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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-(4-Fluorophenyl)thiophene Manufacturer/High quality/Best price/In stock

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications 2-(4-Fluorophenyl)thiophene CAS:58861-48-6

Cas:58861-48-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

58861-48-6 2-(4-FLUOROPHENYL)THIOPHENE

Cas:58861-48-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-(4-fluorophenyl)thiophene

Cas:58861-48-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 58861-48-6 2-(4-Fluorophenyl)thiophene Manufacturer

Cas:58861-48-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

2-(4-fluorophenyl)thiophene

Cas:58861-48-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-(4-FLUOROPHENYL)THIOPHEN

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(4-Fluorophenyl)-thiophene

Cas:58861-48-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

2-(4-FLUOROPHENYL)THIOPHENE

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $0.8 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-(4-Fluorophenyl)-thiophene

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

2-(4-FLUOROPHENYL)THIOPHENE Basic information Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business re

best offer 2-(4-FLUOROPHENYL)THIOPHENE

Cas:58861-48-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 58861-48-6 with best quality

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

cheap price Intermediate 2-(4-Fluorophenyl)thiophene CAS 58861-48-6

Cas:58861-48-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name 2-(4-FLUOROPHENYL)THIOPHENE English synonyms: 2-(4-FLUOROPHENYL)THIOPHENE CAS: 58861-48-6 Molecular formula: C10H7FS Molecular weig

2-(4-Fluorophenyl)thiophene

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

Thiophene, 2-(4-fluorophenyl)-CAS NO.:58861-48-6

Cas:58861-48-6

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

2-(4-Fluorophenyl)thiophene(C10H7FS) CAS 58861-48-6

Cas:58861-48-6

Min.Order:100 Gram

Negotiable

Type:Other

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Hangzhou Think Chemical Co. Ltd

2-(4-Fluorophenyl)thiophene CAS NO.;58861-48-6 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing &a

High purity 2-(4-Fluorophenyl)thiophene CAS NO.;58861-48-6 supplier from china

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Thiophene,2-(4-fluorophenyl)- 58861-48-6

Cas:58861-48-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2-(4-FLUOROPHENYL)THIOPHENE CAS: 58861-48-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

2-(4-FLUOROPHENYL)THIOPHENE CAS: 58861-48-6

Cas:58861-48-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Thiophene,2-(4-fluorophenyl)-

Cas:58861-48-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

2-(4-Fluorophenyl)thiophene cas:58861-48-6

Cas:58861-48-6

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

2-(4-FLUOROPHENYL)THIOPHENE

Cas:58861-48-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2-(4-Fluorophenyl)thiophene

Cas:58861-48-6

Min.Order:1 Gram

FOB Price: $88.0

Type:Trading Company

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

2-(4-Fluorophenyl)thiophene

Cas:58861-48-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:58861-48-6

58861-48-6

Cas:58861-48-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-(4-Fluorophenyl)thiophene

Cas:58861-48-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6

Cas:58861-48-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,4,5-TriMethoxy-N-propionylbenzaMide

Cas:58861-48-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-(4-FLUOROPHENYL)THIOPHENE

Cas:58861-48-6

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-(4-FLUOROPHENYL)THIOPHENE/High quality/Best price

Cas:58861-48-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Synthetic route

2-bromothiophene
1003-09-4

2-bromothiophene

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Suzuki cross-coupling reaction;95%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 15h; Inert atmosphere;85%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 25 - 75℃; Inert atmosphere;82.5%
2-bromothiophene
1003-09-4

2-bromothiophene

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Stage #1: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 2℃; for 0.666667h;
Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 10 - 23℃; for 1.66667h;
Stage #3: With acetic acid In tetrahydrofuran; water at 7℃; for 0.75h;
95%
Stage #1: 2-bromothiophene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In tetrahydrofuran at 50℃; for 0.0833333h; Inert atmosphere;
Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 60℃; for 7h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 30℃; Cooling with ice;
2-Iodothiophene
3437-95-4

2-Iodothiophene

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 100℃; under 2585.81 Torr; for 0.333333h; Suzuki reaction; Microwave irradiation;94%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 100℃; for 0.5h; Microwave irradiation;86.1%
With potassium carbonate; Pd-N-heterocyclic carbene-organic silica In water; N,N-dimethyl-formamide at 100℃; for 0.16h; Suzuki reaction; microwave irradiation;91 % Chromat.
thiophene boronic acid
6165-68-0

thiophene boronic acid

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In ethanol; water at 90℃; Inert atmosphere;92%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In toluene at 90℃; for 0.5h; Schlenk technique; Inert atmosphere;92%
With C33H48Cl2N4O9Pd; oxygen; potassium carbonate In water at 80℃; Suzuki-Miyaura Coupling;85%
Stage #1: thiophene boronic acid; 1-Bromo-4-fluorobenzene With sodium carbonate In water; N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; for 3.03333h; Inert atmosphere;
82%
2-bromothiophene
1003-09-4

2-bromothiophene

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Stage #1: 1-Bromo-4-fluorobenzene With iodine; magnesium In tetrahydrofuran at 36 - 40℃; for 4h; Inert atmosphere;
Stage #2: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20 - 25℃; for 5h; Temperature; Solvent; Inert atmosphere;
91.3%
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; Inert atmosphere;
Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Inert atmosphere;
Stage #3: With sulfuric acid In tetrahydrofuran; water at 40 - 60℃; pH=2.2; Reagent/catalyst;
87.6%
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; for 2h; Inert atmosphere; Sealed tube;
Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Kumada Cross-Coupling; Inert atmosphere;
Stage #3: With water at 40 - 60℃; Reagent/catalyst;
87.6%
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran; ethylene dibromide for 1.5h; Inert atmosphere;
Stage #2: 2-bromothiophene With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 10 - 75℃; for 0.5h;
75%
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In 2-Me-THF Reflux; Inert atmosphere;
Stage #2: 2-bromothiophene; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In 2-Me-THF at 2 - 22℃; Inert atmosphere;
Stage #3: With acetic acid In 2-Me-THF; water for 0.25h; Inert atmosphere;
2-thienyl chloride
96-43-5

2-thienyl chloride

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With potassium phosphate tribasic trihydrate; C31H41P; palladium diacetate In tetrahydrofuran at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere;91%
With C27H39Br2N3Pd; potassium hydroxide In isopropyl alcohol at 82℃; for 0.166667h; Suzuki-Miyaura Coupling;87%
1-ethoxythiocarbonylsulfanyl-4-(4-fluorophenyl)-4-oxobutyl 2,2-dimethylpropionate
517867-11-7

1-ethoxythiocarbonylsulfanyl-4-(4-fluorophenyl)-4-oxobutyl 2,2-dimethylpropionate

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With acetic acid; potassium iodide at 110℃; for 0.0833333h; Microwave irradiation;88%
Multi-step reaction with 2 steps
1: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere
2: silica gel / neat (no solvent) / 215 °C / Inert atmosphere
View Scheme
4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

triethyl(thiophen-2-yl)germane

triethyl(thiophen-2-yl)germane

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); silver tetrafluoroborate In N,N-dimethyl-formamide at 80℃; for 16h; chemoselective reaction;88%
2-bromothiophene
1003-09-4

2-bromothiophene

2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
214360-58-4

2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 70 - 75℃;87%
thiophene boronic acid
6165-68-0

thiophene boronic acid

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere;86%
With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere;86%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; for 3h;86%
4-(4-fluorophenyl)-4-oxopropionic acid
366-77-8

4-(4-fluorophenyl)-4-oxopropionic acid

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With tetraphosphorus decasulfide In toluene for 0.5h; Microwave irradiation;85%
5-(4-fluorophenyl)thiophene-2-carboxaldehyde
249504-38-9

5-(4-fluorophenyl)thiophene-2-carboxaldehyde

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With Pd-γ-Fe2O3 In cyclohexane at 130℃; for 24h; Inert atmosphere; Molecular sieve; Sealed tube;83%
C10H8BrF

C10H8BrF

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With potassium sulfide; iodine In N,N-dimethyl-formamide at 110℃; for 11.8h; Inert atmosphere; chemoselective reaction;76%
C26H37FOS

C26H37FOS

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Stage #1: C26H37FOS With hydrazine hydrate In dimethyl sulfoxide at 80℃;
Stage #2: With potassium hydroxide In dimethyl sulfoxide at 200℃; for 4h;
74.9%
thiophene boronic acid
6165-68-0

thiophene boronic acid

C10H12FS(1+)*F6P(1-)

C10H12FS(1+)*F6P(1-)

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In ethanol at 40℃; for 3h;74%
thiophene
188290-36-0

thiophene

4-fluoroaniline
371-40-4

4-fluoroaniline

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With tert.-butylnitrite In acetonitrile at 25℃; for 0.75h; Flow reactor; Irradiation;74%
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 1h; Green chemistry;
Stage #2: thiophene With 3,4,5-trihydroxybenzoic acid In water; acetone at 20℃; for 12h; Inert atmosphere; Green chemistry;
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 0.666667h;
Stage #2: thiophene In ethanol at 25℃; for 1h; Irradiation; Inert atmosphere;
80 %Chromat.
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water; acetone for 1h; Cooling;
Stage #2: thiophene With 1,2,3,4-tetrahydrocarbazole In dimethyl sulfoxide Inert atmosphere; Darkness; regioselective reaction;
(Z)-1-(4-bromobut-3-en-1-yn-1-yl)-4-fluorobenzene

(Z)-1-(4-bromobut-3-en-1-yn-1-yl)-4-fluorobenzene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With potassium ethyl xanthogenate; tetrabutyl phosphonium bromide In water at 130℃; for 20h; Schlenk technique; chemoselective reaction;73%
2-bromothiophene
1003-09-4

2-bromothiophene

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

A

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

B

4,4'-difluorobiphenyl
398-23-2

4,4'-difluorobiphenyl

C

2,2'-Bithiophene
492-97-7

2,2'-Bithiophene

Conditions
ConditionsYield
Stage #1: 4-flourophenylmagnesium bromide With bismuth(III) chloride
Stage #2: 2-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 90℃; for 1h; Inert atmosphere;
A 72%
B n/a
C n/a
5-(4-fluorophenyl)thiophene-2-carboxylic acid
115933-30-7

5-(4-fluorophenyl)thiophene-2-carboxylic acid

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With copper In sulfolane at 200℃; for 2h;72%
phenyl 5-(4-fluorophenyl)thiophene-2-carboxylate

phenyl 5-(4-fluorophenyl)thiophene-2-carboxylate

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;71%
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h;71%
2-bromothiophene
1003-09-4

2-bromothiophene

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Stage #1: 2-bromothiophene With magnesium; ethylene dibromide In tetrahydrofuran at 20℃; for 0.75h; Kumada Cross-Coupling; Inert atmosphere;
Stage #2: 4-fluoro-1-iodobenzene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20℃; Inert atmosphere; Reflux;
70%
4-[3-(4-fluorophenyl)-3-oxopropyl][1,3]dithietan-2-one
1509927-78-9

4-[3-(4-fluorophenyl)-3-oxopropyl][1,3]dithietan-2-one

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With silica gel In neat (no solvent) at 215℃; Inert atmosphere;70%
thiophene
188290-36-0

thiophene

4-fluorobenzenediazonium tetrafluoroborate
459-45-0

4-fluorobenzenediazonium tetrafluoroborate

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With cymantrene In dimethyl sulfoxide at 25℃; for 0.5h; Inert atmosphere; Irradiation; Flow reactor; regioselective reaction;59%
With epi-Cercosporin In dimethyl sulfoxide at 20℃; for 8h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry; regioselective reaction;57%
With graphitic carbon nitride/reduced graphene oxide nanocomposite In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; UV-irradiation; Green chemistry;60 %Chromat.
thiophene
188290-36-0

thiophene

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; catacxium A; Trimethylacetic acid In N,N-dimethyl-formamide at 110℃; for 12h; Schlenk technique; Inert atmosphere;58%
potassim 4-fluorophenyltrifluoroborate

potassim 4-fluorophenyltrifluoroborate

2-(n-butyltellanyl)thiophene
403617-22-1

2-(n-butyltellanyl)thiophene

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; silver(l) oxide In methanol at 20℃; for 1.5h; Suzuki-Miyaura cross- coupling; Inert atmosphere;56%
thiophen-2-yl magnesium bromide
5713-61-1

thiophen-2-yl magnesium bromide

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Stage #1: thiophen-2-yl magnesium bromide; 4-flourophenylmagnesium bromide With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -10℃; Inert atmosphere;
Stage #2: With oxygen In tetrahydrofuran at 10 - 20℃;
51%
thiophene
188290-36-0

thiophene

triethyl(4-fluorophenyl)germane

triethyl(4-fluorophenyl)germane

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid In 1,4-dioxane at 70℃; for 16h;48%
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2.) NH4PF6 / 1.) MTBE, 23 deg C, 2.) acetone, 23 deg C
2: 74 percent / Pd(dppf)Cl2, K2CO3*H2O / aq. ethanol / 3 h / 40 °C
View Scheme
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C20H15NO

C20H15NO

C30H20FNOS

C30H20FNOS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 48h; Inert atmosphere; Schlenk technique; enantioselective reaction;99%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

1-(naphthalene-1-yl)benzo[h]isoquinoline

1-(naphthalene-1-yl)benzo[h]isoquinoline

C33H20FNS

C33H20FNS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;98%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C23H14FN

C23H14FN

C33H19F2NS

C33H19F2NS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;97%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

2-bromo-5-(4-fluorophenyl)thiophene
1073313-97-9

2-bromo-5-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With N-Bromosuccinimide In dichloromethane95.3%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst;
93.2%
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;
89%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere;
80.4%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;
80%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C8H7ClO2

C8H7ClO2

(2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone

(2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at -20 - 20℃; for 3h; Inert atmosphere;92%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C24H17N

C24H17N

C34H22FNS

C34H22FNS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;92%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-bromo-2-methylbenzoyl chloride
21900-41-4

5-bromo-2-methylbenzoyl chloride

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at -10 - 25℃; for 5.5h; Friedel-Crafts Acylation; Inert atmosphere;90.1%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation;85.7%
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 2.5 - 3.5h;
Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at -12℃;
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃;
Stage #2: With water In tetrahydrofuran cooling with ice;
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

carbon dioxide
124-38-9

carbon dioxide

5-(4-fluorophenyl)thiophene-2-carboxylic acid
115933-30-7

5-(4-fluorophenyl)thiophene-2-carboxylic acid

Conditions
ConditionsYield
With ethylaluminum dichloride In hexane; toluene at 100℃; under 22502.3 Torr; for 3h; Autoclave; Inert atmosphere; regioselective reaction;90%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C8H6BrClO2

C8H6BrClO2

C18H12BrFOS

C18H12BrFOS

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at -20 - 20℃; for 3h; Inert atmosphere;90%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C24H17NO

C24H17NO

C34H22FNOS

C34H22FNOS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;90%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

C25H17N

C25H17N

C35H22FNS

C35H22FNS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;90%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

5-(4-fluorophenyl)thiophene-2-carboxaldehyde
249504-38-9

5-(4-fluorophenyl)thiophene-2-carboxaldehyde

Conditions
ConditionsYield
Stage #1: 2-(4-fluorophenyl)thiophene; N,N-dimethyl-formamide With tris(trimethylsilyl)amine; tetramethylammonium fluoride at 20℃; for 24h; Inert atmosphere; Sealed tube;
Stage #2: With hydrogenchloride In water at 20℃; for 1.5h;
86%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

1-(pyren-1-yl)benzo[h]isoquinoline

1-(pyren-1-yl)benzo[h]isoquinoline

C39H22FNS

C39H22FNS

Conditions
ConditionsYield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;86%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(thiophen-2-yl)ethan-1-ol
1150561-00-4

2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(thiophen-2-yl)ethan-1-ol

3-(2,2,2-trifluoro-1-(5-(4-fluorophenyl)thiophen-2-yl)-1-(thiophen-2-yl)ethyl)-1H-indole

3-(2,2,2-trifluoro-1-(5-(4-fluorophenyl)thiophen-2-yl)-1-(thiophen-2-yl)ethyl)-1H-indole

Conditions
ConditionsYield
With dodecylbenzenesulfonic acid In water at 80℃; for 24h; Green chemistry;83%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-iodo-2-methylbenzoic acid
54811-38-0

5-iodo-2-methylbenzoic acid

(5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanone

(5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanone

Conditions
ConditionsYield
Stage #1: 5-iodo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;
81%
Stage #1: 5-iodo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide for 1h; Reflux;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 30℃; for 1h;
222 g
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-iodo-2-methylbenzoyl chloride
108440-70-6

5-iodo-2-methylbenzoyl chloride

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
898566-17-1

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

Conditions
ConditionsYield
With aluminum (III) chloride Solvent; Temperature; Friedel-Crafts Acylation;80%
Stage #1: 5-iodo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 2℃; for 0.25h;
Stage #2: 2-(4-fluorophenyl)thiophene In dichloromethane at 2 - 20℃; for 2.41667h; Product distribution / selectivity;
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

phenylboronic acid
98-80-6

phenylboronic acid

2-(4-fluorophenyl)-4-phenylthiophene
1415605-87-6

2-(4-fluorophenyl)-4-phenylthiophene

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; cesium trifluoroacetate; p-benzoquinone; silver(l) oxide In acetic acid; trifluoroacetic acid at 20℃; for 15h; regioselective reaction;80%

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