Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Manufacturer/High quality/Best price/In stock

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (1S)-4,5-Dimethoxy-1-(Methylaminoethyl)Benzocyclobutane Hcl supplier in China

Cas:866783-13-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/702.html Product Name (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocy

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

Ivabradine Intermediate (1S)-4,5-Dimethyl-1-[(methylamino)-methyl-benzocyclobutane hydrochloride[CAS:866783-13-3] 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one[CAS:85175-59-3] 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

Chemwill Asia Co., Ltd.

CHemwill -- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

866783-13-3 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 866783-13-3 with competitive price

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM-- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3

Cas:866783-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

(1S)-4,5-Dimethoxy-1-(methylamino)methyl]benzocyclobutane hydrochloride for Ivabardine hcl

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $70.0 / 80.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride CAS:866783-13-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride CAS:866783-13-3

Cas:866783-13-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Synonyms: (1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane Hcl;(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride;(7S)-3,4-Dimet

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Manufactory best quality

Cas:866783-13-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(1S)-4,5-Dimethoxy-1-[(Methylamino)Methyl]Benzocyclobutane Hydrochloride

Cas:866783-13-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Ivabradine intermediate 2

Cas:866783-13-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Ivabradine intermediates 866783-13-3

Cas:866783-13-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Lvabradine intermediate

Cas:866783-13-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (1S)-4,5-Dimethoxy-1-(Methylaminoethyl)Benzocyclobutane Hcl

Cas:866783-13-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

CAS 866783-13-3 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzoc

Cas:866783-13-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Cas:866783-13-3

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Synthetic route

[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
866783-12-2

[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine With acetic acid In ethanol at 20℃; for 0.5h;
Stage #2: With hydrogenchloride at 15 - 20℃; for 1h;
95%
With hydrogenchloride In ethanol; ethyl acetate at 15 - 20℃; for 1h; Industry scale;92%
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine d-camphorsulfonate
1031767-75-5

[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine d-camphorsulfonate

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine d-camphorsulfonate In dichloromethane; water pH=10 - 11;
Stage #2: With hydrogenchloride In ethanol; ethyl acetate at 0 - 5℃; pH=1 - 2;
94%
(7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide
1220993-43-0

(7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Stage #1: (7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide With borane-THF In tetrahydrofuran at 20 - 50℃;
Stage #2: With methanol In tetrahydrofuran at 0 - 5℃; for 0.25h;
Stage #3: With hydrogenchloride In ethyl acetate at 0℃; for 2.5h; Reflux;
88%
Stage #1: (7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide With borane-THF In tetrahydrofuran at 20℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol for 4h;
77%
ethyl ((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)carbamate
148870-55-7

ethyl ((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)carbamate

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Stage #1: ethyl [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]carbamate With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Reflux;
Stage #2: With hydrogenchloride In ethanol; ethyl acetate at 15 - 20℃; for 1h;
85%
3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
35202-54-1

3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium hydroxide; water / 4 h / Reflux
1.2: 20 °C
2.1: ethyl acetate / 1.25 h / 0 °C / Reflux
3.1: hydrogenchloride / dichloromethane; water / 0.08 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium hydroxide; water / 4 h / Reflux
1.2: 20 °C
2.1: acetone / 0.5 h / Reflux; Cooling
3.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium hydroxide; water / 4 h / Reflux
1.2: 20 °C
2.1: ethyl acetate / 1 h / 18 °C / Heating
3.1: hydrogenchloride / dichloromethane; water / 0.33 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
(R,S)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid
41234-23-5

(R,S)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: ethyl acetate / 1.25 h / 0 °C / Reflux
2.1: hydrogenchloride / dichloromethane; water / 0.08 h
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
4.1: dichloromethane; water / 0 - 10 °C
5.1: borane-THF / tetrahydrofuran / 20 - 50 °C
5.2: 0.25 h / 0 - 5 °C
5.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: ethyl acetate / 1 h / 18 °C / Heating
2.1: hydrogenchloride / dichloromethane; water / 0.33 h
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
4.1: dichloromethane; water / 0 - 10 °C
5.1: borane-THF / tetrahydrofuran / 20 - 50 °C
5.2: 0.25 h / 0 - 5 °C
5.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: ethyl acetate / 1 h / 18 °C / Heating
2.1: hydrogenchloride / dichloromethane; water / 0.33 h
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
4.1: dichloromethane; water / 0 - 10 °C
5.1: borane-THF / tetrahydrofuran / 20 - 50 °C
5.2: 0.25 h / 0 - 5 °C
5.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: ethyl acetate / Heating
2.1: hydrogenchloride / dichloromethane; water / 0.33 h
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
4.1: dichloromethane; water / 0 - 10 °C
5.1: borane-THF / tetrahydrofuran / 20 - 50 °C
5.2: 0.25 h / 0 - 5 °C
5.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: acetone / 0.5 h / Reflux; Cooling
2.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
4.1: dichloromethane; water / 0 - 10 °C
5.1: borane-THF / tetrahydrofuran / 20 - 50 °C
5.2: 0.25 h / 0 - 5 °C
5.3: 2.5 h / 0 °C / Reflux
View Scheme
(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid (+)-cinchonine

(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid (+)-cinchonine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / dichloromethane; water / 0.08 h
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
3.1: dichloromethane; water / 0 - 10 °C
4.1: borane-THF / tetrahydrofuran / 20 - 50 °C
4.2: 0.25 h / 0 - 5 °C
4.3: 2.5 h / 0 °C / Reflux
View Scheme
(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid
1220993-44-1

(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
2.1: dichloromethane; water / 0 - 10 °C
3.1: borane-THF / tetrahydrofuran / 20 - 50 °C
3.2: 0.25 h / 0 - 5 °C
3.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C
1.2: 20 °C
2.1: borane-THF / tetrahydrofuran / 20 °C
2.2: 4 h
View Scheme
(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid (S)-(-)-1-(naphthyl)-ethylamine
1346558-07-3

(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid (S)-(-)-1-(naphthyl)-ethylamine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / dichloromethane; water / 0.33 h
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
3.1: dichloromethane; water / 0 - 10 °C
4.1: borane-THF / tetrahydrofuran / 20 - 50 °C
4.2: 0.25 h / 0 - 5 °C
4.3: 2.5 h / 0 °C / Reflux
View Scheme
3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid (S)-(-)-1-(naphthyl)-ethylamine

3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid (S)-(-)-1-(naphthyl)-ethylamine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / dichloromethane; water / 0.33 h
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
3.1: dichloromethane; water / 0 - 10 °C
4.1: borane-THF / tetrahydrofuran / 20 - 50 °C
4.2: 0.25 h / 0 - 5 °C
4.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / dichloromethane; water / 0.33 h
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: acetone / 0.5 h / Reflux; Cooling
4.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / dichloromethane; water / 0.33 h
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / 1.25 h / 0 °C / Reflux
4.1: hydrogenchloride / dichloromethane; water / 0.08 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / dichloromethane; water / 0.33 h
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
(R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid
1220993-48-5

(R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium hydroxide / water / 4 h
1.2: 0.5 h / Cooling with ice-water bath
2.1: ethyl acetate / 1.25 h / 0 °C / Reflux
3.1: hydrogenchloride / dichloromethane; water / 0.08 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium hydroxide / water / 4 h
1.2: 0.5 h / Cooling with ice-water bath
2.1: acetone / 0.5 h / Reflux; Cooling
3.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium hydroxide / water / 4 h
1.2: 0.5 h / Cooling with ice-water bath
2.1: ethyl acetate / 1 h / 18 °C / Heating
3.1: hydrogenchloride / dichloromethane; water / 0.33 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium hydroxide / water / 4 h
1.2: 0.5 h / Cooling with ice-water bath
2.1: ethyl acetate / 1 h / 18 °C / Heating
3.1: hydrogenchloride / dichloromethane; water / 0.33 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium hydroxide / water / 4 h
1.2: 0.5 h / Cooling with ice-water bath
2.1: ethyl acetate / Heating
3.1: hydrogenchloride / dichloromethane; water / 0.33 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
5.1: dichloromethane; water / 0 - 10 °C
6.1: borane-THF / tetrahydrofuran / 20 - 50 °C
6.2: 0.25 h / 0 - 5 °C
6.3: 2.5 h / 0 °C / Reflux
View Scheme
(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid (R)-(-)-1-(naphthyl)-ethylamine

(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid (R)-(-)-1-(naphthyl)-ethylamine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / dichloromethane; water / 0.33 h
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
3.1: dichloromethane; water / 0 - 10 °C
4.1: borane-THF / tetrahydrofuran / 20 - 50 °C
4.2: 0.25 h / 0 - 5 °C
4.3: 2.5 h / 0 °C / Reflux
View Scheme
3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid cinchonidine

3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid cinchonidine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
3.1: dichloromethane; water / 0 - 10 °C
4.1: borane-THF / tetrahydrofuran / 20 - 50 °C
4.2: 0.25 h / 0 - 5 °C
4.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / 1 h / 18 °C / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / 1 h / 18 °C / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / 1.25 h / 0 °C / Reflux
4.1: hydrogenchloride / dichloromethane; water / 0.08 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid (+)-cinchonine

3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid (+)-cinchonine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: hydrogenchloride / water
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / 1 h / 18 °C / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / water
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: acetone / 0.5 h / Reflux; Cooling
4.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / water
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / 1 h / 18 °C / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogenchloride / water
2.1: potassium hydroxide / water / 4 h
2.2: 0.5 h / Cooling with ice-water bath
3.1: ethyl acetate / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid chloride
1220993-45-2

(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1.3,5-triene-7-carboxylic acid chloride

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane; water / 0 - 10 °C
2.1: borane-THF / tetrahydrofuran / 20 - 50 °C
2.2: 0.25 h / 0 - 5 °C
2.3: 2.5 h / 0 °C / Reflux
View Scheme
3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile
35249-62-8

3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C / Inert atmosphere
2.1: potassium hydroxide; water / 4 h / Reflux
2.2: 20 °C
3.1: ethyl acetate / 1.25 h / 0 °C / Reflux
4.1: hydrogenchloride / dichloromethane; water / 0.08 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C / Inert atmosphere
2.1: potassium hydroxide; water / 4 h / Reflux
2.2: 20 °C
3.1: acetone / 0.5 h / Reflux; Cooling
4.1: hydrogenchloride / ethyl acetate; water / 0.08 h / pH 3
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C / Inert atmosphere
2.1: potassium hydroxide; water / 4 h / Reflux
2.2: 20 °C
3.1: ethyl acetate / 1 h / 18 °C / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C / Inert atmosphere
2.1: potassium hydroxide; water / 4 h / Reflux
2.2: 20 °C
3.1: ethyl acetate / 1 h / 18 °C / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C / Inert atmosphere
2.1: potassium hydroxide; water / 4 h / Reflux
2.2: 20 °C
3.1: ethyl acetate / Heating
4.1: hydrogenchloride / dichloromethane; water / 0.33 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C
6.1: dichloromethane; water / 0 - 10 °C
7.1: borane-THF / tetrahydrofuran / 20 - 50 °C
7.2: 0.25 h / 0 - 5 °C
7.3: 2.5 h / 0 °C / Reflux
View Scheme
(R)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile
1214788-46-1

(R)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 2 h / 65 °C
2.1: nitrilase of Rhodococcus erythropolis NCIMB11215 / aq. phosphate buffer; dimethyl sulfoxide / 96 h / 30 °C / pH 7.3 / Enzymatic reaction
3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C
3.2: 20 °C
4.1: borane-THF / tetrahydrofuran / 20 °C
4.2: 4 h
View Scheme
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 2 h / 65 °C
2.1: nitrilase of Rhodococcus rhodochrous NCIMB11216 / aq. phosphate buffer; dimethyl sulfoxide / 96 h / 30 °C / pH 7.3 / Enzymatic reaction
3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C
3.2: 20 °C
4.1: borane-THF / tetrahydrofuran / 20 °C
4.2: 4 h
View Scheme
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 2 h / 65 °C
2.1: over-expressed nitrilase of Rhodococcus rhodochrous NCIMB 11216 / aq. phosphate buffer; dimethyl sulfoxide / 6 h / 30 °C / pH 7 / Enzymatic reaction
3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C
3.2: 20 °C
4.1: borane-THF / tetrahydrofuran / 20 °C
4.2: 4 h
View Scheme
(±)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methylamine
73344-75-9

(±)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methylamine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.25 h / 20 °C
1.2: 12 h / 20 °C
2.1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C
3.1: ethanol / 1 h / Reflux
4.1: sodium hydroxide / ethanol; water; dichloromethane / 1 h / 20 °C / pH 10 - 11
5.1: acetic acid / ethanol / 0.5 h / 20 °C
5.2: 1 h / 15 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.25 h / 20 °C
1.2: 12 h / 20 °C
2.1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C
3.1: ethanol; Isopropyl acetate / 1 h / Reflux
4.1: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11
5.1: acetic acid / ethanol / 0.5 h / 20 °C
5.2: 1 h / 15 - 20 °C
View Scheme
(1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane dextro mandelate

(1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane dextro mandelate

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11
2.1: acetic acid / ethanol / 0.5 h / 20 °C
2.2: 1 h / 15 - 20 °C
View Scheme
C12H15NO3

C12H15NO3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C
2.1: ethanol / 1 h / Reflux
3.1: sodium hydroxide / ethanol; water; dichloromethane / 1 h / 20 °C / pH 10 - 11
4.1: acetic acid / ethanol / 0.5 h / 20 °C
4.2: 1 h / 15 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C
2.1: ethanol; Isopropyl acetate / 1 h / Reflux
3.1: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11
4.1: acetic acid / ethanol / 0.5 h / 20 °C
4.2: 1 h / 15 - 20 °C
View Scheme
({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine
148870-56-8

({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethanol / 1 h / Reflux
2.1: sodium hydroxide / ethanol; water; dichloromethane / 1 h / 20 °C / pH 10 - 11
3.1: acetic acid / ethanol / 0.5 h / 20 °C
3.2: 1 h / 15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: ethanol; Isopropyl acetate / 1 h / Reflux
2.1: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11
3.1: acetic acid / ethanol / 0.5 h / 20 °C
3.2: 1 h / 15 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 0.75 h / Reflux
2.1: water; dichloromethane / pH 10 - 11
2.2: 0 - 5 °C / pH 1 - 2
View Scheme
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}methylamino]-1-propanol
1462470-47-8

3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}methylamino]-1-propanol

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; for 24h;96%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

7,8-dimethoxy-3-(3-iodopropyl)-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

7,8-dimethoxy-3-(3-iodopropyl)-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

ivabradine
155974-00-8

ivabradine

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 7,8-dimethoxy-3-(3-iodopropyl)-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one In N,N-dimethyl-formamide at 20℃; for 6h;
95.8%
With triethylamine In acetonitrile at 20℃; for 12h;
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9

7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
1086026-31-4

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride With potassium carbonate In water at 30℃;
Stage #2: 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one In water at 30 - 60℃; for 24.5h; Reagent/catalyst;
94%
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride With potassium carbonate In N,N-dimethyl-formamide at 25 - 30℃; for 1h;
Stage #2: 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one In N,N-dimethyl-formamide at 5 - 25℃; for 4h;
75%
With potassium carbonate In acetone at 55 - 58℃; for 3h;
In acetone for 18h; Reflux;
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

(S)-3-chloro-N-((3,4-dimethoxybicyclo[4.2,0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine
1031767-71-1

(S)-3-chloro-N-((3,4-dimethoxybicyclo[4.2,0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride With potassium carbonate In water at 40℃;
Stage #2: 1.3-chlorobromopropane In water at 40℃; for 5h;
94%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

C17H26ClNO5

C17H26ClNO5

C29H42N2O7

C29H42N2O7

Conditions
ConditionsYield
With potassium carbonate; sodium iodide for 6h; Reflux;91%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one
85175-59-3

3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
1086026-31-4

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium carbonate; sodium iodide In toluene at 108 - 110℃; for 10h; Temperature; Solvent; Reagent/catalyst;86%
With potassium carbonate; sodium iodide In acetone for 28h; Reflux; Large scale;82.54%
3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

ivabradine hydrochloride
148849-67-6

ivabradine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one With hydrogen; palladium on activated charcoal In ethanol at 55℃; under 3750.38 Torr;
Stage #2: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride In ethanol; water at 20 - 85℃; under 22502.3 Torr;
85%
Stage #1: 3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one With palladium on activated charcoal; hydrogen In ethanol at 55℃; under 3750.38 Torr; Autoclave; Large scale;
Stage #2: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride With palladium on activated charcoal; hydrogen In ethanol; water at 85℃; under 22502.3 Torr; Autoclave; Large scale;
85%
Stage #1: 3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one With palladium on activated charcoal; hydrogen In ethanol at 20 - 55℃; under 3750380 Torr; Autoclave; Inert atmosphere;
Stage #2: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride In ethanol; water at 20 - 85℃; under 63756400 Torr; Inert atmosphere;
85%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9

7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one

3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one hydrochloride

3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one hydrochloride

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride With potassium carbonate In ethyl acetate at 25 - 30℃; for 1h;
Stage #2: 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one In ethyl acetate at 5 - 25℃; for 6h;
Stage #3: With palladium 10% on activated carbon; hydrogen In ethyl acetate at 65 - 70℃; for 6h;
85%
3-[2-(1,3-Dioxolan-2-yl)-ethyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

3-[2-(1,3-Dioxolan-2-yl)-ethyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

ivabradine hydrochloride
148849-67-6

ivabradine hydrochloride

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In ethanol; water at 85℃; under 22502.3 Torr; Autoclave;85%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one
148870-57-9

7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one

3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride
1086026-38-1

3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride; 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one With potassium carbonate In water; toluene at 70℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water
80%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one
85175-59-3

3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one

oxalic acid
144-62-7

oxalic acid

dehydro-ivabradine oxalate
1346558-08-4

dehydro-ivabradine oxalate

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride; 3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one With potassium carbonate; sodium iodide In 1-methyl-pyrrolidin-2-one at 20 - 60℃; Inert atmosphere;
Stage #2: oxalic acid In methanol at 20℃; for 2h;
76%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

(2-{2-[(3-chloropropyl)amino]ethyl}-4,5-dimethoxyphenyl)acetonitrile
1462470-52-5

(2-{2-[(3-chloropropyl)amino]ethyl}-4,5-dimethoxyphenyl)acetonitrile

{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile
1462470-53-6

{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

Conditions
ConditionsYield
With triethylamine In acetonitrile for 6h; Reflux;66%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

3-(7,8-Dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-propanenitrile
1246638-04-9

3-(7,8-Dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-propanenitrile

N-{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methylpropanimidamide
1246638-11-8

N-{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methylpropanimidamide

Conditions
ConditionsYield
Stage #1: 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride; 3-(7,8-Dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-propanenitrile With triethylamine; copper(l) chloride In methanol for 24h; Inert atmosphere; Reflux;
Stage #2: With sodium hydroxide In methanol; dichloromethane; water at 20℃;
46%
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

ivabradine hydrochloride
148849-67-6

ivabradine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 20 - 60 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: potassium carbonate / water / 0.08 h
2.2: Inert atmosphere
3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water / 6 h / 45 °C / 7500.75 Torr
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 12 h / 20 °C
2: hydrogenchloride; pyrographite / acetonitrile / 0.17 h / 70 °C / pH 2 - 3
View Scheme
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
1086026-31-4

3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 20 - 60 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: potassium carbonate / water / 0.08 h
2.2: Inert atmosphere
View Scheme
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
866783-13-3

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

3-{3-[((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-ylmethyl)-methyl-amino]-propyl}-7,8-dimethoxy-1,3-dihydro-benzo[d]azepine-2-one nitrate
1346558-09-5

3-{3-[((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-ylmethyl)-methyl-amino]-propyl}-7,8-dimethoxy-1,3-dihydro-benzo[d]azepine-2-one nitrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 20 - 60 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: potassium carbonate / water / 0.08 h
2.2: Inert atmosphere
3.1: nitric acid / ethanol; water
View Scheme

Downstream Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View