Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiry2-(4-FLUOROPHENYL)THIOPHENE Basic information Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business re
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryProduct name 2-(4-FLUOROPHENYL)THIOPHENE English synonyms: 2-(4-FLUOROPHENYL)THIOPHENE CAS: 58861-48-6 Molecular formula: C10H7FS Molecular weig
1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla
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inquiry2-(4-Fluorophenyl)thiophene CAS NO.;58861-48-6 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing &a
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inquiry2-(4-FLUOROPHENYL)THIOPHENE CAS: 58861-48-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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Cas:58861-48-6
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
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inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
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Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Cas:58861-48-6
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inquiryConditions | Yield |
---|---|
With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Suzuki cross-coupling reaction; | 95% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 15h; Inert atmosphere; | 85% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 25 - 75℃; Inert atmosphere; | 82.5% |
2-bromothiophene
4-flourophenylmagnesium bromide
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
Stage #1: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 2℃; for 0.666667h; Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 10 - 23℃; for 1.66667h; Stage #3: With acetic acid In tetrahydrofuran; water at 7℃; for 0.75h; | 95% |
Stage #1: 2-bromothiophene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In tetrahydrofuran at 50℃; for 0.0833333h; Inert atmosphere; Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 60℃; for 7h; Stage #3: With hydrogenchloride In tetrahydrofuran; water at 30℃; Cooling with ice; |
Conditions | Yield |
---|---|
With potassium carbonate In water; N,N-dimethyl-formamide at 100℃; under 2585.81 Torr; for 0.333333h; Suzuki reaction; Microwave irradiation; | 94% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 100℃; for 0.5h; Microwave irradiation; | 86.1% |
With potassium carbonate; Pd-N-heterocyclic carbene-organic silica In water; N,N-dimethyl-formamide at 100℃; for 0.16h; Suzuki reaction; microwave irradiation; | 91 % Chromat. |
thiophene boronic acid
1-Bromo-4-fluorobenzene
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In ethanol; water at 90℃; Inert atmosphere; | 92% |
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In toluene at 90℃; for 0.5h; Schlenk technique; Inert atmosphere; | 92% |
With C33H48Cl2N4O9Pd; oxygen; potassium carbonate In water at 80℃; Suzuki-Miyaura Coupling; | 85% |
Stage #1: thiophene boronic acid; 1-Bromo-4-fluorobenzene With sodium carbonate In water; N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; for 3.03333h; Inert atmosphere; | 82% |
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-4-fluorobenzene With iodine; magnesium In tetrahydrofuran at 36 - 40℃; for 4h; Inert atmosphere; Stage #2: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20 - 25℃; for 5h; Temperature; Solvent; Inert atmosphere; | 91.3% |
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; Inert atmosphere; Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water at 40 - 60℃; pH=2.2; Reagent/catalyst; | 87.6% |
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; for 2h; Inert atmosphere; Sealed tube; Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Kumada Cross-Coupling; Inert atmosphere; Stage #3: With water at 40 - 60℃; Reagent/catalyst; | 87.6% |
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran; ethylene dibromide for 1.5h; Inert atmosphere; Stage #2: 2-bromothiophene With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 10 - 75℃; for 0.5h; | 75% |
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In 2-Me-THF Reflux; Inert atmosphere; Stage #2: 2-bromothiophene; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In 2-Me-THF at 2 - 22℃; Inert atmosphere; Stage #3: With acetic acid In 2-Me-THF; water for 0.25h; Inert atmosphere; |
Conditions | Yield |
---|---|
With potassium phosphate tribasic trihydrate; C31H41P; palladium diacetate In tetrahydrofuran at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere; | 91% |
With C27H39Br2N3Pd; potassium hydroxide In isopropyl alcohol at 82℃; for 0.166667h; Suzuki-Miyaura Coupling; | 87% |
1-ethoxythiocarbonylsulfanyl-4-(4-fluorophenyl)-4-oxobutyl 2,2-dimethylpropionate
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With acetic acid; potassium iodide at 110℃; for 0.0833333h; Microwave irradiation; | 88% |
Multi-step reaction with 2 steps 1: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: silica gel / neat (no solvent) / 215 °C / Inert atmosphere View Scheme |
4-fluoro-1-iodobenzene
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); silver tetrafluoroborate In N,N-dimethyl-formamide at 80℃; for 16h; chemoselective reaction; | 88% |
2-bromothiophene
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 70 - 75℃; | 87% |
thiophene boronic acid
4-fluoro-1-iodobenzene
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere; | 86% |
With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere; | 86% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; for 3h; | 86% |
4-(4-fluorophenyl)-4-oxopropionic acid
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With tetraphosphorus decasulfide In toluene for 0.5h; Microwave irradiation; | 85% |
5-(4-fluorophenyl)thiophene-2-carboxaldehyde
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With Pd-γ-Fe2O3 In cyclohexane at 130℃; for 24h; Inert atmosphere; Molecular sieve; Sealed tube; | 83% |
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With potassium sulfide; iodine In N,N-dimethyl-formamide at 110℃; for 11.8h; Inert atmosphere; chemoselective reaction; | 76% |
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
Stage #1: C26H37FOS With hydrazine hydrate In dimethyl sulfoxide at 80℃; Stage #2: With potassium hydroxide In dimethyl sulfoxide at 200℃; for 4h; | 74.9% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In ethanol at 40℃; for 3h; | 74% |
Conditions | Yield |
---|---|
With tert.-butylnitrite In acetonitrile at 25℃; for 0.75h; Flow reactor; Irradiation; | 74% |
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 1h; Green chemistry; Stage #2: thiophene With 3,4,5-trihydroxybenzoic acid In water; acetone at 20℃; for 12h; Inert atmosphere; Green chemistry; | |
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: thiophene In ethanol at 25℃; for 1h; Irradiation; Inert atmosphere; | 80 %Chromat. |
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water; acetone for 1h; Cooling; Stage #2: thiophene With 1,2,3,4-tetrahydrocarbazole In dimethyl sulfoxide Inert atmosphere; Darkness; regioselective reaction; |
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With potassium ethyl xanthogenate; tetrabutyl phosphonium bromide In water at 130℃; for 20h; Schlenk technique; chemoselective reaction; | 73% |
2-bromothiophene
4-flourophenylmagnesium bromide
A
2-(4-fluorophenyl)thiophene
B
4,4'-difluorobiphenyl
C
2,2'-Bithiophene
Conditions | Yield |
---|---|
Stage #1: 4-flourophenylmagnesium bromide With bismuth(III) chloride Stage #2: 2-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 90℃; for 1h; Inert atmosphere; | A 72% B n/a C n/a |
5-(4-fluorophenyl)thiophene-2-carboxylic acid
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With copper In sulfolane at 200℃; for 2h; | 72% |
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; | 71% |
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h; | 71% |
Conditions | Yield |
---|---|
Stage #1: 2-bromothiophene With magnesium; ethylene dibromide In tetrahydrofuran at 20℃; for 0.75h; Kumada Cross-Coupling; Inert atmosphere; Stage #2: 4-fluoro-1-iodobenzene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20℃; Inert atmosphere; Reflux; | 70% |
4-[3-(4-fluorophenyl)-3-oxopropyl][1,3]dithietan-2-one
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With silica gel In neat (no solvent) at 215℃; Inert atmosphere; | 70% |
thiophene
4-fluorobenzenediazonium tetrafluoroborate
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With cymantrene In dimethyl sulfoxide at 25℃; for 0.5h; Inert atmosphere; Irradiation; Flow reactor; regioselective reaction; | 59% |
With epi-Cercosporin In dimethyl sulfoxide at 20℃; for 8h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry; regioselective reaction; | 57% |
With graphitic carbon nitride/reduced graphene oxide nanocomposite In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; UV-irradiation; Green chemistry; | 60 %Chromat. |
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; catacxium A; Trimethylacetic acid In N,N-dimethyl-formamide at 110℃; for 12h; Schlenk technique; Inert atmosphere; | 58% |
2-(n-butyltellanyl)thiophene
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; silver(l) oxide In methanol at 20℃; for 1.5h; Suzuki-Miyaura cross- coupling; Inert atmosphere; | 56% |
thiophen-2-yl magnesium bromide
4-flourophenylmagnesium bromide
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
Stage #1: thiophen-2-yl magnesium bromide; 4-flourophenylmagnesium bromide With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -10℃; Inert atmosphere; Stage #2: With oxygen In tetrahydrofuran at 10 - 20℃; | 51% |
Conditions | Yield |
---|---|
With (triphenylphosphine)gold(I) chloride; [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid In 1,4-dioxane at 70℃; for 16h; | 48% |
4-Fluorothiophenol
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2.) NH4PF6 / 1.) MTBE, 23 deg C, 2.) acetone, 23 deg C 2: 74 percent / Pd(dppf)Cl2, K2CO3*H2O / aq. ethanol / 3 h / 40 °C View Scheme |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 48h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 99% |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 98% |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 97% |
2-(4-fluorophenyl)thiophene
2-bromo-5-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With N-Bromosuccinimide In dichloromethane | 95.3% |
2-(4-fluorophenyl)thiophene
5-bromo-2-methylbenzoic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst; | 93.2% |
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃; | 89% |
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere; | 80.4% |
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h; | 80% |
2-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at -20 - 20℃; for 3h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 92% |
2-(4-fluorophenyl)thiophene
5-bromo-2-methylbenzoyl chloride
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at -10 - 25℃; for 5.5h; Friedel-Crafts Acylation; Inert atmosphere; | 90.1% |
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation; | 85.7% |
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 2.5 - 3.5h; Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at -12℃; | |
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃; Stage #2: With water In tetrahydrofuran cooling with ice; |
2-(4-fluorophenyl)thiophene
carbon dioxide
5-(4-fluorophenyl)thiophene-2-carboxylic acid
Conditions | Yield |
---|---|
With ethylaluminum dichloride In hexane; toluene at 100℃; under 22502.3 Torr; for 3h; Autoclave; Inert atmosphere; regioselective reaction; | 90% |
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at -20 - 20℃; for 3h; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 90% |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 90% |
2-(4-fluorophenyl)thiophene
N,N-dimethyl-formamide
5-(4-fluorophenyl)thiophene-2-carboxaldehyde
Conditions | Yield |
---|---|
Stage #1: 2-(4-fluorophenyl)thiophene; N,N-dimethyl-formamide With tris(trimethylsilyl)amine; tetramethylammonium fluoride at 20℃; for 24h; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In water at 20℃; for 1.5h; | 86% |
Conditions | Yield |
---|---|
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 86% |
2-(4-fluorophenyl)thiophene
2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(thiophen-2-yl)ethan-1-ol
Conditions | Yield |
---|---|
With dodecylbenzenesulfonic acid In water at 80℃; for 24h; Green chemistry; | 83% |
2-(4-fluorophenyl)thiophene
5-iodo-2-methylbenzoic acid
Conditions | Yield |
---|---|
Stage #1: 5-iodo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h; | 81% |
Stage #1: 5-iodo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide for 1h; Reflux; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 30℃; for 1h; | 222 g |
2-(4-fluorophenyl)thiophene
5-iodo-2-methylbenzoyl chloride
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
Conditions | Yield |
---|---|
With aluminum (III) chloride Solvent; Temperature; Friedel-Crafts Acylation; | 80% |
Stage #1: 5-iodo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 2℃; for 0.25h; Stage #2: 2-(4-fluorophenyl)thiophene In dichloromethane at 2 - 20℃; for 2.41667h; Product distribution / selectivity; |
2-(4-fluorophenyl)thiophene
phenylboronic acid
2-(4-fluorophenyl)-4-phenylthiophene
Conditions | Yield |
---|---|
With palladium(II) trifluoroacetate; cesium trifluoroacetate; p-benzoquinone; silver(l) oxide In acetic acid; trifluoroacetic acid at 20℃; for 15h; regioselective reaction; | 80% |
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