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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Manufacturer/High quality/Best price/In stock

Cas:85977-52-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

(S)-(-)-1,2,3,4-Tetrahydro-naphthoic acid CAS No.:85977-52-2 Name: (S)-(-)-1,2,3,4-Tetrahydro-naphthoic acid Molecular Structure Molecular Formula: C11H12O2 Molecular Weight: 176.21 CAS Regi

High purity (S)-(-)-1,2,3,4-Tetrahydro-naphthoic acid CAS No.:85977-52-2

Cas:85977-52-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(S)-(-)-1,2,3,4-Tetrahydro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-(-)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic acid

Cas:85977-52-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 85977-52-2 with best quality

Cas:85977-52-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acidCAS85977-52-2

Cas:85977-52-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 25.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Synonyms (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid;tetrahydronaphthalene CAS: 85977-52-2 MF: -

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid CAS: 85977-52-2

Cas:85977-52-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Naphthalenecarboxylicacid, 1,2,3,4-tetrahydro-, (1S)- 85977-52-2

Cas:85977-52-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid CAS: 85977-52-2 MF: C11H12O2 MW: 176.21 EINECS: CHEMICALS;INTERMEDIATESOFPALONOSETRONHYDROCHLORIDE;Aromatics;Chiral Reagents;Intermediates Mol File: 85977-52-2.mol (S)-(-)-1

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 85977-52-2 (S)-1,2,3,4-tetrahydro-naphthoic acid in stock

Cas:85977-52-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid CAS:85977-52-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid CAS:85977-52-2

Cas:85977-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Naphthalenecarboxylicacid, 1,2,3,4-tetrahydro-, (1S)-

Cas:85977-52-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1-Naphthalenecarboxylicacid, 1,2,3,4-tetrahydro-, (1S)-/ LIDE PHARMA- Factory supply / Best price

Cas:85977-52-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(S)-(-)-1,2,3,4-Tetrahedro-Naphthoicacid

Cas:85977-52-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Synonyms: (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylic acid;Palonosetron Intermediate 1;(1S)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic Acid;D-(-)-1,2,3,4-Tetrahydro-1-naphthoic Acid;1-N

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid best quality

Cas:85977-52-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(S)-1,2,3,4-tetrahydro-naphthoic acid

Cas:85977-52-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-1,2,3,4-tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-1,2,3,4-tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Appearance/Colour:Crystalline white or yellow powder Vapor Pressure:2.85E-05mmHg at 25°C Melting Point:54-56 °C Refractive Index:1.576 Boiling Point:342.7 °C at 760 mmHg PKA:4.28±0.20(Predicted) Flash Point:156.4 &deg

85977-52-2 (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid high-quality

Cas:85977-52-2

Min.Order:1 Gram

FOB Price: $5.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (S)-1,2,3,4-Tetrahydro-1-naphthoic acid

Cas:85977-52-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(S)-(-)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic acid

Cas:85977-52-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

(S)-1, 2, 3, 4-Tetrahydronapht

Cas:85977-52-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Cas:85977-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(S)-(-)-1,2,3,4-Tetrahedro-naphthoicacid

Cas:85977-52-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: (S)-(-)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS No.: 85977-52-2 Molecule Formula:C11H12O2 Molecule Weight:176.21 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise St

Lower Price (S)-(-)-1,2,3,4-Tetrahydro-1-Naphthoic Acid

Cas:85977-52-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid ester

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid ester

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran at 20℃; for 16h; Autoclave; Green chemistry;83%
tetralin-1-carboxylic acid
1914-65-4

tetralin-1-carboxylic acid

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
With quinine In ethanol at 0 - 50℃; for 0.5h;43.6%
nach Abtrennung des Cinchonin-Salzes der (R)-1.2.3.4-Tetrahydro-naphthoesaeure-(1) (s.o.) ueber das Chinin-Salz;
Multi-step reaction with 2 steps
1: water; ethanol / 2 h / Reflux
2: hydrogenchloride / water; ethyl acetate / 0.5 h
View Scheme
4-oxo-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
3123-46-4

4-oxo-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: amalgamated zinc; aqueous HCl
2: nach Abtrennung des Cinchonin-Salzes der (R)-1.2.3.4-Tetrahydro-naphthoesaeure-(1) (s.o.) ueber das Chinin-Salz
View Scheme
1-naphthalenecarboxylic acid
86-55-5

1-naphthalenecarboxylic acid

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 4 h / 10 - 40 °C / Green chemistry
1.2: 2 h / 10 - 20 °C / Green chemistry
2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 8 h / 60 °C / 15001.5 Torr / Autoclave; Green chemistry
3.1: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C / Autoclave; Green chemistry
View Scheme
(R)-[1-ethoxy-1-carbonylpropan-2-yl]-1-naphthoic acid ester

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-1-naphthoic acid ester

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 8 h / 60 °C / 15001.5 Torr / Autoclave; Green chemistry
2: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C / Autoclave; Green chemistry
View Scheme
C11H12O2*C20H24N2O2

C11H12O2*C20H24N2O2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate for 0.5h;110 g
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate
141104-65-6

ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate

2-[((S)-1,2,3,4-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester
1092447-54-5

2-[((S)-1,2,3,4-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;100%
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-(-)-1,2,3,4-tetrahydro-1-naphthoyl chloride

(S)-(-)-1,2,3,4-tetrahydro-1-naphthoyl chloride

Conditions
ConditionsYield
With thionyl chloride In toluene at 60 - 65℃; for 2h; Reagent/catalyst; Inert atmosphere;100%
With thionyl chloride In toluene at 35 - 70℃; for 2.5h;
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-1-hydroxymethyl-1,2,3,4-tetrahydronaphthalene
151831-52-6

(S)-1-hydroxymethyl-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 2h;100%
Multi-step reaction with 2 steps
1: sulfuric acid / 16 h / 60 °C
2: C33H29FeMnN2O3P; hydrogen; potassium carbonate / isopropyl alcohol / 21 h / 50 °C / 37503.8 Torr / Autoclave
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(1S)-decahydronaphthalene-1-carboxylic acid

(1S)-decahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In acetic acid under 3000.3 Torr;100%
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

Conditions
ConditionsYield
Stage #1: (S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: With ammonia In tetrahydrofuran; ethanol at 20℃; Inert atmosphere;
90%
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

(S)-8-((triisopropylsilyl)ethynyl)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-8-((triisopropylsilyl)ethynyl)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
With N-tert-butoxycarbonyl-L-phenylalanine; silver(I) acetate; sodium acetate; palladium diacetate In 1,2-dichloro-ethane at 60℃; for 16h; Sealed tube; Schlenk technique;82%
With N-tert-butoxycarbonyl-L-phenylalanine; silver(I) acetate; sodium acetate; palladium diacetate In 1,2-dichloro-ethane at 60℃; for 16h;82.24%
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
83417-23-6

3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine

(S)-(5-amino-3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)(1,2,3,4-tetrahydronaphthalen-1-yl)methanone

(S)-(5-amino-3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)(1,2,3,4-tetrahydronaphthalen-1-yl)methanone

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 3h; regioselective reaction;75%
ethanol
64-17-5

ethanol

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

C13H16O2

C13H16O2

Conditions
ConditionsYield
With sulfuric acid at 60℃; for 16h;52%
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

1,3,8-triaza-spiro[4.5]decan-2,4-dione
13625-39-3

1,3,8-triaza-spiro[4.5]decan-2,4-dione

(S)-8-(1,2,3,4-tetrahydronaphthalene-1-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione

(S)-8-(1,2,3,4-tetrahydronaphthalene-1-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 15h;23.3%
(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

2-{Methyl-[(S)-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)methyl]-amino}-ethanol
780718-92-5

2-{Methyl-[(S)-1-(1,2,3,4-tetrahydro-naphthalen-1-yl)methyl]-amino}-ethanol

Conditions
ConditionsYield
Multistep reaction;
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

methyl (S)-1,2,3,4-tetrahydronaphthalene-1-carboxylate

methyl (S)-1,2,3,4-tetrahydronaphthalene-1-carboxylate

Conditions
ConditionsYield
In diethyl ether
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine
123932-21-8

(S)-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 1.) PCl5, 2.) AlCl3 / 1.) 1,2,4-trichlorobenzene, 120 deg C, 2.) 200 deg C, 3 h
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-5-chloro-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine
123932-25-2

(S)-5-chloro-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 1.) PCl5, 2.) AlCl3 / 1.) 1,2,4-trichlorobenzene, 120 deg C, 2.) 200 deg C, 3 h
3: chlorine, FeCl3*6H2O / acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
2: 1.) PCl5, 2.) AlCl3 / 1.) 1,2,4-trichlorobenzene, 120 deg C, 2.) 200 deg C, 3 h
3: chlorine, FeCl3*6H2O / acetonitrile / 0.25 h / 0 °C
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(R)-5-chloro-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine
123932-23-0

(R)-5-chloro-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 1.) PCl5, 2.) AlCl3 / 1.) 1,2,4-trichlorobenzene, 120 deg C, 2.) 200 deg C, 3 h
3: chlorine, FeCl3*6H2O / acetonitrile / 0.25 h / 0 °C
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-7-chloro-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine
123932-29-6

(S)-7-chloro-2-methyl-1,2,3,4,8,9,10,10a-octahydronaphth<1,8-cd>azepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 1.) PCl5, 2.) AlCl3 / 1.) 1,2,4-trichlorobenzene, 120 deg C, 2.) 200 deg C, 3 h
3: chlorine, FeCl3*6H2O / acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
2: 1.) PCl5, 2.) AlCl3 / 1.) 1,2,4-trichlorobenzene, 120 deg C, 2.) 200 deg C, 3 h
3: chlorine, FeCl3*6H2O / acetonitrile / 0.25 h / 0 °C
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

N-(1-azabicyclo[2.2.2]oct-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide

N-(1-azabicyclo[2.2.2]oct-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
7524-50-7

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

C21H23NO3
1207325-89-0

C21H23NO3

Conditions
ConditionsYield
Stage #1: (S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 0.666667h;
Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With 4-methyl-morpholine In tetrahydrofuran at 0 - 20℃;
3-amino-3-(3-chlorophenyl)propionic acid methyl ester
277745-44-5

3-amino-3-(3-chlorophenyl)propionic acid methyl ester

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

C21H22ClNO3
1269634-46-9

C21H22ClNO3

Conditions
ConditionsYield
Stage #1: (S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrachloromethane at 0℃;
Stage #2: 3-amino-3-(3-chlorophenyl)propionic acid methyl ester With 4-methyl-morpholine In tetrahydrofuran at 0 - 20℃;
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

(S)-(1,2,3,4-tetrahydronaphthalen-1-yl)methanamine

(S)-(1,2,3,4-tetrahydronaphthalen-1-yl)methanamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 55 °C / Inert atmosphere
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

methyl 3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]amino}pyridine-4-carboxylate
1616267-17-4

methyl 3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]amino}pyridine-4-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 55 °C / Inert atmosphere
3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 1.5 h / 128 °C / Microwave irradiation; Inert atmosphere
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]amino}pyridine-4-carboxylic acid
1616266-02-4

3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]amino}pyridine-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 55 °C / Inert atmosphere
3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 1.5 h / 128 °C / Microwave irradiation; Inert atmosphere
4.1: sodium hydroxide / methanol / 1 h / 50 °C / Inert atmosphere
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

C19H25ClN2O

C19H25ClN2O

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 2.5 h / 35 - 70 °C
2.1: toluene / 1.5 h / 70 °C / Industrial scale
3.1: boron trifluoride methanol complex; sodium tetrahydroborate / methanol / 3.3 h / -5 - 105 °C
3.2: 1 h / 70 °C / Cooling with ice
3.3: 35 °C
4.1: toluene / 12.08 h / 12 - 105 °C
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

palonosetron

palonosetron

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / toluene / 2.5 h / 35 - 70 °C
2.1: toluene / 1.5 h / 70 °C / Industrial scale
3.1: boron trifluoride methanol complex; sodium tetrahydroborate / methanol / 3.3 h / -5 - 105 °C
3.2: 1 h / 70 °C / Cooling with ice
3.3: 35 °C
4.1: toluene / 12.08 h / 12 - 105 °C
5.1: boron trifluoride methanol complex / 3.5 h / 40 - 105 °C / Industrial scale
5.2: 0.5 h / 105 °C / Industrial scale
5.3: Industrial scale
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

palonosetron hydrochloride

palonosetron hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: thionyl chloride / toluene / 2.5 h / 35 - 70 °C
2.1: toluene / 1.5 h / 70 °C / Industrial scale
3.1: boron trifluoride methanol complex; sodium tetrahydroborate / methanol / 3.3 h / -5 - 105 °C
3.2: 1 h / 70 °C / Cooling with ice
3.3: 35 °C
4.1: toluene / 12.08 h / 12 - 105 °C
5.1: boron trifluoride methanol complex / 3.5 h / 40 - 105 °C / Industrial scale
5.2: 0.5 h / 105 °C / Industrial scale
5.3: Industrial scale
6.1: hydrogenchloride / water / 0.08 h / Industrial scale
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 2 h / 60 - 65 °C / Inert atmosphere
2.1: L-Selectride / tetrahydrofuran / 1 h / 5 - 15 °C / Inert atmosphere
3.1: ethanol / 4 h / 15 - 25 °C / Inert atmosphere
3.2: 2 h / 15 - 25 °C / Inert atmosphere
4.1: toluene / 14 h / 0 - 20 °C / Inert atmosphere
4.2: 5 h / 100 - 110 °C
4.3: 1 h / 100 - 110 °C
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 2 h / 60 - 65 °C / Inert atmosphere
2.1: ethyl acetate / 2 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 10 °C / Reflux
4.1: toluene / 14 h / 0 - 20 °C / Inert atmosphere
4.2: 5 h / 100 - 110 °C
4.3: 1 h / 100 - 110 °C
View Scheme
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / ethyl acetate / 1.05 h / 20 °C
1.2: 3 h / 50 °C
2.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 3 h / 15 - 65 °C
3.1: bis(trichloromethyl) carbonate / toluene / 3.5 h / Reflux
3.2: 4 h / Reflux
3.3: 2 h / Reflux
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalene-1S-carboxamide

N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalene-1S-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 2.5 h / 35 - 70 °C
2: toluene / 1.5 h / 70 °C / Industrial scale
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 2 h / 60 - 65 °C / Inert atmosphere
2: ethyl acetate / 2 h / 20 °C
View Scheme
(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
85977-52-2

(S)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

C18H26N2

C18H26N2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 2.5 h / 35 - 70 °C
2.1: toluene / 1.5 h / 70 °C / Industrial scale
3.1: boron trifluoride methanol complex; sodium tetrahydroborate / methanol / 3.3 h / -5 - 105 °C
3.2: 1 h / 70 °C / Cooling with ice
3.3: 35 °C
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 2 h / 60 - 65 °C / Inert atmosphere
2.1: L-Selectride / tetrahydrofuran / 1 h / 5 - 15 °C / Inert atmosphere
3.1: ethanol / 4 h / 15 - 25 °C / Inert atmosphere
3.2: 2 h / 15 - 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / toluene / 2 h / 60 - 65 °C / Inert atmosphere
2: ethyl acetate / 2 h / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 10 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / ethyl acetate / 1.05 h / 20 °C
1.2: 3 h / 50 °C
2.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 3 h / 15 - 65 °C
View Scheme

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