Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma
Manufacturer supply 2'-Deoxy-2'-fluoroguanosine CAS 78842-13-4 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its i
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inquiry2'-Deoxy-2'-fluoroguanosine CAS:78842-13-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual
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Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryPRODUCT DETAILS
Cas:78842-13-4
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryNewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:78842-13-4
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inquiry2'-Deoxy-2'-fluoro-Guanosine/2'-Fluoro-2'-dG /deoxy nucleoside / modified nucleoside/ intermediate/ white powder with cas no.78842-13-4/ worldwide Top Pharma factory vendor with most competitive price Our Strength: -Flexible:
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inquiry2'-Deoxy-2'-fluoroguanosine Basic information Product Name: 2'-Deoxy-2'-fluoroguanosine Synonyms: 2'-deoxy-2'-fluoroguanosine;2'-FdG;2'-Fluoro -2'-deoxyguanosine;2'-F-2'-dG;Guanosine,2'-deoxy-2
Cas:78842-13-4
Min.Order:1 Gram
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inquiry78842-13-4 Appearance:95%+ Package:R&D,Pilot run Application:78842-13-4 Transportation:per client require Port:Express ,Air, Sea
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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Cas:78842-13-4
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo
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Min.Order:100 Gram
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inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
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inquiry1.High purity, like 99%, 99.9%, 99.95%, 99.99%2.Quality control, test sample before shipping and keep sample for 3 years after shipping;3. Prompt shipment with professional documents;4. Packing as your request, with photo before shipment;5. Mixed con
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
In water for 20h; Ambient temperature; adenosine deaminase; | 83% |
With ADase Substitution; |
2’-fluoro-N2-isobutyryl-2’-deoxyguanosine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
With ammonia at 20℃; for 16h; | 80% |
With ammonium hydroxide at 55℃; for 24h; Yield given; |
A
2'-chloro-2'-deoxyguanosine
B
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
With ammonium hydroxide In pyridine at 50℃; for 3h; | A n/a B 44% |
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
With ammonia In methanol at 0℃; for 24h; | 13% |
N2-isobutyryl-3'-O,5'-O-bis(tetrahydrofuranyl)-2'-deoxy-2'-fluoroguanosine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
With ammonium hydroxide; acetic acid 1.) pyridine, 50 deg C, 3 h; 2.) H2O, 30 deg C, 2 h; Yield given. Multistep reaction; |
1-O-acetyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranoside
A
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multistep reaction; |
2'-deoxy-2'-fluorocytidine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: E. coli BMT-4D/1A 2: ADase View Scheme |
2,6-diaminopurine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: E. coli BMT-4D/1A 2: ADase View Scheme | |
Multi-step reaction with 2 steps 1: E. coli BMT-4D/1A 2: ADase View Scheme |
2'-deoxy-2'-fluorouridine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: E. coli BMT-4D/1A 2: ADase View Scheme |
9-β-D-arabinofuranosylguanine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) TMSCl, pyridine, 3.) NH4OH 2: TsOH / dioxane 3: DMAP / CH2Cl2 4: TBAF / tetrahydrofuran 5: Dowex-50 / methanol 6: NH4OH / 24 h / 55 °C View Scheme | |
Multi-step reaction with 10 steps 1: 1.) TMSCl, pyridine, 3.) NH4OH 2: pyridine 4: HF*pyridine 5: TsOH / dioxane 6: NaOH / pyridine; methanol 7: DMAP / CH2Cl2 8: TBAF / tetrahydrofuran 9: Dowex-50 / methanol 10: NH4OH / 24 h / 55 °C View Scheme |
2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1.) BCl3, 2.) NaOH / 1.) CH2Cl2 2: adenosine deaminase / 72 h / 37 °C / phosphate buffer, pH 7-7.5 3: 1.) TMSCl, pyridine, 3.) NH4OH 4: TsOH / dioxane 5: DMAP / CH2Cl2 6: TBAF / tetrahydrofuran 7: Dowex-50 / methanol 8: NH4OH / 24 h / 55 °C View Scheme | |
Multi-step reaction with 12 steps 1: 1.) BCl3, 2.) NaOH / 1.) CH2Cl2 2: adenosine deaminase / 72 h / 37 °C / phosphate buffer, pH 7-7.5 3: 1.) TMSCl, pyridine, 3.) NH4OH 4: pyridine 6: HF*pyridine 7: TsOH / dioxane 8: NaOH / pyridine; methanol 9: DMAP / CH2Cl2 10: TBAF / tetrahydrofuran 11: Dowex-50 / methanol 12: NH4OH / 24 h / 55 °C View Scheme |
N2-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: DMAP / CH2Cl2 2: TBAF / tetrahydrofuran 3: Dowex-50 / methanol 4: NH4OH / 24 h / 55 °C View Scheme | |
Multi-step reaction with 4 steps 1: pyridine, (N,N-dimethylamino)pyrydine / CH2Cl2 / 1 h / 5 °C 2: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C 3: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C 4: 80 percent / sat. NH3 in MeOH / 16 h / 20 °C View Scheme |
Acetic acid (2R,3S,4R,5R)-4-hydroxy-5-hydroxymethyl-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: TsOH / dioxane 2: NaOH / pyridine; methanol 3: DMAP / CH2Cl2 4: TBAF / tetrahydrofuran 5: Dowex-50 / methanol 6: NH4OH / 24 h / 55 °C View Scheme |
N2-isobutyryl-9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 2: HF*pyridine 3: TsOH / dioxane 4: NaOH / pyridine; methanol 5: DMAP / CH2Cl2 6: TBAF / tetrahydrofuran 7: Dowex-50 / methanol 8: NH4OH / 24 h / 55 °C View Scheme |
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: NaOH / pyridine; methanol 2: DMAP / CH2Cl2 3: TBAF / tetrahydrofuran 4: Dowex-50 / methanol 5: NH4OH / 24 h / 55 °C View Scheme |
Acetic acid (2R,3S,3aR,9aR)-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: HF*pyridine 2: TsOH / dioxane 3: NaOH / pyridine; methanol 4: DMAP / CH2Cl2 5: TBAF / tetrahydrofuran 6: Dowex-50 / methanol 7: NH4OH / 24 h / 55 °C View Scheme |
2,6-diamino-9-(β-D-arabinofuranosyl)-purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: adenosine deaminase / 72 h / 37 °C / phosphate buffer, pH 7-7.5 2: 1.) TMSCl, pyridine, 3.) NH4OH 3: TsOH / dioxane 4: DMAP / CH2Cl2 5: TBAF / tetrahydrofuran 6: Dowex-50 / methanol 7: NH4OH / 24 h / 55 °C View Scheme | |
Multi-step reaction with 11 steps 1: adenosine deaminase / 72 h / 37 °C / phosphate buffer, pH 7-7.5 2: 1.) TMSCl, pyridine, 3.) NH4OH 3: pyridine 5: HF*pyridine 6: TsOH / dioxane 7: NaOH / pyridine; methanol 8: DMAP / CH2Cl2 9: TBAF / tetrahydrofuran 10: Dowex-50 / methanol 11: NH4OH / 24 h / 55 °C View Scheme |
1-O-acetyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranoside
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 23 percent / p-TsOH / 0.83 h / 160 °C / 25 Torr 2: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 3: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 4: 79 percent / MeONa / methanol / 1 h / Ambient temperature 5: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme |
2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 79 percent / MeONa / methanol / 1 h / Ambient temperature 2: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme |
2,6-diazido-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 2: 79 percent / MeONa / methanol / 1 h / Ambient temperature 3: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme |
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 59 percent / mercuric cyanide / various solvent(s) / 24 h / Ambient temperature 2: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 3: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 4: 79 percent / MeONa / methanol / 1 h / Ambient temperature 5: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme |
2,6-dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 2: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 3: 79 percent / MeONa / methanol / 1 h / Ambient temperature 4: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme |
2,6-dichloro-7H-purine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 59 percent / mercuric cyanide / various solvent(s) / 24 h / Ambient temperature 2: 75 percent / NaN3 / ethanol; H2O / 1.) reflux, 1 h, 2.) room temperature, 20 h 3: 94 percent / H2 / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature 4: 79 percent / MeONa / methanol / 1 h / Ambient temperature 5: 83 percent / H2O / 20 h / Ambient temperature; adenosine deaminase View Scheme |
3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: DMSO, acetic anhydride 2: NaBH4 / 1.5 h / 0 °C 3: 80 percent / pyridine / 20 h / 60 °C 4: 80 percent / n-Bu4NF 5: 82 percent / p-toluenesulfonic acid / dioxane / 2 h / 23 °C 6: 78 percent / NaOH / acetonitrile; methanol; H2O 7: pyridine, (N,N-dimethylamino)pyrydine / CH2Cl2 / 1 h / 5 °C 8: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C 9: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C 10: 80 percent / sat. NH3 in MeOH / 16 h / 20 °C View Scheme |
2-amino-9-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1H-purin-6(9H)-one
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: NaBH4 / 1.5 h / 0 °C 2: 80 percent / pyridine / 20 h / 60 °C 3: 80 percent / n-Bu4NF 4: 82 percent / p-toluenesulfonic acid / dioxane / 2 h / 23 °C 5: 78 percent / NaOH / acetonitrile; methanol; H2O 6: pyridine, (N,N-dimethylamino)pyrydine / CH2Cl2 / 1 h / 5 °C 7: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C 8: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C 9: 80 percent / sat. NH3 in MeOH / 16 h / 20 °C View Scheme |
N2-isobutyryl-9-(2-O-isobutyryl-β-D-arabinofuranosyl)guanine
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 82 percent / p-toluenesulfonic acid / dioxane / 2 h / 23 °C 2: 78 percent / NaOH / acetonitrile; methanol; H2O 3: pyridine, (N,N-dimethylamino)pyrydine / CH2Cl2 / 1 h / 5 °C 4: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C 5: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C 6: 80 percent / sat. NH3 in MeOH / 16 h / 20 °C View Scheme |
Isobutyric acid (2R,3S,4R,5R)-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-3-yl ester
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 78 percent / NaOH / acetonitrile; methanol; H2O 2: pyridine, (N,N-dimethylamino)pyrydine / CH2Cl2 / 1 h / 5 °C 3: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C 4: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C 5: 80 percent / sat. NH3 in MeOH / 16 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With pyridine; 1H-imidazole at 25℃; for 15h; Time; | 99% |
With pyridine; 1H-imidazole at 25℃; for 15h; | 99% |
With 1H-imidazole In pyridine at 25℃; for 15h; | 99% |
With pyridine; 1H-imidazole at 25℃; for 15h; | 83% |
2'-deoxy-2'-fluoroguanosine
8-bromo-2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
With bromine In water | 94% |
With N-Bromosuccinimide In water at 0℃; for 2.33333h; Inert atmosphere; | 47% |
acetic anhydride
2'-deoxy-2'-fluoroguanosine
mono-4-methoxytrityl chloride
C34H32FN5O7
Conditions | Yield |
---|---|
Stage #1: acetic anhydride; 2'-deoxy-2'-fluoroguanosine With pyridine at 0 - 25℃; for 10h; Stage #2: mono-4-methoxytrityl chloride With silver nitrate at 0 - 25℃; for 10h; | 93% |
2'-deoxy-2'-fluoroguanosine
mono-4-methoxytrityl chloride
C30H28FN5O5
Conditions | Yield |
---|---|
Stage #1: 2'-deoxy-2'-fluoroguanosine With pyridine; acetic anhydride at 0 - 20℃; for 10h; Stage #2: mono-4-methoxytrityl chloride With silver nitrate at 20℃; for 10h; Stage #3: With ammonia In methanol at 20℃; for 14h; | 87.5% |
Stage #1: 2'-deoxy-2'-fluoroguanosine With acetic anhydride In pyridine at 0 - 20℃; for 10h; Stage #2: mono-4-methoxytrityl chloride With silver nitrate In pyridine at 20℃; for 10h; Stage #3: With ammonia In methanol at 20℃; for 14h; | 9.2 g |
acetic anhydride
2'-deoxy-2'-fluoroguanosine
2’-fluoro-2’-deoxyguanosine-3’,5’-O-diacetate
Conditions | Yield |
---|---|
With pyridine In N,N-dimethyl-formamide at 23℃; for 12h; Inert atmosphere; | 79% |
With dmap; triethylamine In acetonitrile at 20℃; for 2h; | 78% |
With pyridine at 20℃; | 5 g |
tert-butyldimethylsilyl chloride
2'-deoxy-2'-fluoroguanosine
C16H26FN5O4Si
Conditions | Yield |
---|---|
Stage #1: tert-butyldimethylsilyl chloride; 2'-deoxy-2'-fluoroguanosine With pyridine; 1H-imidazole at 25℃; for 15h; Stage #2: With acetic acid In tetrahydrofuran; water at 80℃; for 13h; | 60.9% |
Stage #1: tert-butyldimethylsilyl chloride; 2'-deoxy-2'-fluoroguanosine With 1H-imidazole In pyridine at 25℃; for 15h; Stage #2: With acetic acid In tetrahydrofuran; water at 80℃; for 13h; | 31.2 g |
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 45% |
2'-deoxy-2'-fluoroguanosine
Conditions | Yield |
---|---|
With phosphorous acid trimethyl ester; trichlorophosphate at 0℃; for 2h; |
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