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Jinan Finer Chemical Co., Ltd

Product Description Product Name 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene CAS No. 1132832-75-7 Appearance White powder Assay ≥99% Capacity 50mt/year

2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene

Cas:1132832-75-7

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene

Cas:1132832-75-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif

2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene

Cas:1132832-75-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(5-Bromo-2-methylphenyl)-[5-(4-fluorophenyl)-thiophen-2-yl]-methanone

Cas:1132832-75-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

CAS NO.:1132832-75-7 Canagliflozin INT1 1.Large qty in stock 2.High quality 3.Lowest price 4.Best service Our Advantage 1. Risk-free guarantee,15days refund 2. Most of the products in stock,can ship within 7days after the order 3

CAS NO.:1132832-75-7 Canagliflozin INT1

Cas:1132832-75-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 1132832-75-7 with best quality

Cas:1132832-75-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:10 Kilogram

FOB Price: $100.0 / 120.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Canagliflozin Intermediate (CAS: 1132832-75-7) Pharmaceutical Raw Material

Cas:1132832-75-7

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methanone, (5-bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]- 1132832-75-7

Cas:1132832-75-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Methanone, (5-bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]-/ LIDE PHARMA- Factory supply / Best price

Cas:1132832-75-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone CAS:1132832-75-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone CAS:1132832-75-7

Cas:1132832-75-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methanone, (5-bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]-

Cas:1132832-75-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Methanone, (5-bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]-

Cas:1132832-75-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:1132832-75-7

1132832-75-7

Cas:1132832-75-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(5-BROMO-2-METHYLPHENYL)(5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHANONE

Cas:1132832-75-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName:(5-bromo-2-Methylphenyl)(5-(4-fluoroph... CasNo:1132832-75-7 Molecular Formula:C18H12BrFOS Appearance:white powder Application:Intermediates DeliveryTime:5 days PackAge:1kg/bag,35kg/bag Port:Shanghai ProductionCapacity:1000 Kilogram

(5-bromo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone CAS NO.1132832-75-7

Cas:1132832-75-7

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

(5-Bromo-2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone

Cas:1132832-75-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methanone, (5-bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]-

Cas:1132832-75-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(5-bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]- Methanone

Cas:1132832-75-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(5-Bromo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (5-Bromo-2-Methylphenyl)(5-(4-Fluorophenyl)thiophen-2-yl)methanone CAS No.: 1132832-75-7 Molecule Formula:C18H12BrFOS Molecule Weight:375.25 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufactu

High Quality (5-Bromo-2-Methylphenyl)(5-(4-Fluorophenyl)thiophen-2-yl)methanone

Cas:1132832-75-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1132832-75-7 (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting Canagliflozin iMpurity B;Canagliflozin INT1; 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene CAS:1132832-75-7 , Please contact us by ema

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1132832-75-7 (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

Cas:1132832-75-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst;
93.2%
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;
89%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere;
80.4%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h;
Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;
80%
2-(4-fluorophenyl)thiophene
58861-48-6

2-(4-fluorophenyl)thiophene

5-bromo-2-methylbenzoyl chloride
21900-41-4

5-bromo-2-methylbenzoyl chloride

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at -10 - 25℃; for 5.5h; Friedel-Crafts Acylation; Inert atmosphere;90.1%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation;85.7%
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 2.5 - 3.5h;
Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at -12℃;
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃;
Stage #2: With water In tetrahydrofuran cooling with ice;
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / ethanol; water / 90 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C
2.2: cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 22 h / 140 - 150 °C
2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C
3: thionyl chloride / toluene / 21 h / 90 °C
4: iron(III) chloride / dichloromethane / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium propionate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride / Isopropyl acetate / Reflux
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / Dimethyl ether; water / 70 - 75 °C
3.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C
3.2: 0 - 35 °C
View Scheme
5-bromo-2-methylbenzoic acid
79669-49-1

5-bromo-2-methylbenzoic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C
2.2: cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine / dichloromethane / 20 °C / Inert atmosphere
2.1: hydrogenchloride; magnesium; iodine / diethyl ether / 0.33 h / Inert atmosphere; Reflux
2.2: 20 °C / Inert atmosphere
View Scheme
5-(4-fluorophenyl)thiophene-2-carboxylic acid
115933-30-7

5-(4-fluorophenyl)thiophene-2-carboxylic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 21 h / 90 °C
2: iron(III) chloride / dichloromethane / 20 h / 20 °C
View Scheme
5-(4-fluorophenyl)thiophene-2-carbonyl chloride
918487-45-3

5-(4-fluorophenyl)thiophene-2-carbonyl chloride

para-bromotoluene
106-38-7

para-bromotoluene

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
With iron(III) chloride In dichloromethane at 20℃; for 20h;0.77 g
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 22 h / 140 - 150 °C
2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C
3: thionyl chloride / toluene / 21 h / 90 °C
4: iron(III) chloride / dichloromethane / 20 h / 20 °C
View Scheme
5-(4-fluorophenyl)thiophene-2-carboxaldehyde
249504-38-9

5-(4-fluorophenyl)thiophene-2-carboxaldehyde

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C
2: thionyl chloride / toluene / 21 h / 90 °C
3: iron(III) chloride / dichloromethane / 20 h / 20 °C
View Scheme
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 25 - 75 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.1 h / 25 - 30 °C / Inert atmosphere
2.2: 0 - 15 °C / Inert atmosphere
View Scheme
2-bromo-5-(4-fluorophenyl)thiophene
1073313-97-9

2-bromo-5-(4-fluorophenyl)thiophene

5-bromo-N-methoxy-N,2-dimethylbenzamide
842135-03-9

5-bromo-N-methoxy-N,2-dimethylbenzamide

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Stage #1: 2-bromo-5-(4-fluorophenyl)thiophene With hydrogenchloride; iodine; magnesium In diethyl ether for 0.333333h; Inert atmosphere; Reflux;
Stage #2: 5-bromo-N-methoxy-N,2-dimethylbenzamide In tetrahydrofuran; diethyl ether at 20℃; Inert atmosphere;
0.402 g
fluorobenzene
462-06-6

fluorobenzene

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 2 h / Cooling with ice; Reflux
2.1: tetraphosphorus decasulfide / toluene / 0.5 h / Microwave irradiation
3.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C
3.2: 4 h / -15 - 35 °C
View Scheme
4-(4-fluorophenyl)-4-oxopropionic acid
366-77-8

4-(4-fluorophenyl)-4-oxopropionic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetraphosphorus decasulfide / toluene / 0.5 h / Microwave irradiation
2.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C
2.2: 4 h / -15 - 35 °C
View Scheme
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
214360-58-4

2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / Dimethyl ether; water / 70 - 75 °C
2.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C
2.2: 0 - 35 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene
1030825-20-7

2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at -20 - -10℃; for 48h; Reagent/catalyst; Temperature; Concentration; Solvent;97.7%
With hydrogen In isopropyl alcohol at 100℃; under 22502.3 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave;97%
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With aluminum (III) chloride In tetrahydrofuran at 0 - 5℃; for 0.5h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran Reflux;
92%
methanesulfonic acid
75-75-2

methanesulfonic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

C14H18O10

C14H18O10

C33H33FO11S

C33H33FO11S

Conditions
ConditionsYield
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With n-butyllithium In tetrahydrofuran; N,N-dimethyl-formamide at -50 - -40℃; for 3h; Inert atmosphere;
Stage #2: C14H18O10 In tetrahydrofuran; N,N-dimethyl-formamide for 8h; Inert atmosphere;
Stage #3: methanesulfonic acid In tetrahydrofuran at 20℃;
85.8%
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

(5-bromo-2-[D3]methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)ketone

(5-bromo-2-[D3]methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)ketone

Conditions
ConditionsYield
With [D]-sodium hydroxide In water-d2 at 160℃; for 8h;84%
methanesulfonic acid
75-75-2

methanesulfonic acid

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

C10H18O14S4

C10H18O14S4

C29H33FO15S5

C29H33FO15S5

Conditions
ConditionsYield
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With potassium hexamethylsilazane In tetrahydrofuran; toluene at -50 - -40℃; for 3h; Inert atmosphere;
Stage #2: C10H18O14S4 In tetrahydrofuran; toluene for 8h; Inert atmosphere;
Stage #3: methanesulfonic acid In tetrahydrofuran at 20℃;
83.9%
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

2-(5-bromo-2-methyl[1,1-D2]benzyl)-5-(4-fluorophenyl)thiophene

2-(5-bromo-2-methyl[1,1-D2]benzyl)-5-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
With aluminum (III) chloride; sodium borodeuteride In acetonitrile at 55℃; for 0.166667h; Inert atmosphere;82%
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

(1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol
1413373-77-9

(1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 3 h / 0 - 20 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 0.08 h / -70 °C / Inert atmosphere
2.2: 0.25 h / -70 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1030825-21-8

(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C
2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
2.2: -75 - -70 °C
2.3: 12 h / -75 - 30 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C
2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
2.2: -75 - -70 °C
2.3: 12 h / -75 - 30 °C
3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 0.25 h / 20 °C
1.2: 50 - 60 °C
2.1: iodine; magnesium / tetrahydrofuran / 25 - 35 °C / Inert atmosphere
2.2: 2 h / 0 - 5 °C / Inert atmosphere
3.1: methanesulfonic acid / water / 20 °C
4.1: triethylsilane / acetonitrile; dichloromethane / 0.25 h / 0 - 5 °C / Inert atmosphere
4.2: 0 - 30 °C / Inert atmosphere
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C
2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
2.2: -75 - -70 °C
2.3: 12 h / -75 - 30 °C
3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C
4.1: dmap / acetone / 5 h / 0.25 - 0.5 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

(2S,3R,4R,5S,6R)-2-3-((5-(4-fluorophenyl)thiophen-[1,1-D2]methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyrantriol

(2S,3R,4R,5S,6R)-2-3-((5-(4-fluorophenyl)thiophen-[1,1-D2]methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyrantriol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride; sodium borodeuteride / acetonitrile / 0.17 h / 55 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; toluene / 0.55 h / -78 - -66 °C / Inert atmosphere
2.2: 5 h / -78 - -60 °C
3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -50 - 20 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)[1,1-D2]methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)[1,1-D2]methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride; sodium borodeuteride / acetonitrile / 0.17 h / 55 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; toluene / 0.55 h / -78 - -66 °C / Inert atmosphere
2.2: 5 h / -78 - -60 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

2-(5-bromo-2-[D3]methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-bromo-2-[D3]methylbenzyl)-5-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: [D]-sodium hydroxide / water-d2 / 8 h / 160 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 55 °C / Inert atmosphere
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

trimethyl orthoformate
149-73-5

trimethyl orthoformate

2-[(5-bromo-2-methylphenyl)(dimethoxy)methyl]-5-(4-fluorophenyl)thiophene

2-[(5-bromo-2-methylphenyl)(dimethoxy)methyl]-5-(4-fluorophenyl)thiophene

Conditions
ConditionsYield
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone; trimethyl orthoformate at 20℃; for 0.25h;
Stage #2: With toluene-4-sulfonic acid In methanol at 50 - 60℃;
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

[5-(4-fluorophenyl)-thiophen-2-yl]-[2-methyl-5-(3,4,5-trihydroxy-6-hydroxymethyl-2-methoxy-tetrahydropyran-2-yl)-phenyl]methanone

[5-(4-fluorophenyl)-thiophen-2-yl]-[2-methyl-5-(3,4,5-trihydroxy-6-hydroxymethyl-2-methoxy-tetrahydropyran-2-yl)-phenyl]methanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 0.25 h / 20 °C
1.2: 50 - 60 °C
2.1: iodine; magnesium / tetrahydrofuran / 25 - 35 °C / Inert atmosphere
2.2: 2 h / 0 - 5 °C / Inert atmosphere
3.1: methanesulfonic acid / water / 20 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

C32H33FO9S

C32H33FO9S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / -50 - -40 °C / Inert atmosphere
1.2: 8 h / Inert atmosphere
1.3: 20 °C
2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C
2.2: Inert atmosphere
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]glucitol

1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]glucitol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / -50 - -40 °C / Inert atmosphere
1.2: 8 h / Inert atmosphere
1.3: 20 °C
2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C
2.2: Inert atmosphere
3.1: lithium hydroxide; water / methanol / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / -50 - -40 °C / Inert atmosphere
1.2: 8 h / Inert atmosphere
1.3: 20 °C
2.1: lithium borohydride; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C
2.2: -30 - 20 °C / Inert atmosphere
3.1: sodium hydroxide; water / tetrahydrofuran / 20 °C
View Scheme
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
1132832-75-7

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

C28H33FO13S5

C28H33FO13S5

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / -50 - -40 °C / Inert atmosphere
1.2: 8 h / Inert atmosphere
1.3: 20 °C
2.1: lithium borohydride; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C
2.2: -30 - 20 °C / Inert atmosphere
View Scheme

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