2-(4-Fluorophenyl)thiophene supplier

Name
2-(4-FLUOROPHENYL)THIOPHENE
EINECS 611-756-1
CAS No. 58861-48-6
Article Data53
CAS DataBase
Density 1.201 g/cm³
Solubility
Melting Point 51.0 to 55.0 °C
Formula C₁₀H₇FS
Boiling Point 252.316 °C at 760 mmHg
Molecular Weight 178.23
Flash Point 106.397 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-(4-Fluorophenyl)thiophene;
PSA 28.24000
LogP 3.55420

Synthetic route

: 1003-09-4
2-bromothiophene

: 1765-93-1
4-fluoroboronic acid

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Suzuki cross-coupling reaction;	95%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 15h; Inert atmosphere;	85%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 25 - 75℃; Inert atmosphere;	82.5%

: 1003-09-4
2-bromothiophene

: 352-13-6
4-flourophenylmagnesium bromide

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
Stage #1: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 2℃; for 0.666667h; Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 10 - 23℃; for 1.66667h; Stage #3: With acetic acid In tetrahydrofuran; water at 7℃; for 0.75h;	95%
Stage #1: 2-bromothiophene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In tetrahydrofuran at 50℃; for 0.0833333h; Inert atmosphere; Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 60℃; for 7h; Stage #3: With hydrogenchloride In tetrahydrofuran; water at 30℃; Cooling with ice;

: 3437-95-4
2-Iodothiophene

: 1765-93-1
4-fluoroboronic acid

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With potassium carbonate In water; N,N-dimethyl-formamide at 100℃; under 2585.81 Torr; for 0.333333h; Suzuki reaction; Microwave irradiation;	94%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 100℃; for 0.5h; Microwave irradiation;	86.1%
With potassium carbonate; Pd-N-heterocyclic carbene-organic silica In water; N,N-dimethyl-formamide at 100℃; for 0.16h; Suzuki reaction; microwave irradiation;	91 % Chromat.

: 6165-68-0
thiophene boronic acid

: 460-00-4
1-Bromo-4-fluorobenzene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In ethanol; water at 90℃; Inert atmosphere;	92%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In toluene at 90℃; for 0.5h; Schlenk technique; Inert atmosphere;	92%
With C33H48Cl2N4O9Pd; oxygen; potassium carbonate In water at 80℃; Suzuki-Miyaura Coupling;	85%
Stage #1: thiophene boronic acid; 1-Bromo-4-fluorobenzene With sodium carbonate In water; N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; for 3.03333h; Inert atmosphere;	82%

: 1003-09-4
2-bromothiophene

: 460-00-4
1-Bromo-4-fluorobenzene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
Stage #1: 1-Bromo-4-fluorobenzene With iodine; magnesium In tetrahydrofuran at 36 - 40℃; for 4h; Inert atmosphere; Stage #2: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20 - 25℃; for 5h; Temperature; Solvent; Inert atmosphere;	91.3%
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; Inert atmosphere; Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water at 40 - 60℃; pH=2.2; Reagent/catalyst;	87.6%
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; for 2h; Inert atmosphere; Sealed tube; Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Kumada Cross-Coupling; Inert atmosphere; Stage #3: With water at 40 - 60℃; Reagent/catalyst;	87.6%
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran; ethylene dibromide for 1.5h; Inert atmosphere; Stage #2: 2-bromothiophene With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 10 - 75℃; for 0.5h;	75%
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In 2-Me-THF Reflux; Inert atmosphere; Stage #2: 2-bromothiophene; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In 2-Me-THF at 2 - 22℃; Inert atmosphere; Stage #3: With acetic acid In 2-Me-THF; water for 0.25h; Inert atmosphere;

: 96-43-5
2-thienyl chloride

: 1765-93-1
4-fluoroboronic acid

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With potassium phosphate tribasic trihydrate; C31H41P; palladium diacetate In tetrahydrofuran at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere;	91%
With C27H39Br2N3Pd; potassium hydroxide In isopropyl alcohol at 82℃; for 0.166667h; Suzuki-Miyaura Coupling;	87%

: 517867-11-7
1-ethoxythiocarbonylsulfanyl-4-(4-fluorophenyl)-4-oxobutyl 2,2-dimethylpropionate

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With acetic acid; potassium iodide at 110℃; for 0.0833333h; Microwave irradiation;	88%
Multi-step reaction with 2 steps 1: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: silica gel / neat (no solvent) / 215 °C / Inert atmosphere View Scheme

: 352-34-1
4-fluoro-1-iodobenzene

: triethyl(thiophen-2-yl)germane

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); silver tetrafluoroborate In N,N-dimethyl-formamide at 80℃; for 16h; chemoselective reaction;	88%

: 1003-09-4
2-bromothiophene

: 214360-58-4
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 70 - 75℃;	87%

: 6165-68-0
thiophene boronic acid

: 352-34-1
4-fluoro-1-iodobenzene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere;	86%
With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere;	86%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; for 3h;	86%

: 366-77-8
4-(4-fluorophenyl)-4-oxopropionic acid

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With tetraphosphorus decasulfide In toluene for 0.5h; Microwave irradiation;	85%

: 249504-38-9
5-(4-fluorophenyl)thiophene-2-carboxaldehyde

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With Pd-γ-Fe2O3 In cyclohexane at 130℃; for 24h; Inert atmosphere; Molecular sieve; Sealed tube;	83%

: C10H8BrF

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With potassium sulfide; iodine In N,N-dimethyl-formamide at 110℃; for 11.8h; Inert atmosphere; chemoselective reaction;	76%

: C26H37FOS

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
Stage #1: C26H37FOS With hydrazine hydrate In dimethyl sulfoxide at 80℃; Stage #2: With potassium hydroxide In dimethyl sulfoxide at 200℃; for 4h;	74.9%

: 6165-68-0
thiophene boronic acid

: C10H12FS(1+)*F6P(1-)

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In ethanol at 40℃; for 3h;	74%

: 188290-36-0
thiophene

: 371-40-4
4-fluoroaniline

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With tert.-butylnitrite In acetonitrile at 25℃; for 0.75h; Flow reactor; Irradiation;	74%
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 1h; Green chemistry; Stage #2: thiophene With 3,4,5-trihydroxybenzoic acid In water; acetone at 20℃; for 12h; Inert atmosphere; Green chemistry;
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: thiophene In ethanol at 25℃; for 1h; Irradiation; Inert atmosphere;	80 %Chromat.
Stage #1: 4-fluoroaniline With tetrafluoroboric acid; sodium nitrite In water; acetone for 1h; Cooling; Stage #2: thiophene With 1,2,3,4-tetrahydrocarbazole In dimethyl sulfoxide Inert atmosphere; Darkness; regioselective reaction;

: (Z)-1-(4-bromobut-3-en-1-yn-1-yl)-4-fluorobenzene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With potassium ethyl xanthogenate; tetrabutyl phosphonium bromide In water at 130℃; for 20h; Schlenk technique; chemoselective reaction;	73%

: 1003-09-4
2-bromothiophene

: 352-13-6
4-flourophenylmagnesium bromide

A: 58861-48-6
2-(4-fluorophenyl)thiophene

B: 398-23-2
4,4'-difluorobiphenyl

C: 492-97-7
2,2'-Bithiophene

Conditions

Conditions	Yield
Stage #1: 4-flourophenylmagnesium bromide With bismuth(III) chloride Stage #2: 2-bromothiophene With potassium phosphate; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 90℃; for 1h; Inert atmosphere;	A 72% B n/a C n/a

...Expand

: 115933-30-7
5-(4-fluorophenyl)thiophene-2-carboxylic acid

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With copper In sulfolane at 200℃; for 2h;	72%

: phenyl 5-(4-fluorophenyl)thiophene-2-carboxylate

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	71%
With nickel(II) acetate tetrahydrate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 170℃; for 24h;	71%

: 1003-09-4
2-bromothiophene

: 352-34-1
4-fluoro-1-iodobenzene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
Stage #1: 2-bromothiophene With magnesium; ethylene dibromide In tetrahydrofuran at 20℃; for 0.75h; Kumada Cross-Coupling; Inert atmosphere; Stage #2: 4-fluoro-1-iodobenzene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20℃; Inert atmosphere; Reflux;	70%

: 1509927-78-9
4-[3-(4-fluorophenyl)-3-oxopropyl][1,3]dithietan-2-one

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With silica gel In neat (no solvent) at 215℃; Inert atmosphere;	70%

: 188290-36-0
thiophene

: 459-45-0
4-fluorobenzenediazonium tetrafluoroborate

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With cymantrene In dimethyl sulfoxide at 25℃; for 0.5h; Inert atmosphere; Irradiation; Flow reactor; regioselective reaction;	59%
With epi-Cercosporin In dimethyl sulfoxide at 20℃; for 8h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry; regioselective reaction;	57%
With graphitic carbon nitride/reduced graphene oxide nanocomposite In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; UV-irradiation; Green chemistry;	60 %Chromat.

: 188290-36-0
thiophene

: 460-00-4
1-Bromo-4-fluorobenzene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; catacxium A; Trimethylacetic acid In N,N-dimethyl-formamide at 110℃; for 12h; Schlenk technique; Inert atmosphere;	58%

: potassim 4-fluorophenyltrifluoroborate

: 403617-22-1
2-(n-butyltellanyl)thiophene

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; silver(l) oxide In methanol at 20℃; for 1.5h; Suzuki-Miyaura cross- coupling; Inert atmosphere;	56%

: 5713-61-1
thiophen-2-yl magnesium bromide

: 352-13-6
4-flourophenylmagnesium bromide

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
Stage #1: thiophen-2-yl magnesium bromide; 4-flourophenylmagnesium bromide With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -10℃; Inert atmosphere; Stage #2: With oxygen In tetrahydrofuran at 10 - 20℃;	51%

: 188290-36-0
thiophene

: triethyl(4-fluorophenyl)germane

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid In 1,4-dioxane at 70℃; for 16h;	48%

: 371-42-6
4-Fluorothiophenol

: 58861-48-6
2-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2.) NH4PF6 / 1.) MTBE, 23 deg C, 2.) acetone, 23 deg C 2: 74 percent / Pd(dppf)Cl2, K2CO3*H2O / aq. ethanol / 3 h / 40 °C View Scheme

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C20H15NO

: C30H20FNOS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 48h; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 1-(naphthalene-1-yl)benzo[h]isoquinoline

: C33H20FNS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	98%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C23H14FN

: C33H19F2NS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	97%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 1073313-97-9
2-bromo-5-(4-fluorophenyl)thiophene

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane	95.3%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1132832-75-7
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst;	93.2%
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;	89%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere;	80.4%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;	80%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C8H7ClO2

: (2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -20 - 20℃; for 3h; Inert atmosphere;	92%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C24H17N

: C34H22FNS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	92%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 21900-41-4
5-bromo-2-methylbenzoyl chloride

: 1132832-75-7
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -10 - 25℃; for 5.5h; Friedel-Crafts Acylation; Inert atmosphere;	90.1%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation;	85.7%
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 2.5 - 3.5h; Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at -12℃;
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃; Stage #2: With water In tetrahydrofuran cooling with ice;

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 124-38-9
carbon dioxide

: 115933-30-7
5-(4-fluorophenyl)thiophene-2-carboxylic acid

Conditions

Conditions	Yield
With ethylaluminum dichloride In hexane; toluene at 100℃; under 22502.3 Torr; for 3h; Autoclave; Inert atmosphere; regioselective reaction;	90%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C8H6BrClO2

: C18H12BrFOS

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -20 - 20℃; for 3h; Inert atmosphere;	90%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C24H17NO

: C34H22FNOS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	90%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: C25H17N

: C35H22FNS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	90%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 249504-38-9
5-(4-fluorophenyl)thiophene-2-carboxaldehyde

Conditions

Conditions	Yield
Stage #1: 2-(4-fluorophenyl)thiophene; N,N-dimethyl-formamide With tris(trimethylsilyl)amine; tetramethylammonium fluoride at 20℃; for 24h; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In water at 20℃; for 1.5h;	86%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 1-(pyren-1-yl)benzo[h]isoquinoline

: C39H22FNS

Conditions

Conditions	Yield
With 2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-methylbutyric acid; C30H33O2Rh; silver fluoride In N,N-dimethyl-formamide at 60℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	86%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 1150561-00-4
2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(thiophen-2-yl)ethan-1-ol

: 3-(2,2,2-trifluoro-1-(5-(4-fluorophenyl)thiophen-2-yl)-1-(thiophen-2-yl)ethyl)-1H-indole

Conditions

Conditions	Yield
With dodecylbenzenesulfonic acid In water at 80℃; for 24h; Green chemistry;	83%

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 54811-38-0
5-iodo-2-methylbenzoic acid

: (5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanone

Conditions

Conditions	Yield
Stage #1: 5-iodo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;	81%
Stage #1: 5-iodo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide for 1h; Reflux; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 30℃; for 1h;	222 g

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 108440-70-6
5-iodo-2-methylbenzoyl chloride

: 898566-17-1
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

Conditions

Conditions	Yield
With aluminum (III) chloride Solvent; Temperature; Friedel-Crafts Acylation;	80%
Stage #1: 5-iodo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 2℃; for 0.25h; Stage #2: 2-(4-fluorophenyl)thiophene In dichloromethane at 2 - 20℃; for 2.41667h; Product distribution / selectivity;

: 58861-48-6
2-(4-fluorophenyl)thiophene

: 98-80-6
phenylboronic acid

: 1415605-87-6
2-(4-fluorophenyl)-4-phenylthiophene

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; cesium trifluoroacetate; p-benzoquinone; silver(l) oxide In acetic acid; trifluoroacetic acid at 20℃; for 15h; regioselective reaction;	80%

2-(4-Fluorophenyl)thiophene Specification

The 2-(4-Fluorophenyl)thiophene with the CAS number 58861-48-6 is also called Thiophene,2-(4-fluorophenyl)-. Its molecular formula is C₁₀H₇FS. This chemical is a kind of organics. It should be stored in dry and cool environment.

The properties of the 2-(4-Fluorophenyl)thiophene are: (1)ACD/LogP: 3.83; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4; (4)ACD/LogD (pH 7.4): 4; (5)ACD/BCF (pH 5.5): 391; (6)ACD/BCF (pH 7.4): 391; (7)ACD/KOC (pH 5.5): 2497; (8)ACD/KOC (pH 7.4): 2497; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 28.24 Å²; (13)Index of Refraction: 1.578; (14)Molar Refractivity: 49.223 cm³; (15)Molar Volume: 148.407 cm³; (16)Polarizability: 19.513×10^-24cm³; (17)Surface Tension: 39.02 dyne/cm; (18)Enthalpy of Vaporization: 46.986 kJ/mol; (19)Vapour Pressure: 0.031 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1ccc(cc1)c2cccs2
(2)InChI: InChI=1/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
(3)InChIKey: PURJRGMZIKXDMW-UHFFFAOYAA

Product Name

2-(4-FLUOROPHENYL)THIOPHENE

Synthetic route

2-(4-Fluorophenyl)thiophene Specification

Related Products

Hot Products