Product Description Product Name 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene CAS No. 1132832-75-7 Appearance White powder Assay ≥99% Capacity 50mt/year
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inquiryProName:(5-bromo-2-Methylphenyl)(5-(4-fluoroph... CasNo:1132832-75-7 Molecular Formula:C18H12BrFOS Appearance:white powder Application:Intermediates DeliveryTime:5 days PackAge:1kg/bag,35kg/bag Port:Shanghai ProductionCapacity:1000 Kilogram
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inquiryProduct name: (5-Bromo-2-Methylphenyl)(5-(4-Fluorophenyl)thiophen-2-yl)methanone CAS No.: 1132832-75-7 Molecule Formula:C18H12BrFOS Molecule Weight:375.25 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufactu
Cas:1132832-75-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiry2-(4-fluorophenyl)thiophene
5-bromo-2-methylbenzoic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst; | 93.2% |
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃; | 89% |
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere; | 80.4% |
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h; | 80% |
2-(4-fluorophenyl)thiophene
5-bromo-2-methylbenzoyl chloride
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at -10 - 25℃; for 5.5h; Friedel-Crafts Acylation; Inert atmosphere; | 90.1% |
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation; | 85.7% |
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 2.5 - 3.5h; Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at -12℃; | |
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃; Stage #2: With water In tetrahydrofuran cooling with ice; |
1-Bromo-4-fluorobenzene
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / ethanol; water / 90 °C / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C 2.2: cooling with ice View Scheme | |
Multi-step reaction with 4 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 22 h / 140 - 150 °C 2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C 3: thionyl chloride / toluene / 21 h / 90 °C 4: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium propionate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride / Isopropyl acetate / Reflux 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / Dimethyl ether; water / 70 - 75 °C 3.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C 3.2: 0 - 35 °C View Scheme |
5-bromo-2-methylbenzoic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 20 °C 2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C 2.2: cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine / dichloromethane / 20 °C / Inert atmosphere 2.1: hydrogenchloride; magnesium; iodine / diethyl ether / 0.33 h / Inert atmosphere; Reflux 2.2: 20 °C / Inert atmosphere View Scheme |
5-(4-fluorophenyl)thiophene-2-carboxylic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / toluene / 21 h / 90 °C 2: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme |
5-(4-fluorophenyl)thiophene-2-carbonyl chloride
para-bromotoluene
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
With iron(III) chloride In dichloromethane at 20℃; for 20h; | 0.77 g |
thiophene-2-carbaldehyde
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 22 h / 140 - 150 °C 2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C 3: thionyl chloride / toluene / 21 h / 90 °C 4: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme |
5-(4-fluorophenyl)thiophene-2-carboxaldehyde
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C 2: thionyl chloride / toluene / 21 h / 90 °C 3: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme |
4-fluoroboronic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 25 - 75 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.1 h / 25 - 30 °C / Inert atmosphere 2.2: 0 - 15 °C / Inert atmosphere View Scheme |
2-bromo-5-(4-fluorophenyl)thiophene
5-bromo-N-methoxy-N,2-dimethylbenzamide
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Stage #1: 2-bromo-5-(4-fluorophenyl)thiophene With hydrogenchloride; iodine; magnesium In diethyl ether for 0.333333h; Inert atmosphere; Reflux; Stage #2: 5-bromo-N-methoxy-N,2-dimethylbenzamide In tetrahydrofuran; diethyl ether at 20℃; Inert atmosphere; | 0.402 g |
fluorobenzene
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 2 h / Cooling with ice; Reflux 2.1: tetraphosphorus decasulfide / toluene / 0.5 h / Microwave irradiation 3.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C 3.2: 4 h / -15 - 35 °C View Scheme |
4-(4-fluorophenyl)-4-oxopropionic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetraphosphorus decasulfide / toluene / 0.5 h / Microwave irradiation 2.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C 2.2: 4 h / -15 - 35 °C View Scheme |
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / Dimethyl ether; water / 70 - 75 °C 2.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C 2.2: 0 - 35 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at -20 - -10℃; for 48h; Reagent/catalyst; Temperature; Concentration; Solvent; | 97.7% |
With hydrogen In isopropyl alcohol at 100℃; under 22502.3 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave; | 97% |
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With aluminum (III) chloride In tetrahydrofuran at 0 - 5℃; for 0.5h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran Reflux; | 92% |
methanesulfonic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With n-butyllithium In tetrahydrofuran; N,N-dimethyl-formamide at -50 - -40℃; for 3h; Inert atmosphere; Stage #2: C14H18O10 In tetrahydrofuran; N,N-dimethyl-formamide for 8h; Inert atmosphere; Stage #3: methanesulfonic acid In tetrahydrofuran at 20℃; | 85.8% |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
With [D]-sodium hydroxide In water-d2 at 160℃; for 8h; | 84% |
methanesulfonic acid
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With potassium hexamethylsilazane In tetrahydrofuran; toluene at -50 - -40℃; for 3h; Inert atmosphere; Stage #2: C10H18O14S4 In tetrahydrofuran; toluene for 8h; Inert atmosphere; Stage #3: methanesulfonic acid In tetrahydrofuran at 20℃; | 83.9% |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
With aluminum (III) chloride; sodium borodeuteride In acetonitrile at 55℃; for 0.166667h; Inert atmosphere; | 82% |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
(1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 3 h / 0 - 20 °C 2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 0.08 h / -70 °C / Inert atmosphere 2.2: 0.25 h / -70 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 2.2: -75 - -70 °C 2.3: 12 h / -75 - 30 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 2.2: -75 - -70 °C 2.3: 12 h / -75 - 30 °C 3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 0.25 h / 20 °C 1.2: 50 - 60 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 35 °C / Inert atmosphere 2.2: 2 h / 0 - 5 °C / Inert atmosphere 3.1: methanesulfonic acid / water / 20 °C 4.1: triethylsilane / acetonitrile; dichloromethane / 0.25 h / 0 - 5 °C / Inert atmosphere 4.2: 0 - 30 °C / Inert atmosphere View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 2.2: -75 - -70 °C 2.3: 12 h / -75 - 30 °C 3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C 4.1: dmap / acetone / 5 h / 0.25 - 0.5 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; sodium borodeuteride / acetonitrile / 0.17 h / 55 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; toluene / 0.55 h / -78 - -66 °C / Inert atmosphere 2.2: 5 h / -78 - -60 °C 3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -50 - 20 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride; sodium borodeuteride / acetonitrile / 0.17 h / 55 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; toluene / 0.55 h / -78 - -66 °C / Inert atmosphere 2.2: 5 h / -78 - -60 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: [D]-sodium hydroxide / water-d2 / 8 h / 160 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 55 °C / Inert atmosphere View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
trimethyl orthoformate
Conditions | Yield |
---|---|
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone; trimethyl orthoformate at 20℃; for 0.25h; Stage #2: With toluene-4-sulfonic acid In methanol at 50 - 60℃; |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 0.25 h / 20 °C 1.2: 50 - 60 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 35 °C / Inert atmosphere 2.2: 2 h / 0 - 5 °C / Inert atmosphere 3.1: methanesulfonic acid / water / 20 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: Inert atmosphere View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: Inert atmosphere 3.1: lithium hydroxide; water / methanol / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: lithium borohydride; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: -30 - 20 °C / Inert atmosphere 3.1: sodium hydroxide; water / tetrahydrofuran / 20 °C View Scheme |
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: lithium borohydride; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: -30 - 20 °C / Inert atmosphere View Scheme |
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