Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
We have most reliable quality, competitive prices and full documents for this APIs 1. GMP WORKSHOP 2. DMF Appearance:White to off-white powder Storage:2~8℃,protected from light Application:Canagliflozin(Invokana) is an oral diabet
Cas:842133-18-0
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryname:Canagliflozin cas:842133-18-0 Molecular Formula:C24H25FO5S Molecular Weight:444.52 Appearance:White to Off-White crystalline Solid Package:as requested Application:cas:842133-18-0
Cas:842133-18-0
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:842133-18-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W
Cas:842133-18-0
Min.Order:1 Kilogram
FOB Price: $825.0 / 1100.0
Type:Trading Company
inquiryUnique advantages of Canagliflozin Cas 842133-18-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:25kg/drum Application:medicine raw mat
Cas:842133-18-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryCanagliflozin CAS No.:842133-18-0 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thi
Cas:842133-18-0
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:842133-18-0
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:842133-18-0
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:842133-18-0
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryName:Canagliflozin The alias:Canaglifozion;D-Glucitol CAS NO: 842133-18-0 Molecular formula:C24H25FO5S Molecular weight:444.52 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data stor
Cas:842133-18-0
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
Cas:842133-18-0
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryOur company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company
Cas:842133-18-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:842133-18-0
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:842133-18-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryName: Canaglifozin Synonyms: (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol CAS: 842133-18-0 MF: C24H25FO5S Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or off-white crystalline powder Storage:Store in seale
Cas:842133-18-0
Min.Order:100 Gram
Negotiable
Type:Other
inquiryAppearance:White powder Storage:R.T Package:25kg/drum Application:Canagliflozin is an SGLT2 inhibitor drug that can reduce blood Chemicalbook sugar by breaking down glucose and excreting it from the body through the kidneys. Transportation:Express/S
Cas:842133-18-0
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White crystalline powder Storage: Ke
Cas:842133-18-0
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:842133-18-0
Min.Order:1 Gram
FOB Price: $16.5 / 31.6
Type:Trading Company
inquiry842133-18-0 low price global Canagliflozin Canagliflozin (canagliflozin) is an SGLT2 inhibitor drug that lowers blood sugar by breaking down glucose and excreting it through the kidneys. In addition to good blood sugar control, canagliflozin (canagl
Cas:842133-18-0
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:842133-18-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:842133-18-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:842133-18-0
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:842133-18-0
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:842133-18-0
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:842133-18-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
CANAGLIFLOZIN (842133-18-0) Information Canagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is mainly used clinically for adult type 2 diabetes, as an adjuvant trea
Cas:842133-18-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry(3R,4R,5S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
canagliflozin
Conditions | Yield |
---|---|
With water; sodium hydroxide In tetrahydrofuran; methanol at 20 - 25℃; for 1.16667h; | 98% |
With di(n-butyl)tin oxide In methanol for 24h; Reflux; Inert atmosphere; | 95% |
With methanol; sodium methylate In tetrahydrofuran at 0 - 10℃; for 3h; Reagent/catalyst; | 94.9% |
canagliflozin
Conditions | Yield |
---|---|
With sodium methylate In tetrahydrofuran; methanol at 40℃; for 2h; | 96% |
canagliflozin
Conditions | Yield |
---|---|
With water; lithium hydroxide In methanol at 0 - 5℃; for 16h; | 93.3% |
canagliflozin
Conditions | Yield |
---|---|
With water; lithium hydroxide In methanol at 0 - 5℃; for 16h; | 92.1% |
canagliflozin
Conditions | Yield |
---|---|
With water; potassium hydroxide In tetrahydrofuran; methanol at 0 - 5℃; for 16h; Reagent/catalyst; Solvent; | 92.1% |
canagliflozin
Conditions | Yield |
---|---|
With trimethylsilyl iodide In dichloromethane at 0 - 20℃; for 8h; Inert atmosphere; Schlenk technique; Glovebox; | 92% |
With palladium 10% on activated carbon In dichloromethane Inert atmosphere; | 90% |
With trimethylsilyl iodide In dichloromethane at 0 - 30℃; Concentration; Reagent/catalyst; Temperature; Solvent; | 90% |
(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-thiyl tris(2,2-dimethylpropanoate)
canagliflozin
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 2h; Reflux; Large scale; | 91% |
With methanol; sodium methylate at 60℃; for 16h; Product distribution / selectivity; | 90% |
Multi-step reaction with 2 steps 1: methanol / 16 h / 20 - 60 °C 2: water / 1 h / 0 °C View Scheme |
(2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxylmethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
canagliflozin
Conditions | Yield |
---|---|
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at -40 - 0℃; for 3h; | 90% |
Stage #1: (2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxylmethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol With aluminum (III) chloride In dichloromethane; acetonitrile at -5℃; for 0.5h; Stage #2: With triethylsilane In dichloromethane; acetonitrile at -5 - 10℃; for 2h; | 79% |
With triethylsilane; acetonitrile boron trifluoride complex In n-heptane at -5 - 5℃; for 5h; | 77.5% |
canagliflozin
Conditions | Yield |
---|---|
With methanol Temperature; | 85% |
(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
canagliflozin
Conditions | Yield |
---|---|
Stage #1: (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at -25 - -10℃; for 2h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water at -10℃; Temperature; | 81.36% |
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane Inert atmosphere; Cooling with acetone-dry ice; Cooling with ice; enantioselective reaction; | 56.7% |
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at 0 - 5℃; |
canagliflozin
Conditions | Yield |
---|---|
In tert-butyl methyl ether; water for 1h; | 80% |
2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside
canagliflozin
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 4h; | 73% |
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 4h; Inert atmosphere; | 68% |
levoglucosan
canagliflozin
Conditions | Yield |
---|---|
Stage #1: levoglucosan With diisobutylaluminium hydride In toluene at 20℃; for 0.116667h; Inert atmosphere; Schlenk technique; Stage #2: bis(3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl)chloroalane In dibutyl ether; toluene at 140℃; for 20h; | 50% |
1-[1-hydroxy-2,3,4,6-tetra-O-(trimethylsilyl)-β-D-glucopyranosyl]-4-methyl-3-[[5-(4-fluorophenyl)-2-thienyl]methyl]benzene
canagliflozin
Conditions | Yield |
---|---|
With triethylsilane; boron trifluoride diethyl etherate In 1,1-dichloroethane at -30 - 20℃; for 1.5 - 2h; Product distribution / selectivity; |
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: trimethylsilylmethyllithium / toluene; diethyl ether; pentane / 0.75 h / -50 °C / Inert atmosphere 1.2: 1 h / 25 °C 2.1: ethyl acetate; toluene / 21 h / 75 °C / Inert atmosphere 3.1: methanol / 16 h / 20 - 60 °C 4.1: water / 1 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: n-hexyllithium / toluene; hexane; cyclopentyl methyl ether / 1.17 h / -45 - -25 °C / Inert atmosphere 2.1: zinc dibromide; lithium bromide / cyclopropyl methyl ether / -25 - 0 °C 2.2: 48.5 h / 20 - 65 °C 3.1: methanol / 16 h / 20 - 60 °C 4.1: water / 1 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; potassium bromide; sodium hydrogencarbonate / water; dichloromethane / 0.25 h / 20 °C 1.2: 20 - 35 °C 1.3: -70 - -30 °C / Inert atmosphere 2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -40 - -20 °C / Inert atmosphere 3.1: trimethylsilyl iodide / dichloromethane / 0 - 30 °C View Scheme |
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: zinc dibromide; lithium bromide / cyclopropyl methyl ether / -25 - 0 °C 1.2: 48.5 h / 20 - 65 °C 2.1: methanol / 16 h / 20 - 60 °C 3.1: water / 1 h / 0 °C View Scheme |
canagliflozin
Conditions | Yield |
---|---|
With water at 0℃; for 1h; |
C36H28F2S2Zn
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethyl acetate; toluene / 21 h / 75 °C / Inert atmosphere 2: methanol / 16 h / 20 - 60 °C 3: water / 1 h / 0 °C View Scheme |
alpha-D-glucopyranose
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / dmap / dichloromethane / 20.5 h / 0 - 20 °C / Inert atmosphere 2.1: trimethylsilyl bromide / zinc dibromide / dichloromethane / 24 h / 20 °C / Inert atmosphere 2.2: 0 °C / pH 7 - 8 3.1: n-butyllithium; zinc dibromide / n-heptane; toluene; dibutyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere 3.2: 6.5 h / 95 °C 4.1: methanol / sodium methylate / 16 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: pyridine; dmap; thionyl chloride / dichloromethane / 2 h / 48 - 50 °C / Reflux; Large scale 2: zinc dibromide; trimethylsilyl bromide / dichloromethane / 10 - 25 °C / Inert atmosphere 3: zinc dibromide; lithium bromide / diethyl ether / -76 °C 4: methanol View Scheme | |
Multi-step reaction with 4 steps 1.1: pyridine; dmap / dichloromethane / 20.5 h / 0 - 20 °C / Inert atmosphere 2.1: zinc dibromide / dichloromethane / 0.08 h / 20 °C / Inert atmosphere 2.2: 24 h / 20 °C 3.1: isopropylmagnesium chloride; lithium chloride; n-butyllithium / tetrahydrofuran; hexane / 3 h / -10 °C / Inert atmosphere 4.1: water; potassium hydroxide / tetrahydrofuran; methanol / 16 h / 0 - 5 °C View Scheme |
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium; zinc dibromide / n-heptane; toluene; dibutyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere 1.2: 6.5 h / 95 °C 2.1: methanol / sodium methylate / 16 h / 60 °C View Scheme |
1,2,3,4,6-penta-O-pivaloyl-D-glucopyranoside
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trimethylsilyl bromide / zinc dibromide / dichloromethane / 24 h / 20 °C / Inert atmosphere 1.2: 0 °C / pH 7 - 8 2.1: n-butyllithium; zinc dibromide / n-heptane; toluene; dibutyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere 2.2: 6.5 h / 95 °C 3.1: methanol / sodium methylate / 16 h / 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: zinc dibromide; trimethylsilyl bromide / dichloromethane / 10 - 25 °C / Inert atmosphere 2: zinc dibromide; lithium bromide / diethyl ether / -76 °C 3: methanol View Scheme |
1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / Reflux 1.2: 1 h / 20 °C 1.3: 5 h / 20 - 150 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium; ethylene dibromide / tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux 1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere View Scheme |
levoglucosan
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1H-imidazole / tetrahydrofuran / 0 °C 2.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / Reflux 2.2: 1 h / 20 °C 2.3: 5 h / 20 - 150 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Schlenk technique 2.1: magnesium; ethylene dibromide / tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux 2.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere View Scheme |
1,6-anhydro-β-D-glucopyranose 2,4-O-phenylboronate
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: water / dimethylsulfoxide-d6 / 1 h / 20 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / toluene / 0.12 h / 20 °C / Inert atmosphere; Schlenk technique 2.2: 20 h / 140 °C View Scheme |
2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / toluene; di-isopropyl ether; hexane / 0 °C / Inert atmosphere; Schlenk technique 1.2: 90 °C / Inert atmosphere; Schlenk technique 2.1: diisobutylaluminium hydride / toluene / 0.12 h / 20 °C / Inert atmosphere; Schlenk technique 2.2: 20 h / 140 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 1.2: -75 - -70 °C 1.3: 12 h / -75 - 30 °C 2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 3 h / 20 °C 2.1: triethylsilane; boron trifluoride diethyl etherate / chloroform / 3 h / -40 - 20 °C / Inert atmosphere 3.1: palladium 10% on activated carbon / dichloromethane / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: n-butyllithium / toluene / -18 - -5 °C 2: methanol / 0 - 20 °C 3: acetonitrile boron trifluoride complex; triethylsilane / n-heptane / 5 h / -5 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium iodide; copper(l) iodide; N,N`-dimethylethylenediamine / toluene; diethylene glycol dimethyl ether / 36 h / Inert atmosphere; Reflux 2.1: tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere 2.2: 2 h / 0 - 5 °C 2.3: 2 h / Cooling 3.1: 4-methyl-morpholine; dmap / toluene; ethyl acetate / 15 h / 0 - 20 °C 4.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 4 h / 0 °C 5.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 19.5 h / 20 - 24 °C View Scheme |
2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene
3,4,6-tri-O-benzyl-D-glucal epoxide
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tri-n-butyllithium magnesate complex / tetrahydrofuran; hexane; diethyl ether / 0.33 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tri-n-butyllithium magnesate complex / tetrahydrofuran; hexane; diethyl ether / 0.33 h / 0 °C / Inert atmosphere 1.2: 0.5 h / 0 °C / Inert atmosphere 1.3: 0 - 20 °C / Inert atmosphere 2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 0 - 20 °C View Scheme |
canagliflozin
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 0 - 20℃; for 1h; | 0.31 g |
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -70 - -60 °C / Inert atmosphere 2.1: methanesulfonic acid / tetrahydrofuran; toluene; hexane / -70 - 30 °C / Inert atmosphere 3.1: triethylsilane / dichloromethane / -75 - -70 °C 3.2: -75 - 0 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1.5 h / -80 - -70 °C 1.2: -80 - -70 °C 1.3: -80 - 20 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1.5 h / -80 - -70 °C 2.2: -80 - -70 °C 2.3: -80 - 20 °C 3.1: triethylsilane / dichloromethane; acetonitrile / 1 h / -55 - -40 °C / Inert atmosphere 3.2: 2 h / -55 - -40 °C View Scheme | |
Multi-step reaction with 3 steps 1: n-butyllithium / toluene / -18 - -5 °C 2: methanol / 0 - 20 °C 3: acetonitrile boron trifluoride complex; triethylsilane / n-heptane / 5 h / -5 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -75 - -70 °C / Inert atmosphere; Large scale 1.2: 1 h / -60 - 20 °C / Large scale 1.3: Large scale 2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: TurboGrignard / tetrahydrofuran / 1 h / -18 - -13 °C / Inert atmosphere; Large scale 1.2: 1 h / -15 - -10 °C / Large scale 1.3: 1 h / 20 °C / Large scale 2.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 10 °C / Large scale 3.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile; water / 5 - 20 °C / Large scale 4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C / Large scale View Scheme |
D-Glucono-1,5-lactone
canagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 4-methyl-morpholine / tetrahydrofuran / -10 - 30 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -70 - -60 °C / Inert atmosphere 3.1: methanesulfonic acid / tetrahydrofuran; toluene; hexane / -70 - 30 °C / Inert atmosphere 4.1: triethylsilane / dichloromethane / -75 - -70 °C 4.2: -75 - 0 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: trifluoroacetic acid 2.1: s-butylmagnesium chloride; lithium chloride / toluene; tetrahydrofuran / 2 h / -5 - 0 °C 2.2: -45 - -35 °C 3.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 1 h / 30 - 42 °C 4.1: sodium methylate / methanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: trifluoroacetic acid 2.1: s-butylmagnesium chloride; lithium chloride / toluene; tetrahydrofuran / 2 h / -5 - 0 °C 2.2: -45 - -35 °C 3.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 1 h / 30 - 42 °C 4.1: sodium methylate / methanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: 4-methyl-morpholine / tetrahydrofuran / 20 °C / Inert atmosphere; Large scale 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -75 - -70 °C / Inert atmosphere; Large scale 2.2: 1 h / -60 - 20 °C / Large scale 2.3: Large scale 3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C View Scheme |
canagliflozin
L-proline
L-proline-(2S,3R,4R,5S,6R)-2-{3-[5-(4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
Conditions | Yield |
---|---|
In n-heptane; ethyl acetate at 60 - 65℃; for 5h; Solvent; Inert atmosphere; | 93% |
In acetone for 0.166667h; Product distribution / selectivity; | |
In ethanol; water | 0.3 g |
canagliflozin
acetic anhydride
(3R,4R,5S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Conditions | Yield |
---|---|
With dmap; triethylamine In ethyl acetate at 20 - 30℃; for 1h; | 80% |
With 4-methyl-morpholine; dmap In tetrahydrofuran at -10 - 20℃; for 1.25h; | 78% |
With 4-methyl-morpholine; dmap In dichloromethane at -5 - 5℃; for 4h; Reagent/catalyst; | 69.5% |
isonipecotic acid
canagliflozin
Conditions | Yield |
---|---|
In water; acetone at 40℃; for 6h; Solvent; | 80% |
canagliflozin
(S)-2-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
In dichloromethane at 20 - 30℃; Reagent/catalyst; | 66% |
canagliflozin
Conditions | Yield |
---|---|
Stage #1: canagliflozin With dihydrogen peroxide In water; acetonitrile at 60℃; for 12h; Stage #2: With dihydrogen peroxide; fluorophosphoric acid In water; acetonitrile at 25℃; for 48h; | 35% |
Multi-step reaction with 3 steps 1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / ethanol / 24 h / 20 °C 2: sodium tetrahydroborate / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere 3: dihydrogen peroxide; sulfuric acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With 4-methyl-morpholine In dichloromethane at -10 - 20℃; for 1h; | A 19.1% B 21.4% |
canagliflozin
Conditions | Yield |
---|---|
With water In acetone at 20℃; for 18h; Product distribution / selectivity; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View