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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White To Yellowish Powder ACCORDANT Purity ≥98.

High quality 79669-49-1 2-Methyl-5-bromobenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Bromo-2-Methylbenzoic Acid supplier in China

Cas:79669-49-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

5-Bromo-2-methylbenzoic acid CAS NO.:79669-49-1 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing &

High purity 5-Bromo-2-methylbenzoic acid CAS NO.:79669-49-1 supplier from china

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-Bromo-2-Methylbenzoic Acid

Cas:79669-49-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 79669-49-1 Benzoic acid,5-bromo-2-methyl-

Cas:79669-49-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

2-METHYL-5-BROMOBENZOIC ACID

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Bromo-o-toluic acid (COOH=1)

Cas:79669-49-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1481.html Product Name 5-Bromo-2-methylbenzoic acid

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Gram

FOB Price: $5.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

5-Bromo-2-methylbenzoic acid Basic information Product Name: 5-Bromo-2-methylbenzoic acid Synonyms: 5-BROMO-2-METHYLBENZOIC ACID;2-METHYL-5-BROMOBENZOIC ACID;5-Brom

5-Bromo-2-methylbenzoic acid 79669-49-1

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 79669-49-1 with best quality

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

CAS 79669-49-1 Name 5-Bromo-2-methylbenzoic acid Appearance White Powder Application Pharmaceutical Appearance: white powder Storage:Store in cool a

5-Bromo-2-methylbenzoicacid

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Hot sale 5-Bromo-2-methylbenzoic acid (CAS:79669-49-1)

Cas:79669-49-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoic acid,5-bromo-2-methyl- 79669-49-1

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Benzoic acid,5-bromo-2-methyl-/ LIDE PHARMA- Factory supply / Best price

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 5-Bromo-2-methylbenzoic acid CAS: 79669-49-1 MF: C8H7BrO2 MW: 215.04 EINECS: 628-605-0 Mol File: 79669-49-1.mol 5-Bromo-2-methylbenzoic acid Structure 5-Bromo-2-methylbenzoic acid Chemical Properties Melting point

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $68.0 / 75.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

5-Bromo-2-methylbenzoic acid CAS:79669-49-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

5-Bromo-2-methylbenzoic acid CAS:79669-49-1

Cas:79669-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzoic acid,5-bromo-2-methyl-

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:79669-49-1

Cas:79669-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

5-Bromo-2-methylbenzoic acid CAS 79669-49-1

Cas:79669-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

79669-49-1 5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. 2-Methyl-5-bromobenzoic acid is used in organic synthesis and pharmaceutical intermediates. It is used in the synthesis of 5-bromo-2-methyl-N-(quinolin-8-yl)benzamide, (5-Bromo-2-methylphenyl)(thiophen-2-y

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-METHYL-5-BROMOBENZOIC ACID

Cas:79669-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Bromo-2-methylbenzoic acid

Cas:79669-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid88%
Stage #1: ortho-methylbenzoic acid With bromine; iron at 20℃; for 2h;
Stage #2: With hydrogenchloride In methanol; water at 20℃;
19%
With bromine by/at 167 degree melting substance;
5-iodo-2-methylbenzoic acid
54811-38-0

5-iodo-2-methylbenzoic acid

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; bromine; iron Concentration; Solvent; Molecular sieve;85%
3-Bromo-6-methyl-benzonitrile
156001-51-3

3-Bromo-6-methyl-benzonitrile

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With sulfuric acid at 160 - 170℃;
4-Methyl-3-nitroanilin
119-32-4

4-Methyl-3-nitroanilin

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
durch Austausch von NH2 gegen Br, Reduktion des Produkts zu 4-Brom-2-amino-toluol und Austausch von NH2 gegen CO2H; by/at 167 degree melting substance;
2,β,β-Tribrom-4-methyl-styrol

2,β,β-Tribrom-4-methyl-styrol

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With pyridine; potassium permanganate
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

bromine
7726-95-6

bromine

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

water
7732-18-5

water

bromine
7726-95-6

bromine

A

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

B

2-bromophthalide

2-bromophthalide

Conditions
ConditionsYield
at 140℃;
diethyl ether
60-29-7

diethyl ether

2,4-dibromotoluene
31543-75-6

2,4-dibromotoluene

magnesium

magnesium

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
Behandlung mit CO2;
5-bromo-11-nitro-1.2-dimethyl-benzene

5-bromo-11-nitro-1.2-dimethyl-benzene

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With potassium permanganate by/at 174-176 degree melting substance;
asymm. bromo-o-xylene

asymm. bromo-o-xylene

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With nitric acid by/at 174-176 degree melting substance;
diazotized 5-amino-2-methyl-benzoic acid

diazotized 5-amino-2-methyl-benzoic acid

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With hydrogen bromide; copper(I) bromide
silver salt of/the/ o-toluic acid

silver salt of/the/ o-toluic acid

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With bromine by/at 167 degree melting substance;
2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydriodic acid; yellow phosphorus
2: water; bromine / 140 °C
View Scheme
2-cyano-4-nitrotoluene
939-83-3

2-cyano-4-nitrotoluene

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium; methanol / Hydrogenation
2: aqueous potassium tetrabromocuprate (I)-solution
3: aqueous sulfuric acid / 160 - 170 °C
View Scheme
3-cyano-4-methylaniline
50670-64-9

3-cyano-4-methylaniline

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous potassium tetrabromocuprate (I)-solution
2: aqueous sulfuric acid / 160 - 170 °C
View Scheme
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

A

3-bromo-2-methylbenzoic acid
76006-33-2

3-bromo-2-methylbenzoic acid

B

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With bromine; iron at 0 - 20℃;
With bromine; iron at 0 - 20℃;
With bromine; iron at 20℃; for 24h; Title compound not separated from byproducts.;
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

3-bromo-4-methylbenzoic acid
7697-26-9

3-bromo-4-methylbenzoic acid

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With bromine In dichloromethane
With bromine In dichloromethane
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-bromo-2-methylbenzoyl chloride
21900-41-4

5-bromo-2-methylbenzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;100%
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 6h;100%
With thionyl chloride; N,N-dimethyl-formamide for 7h; Reflux;70%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

(5-bromo-2-methylphenyl)methanol
258886-04-3

(5-bromo-2-methylphenyl)methanol

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 25.5h;100%
With borane-THF In tetrahydrofuran; diethyl ether at 50℃; Inert atmosphere;95%
With borane-THF In tetrahydrofuran; diethyl ether at 50℃; for 3h;95%
methanol
67-56-1

methanol

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

methyl 2-methyl-5-bromobenzoate
79669-50-4

methyl 2-methyl-5-bromobenzoate

Conditions
ConditionsYield
Stage #1: methanol; 5-bromo-2-methylbenzoic acid With diazomethyl-trimethyl-silane In hexane at 20℃; for 1.16667h;
Stage #2: With acetic acid In hexane for 0.75h;
99%
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride; N,N-dimethyl-formamide at 0℃; for 3h; Reflux; Inert atmosphere;
Stage #2: methanol
98%
With sulfuric acid at 20℃; for 5h; Time; Cooling with ice; Reflux;97%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 2-methyl-5-bromobenzoate
79669-50-4

methyl 2-methyl-5-bromobenzoate

Conditions
ConditionsYield
With methanol In diethyl ether; toluene at 0 - 20℃; for 1h;99%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

methyl iodide
74-88-4

methyl iodide

methyl 2-methyl-5-bromobenzoate
79669-50-4

methyl 2-methyl-5-bromobenzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h;99%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h;
2-aminopyridine
504-29-0

2-aminopyridine

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-bromo-2-methyl-N-(pyridin-2-yl)benzamide

5-bromo-2-methyl-N-(pyridin-2-yl)benzamide

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 2-aminopyridine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 30℃; Inert atmosphere;
99%
4-amino-3,5-dimethyl-benzoic acid methyl ester
3095-48-5

4-amino-3,5-dimethyl-benzoic acid methyl ester

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

methyl 4-[(5-bromo-2-methyl-benzoyl)amino]-3,5-dimethyl-benzoate
1529760-92-6

methyl 4-[(5-bromo-2-methyl-benzoyl)amino]-3,5-dimethyl-benzoate

Conditions
ConditionsYield
Stage #1: 4-amino-3,5-dimethyl-benzoic acid methyl ester; 5-bromo-2-methylbenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 50℃; for 16h;
97%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

C9H10BrNO2

C9H10BrNO2

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
97%
ethanol
64-17-5

ethanol

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

ethyl 5-bromo-2-methylbenzoate
359629-91-7

ethyl 5-bromo-2-methylbenzoate

Conditions
ConditionsYield
With sulfuric acid In benzene Cooling with ice; Reflux;96%
With sulfuric acid Reflux;95%
With sulfuric acid Reflux;95%
sulfuric acid at 0 - 100℃; for 15h; Inert atmosphere;69%
3,5-dimethyl-4-aminobenzoic acid ethyl ester
3095-47-4

3,5-dimethyl-4-aminobenzoic acid ethyl ester

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

methyl 3-[(5-bromo-2-methyl-benzoyl)amino]-2,4-dimethyl-benzoate
1529760-86-8

methyl 3-[(5-bromo-2-methyl-benzoyl)amino]-2,4-dimethyl-benzoate

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 2h;
Stage #2: 4-amino-3,5-dimethylbenzoic acid ethyl ester With pyridine; dmap In dichloromethane at 0 - 20℃; for 2h;
95.5%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

3-bromo-6-methyl-2-((triisopropylsilyl)ethynyl)benzoic acid

3-bromo-6-methyl-2-((triisopropylsilyl)ethynyl)benzoic acid

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium hydrogencarbonate In tert-Amyl alcohol at 30℃; for 24h;95%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium carbonate In tert-Amyl alcohol at 80℃; for 24h; Sealed tube; Schlenk technique;88%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst;
93.2%
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;
89%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere;
80.4%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;
80%
tributyl borane
122-56-5

tributyl borane

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-butyl-2-methylbenzoic acid

5-butyl-2-methylbenzoic acid

Conditions
ConditionsYield
In tetrahydrofuran Suzuki-Miyaura Coupling; Inert atmosphere;92%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

(3R,4S)-tert-butyl 3-amino-4-fluoropyrrolidine-1-carboxylate

(3R,4S)-tert-butyl 3-amino-4-fluoropyrrolidine-1-carboxylate

tert-butyl (3R,4S)-3-(5-bromo-2-methylbenzamido)-4-fluoropyrrolidine-1-carboxylate

tert-butyl (3R,4S)-3-(5-bromo-2-methylbenzamido)-4-fluoropyrrolidine-1-carboxylate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;92%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

2-[D3]-methyl-5-bromobenzoic acid

2-[D3]-methyl-5-bromobenzoic acid

Conditions
ConditionsYield
With [D]-sodium hydroxide In water-d2 at 20 - 160℃; for 6.5h;90%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

4-Aminobenzonitrile
873-74-5

4-Aminobenzonitrile

C15H11BrN2O

C15H11BrN2O

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;88%
triethyl borane
97-94-9

triethyl borane

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-ethyl-2-methylbenzoic acid

5-ethyl-2-methylbenzoic acid

Conditions
ConditionsYield
In tetrahydrofuran Suzuki-Miyaura Coupling; Inert atmosphere;87%
N-methylmaleimide
930-88-1

N-methylmaleimide

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

C12H12BrNO2

C12H12BrNO2

Conditions
ConditionsYield
With sodium dihydrogenphosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; water at 85℃; for 16h; Green chemistry; chemoselective reaction;84%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-bromo-2-methyl-3-nitro-benzoic acid
107650-20-4

5-bromo-2-methyl-3-nitro-benzoic acid

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With sulfuric acid at -10℃; for 0.166667h;
Stage #2: With potassium nitrate at -10℃; for 1h;
82.5%
With sulfuric acid; nitric acid In acetone at -5 - 0℃; for 2.25h; Cooling with acetone-ice;52%
N-acetylpiperidine
13889-98-0

N-acetylpiperidine

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

1-[4-(5-bromo-2-methyl-benzoyl)-piperazin-1-yl]-ethanone
1431542-16-3

1-[4-(5-bromo-2-methyl-benzoyl)-piperazin-1-yl]-ethanone

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.333333h;
Stage #2: N-acetylpiperidine In dichloromethane at 20℃; for 1h;
82%
Stage #1: 5-bromo-2-methylbenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.333333h;
Stage #2: N-acetylpiperidine In dichloromethane at 20℃; for 1h;
82%
Stage #1: 5-bromo-2-methylbenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.333333h;
Stage #2: N-acetylpiperidine In dichloromethane at 20℃; for 1h;
82%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

methyl 3-amino-2,4-dimethyl-benzoate
24812-89-3

methyl 3-amino-2,4-dimethyl-benzoate

methyl 3-[(5-bromo-2-methyl-benzoyl)amino]-2,4-dimethyl-benzoate
1529760-86-8

methyl 3-[(5-bromo-2-methyl-benzoyl)amino]-2,4-dimethyl-benzoate

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid; methyl 3-amino-2,4-dimethyl-benzoate With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 50℃; for 16h;
80%
4-amino-3,5-dimethyl-benzoic acid methyl ester
3095-48-5

4-amino-3,5-dimethyl-benzoic acid methyl ester

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

methyl 3-[(5-bromo-2-methyl-benzoyl)amino]-2,4-dimethyl-benzoate
1529760-86-8

methyl 3-[(5-bromo-2-methyl-benzoyl)amino]-2,4-dimethyl-benzoate

Conditions
ConditionsYield
Stage #1: 4-amino-3,5-dimethyl-benzoic acid methyl ester; 5-bromo-2-methylbenzoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h;
Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 50℃; for 16h;
80%
2-amino-1-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)-3-phenylpropan-1-one

2-amino-1-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)-3-phenylpropan-1-one

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-bromo-N-(1-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)-2-methylbenzamide

5-bromo-N-(1-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)-2-methylbenzamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;79%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-bromo-2-methylbenzoyl fluoride

5-bromo-2-methylbenzoyl fluoride

Conditions
ConditionsYield
With (3,3-difluorocycloprop-1-ene-1,2-diyl)dibenzene In dichloromethane at 50℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;79%
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C
2: cesium fluoride / acetonitrile / 80 °C
View Scheme
3,5-dimethyl-4-aminobenzoic acid ethyl ester
3095-47-4

3,5-dimethyl-4-aminobenzoic acid ethyl ester

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

ethyl 4-[(5-bromo-2-methyl-benzoyl)amino]-3,5-dimethyl-benzoate
1529761-04-3

ethyl 4-[(5-bromo-2-methyl-benzoyl)amino]-3,5-dimethyl-benzoate

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In tetrahydrofuran; dichloromethane at 0 - 20℃; for 2h;
Stage #2: 4-amino-3,5-dimethylbenzoic acid ethyl ester With pyridine; dmap In dichloromethane at 0 - 20℃; for 5h;
75.2%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

acetonitrile
75-05-8

acetonitrile

2-acetyl-6-bromoisoindolin-1-one

2-acetyl-6-bromoisoindolin-1-one

Conditions
ConditionsYield
With iron(III)-acetylacetonate; copper(II) nitrate; Selectfluor at 80℃; for 8h; Schlenk technique; Inert atmosphere;74%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

3-chlorophenylboronic acid
63503-60-6

3-chlorophenylboronic acid

3'-chloro-4-methylbiphenyl-3-carboxylic acid
1482106-89-7

3'-chloro-4-methylbiphenyl-3-carboxylic acid

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; acetonitrile at 80℃; for 18h; Inert atmosphere;73.2%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; acetonitrile at 80℃; for 18h; Inert atmosphere;73.2%
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

5-bromo-2-(difluoromethyl)benzoic acid
1630983-04-8

5-bromo-2-(difluoromethyl)benzoic acid

Conditions
ConditionsYield
With sodium persulfate; silver nitrate; Selectfluor In water; acetonitrile at 80℃; for 3h; Inert atmosphere; Schlenk technique; Cooling with liquid nitrogen;73%

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