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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Canagliflozin

Cas:842133-18-0

Min.Order:10 Gram

FOB Price: $10.0

Type:Manufacturers

inquiry

Senova Technology Company Limited

We have most reliable quality, competitive prices and full documents for this APIs 1. GMP WORKSHOP 2. DMF Appearance:White to off-white powder Storage:2~8℃,protected from light Application:Canagliflozin(Invokana) is an oral diabet

Canagliflozin(cas#842133-18-0)

Cas:842133-18-0

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Chemvon Biotechnology Co. Ltd.

name:Canagliflozin cas:842133-18-0 Molecular Formula:C24H25FO5S Molecular Weight:444.52 Appearance:White to Off-White crystalline Solid Package:as requested Application:cas:842133-18-0

Canagliflozin

Cas:842133-18-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Canagliflozin Manufacturer/High quality/Best price/In stock

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W

98% up Canagliflozin 842133-18-0

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $825.0 / 1100.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Canagliflozin Cas 842133-18-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:25kg/drum Application:medicine raw mat

Manufacturer high quality Canagliflozin Cas 842133-18-0 with good price

Cas:842133-18-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Canagliflozin CAS No.:842133-18-0 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thi

High purity Canagliflozin CAS No.:842133-18-0 supplier from china

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Canagliflozin

Cas:842133-18-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Canagliflozin 842133-18-0 GMP Manufacturer

Cas:842133-18-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Canagliflozin

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Canagliflozin The alias:Canaglifozion;D-Glucitol CAS NO: 842133-18-0 Molecular formula:C24H25FO5S Molecular weight:444.52 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data stor

Canagliflozin/CAS:842133-18-0/Manufacturer

Cas:842133-18-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Canagliflozin

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol

Cas:842133-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

China factory supplyCAS 842133-18-0 with high-quality service

Cas:842133-18-0

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High purity Canagliflozin 99%

Cas:842133-18-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Canaglifozin Synonyms: (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol CAS: 842133-18-0 MF: C24H25FO5S Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/

Canaglifozin

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or off-white crystalline powder Storage:Store in seale

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R.T Package:25kg/drum Application:Canagliflozin is an SGLT2 inhibitor drug that can reduce blood Chemicalbook sugar by breaking down glucose and excreting it from the body through the kidneys. Transportation:Express/S

Factory price high quality Canagliflozin

Cas:842133-18-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White crystalline powder Storage: Ke

High purity Canagliflozin 99%

Cas:842133-18-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Oral diabetes drugs Canagliflozin/CAS:842133-18-0

Cas:842133-18-0

Min.Order:1 Gram

FOB Price: $16.5 / 31.6

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

842133-18-0 low price global Canagliflozin Canagliflozin (canagliflozin) is an SGLT2 inhibitor drug that lowers blood sugar by breaking down glucose and excreting it through the kidneys. In addition to good blood sugar control, canagliflozin (canagl

842133-18-0 low price global Canagliflozin

Cas:842133-18-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

canagliflozin

Cas:842133-18-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Canagliflozin manufacturer with low price

Cas:842133-18-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Oral diabetes drugs Canagliflozin

Cas:842133-18-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Canagliflozin cas:842133-18-0

Cas:842133-18-0

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-

Cas:842133-18-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Canagliflozin

Cas:842133-18-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Luhan Pharmachem Co., Lt

CANAGLIFLOZIN (842133-18-0) Information Canagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is mainly used clinically for adult type 2 diabetes, as an adjuvant trea

Canagliflozin,High Purity

Cas:842133-18-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(3R,4R,5S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
866607-35-4

(3R,4R,5S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran; methanol at 20 - 25℃; for 1.16667h;98%
With di(n-butyl)tin oxide In methanol for 24h; Reflux; Inert atmosphere;95%
With methanol; sodium methylate In tetrahydrofuran at 0 - 10℃; for 3h; Reagent/catalyst;94.9%
(2S,3S,4R,5R,6R)-6-(benzoylmethyl)-3,4,5-tribenzoyl-2-{3-[(5-(4-fluorophenyl)-2-thienyl)methyl]-4-methylphenyl}-2H-glucopyranoside

(2S,3S,4R,5R,6R)-6-(benzoylmethyl)-3,4,5-tribenzoyl-2-{3-[(5-(4-fluorophenyl)-2-thienyl)methyl]-4-methylphenyl}-2H-glucopyranoside

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran; methanol at 40℃; for 2h;96%
C44H45Cl12FO9S

C44H45Cl12FO9S

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With water; lithium hydroxide In methanol at 0 - 5℃; for 16h;93.3%
C44H49Cl8FO9S

C44H49Cl8FO9S

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With water; lithium hydroxide In methanol at 0 - 5℃; for 16h;92.1%
C44H53Cl4FO9S

C44H53Cl4FO9S

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With water; potassium hydroxide In tetrahydrofuran; methanol at 0 - 5℃; for 16h; Reagent/catalyst; Solvent;92.1%
(2R,3R,4R,5S,6S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-6-(3-((5-(4-fluorophenyl)-thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran

(2R,3R,4R,5S,6S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-6-(3-((5-(4-fluorophenyl)-thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With trimethylsilyl iodide In dichloromethane at 0 - 20℃; for 8h; Inert atmosphere; Schlenk technique; Glovebox;92%
With palladium 10% on activated carbon In dichloromethane Inert atmosphere;90%
With trimethylsilyl iodide In dichloromethane at 0 - 30℃; Concentration; Reagent/catalyst; Temperature; Solvent;90%
(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-thiyl tris(2,2-dimethylpropanoate)
1283129-18-9

(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-thiyl tris(2,2-dimethylpropanoate)

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 2h; Reflux; Large scale;91%
With methanol; sodium methylate at 60℃; for 16h; Product distribution / selectivity;90%
Multi-step reaction with 2 steps
1: methanol / 16 h / 20 - 60 °C
2: water / 1 h / 0 °C
View Scheme
(2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxylmethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1358581-37-9

(2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxylmethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at -40 - 0℃; for 3h;90%
Stage #1: (2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxylmethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol With aluminum (III) chloride In dichloromethane; acetonitrile at -5℃; for 0.5h;
Stage #2: With triethylsilane In dichloromethane; acetonitrile at -5 - 10℃; for 2h;
79%
With triethylsilane; acetonitrile boron trifluoride complex In n-heptane at -5 - 5℃; for 5h;77.5%
C44H57FO9S

C44H57FO9S

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With methanol Temperature;85%
(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1030825-21-8

(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Stage #1: (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at -25 - -10℃; for 2h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water at -10℃; Temperature;
81.36%
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane Inert atmosphere; Cooling with acetone-dry ice; Cooling with ice; enantioselective reaction;56.7%
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane at 0 - 5℃;
(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol piperdine-4-carboxylic acid complex

(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol piperdine-4-carboxylic acid complex

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
In tert-butyl methyl ether; water for 1h;80%
2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside
1432591-84-8

2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 4h;73%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;68%
bis(3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl)chloroalane

bis(3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl)chloroalane

levoglucosan
498-07-7

levoglucosan

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Stage #1: levoglucosan With diisobutylaluminium hydride In toluene at 20℃; for 0.116667h; Inert atmosphere; Schlenk technique;
Stage #2: bis(3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl)chloroalane In dibutyl ether; toluene at 140℃; for 20h;
50%
1-[1-hydroxy-2,3,4,6-tetra-O-(trimethylsilyl)-β-D-glucopyranosyl]-4-methyl-3-[[5-(4-fluorophenyl)-2-thienyl]methyl]benzene
1132832-76-8

1-[1-hydroxy-2,3,4,6-tetra-O-(trimethylsilyl)-β-D-glucopyranosyl]-4-methyl-3-[[5-(4-fluorophenyl)-2-thienyl]methyl]benzene

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With triethylsilane; boron trifluoride diethyl etherate In 1,1-dichloroethane at -30 - 20℃; for 1.5 - 2h; Product distribution / selectivity;
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
898566-17-1

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trimethylsilylmethyllithium / toluene; diethyl ether; pentane / 0.75 h / -50 °C / Inert atmosphere
1.2: 1 h / 25 °C
2.1: ethyl acetate; toluene / 21 h / 75 °C / Inert atmosphere
3.1: methanol / 16 h / 20 - 60 °C
4.1: water / 1 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-hexyllithium / toluene; hexane; cyclopentyl methyl ether / 1.17 h / -45 - -25 °C / Inert atmosphere
2.1: zinc dibromide; lithium bromide / cyclopropyl methyl ether / -25 - 0 °C
2.2: 48.5 h / 20 - 65 °C
3.1: methanol / 16 h / 20 - 60 °C
4.1: water / 1 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; potassium bromide; sodium hydrogencarbonate / water; dichloromethane / 0.25 h / 20 °C
1.2: 20 - 35 °C
1.3: -70 - -30 °C / Inert atmosphere
2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -40 - -20 °C / Inert atmosphere
3.1: trimethylsilyl iodide / dichloromethane / 0 - 30 °C
View Scheme
C18H14FLiS

C18H14FLiS

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: zinc dibromide; lithium bromide / cyclopropyl methyl ether / -25 - 0 °C
1.2: 48.5 h / 20 - 65 °C
2.1: methanol / 16 h / 20 - 60 °C
3.1: water / 1 h / 0 °C
View Scheme
(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyltris(2,2-dimethylpropanoate)

(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyltris(2,2-dimethylpropanoate)

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With water at 0℃; for 1h;
C36H28F2S2Zn
1283129-24-7

C36H28F2S2Zn

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethyl acetate; toluene / 21 h / 75 °C / Inert atmosphere
2: methanol / 16 h / 20 - 60 °C
3: water / 1 h / 0 °C
View Scheme
alpha-D-glucopyranose
492-62-6

alpha-D-glucopyranose

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / dmap / dichloromethane / 20.5 h / 0 - 20 °C / Inert atmosphere
2.1: trimethylsilyl bromide / zinc dibromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
2.2: 0 °C / pH 7 - 8
3.1: n-butyllithium; zinc dibromide / n-heptane; toluene; dibutyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere
3.2: 6.5 h / 95 °C
4.1: methanol / sodium methylate / 16 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine; dmap; thionyl chloride / dichloromethane / 2 h / 48 - 50 °C / Reflux; Large scale
2: zinc dibromide; trimethylsilyl bromide / dichloromethane / 10 - 25 °C / Inert atmosphere
3: zinc dibromide; lithium bromide / diethyl ether / -76 °C
4: methanol
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine; dmap / dichloromethane / 20.5 h / 0 - 20 °C / Inert atmosphere
2.1: zinc dibromide / dichloromethane / 0.08 h / 20 °C / Inert atmosphere
2.2: 24 h / 20 °C
3.1: isopropylmagnesium chloride; lithium chloride; n-butyllithium / tetrahydrofuran; hexane / 3 h / -10 °C / Inert atmosphere
4.1: water; potassium hydroxide / tetrahydrofuran; methanol / 16 h / 0 - 5 °C
View Scheme
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
898566-17-1

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide
81058-27-7

2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium; zinc dibromide / n-heptane; toluene; dibutyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere
1.2: 6.5 h / 95 °C
2.1: methanol / sodium methylate / 16 h / 60 °C
View Scheme
1,2,3,4,6-penta-O-pivaloyl-D-glucopyranoside
1213234-53-7

1,2,3,4,6-penta-O-pivaloyl-D-glucopyranoside

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trimethylsilyl bromide / zinc dibromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
1.2: 0 °C / pH 7 - 8
2.1: n-butyllithium; zinc dibromide / n-heptane; toluene; dibutyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere
2.2: 6.5 h / 95 °C
3.1: methanol / sodium methylate / 16 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: zinc dibromide; trimethylsilyl bromide / dichloromethane / 10 - 25 °C / Inert atmosphere
2: zinc dibromide; lithium bromide / diethyl ether / -76 °C
3: methanol
View Scheme
1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose
1432591-75-7

1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / Reflux
1.2: 1 h / 20 °C
1.3: 5 h / 20 - 150 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
View Scheme
levoglucosan
498-07-7

levoglucosan

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1H-imidazole / tetrahydrofuran / 0 °C
2.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / Reflux
2.2: 1 h / 20 °C
2.3: 5 h / 20 - 150 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: magnesium; ethylene dibromide / tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
2.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
View Scheme
1,6-anhydro-β-D-glucopyranose 2,4-O-phenylboronate
32741-93-8

1,6-anhydro-β-D-glucopyranose 2,4-O-phenylboronate

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water / dimethylsulfoxide-d6 / 1 h / 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene / 0.12 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 20 h / 140 °C
View Scheme
2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene
1030825-20-7

2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / toluene; di-isopropyl ether; hexane / 0 °C / Inert atmosphere; Schlenk technique
1.2: 90 °C / Inert atmosphere; Schlenk technique
2.1: diisobutylaluminium hydride / toluene / 0.12 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 20 h / 140 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
1.2: -75 - -70 °C
1.3: 12 h / -75 - 30 °C
2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 3 h / 20 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / chloroform / 3 h / -40 - 20 °C / Inert atmosphere
3.1: palladium 10% on activated carbon / dichloromethane / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium / toluene / -18 - -5 °C
2: methanol / 0 - 20 °C
3: acetonitrile boron trifluoride complex; triethylsilane / n-heptane / 5 h / -5 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium iodide; copper(l) iodide; N,N`-dimethylethylenediamine / toluene; diethylene glycol dimethyl ether / 36 h / Inert atmosphere; Reflux
2.1: tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
2.2: 2 h / 0 - 5 °C
2.3: 2 h / Cooling
3.1: 4-methyl-morpholine; dmap / toluene; ethyl acetate / 15 h / 0 - 20 °C
4.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 4 h / 0 °C
5.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 19.5 h / 20 - 24 °C
View Scheme
2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene
1030825-20-7

2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene

3,4,6-tri-O-benzyl-D-glucal epoxide
74372-90-0

3,4,6-tri-O-benzyl-D-glucal epoxide

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tri-n-butyllithium magnesate complex / tetrahydrofuran; hexane; diethyl ether / 0.33 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tri-n-butyllithium magnesate complex / tetrahydrofuran; hexane; diethyl ether / 0.33 h / 0 °C / Inert atmosphere
1.2: 0.5 h / 0 °C / Inert atmosphere
1.3: 0 - 20 °C / Inert atmosphere
2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 0 - 20 °C
View Scheme
(2S,3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3-ol

(2S,3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3-ol

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 0 - 20℃; for 1h;0.31 g
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
32469-28-6, 55515-28-1, 55515-29-2, 32384-65-9

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -70 - -60 °C / Inert atmosphere
2.1: methanesulfonic acid / tetrahydrofuran; toluene; hexane / -70 - 30 °C / Inert atmosphere
3.1: triethylsilane / dichloromethane / -75 - -70 °C
3.2: -75 - 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1.5 h / -80 - -70 °C
1.2: -80 - -70 °C
1.3: -80 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1.5 h / -80 - -70 °C
2.2: -80 - -70 °C
2.3: -80 - 20 °C
3.1: triethylsilane / dichloromethane; acetonitrile / 1 h / -55 - -40 °C / Inert atmosphere
3.2: 2 h / -55 - -40 °C
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium / toluene / -18 - -5 °C
2: methanol / 0 - 20 °C
3: acetonitrile boron trifluoride complex; triethylsilane / n-heptane / 5 h / -5 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -75 - -70 °C / Inert atmosphere; Large scale
1.2: 1 h / -60 - 20 °C / Large scale
1.3: Large scale
2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: TurboGrignard / tetrahydrofuran / 1 h / -18 - -13 °C / Inert atmosphere; Large scale
1.2: 1 h / -15 - -10 °C / Large scale
1.3: 1 h / 20 °C / Large scale
2.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 10 °C / Large scale
3.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile; water / 5 - 20 °C / Large scale
4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C / Large scale
View Scheme
D-Glucono-1,5-lactone
90-80-2

D-Glucono-1,5-lactone

canagliflozin
842133-18-0

canagliflozin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine / tetrahydrofuran / -10 - 30 °C
2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -70 - -60 °C / Inert atmosphere
3.1: methanesulfonic acid / tetrahydrofuran; toluene; hexane / -70 - 30 °C / Inert atmosphere
4.1: triethylsilane / dichloromethane / -75 - -70 °C
4.2: -75 - 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid
2.1: s-butylmagnesium chloride; lithium chloride / toluene; tetrahydrofuran / 2 h / -5 - 0 °C
2.2: -45 - -35 °C
3.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 1 h / 30 - 42 °C
4.1: sodium methylate / methanol / 1 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid
2.1: s-butylmagnesium chloride; lithium chloride / toluene; tetrahydrofuran / 2 h / -5 - 0 °C
2.2: -45 - -35 °C
3.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 1 h / 30 - 42 °C
4.1: sodium methylate / methanol / 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine / tetrahydrofuran / 20 °C / Inert atmosphere; Large scale
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -75 - -70 °C / Inert atmosphere; Large scale
2.2: 1 h / -60 - 20 °C / Large scale
2.3: Large scale
3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C
View Scheme
canagliflozin
842133-18-0

canagliflozin

L-proline
147-85-3

L-proline

L-proline-(2S,3R,4R,5S,6R)-2-{3-[5-(4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
1409936-68-0

L-proline-(2S,3R,4R,5S,6R)-2-{3-[5-(4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

Conditions
ConditionsYield
In n-heptane; ethyl acetate at 60 - 65℃; for 5h; Solvent; Inert atmosphere;93%
In acetone for 0.166667h; Product distribution / selectivity;
In ethanol; water0.3 g
canagliflozin
842133-18-0

canagliflozin

acetic anhydride
108-24-7

acetic anhydride

(3R,4R,5S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
866607-35-4

(3R,4R,5S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
With dmap; triethylamine In ethyl acetate at 20 - 30℃; for 1h;80%
With 4-methyl-morpholine; dmap In tetrahydrofuran at -10 - 20℃; for 1.25h;78%
With 4-methyl-morpholine; dmap In dichloromethane at -5 - 5℃; for 4h; Reagent/catalyst;69.5%
isonipecotic acid
498-94-2

isonipecotic acid

canagliflozin
842133-18-0

canagliflozin

(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol piperdine-4-carboxylic acid complex

(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol piperdine-4-carboxylic acid complex

Conditions
ConditionsYield
In water; acetone at 40℃; for 6h; Solvent;80%
canagliflozin
842133-18-0

canagliflozin

(S)-2-methylpyrrolidine-2-carboxylic acid
42856-71-3

(S)-2-methylpyrrolidine-2-carboxylic acid

(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol alpha-methyl-L-proline

(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol alpha-methyl-L-proline

Conditions
ConditionsYield
In dichloromethane at 20 - 30℃; Reagent/catalyst;66%
canagliflozin
842133-18-0

canagliflozin

(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)(hydroperoxy)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)(hydroperoxy)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Stage #1: canagliflozin With dihydrogen peroxide In water; acetonitrile at 60℃; for 12h;
Stage #2: With dihydrogen peroxide; fluorophosphoric acid In water; acetonitrile at 25℃; for 48h;
35%
Multi-step reaction with 3 steps
1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / ethanol / 24 h / 20 °C
2: sodium tetrahydroborate / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
3: dihydrogen peroxide; sulfuric acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
View Scheme
canagliflozin
842133-18-0

canagliflozin

acetic anhydride
108-24-7

acetic anhydride

A

C31H33FO7S

C31H33FO7S

B

C28H29FO7S

C28H29FO7S

Conditions
ConditionsYield
With 4-methyl-morpholine In dichloromethane at -10 - 20℃; for 1h;A 19.1%
B 21.4%
canagliflozin
842133-18-0

canagliflozin

(1S)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hemihydrate

(1S)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hemihydrate

Conditions
ConditionsYield
With water In acetone at 20℃; for 18h; Product distribution / selectivity;
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