Sodium; 5-((3aR,6S,6aS)-1-benzyl-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoate

biotin
58-85-5

biotin

Conditions
ConditionsYield
With hydrogen bromide for 2h; Heating;
methanol
67-56-1

methanol

biotin
58-85-5

biotin

biotin methyl ester

biotin methyl ester

Conditions
ConditionsYield
With hydrogenchloride for 15h;100%
With sulfuric acid100%
Stage #1: methanol With acetyl chloride at 0℃; for 0.166667h;
Stage #2: biotin for 1h; Reflux;
100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

biotin
58-85-5

biotin

biotin N-Hydroxysuccinimide ester
35013-72-0

biotin N-Hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;98%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;95%
ethanol
64-17-5

ethanol

biotin
58-85-5

biotin

5-[(3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl]-pentanoic acid ethyl ester
87573-52-2

5-[(3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl]-pentanoic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid100%
With sulfuric acid at 20℃;97%
With hydrogenchloride at 0 - 20℃; for 24h;91%
methyl 10-aminodecanoate hydrochloride
106590-42-5

methyl 10-aminodecanoate hydrochloride

biotin
58-85-5

biotin

10-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-decanoic acid methyl ester

10-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-decanoic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide100%
glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

biotin
58-85-5

biotin

[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-acetic acid methyl ester

[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-acetic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide100%
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate
153086-78-3

tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

biotin
58-85-5

biotin

tert-butyl-N-(2-(2-(2-(5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno(3,4-d)imidazol-6-yl)pentanoylamino)ethoxy)ethoxy)ethyl)carbamate
175885-18-4

tert-butyl-N-(2-(2-(2-(5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno(3,4-d)imidazol-6-yl)pentanoylamino)ethoxy)ethoxy)ethyl)carbamate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 17.5h; Inert atmosphere;100%
Stage #1: biotin With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate In dichloromethane at 20℃; for 16h;
96%
C2HF3O2*C6H14N4O2
929537-66-6

C2HF3O2*C6H14N4O2

biotin
58-85-5

biotin

N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
945633-30-7

N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Conditions
ConditionsYield
With 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide100%
C8H17NO5

C8H17NO5

biotin
58-85-5

biotin

C19H33N3O7S
1123762-87-7

C19H33N3O7S

Conditions
ConditionsYield
With 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide100%
1-(benzylthio)-3-(tert-butyldiphenylsilyloxy)propan-2-amine
1278996-71-6

1-(benzylthio)-3-(tert-butyldiphenylsilyloxy)propan-2-amine

biotin
58-85-5

biotin

1-(benzylthio)-3-(tert-butyldiphenylsilyloxy)propan-2-biotinylamide
1278996-72-7

1-(benzylthio)-3-(tert-butyldiphenylsilyloxy)propan-2-biotinylamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h;100%
N,N-dimethylethylenediamine

N,N-dimethylethylenediamine

biotin
58-85-5

biotin

2-N-biotinyl-N,N-dimethylethan-1,2-diamine
1338832-53-3

2-N-biotinyl-N,N-dimethylethan-1,2-diamine

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 24h;100%

biotin
58-85-5

biotin

C41H56N4O7S

C41H56N4O7S

Conditions
ConditionsYield
Stage #1: biotin With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 40℃; for 0.5h; Inert atmosphere;
Stage #2: 3-{2-[2-(3-{[Bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-propoxy)-ethoxy]-ethoxy}-propylamine With triethylamine In N,N-dimethyl-formamide Inert atmosphere;
100%
N-(4-(4-(4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)piperidin-1-yl)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

N-(4-(4-(4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)piperidin-1-yl)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

biotin
58-85-5

biotin

N-(4-(2,6-dimethyl-4-(4-((13-oxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)piperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide

N-(4-(2,6-dimethyl-4-(4-((13-oxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecyl)oxy)piperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃;100%
N-(3-aminopropyl)-N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxybenzenesulfonamide hydrochloride

N-(3-aminopropyl)-N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxybenzenesulfonamide hydrochloride

biotin
58-85-5

biotin

N-(3-((N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxyphenyl)sulfonamido)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

N-(3-((N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxyphenyl)sulfonamido)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide100%
3-butene-1-amine
2524-49-4

3-butene-1-amine

biotin
58-85-5

biotin

C14H23N3O2S

C14H23N3O2S

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 24h; Inert atmosphere;100%
N-(3-aminopropyl)-N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxybenzenesulfonamide hydrochloride

N-(3-aminopropyl)-N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxybenzenesulfonamide hydrochloride

biotin
58-85-5

biotin

N-(3-((N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxyphenyl)sulfonamido)propyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

N-(3-((N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxyphenyl)sulfonamido)propyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide100%
1,6-Hexanediamine
124-09-4

1,6-Hexanediamine

biotin
58-85-5

biotin

N-(6-aminohexyl)-5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d] imidazol-4-yl)pentanamide
65953-56-2

N-(6-aminohexyl)-5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d] imidazol-4-yl)pentanamide

Conditions
ConditionsYield
Stage #1: biotin With di(succinimido) carbonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 6h; Inert atmosphere;
Stage #2: 1,6-Hexanediamine In N,N-dimethyl-formamide Inert atmosphere;
99%
C29H37N5O4
1071926-11-8

C29H37N5O4

biotin
58-85-5

biotin

C39H51N7O6S
1071926-14-1

C39H51N7O6S

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h;99%
8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine

8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine

biotin
58-85-5

biotin

C28H35IN8O4S2
1418215-37-8

C28H35IN8O4S2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 9h; Sonication; Inert atmosphere;99%
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 9h; Sonication;99%
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 9h; Sonication;99%
ethylenediamine
107-15-3

ethylenediamine

biotin
58-85-5

biotin

N-(2-aminoethyl)-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide

N-(2-aminoethyl)-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide

Conditions
ConditionsYield
Stage #1: biotin With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 48 - 63℃; for 0.583333 - 0.666667h;
Stage #2: ethylenediamine In N,N-dimethyl-formamide for 72h;
99%
2,3,4,5,6-pentafluorophenol
771-61-9

2,3,4,5,6-pentafluorophenol

biotin
58-85-5

biotin

biotin pentafluorophenyl ester
120550-35-8

biotin pentafluorophenyl ester

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide 0-5 deg C, 2.5 h; room temperature, 16 h;98%
With pyridine; dicyclohexyl-carbodiimide at 20 - 50℃;95%
With pyridine; 2`,3`-dideoxycytidine at 20℃; for 24h;93%
octanol
111-87-5

octanol

biotin
58-85-5

biotin

biotin octan-1-ol ester

biotin octan-1-ol ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 48h; Heating;98%
2-[2-(2-azidoethoxy)ethoxy]ethanol
86520-52-7

2-[2-(2-azidoethoxy)ethoxy]ethanol

biotin
58-85-5

biotin

C16H27N5O5S
1085938-08-4

C16H27N5O5S

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;98%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere;65%
acetyl chloride
75-36-5

acetyl chloride

biotin
58-85-5

biotin

biotin methyl ester
608-16-2

biotin methyl ester

Conditions
ConditionsYield
Stage #1: acetyl chloride In methanol at 0℃; for 0.25h;
Stage #2: biotin In methanol at 20℃; for 0.5h;
98%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-Trp-OH
35737-15-6

Fmoc-Trp-OH

Fmoc-Lys-OH
105047-45-8

Fmoc-Lys-OH

Fmoc-D-Phe-OH
86123-10-6

Fmoc-D-Phe-OH

(9-fluorenylmethoxycarbonyl)-L-histidine
116611-64-4

(9-fluorenylmethoxycarbonyl)-L-histidine

biotin
58-85-5

biotin

C56H70N14O8S

C56H70N14O8S

Conditions
ConditionsYield
Stage #1: Fmoc-Lys-OH With dmap; diisopropyl-carbodiimide In N,N-dimethyl-formamide for 4h;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.166667h;
Stage #3: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Trp-OH; Fmoc-D-Phe-OH; (9-fluorenylmethoxycarbonyl)-L-histidine; biotin Further stages;
98%
N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2,4-dinitroaniline
929521-54-0

N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2,4-dinitroaniline

biotin
58-85-5

biotin

C22H32N6O8S

C22H32N6O8S

Conditions
ConditionsYield
Stage #1: biotin With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide
Stage #2: N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2,4-dinitroaniline In N,N-dimethyl-formamide for 0.166667h;
98%
4-azidoaniline
14860-64-1

4-azidoaniline

biotin
58-85-5

biotin

N-(4-azidophenyl)biotinamide

N-(4-azidophenyl)biotinamide

Conditions
ConditionsYield
Stage #1: biotin With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; Inert atmosphere;
Stage #2: 4-azidoaniline In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Inert atmosphere;
98%
bis(pentafluorophenyl)carbonate
59483-84-0

bis(pentafluorophenyl)carbonate

biotin
58-85-5

biotin

biotin pentafluorophenyl ester
120550-35-8

biotin pentafluorophenyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide for 2h;97%
biotin
58-85-5

biotin

5-((3aS,4S,6aR)-5-oxido-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
23015-53-4

5-((3aS,4S,6aR)-5-oxido-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid

Conditions
ConditionsYield
With sodium peroxoborate tetrahydrate; acetic acid at 20℃; for 1.33333h;97%
With dihydrogen peroxide In acetic acid for 12h; Ambient temperature;
di-tert-butyl 4-<2-(tert-butoxycarbonyl)ethyl>-4-nitroheptanedicarboxylate
136587-00-3

di-tert-butyl 4-<2-(tert-butoxycarbonyl)ethyl>-4-nitroheptanedicarboxylate

biotin
58-85-5

biotin

Biotinamidotris[2-(tert-butoxycarbonyl)ethyl]methane
353737-53-8

Biotinamidotris[2-(tert-butoxycarbonyl)ethyl]methane

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 13h;97%
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