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Sinoway Industrial Co., Ltd.

1. High quality: CP.EP 2. Big capacity: 50mt per month 3. A lower price with high quality 4. Certificate: GMP, COA 5. Package: Packed with multi-layer paper bags, with polyethylene inner bag, net weight 25kg per bag. 6. Storage should be stored

Elagollix intermediate 830346-48-0 for R&D purpose

Cas:830346-48-0

Min.Order:25 Kilogram

FOB Price: $100.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS 830346-48-0 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS 830346-48-0

Cas:830346-48-0

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione CAS No.:830346-48-0 Name: 5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione Molecular Struct

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 830346-48-0 with competitive price

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

Hotsale 5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $9.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS:830346-48-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemi

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS:830346-48-0

Cas:830346-48-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2,4(1H,3H)-Pyrimidinedione, 5-bromo-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-

Cas:830346-48-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

5-bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Cas:830346-48-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

cas:830346-48-0

Cas:830346-48-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship

TIANFU CHEM 830346-48-0 5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 5-Bromo-1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione CAS No.:830346-48-0 Molecule Formula:C13H9BrF4N2O2 Molecule Weight:381.12 Purity: 98.0% Package: 25kg/drum Description:White powder Manufactu

High Quality 5-Bromo-1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione

Cas:830346-48-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5-bromo-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

NANJING SUNNY PHARMATECH CO., LTD

Our product has a very high quality and now we are exporting to customers overseas with very positive feedback. With best price, quality and service from Nanjing Sunny, we are confident to set up a very nice cooperation with customers all over the w

5-Bromo-1-(2-fluoro-6-trif luoromethyl-benzyl)-6-me thyl-1H-pyrimidine-2,4-di one

Cas:830346-48-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate

1-(2-fluoro-6-(trifluoro methyl)benzyl)-5-iodo- 6-methylpyrimidine-2,4 (1H,3H)-dione

Cas:830346-48-0

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Cas:830346-48-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Cas:830346-48-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
830346-47-9

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

Conditions
ConditionsYield
With bromine In acetic acid at 20℃;97.5%
With bromine; acetic acid for 14h;96%
With bromine; acetic acid at 20℃; for 3h;87%
5-bromo-6-methyluracil
15018-56-1

5-bromo-6-methyluracil

1-(bromomethyl)-2-fluoro-6-(trifluoromethyl)benzene
239087-08-2

1-(bromomethyl)-2-fluoro-6-(trifluoromethyl)benzene

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 75 - 85℃;81%
N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea
830346-46-8

N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetonitrile / 20 h / 0 - 20 °C
2: bromine; acetic acid / 2 h
View Scheme
Multi-step reaction with 2 steps
1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 16 h / 0 - 25 °C / Inert atmosphere
2: acetic acid; bromine / 14 h
View Scheme
2-fluoro-6-(trifluoromethyl)benzonitrile
133116-83-3

2-fluoro-6-(trifluoromethyl)benzonitrile

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: borane-THF / tetrahydrofuran / 60 °C / Heating / reflux
1.2: 20 °C
2.1: hydrogenchloride; water / 6 h / Heating / reflux
3.1: sodium iodide / acetonitrile / 20 h / 0 - 20 °C
4.1: bromine; acetic acid / 2 h
View Scheme
(2-fluoro-6-(trifluoromethyl) phenyl)methanamine
239087-06-0

(2-fluoro-6-(trifluoromethyl) phenyl)methanamine

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; water / 6 h / Heating / reflux
2: sodium iodide / acetonitrile / 20 h / 0 - 20 °C
3: bromine; acetic acid / 2 h
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 12 h / 100 °C
2: sodium iodide; chloro-trimethyl-silane / acetonitrile / 16 h / 0 - 25 °C / Inert atmosphere
3: acetic acid; bromine / 14 h
View Scheme
N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea
830346-46-8

N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea

ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

Conditions
ConditionsYield
With trimethylsilyl bromide In N,N-dimethyl acetamide at 0 - 80℃; for 16h; Inert atmosphere;32.7 g
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-N-(tert-butoxycarbonyl)phenylglycinol
67341-01-9, 117049-14-6, 138457-46-2, 102089-74-7

(R)-N-(tert-butoxycarbonyl)phenylglycinol

{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
830346-49-1

{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h;100%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 14h;99%
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In toluene at 5 - 20℃;70%
N-(benzyloxycarbonyl)-1(R)-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
832711-65-6

N-(benzyloxycarbonyl)-1(R)-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[N-(benzyloxycarbonyl)-1(R)-1,2,3,4-tetrahydroisoquinoline]methylpyrimidine-2,4(1H,3H)-dione
832711-58-7

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[N-(benzyloxycarbonyl)-1(R)-1,2,3,4-tetrahydroisoquinoline]methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h;100%
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C7H6FIOZn

C7H6FIOZn

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-59-0

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine In dimethyl sulfoxide at 60 - 70℃; for 6h; Inert atmosphere;83%
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-59-0

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Stage #1: (2-fluoro-3-methoxyphenyl)boronic acid With potassium iodide; potassium hydroxide In water; acetone at 25 - 30℃; for 0.166667h; Inert atmosphere;
Stage #2: 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione With tri tert-butylphosphoniumtetrafluoroborate In water; acetone at 25 - 45℃; for 0.583333h; Inert atmosphere; Further stages;
79.2%
Stage #1: 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide In water; acetone for 0.5h;
Stage #2: With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate In water; acetone at 70℃; for 10h;
76%
Stage #1: 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide In water; acetone at 30℃; for 0.166667h;
Stage #2: With palladium diacetate; ruphos In water; acetone at 30 - 52℃; for 6h;
1-phenylmethylpiperazine
2759-28-6

1-phenylmethylpiperazine

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

5-(4-benzyl-piperazin-1-yl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
1308380-31-5

5-(4-benzyl-piperazin-1-yl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
In acetonitrile at 120℃; for 1.5h; microwave irradiation;79%
In acetonitrile at 120℃; for 1.5h; Microwave irradiation;79%
In acetonitrile at 120℃; for 1.5h; Microwave irradiation;79%
In acetonitrile at 120℃; Microwave irradiation;79%
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C7H6BrFMgO

C7H6BrFMgO

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-59-0

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 0 - 45℃;77%
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-tert-butyl N-(2-hydroxy-1-phenylethyl)-N-methylcarbamate
152547-72-3

(R)-tert-butyl N-(2-hydroxy-1-phenylethyl)-N-methylcarbamate

3-[2(R)-{N-tert-butoxycarbonyl-N-methylamino}-2-phenylethyl]-5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
832711-54-3

3-[2(R)-{N-tert-butoxycarbonyl-N-methylamino}-2-phenylethyl]-5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

tert-butyl N-[2-hydroxy-1-(2-methoxyphenyl)ethyl]carbamate
869984-24-7

tert-butyl N-[2-hydroxy-1-(2-methoxyphenyl)ethyl]carbamate

C27H28BrF4N3O5
869984-25-8

C27H28BrF4N3O5

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C15H23NO4
869984-29-2

C15H23NO4

C28H30BrF4N3O5
869984-30-5

C28H30BrF4N3O5

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol
79069-15-1

N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol

C28H30BrF4N3O5
1044526-13-7

C28H30BrF4N3O5

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-2-tertbutoxycarbonylamino-1-propanol
79069-13-9, 127516-56-7, 147252-84-4, 106391-86-0

(R)-2-tertbutoxycarbonylamino-1-propanol

C21H24BrF4N3O4
1044526-16-0

C21H24BrF4N3O4

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(S)-2-t-butoxycarbonylaminopropan-1-ol
79069-13-9

(S)-2-t-butoxycarbonylaminopropan-1-ol

C21H24BrF4N3O4
1044526-09-1

C21H24BrF4N3O4

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(S)-tert-butyl 1-hydroxybutan-2-ylcarbamate
150736-72-4

(S)-tert-butyl 1-hydroxybutan-2-ylcarbamate

C22H26BrF4N3O4
1044526-11-5

C22H26BrF4N3O4

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate
150736-71-3

tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate

C22H26BrF4N3O4
1044526-18-2

C22H26BrF4N3O4

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
1308380-33-7

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetonitrile / 1.5 h / 120 °C / microwave irradiation
2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-3-(2-amino-2-(2-methoxyphenyl)ethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
1308378-40-6

(R)-3-(2-amino-2-(2-methoxyphenyl)ethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetonitrile / 1.5 h / 120 °C / microwave irradiation
2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
4: potassium carbonate / N,N-dimethyl-formamide / 70 °C
5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

[(R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
1308380-37-1

[(R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 1.5 h / 120 °C / microwave irradiation
2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
4: potassium carbonate / N,N-dimethyl-formamide / 70 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
1308378-32-6

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetonitrile / 1.5 h / 120 °C / microwave irradiation
2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-3-(2-amino-2-(2-hydroxyphenyl)ethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
1308379-59-0

(R)-3-(2-amino-2-(2-hydroxyphenyl)ethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-tert-butyl (2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-(2-hydroxyphenyl)ethyl)carbamate

(R)-tert-butyl (2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-(2-hydroxyphenyl)ethyl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

(R)-2-(2-(1-amino-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl)phenoxy)acetic acid
1308379-69-2

(R)-2-(2-(1-amino-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl)phenoxy)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
8.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid
1308379-70-5

4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
8.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C43H50F4N6O9

C43H50F4N6O9

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C45H54F4N6O9

C45H54F4N6O9

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere
5.2: 0.33 h / 20 °C / Inert atmosphere
6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
1308378-34-8

1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C37H40F4N6O6

C37H40F4N6O6

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
4: potassium carbonate / N,N-dimethyl-formamide / 70 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C38H42F4N6O6

C38H42F4N6O6

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
4: potassium carbonate / N,N-dimethyl-formamide / 70 °C
View Scheme
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
830346-48-0

5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione

C37H39F5N6O6

C37H39F5N6O6

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C
4: potassium carbonate / N,N-dimethyl-formamide / 70 °C
View Scheme

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