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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Epinastine Manufacturer/High quality/Best price/In stock

Cas:80012-43-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

epinastine manufacturer/supplier

Cas:80012-43-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipmen Appearance:White to off-white crystalline powder Storage:Cool dry place Package:1kg/foil bag Application:

Factory supply Epinastine Base Cas 80012-43-7 with high quality and good price

Cas:80012-43-7

Min.Order:1 Kilogram

FOB Price: $2500.0 / 2727.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Epinastine 80012-43-7 GMP Manufacturer

Cas:80012-43-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Epinastine

Cas:80012-43-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Epinastine

Cas:80012-43-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Epinastine 80012-43-7

Cas:80012-43-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 80012-43-7 with best quality

Cas:80012-43-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name Epinastine Synonyms 3-Amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine Molecular Formula C16H15N3 Molecular Weight

Epinastine

Cas:80012-43-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine,9,13b-dihydro- 80012-43-7

Cas:80012-43-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Epinastine with CAS:80012-43-7

Cas:80012-43-7

Min.Order:1 Gram

FOB Price: $74.0 / 84.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Epinastine CAS:80012-43-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Epinastine CAS:80012-43-7

Cas:80012-43-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine,9,13b-dihydro-

Cas:80012-43-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine,9,13b-dihydro-

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Epinastine

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

epinastine competitive price

Cas:80012-43-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Epinastine Hydrochloride

Cas:80012-43-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Epinastine

Cas:80012-43-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Epinastine CAS No.:80012-43-7 Molecule Formula:C16H15N3 Molecule Weight:249.31 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING I

Lower Price Epinastine on stock

Cas:80012-43-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Epinastine

Cas:80012-43-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Epinastine Chemical Properties Melting point 205-208° Boiling point 428.0±55.0 °C(Predicted) density 1.32±0.1 g/cm3(Predicted) storage temp. Keep in dark place,Inert atmosphere,Room temperature pka 11.2(at 25℃

Epinastine

Cas:80012-43-7

Min.Order:1 Gram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine,9,13b-dihydro-

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Epinastine

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Epinastine, CAS 80012-43-7, white powder, commercial Qty Shanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We specialize

Epinastine

Cas:80012-43-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Epinastine

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Epinastine Cas no.80012-43-7 98%

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

epinastine

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

Epinastine

Cas:80012-43-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

3-methoxycarbonylamino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine

3-methoxycarbonylamino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 2h;98%
With hydrogenchloride at 95℃; for 31h;73%
3-amino-9,13b-dihydro-1H-dibenzimidazo<1,5-a>azepine hydrobromide
127786-29-2

3-amino-9,13b-dihydro-1H-dibenzimidazo<1,5-a>azepine hydrobromide

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 3h; pH=> 10;92%
bromocyane
506-68-3

bromocyane

6-aminomethyldibenzo[b,e]azepine

6-aminomethyldibenzo[b,e]azepine

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
In ethanol at 30℃; for 10h; Temperature;88.6%
N-(9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-yl)benzamide

N-(9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-yl)benzamide

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
With hydrogenchloride In water at 100℃; for 2h; Temperature;70.1%
6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate
127785-96-0

6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
With sodium hydroxide In water at 25 - 30℃; for 0.5h;
6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine
41218-84-2

6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / toluene / 15 h / 70 °C
2: hydrogenchloride / 31 h / 95 °C
View Scheme
Multi-step reaction with 3 steps
1: acetone / 3 h / 0 °C
2: 2-chloro-1-methyl-pyridinium iodide; triethylamine / N,N-dimethyl-formamide / 10 h / 25 °C
3: hydrogenchloride / water / 2 h / 100 °C
View Scheme
2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione
143878-20-0

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol / 4 h / Reflux
2: dichloromethane / 4 h / 20 °C
View Scheme
bromocyane
506-68-3

bromocyane

6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine
41218-84-2

6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
In dichloromethane at 20℃; for 4h;
In methanol; ethyl acetate at 10 - 20℃; for 6h; Temperature; Solvent;
C21H20N2O

C21H20N2O

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: polyphosphoric acid / dichloromethane / 0.5 h / 160 °C
2: 5%-palladium/activated carbon / methanol / 1 h / 80 °C
3: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
C21H18N2

C21H18N2

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5%-palladium/activated carbon / methanol / 1 h / 80 °C
2: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
C23H20N2O2

C23H20N2O2

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5%-palladium/activated carbon / 3 h / 40 °C
2: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
(2-aminophenyl)(phenyl)methanone
2835-77-0

(2-aminophenyl)(phenyl)methanone

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; ethyl acetate / 10 h / 5 °C
2.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 15 °C
2.2: 12 h
3.1: polyphosphoric acid / dichloromethane / 2 h / 120 °C
4.1: hydrogenchloride / ethyl acetate; water / 4 h / 20 °C
5.1: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; ethyl acetate / 10 h / 5 °C
2.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 15 °C
2.2: 12 h
3.1: polyphosphoric acid / dichloromethane / 1.5 h / 130 °C
4.1: 5%-palladium/activated carbon / 3 h / 40 °C
5.1: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; ethyl acetate / 10 h / 5 °C
2.1: 4,5-dicyano-1H-imidazole / ethyl acetate / 1 h / 35 °C
2.2: 2 h
3.1: polyphosphoric acid / dichloromethane / 0.5 h / 160 °C
4.1: 5%-palladium/activated carbon / methanol / 1 h / 80 °C
5.1: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
C30H24N2O2

C30H24N2O2

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / ethyl acetate / 2 h / 60 °C
2: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
2-benzylaniline
28059-64-5

2-benzylaniline

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 4,5-dicyano-1H-imidazole / ethyl acetate / 1 h / 35 °C
1.2: 2 h
2.1: polyphosphoric acid / dichloromethane / 0.5 h / 160 °C
3.1: 5%-palladium/activated carbon / methanol / 1 h / 80 °C
4.1: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 15 °C
1.2: 12 h
2.1: polyphosphoric acid / dichloromethane / 2 h / 120 °C
3.1: hydrogenchloride / ethyl acetate; water / 4 h / 20 °C
4.1: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 15 °C
1.2: 12 h
2.1: polyphosphoric acid / dichloromethane / 1.5 h / 130 °C
3.1: 5%-palladium/activated carbon / 3 h / 40 °C
4.1: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
C20H24N2O3

C20H24N2O3

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: polyphosphoric acid / dichloromethane / 2 h / 120 °C
2: hydrogenchloride / ethyl acetate; water / 4 h / 20 °C
3: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: polyphosphoric acid / dichloromethane / 1.5 h / 130 °C
2: 5%-palladium/activated carbon / 3 h / 40 °C
3: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
C20H22N2O2

C20H22N2O2

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / ethyl acetate; water / 4 h / 20 °C
2: ethyl acetate; methanol / 6 h / 10 - 20 °C
View Scheme
6-(chloromethyl)-11H-dibenzazepine
21535-44-4

6-(chloromethyl)-11H-dibenzazepine

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dichloromethane / 3 h / Reflux
2: hydrogenchloride / methanol; water / 2 h / Reflux
3: palladium 10% on activated carbon; hydrogen / water; ethanol / 5 h / 20 °C
4: ethanol / 10 h / 30 °C
View Scheme
6-bromomethyldibenzo[b,e]azepine

6-bromomethyldibenzo[b,e]azepine

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dichloromethane / 3 h / Reflux
2: hydrogenchloride / water; ethanol / 2 h / Reflux
3: palladium 10% on activated carbon; hydrogen / water; ethanol / 5 h / 20 °C
4: ethanol / 10 h / 30 °C
View Scheme
C21H24N5(1+)*Cl(1-)

C21H24N5(1+)*Cl(1-)

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / methanol; water / 2 h / Reflux
2: palladium 10% on activated carbon; hydrogen / water; ethanol / 5 h / 20 °C
3: ethanol / 10 h / 30 °C
View Scheme
C21H24N5(1+)*Br(1-)

C21H24N5(1+)*Br(1-)

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; ethanol / 2 h / Reflux
2: palladium 10% on activated carbon; hydrogen / water; ethanol / 5 h / 20 °C
3: ethanol / 10 h / 30 °C
View Scheme
6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine maleate

6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine maleate

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / tert-butyl methyl ether; water / 2 h / 20 °C / Large scale
2: acetone / 3 h / 0 °C
3: 2-chloro-1-methyl-pyridinium iodide; triethylamine / N,N-dimethyl-formamide / 10 h / 25 °C
4: hydrogenchloride / water / 2 h / 100 °C
View Scheme
C23H21N3OS

C23H21N3OS

epinastine
80012-43-7

epinastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / N,N-dimethyl-formamide / 10 h / 25 °C
2: hydrogenchloride / water / 2 h / 100 °C
View Scheme
epinastine
80012-43-7

epinastine

epinastine hydrochloride
108929-04-0

epinastine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; water; ethyl acetate for 0.5h; Product distribution / selectivity;92%
With hydrogenchloride In tetrahydrofuran; water at 40℃; for 4h; pH=3.6; Temperature; Solvent; pH-value;89.7%
With hydrogenchloride In water at 0 - 60℃; for 0.5h; Product distribution / selectivity;
With hydrogenchloride In methanol; water at -10 - 20℃; for 10h; Temperature; Solvent;
mefenamic Acid
61-68-7

mefenamic Acid

epinastine
80012-43-7

epinastine

N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)-2-((2,3-dimethylphenyl)amino)benzamide

N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)-2-((2,3-dimethylphenyl)amino)benzamide

Conditions
ConditionsYield
Stage #1: mefenamic Acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran for 0.333333h; Inert atmosphere;
Stage #2: epinastine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 6h;
57%
epinastine
80012-43-7

epinastine

salicylic acid
69-72-7

salicylic acid

N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)-2-hydroxybenzamide

N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)-2-hydroxybenzamide

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃; for 12h;48%
epinastine
80012-43-7

epinastine

3-amino-7-bromo-9,13-dihydro-1H-dibenzo[c,f]-imidazo[1,5-a]azepine

3-amino-7-bromo-9,13-dihydro-1H-dibenzo[c,f]-imidazo[1,5-a]azepine

Conditions
ConditionsYield
With bromine In chloroform at 20℃; for 10h;46%
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

epinastine
80012-43-7

epinastine

(2S)-N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)-2-(6-methoxynaphthalen-2-yl)propaamide

(2S)-N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)-2-(6-methoxynaphthalen-2-yl)propaamide

Conditions
ConditionsYield
Stage #1: epinastine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid With HATU In tetrahydrofuran for 2h; Inert atmosphere;
37%
epinastine
80012-43-7

epinastine

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)acetamide

2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: epinastine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 2h; Inert atmosphere;
16%

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