1. High quality: CP.EP 2. Big capacity: 50mt per month 3. A lower price with high quality 4. Certificate: GMP, COA 5. Package: Packed with multi-layer paper bags, with polyethylene inner bag, net weight 25kg per bag. 6. Storage should be stored
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inquiry5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione CAS 830346-48-0 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its
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inquiry5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione CAS No.:830346-48-0 Name: 5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione Molecular Struct
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
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Min.Order:1 Gram
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inquiryProduct name: 5-Bromo-1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione CAS No.:830346-48-0 Molecule Formula:C13H9BrF4N2O2 Molecule Weight:381.12 Purity: 98.0% Package: 25kg/drum Description:White powder Manufactu
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inquiry1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
With bromine In acetic acid at 20℃; | 97.5% |
With bromine; acetic acid for 14h; | 96% |
With bromine; acetic acid at 20℃; for 3h; | 87% |
5-bromo-6-methyluracil
1-(bromomethyl)-2-fluoro-6-(trifluoromethyl)benzene
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 75 - 85℃; | 81% |
N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium iodide / acetonitrile / 20 h / 0 - 20 °C 2: bromine; acetic acid / 2 h View Scheme | |
Multi-step reaction with 2 steps 1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 16 h / 0 - 25 °C / Inert atmosphere 2: acetic acid; bromine / 14 h View Scheme |
2-fluoro-6-(trifluoromethyl)benzonitrile
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: borane-THF / tetrahydrofuran / 60 °C / Heating / reflux 1.2: 20 °C 2.1: hydrogenchloride; water / 6 h / Heating / reflux 3.1: sodium iodide / acetonitrile / 20 h / 0 - 20 °C 4.1: bromine; acetic acid / 2 h View Scheme |
(2-fluoro-6-(trifluoromethyl) phenyl)methanamine
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride; water / 6 h / Heating / reflux 2: sodium iodide / acetonitrile / 20 h / 0 - 20 °C 3: bromine; acetic acid / 2 h View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 12 h / 100 °C 2: sodium iodide; chloro-trimethyl-silane / acetonitrile / 16 h / 0 - 25 °C / Inert atmosphere 3: acetic acid; bromine / 14 h View Scheme |
N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea
ethyl 2-bromoacetoacetate
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
With trimethylsilyl bromide In N,N-dimethyl acetamide at 0 - 80℃; for 16h; Inert atmosphere; | 32.7 g |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(R)-N-(tert-butoxycarbonyl)phenylglycinol
{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; | 100% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran for 14h; | 99% |
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In toluene at 5 - 20℃; | 70% |
N-(benzyloxycarbonyl)-1(R)-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[N-(benzyloxycarbonyl)-1(R)-1,2,3,4-tetrahydroisoquinoline]methylpyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; | 100% |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine In dimethyl sulfoxide at 60 - 70℃; for 6h; Inert atmosphere; | 83% |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(2-fluoro-3-methoxyphenyl)boronic acid
5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
Stage #1: (2-fluoro-3-methoxyphenyl)boronic acid With potassium iodide; potassium hydroxide In water; acetone at 25 - 30℃; for 0.166667h; Inert atmosphere; Stage #2: 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione With tri tert-butylphosphoniumtetrafluoroborate In water; acetone at 25 - 45℃; for 0.583333h; Inert atmosphere; Further stages; | 79.2% |
Stage #1: 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide In water; acetone for 0.5h; Stage #2: With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate In water; acetone at 70℃; for 10h; | 76% |
Stage #1: 5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide In water; acetone at 30℃; for 0.166667h; Stage #2: With palladium diacetate; ruphos In water; acetone at 30 - 52℃; for 6h; |
1-phenylmethylpiperazine
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
5-(4-benzyl-piperazin-1-yl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
Conditions | Yield |
---|---|
In acetonitrile at 120℃; for 1.5h; microwave irradiation; | 79% |
In acetonitrile at 120℃; for 1.5h; Microwave irradiation; | 79% |
In acetonitrile at 120℃; for 1.5h; Microwave irradiation; | 79% |
In acetonitrile at 120℃; Microwave irradiation; | 79% |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 0 - 45℃; | 77% |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(R)-tert-butyl N-(2-hydroxy-1-phenylethyl)-N-methylcarbamate
3-[2(R)-{N-tert-butoxycarbonyl-N-methylamino}-2-phenylethyl]-5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
tert-butyl N-[2-hydroxy-1-(2-methoxyphenyl)ethyl]carbamate
C27H28BrF4N3O5
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
C15H23NO4
C28H30BrF4N3O5
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol
C28H30BrF4N3O5
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(R)-2-tertbutoxycarbonylamino-1-propanol
C21H24BrF4N3O4
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(S)-2-t-butoxycarbonylaminopropan-1-ol
C21H24BrF4N3O4
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(S)-tert-butyl 1-hydroxybutan-2-ylcarbamate
C22H26BrF4N3O4
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate
C22H26BrF4N3O4
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction; |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetonitrile / 1.5 h / 120 °C / microwave irradiation 2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 2 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(R)-3-(2-amino-2-(2-methoxyphenyl)ethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetonitrile / 1.5 h / 120 °C / microwave irradiation 2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C 4: potassium carbonate / N,N-dimethyl-formamide / 70 °C 5: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
[(R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetonitrile / 1.5 h / 120 °C / microwave irradiation 2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C 4: potassium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetonitrile / 1.5 h / 120 °C / microwave irradiation 2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(R)-3-(2-amino-2-(2-hydroxyphenyl)ethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere 5.2: 0.33 h / 20 °C / Inert atmosphere View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere 5.2: 0.33 h / 20 °C / Inert atmosphere 6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
(R)-2-(2-(1-amino-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl)phenoxy)acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere 5.2: 0.33 h / 20 °C / Inert atmosphere 6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C 8.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere 5.2: 0.33 h / 20 °C / Inert atmosphere 6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C 8.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere 5.2: 0.33 h / 20 °C / Inert atmosphere 6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: acetonitrile / 1.5 h / 120 °C / Microwave irradiation 2.1: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 5 h / 20 °C / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere 5.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere 5.2: 0.33 h / 20 °C / Inert atmosphere 6.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C 4: potassium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C 4: potassium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme |
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4-(1H,3H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetonitrile / 120 °C / Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C 4: potassium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme |
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