Multi-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Self Innovation Appeara
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Cas:879551-04-9
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inquiryDayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif
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inquiryProduct Name: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Synonyms: (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one;(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyloxolan-
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inquiry(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one CAS:879551-04-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryMelting point 142-143℃ (ethyl acetate heptane ) Boiling point 352.7±42.0 °C(Predicted) density 1.42±0.1 g/cm3(Predicted) pka 11.46±0.6
Cas:879551-04-9
Min.Order:100 Kilogram
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Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct name: (3R,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)-3-Methyloxolan-2-One CAS No.: 879551-04-9 Molecule Formula:C6H9FO4 Molecule Weight:164.13 Purity: 99.0% Package: 25kg/drum Description:White or off-white crystalline powder Manufac
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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Cas:879551-04-9
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inquiryFandaChem (www.fandachem.com), a China-based chemical company, specialize in exporting Sofosbuvir intermediate,CAS: 879551-04-9, Please contact us by email freely. Appearance:white powder Storage:Store in dry, dark and ventilated place Package:as c
Cas:879551-04-9
Min.Order:100 Gram
Negotiable
Type:Other
inquiry(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With trifluoroacetic acid In water; acetonitrile at 80℃; for 1.5h; | 100% |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate; dihydrogen peroxide In tetrahydrofuran; water at 0 - 5℃; for 1h; | 100% |
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With methanesulfonic acid In ethanol for 5h; Reagent/catalyst; Solvent; Reflux; | 95.3% |
With sodium methylate In methanol at 20℃; for 2h; |
(4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Stage #1: (4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide With triethylamine tris(hydrogen fluoride) In dichloromethane at 90℃; for 3h; Stage #2: With hydrogenchloride; barium(II) chloride In dichloromethane at 50℃; for 5h; Solvent; Temperature; Concentration; | 89% |
Multi-step reaction with 2 steps 1.1: tetraethylammonium fluoride / 1,4-dioxane / 16 h / 120 °C 1.2: 3 h / 20 °C 2.1: water; hydrogenchloride / ethanol / 48 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine tris(hydrogen fluoride) / 2 h / 82 - 85 °C 2.1: hydrogenchloride / 0.5 h / 90 - 92 °C 2.2: 4 h View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 50℃; for 24h; Reagent/catalyst; Solvent; Temperature; Concentration; | 88% |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With trifluoroacetic acid In 1,4-dioxane; water at 20℃; for 48h; | A 83% B 6% |
(S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-benzyloxazolidin-2-one
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate; dihydrogen peroxide In tetrahydrofuran; water at 0 - 5℃; for 1h; | 70% |
(S)-3-((2R,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoyl)-4-isopropyloxazolidin-2-one
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate; dihydrogen peroxide In tetrahydrofuran; water at 0 - 5℃; for 1h; | 67% |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With water; potassium hydroxide In ethanol for 4h; Reflux; | 45% |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Stage #1: C6H15N*C11H19FO8S With hydrogenchloride; water at 90℃; for 0.5h; Stage #2: With barium(II) chloride In water at 90℃; for 4h; | |
Stage #1: C6H15N*C11H19FO8S With hydrogenchloride at 90 - 92℃; for 0.5h; Stage #2: With barium(II) chloride In water for 4h; Temperature; |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With water; acetic acid at 95℃; for 2 - 5h; Product distribution / selectivity; |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With water; acetic acid at 95℃; for 2 - 5h; Product distribution / selectivity; |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With water; acetic acid at 95℃; for 2 - 5h; Product distribution / selectivity; |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With water; acetic acid at 90℃; for 2h; optical yield given as %de; |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With water; acetic acid at 90℃; for 2h; optical yield given as %de; |
C11H19FO5
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 20℃; for 15h; | |
With hydrogenchloride; water In ethanol at 20℃; for 21h; |
(2S,3R)-3-[(4R)-2,2-dimethyl-[1,3]dioxolane-4-yl]-2,3-dihydroxy-2-methylpropionic acid ethyl ester
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: fluorosulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride) / acetonitrile / 5 h / -15 - 90 °C 2: 2,2-dimethoxy-propane; hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C 3: hydrogenchloride; water / ethanol / 21 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C 2.1: tetraethylammonium fluoride / 1,4-dioxane / 16 h / 120 °C 2.2: 3 h / 20 °C 3.1: water; hydrogenchloride / ethanol / 48 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: Isopropyl acetate; triethylamine; thionyl chloride / acetonitrile / 1 h / 6 - 9 °C 1.2: 0.5 h 2.1: triethylamine tris(hydrogen fluoride) / 2 h / 82 - 85 °C 3.1: hydrogenchloride / 0.5 h / 90 - 92 °C 3.2: 4 h View Scheme |
C10H18O6
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: fluorosulfonyl fluoride; triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene hydrofluoride / acetonitrile / 5 h / 0 - 55 °C 2: 2,2-dimethoxy-propane; water; sulfuric acid / 1,4-dioxane / 16 h / 20 °C / pH 2 - 3 / Cooling with ice 3: hydrogenchloride; water / ethanol / 18 h / 20 °C View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2,2-dimethoxy-propane; water; sulfuric acid / 1,4-dioxane / 16 h / 20 °C / pH 2 - 3 / Cooling with ice 2: hydrogenchloride; water / ethanol / 18 h / 20 °C View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With hydrogenchloride; water In ethanol at 20℃; for 18h; Solvent; |
C11H18O4
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium permanganate / acetone / 5 h / 0 - 5 °C 2.1: triethylamine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C 3.1: tetraethylammonium fluoride / 1,4-dioxane / 16 h / 120 °C 3.2: 3 h / 20 °C 4.1: water; hydrogenchloride / ethanol / 48 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate; sodium permanganate; ethylene glycol / acetone / 1.5 h / -15 - 10 °C 2.1: Isopropyl acetate; triethylamine; thionyl chloride / acetonitrile / 1 h / 6 - 9 °C 2.2: 0.5 h 3.1: triethylamine tris(hydrogen fluoride) / 2 h / 82 - 85 °C 4.1: hydrogenchloride / 0.5 h / 90 - 92 °C 4.2: 4 h View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With hydrogenchloride; water In ethanol at 20℃; for 48h; | 110 g |
ethyl 2-fluoropropionate
2,3-isopropylidene-glyceraldehyde
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
Stage #1: ethyl 2-fluoropropionate; 2,3-isopropylidene-glyceraldehyde With lithium diisopropyl amide In tetrahydrofuran at -70 - 20℃; for 2h; Stage #2: With acetic acid In water at 90℃; for 2h; |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 4h; Reflux; |
(S,E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropionic acid ethyl ester
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; dihydrogen peroxide / ethanol; benzonitrile / 0 °C 2: triethylamine; triethylamine tris(hydrogen fluoride) / 80 °C / Inert atmosphere 3: hydrogenchloride / ethanol; water / 24 h / 50 °C View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine; triethylamine tris(hydrogen fluoride) / 80 °C / Inert atmosphere 2: hydrogenchloride / ethanol; water / 24 h / 50 °C View Scheme |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With acetic acid In water at 90℃; for 1h; Overall yield = 28.9 g; |
A
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
B
(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
With acetic acid In water at 90℃; for 1h; Overall yield = 8.72 g; |
ethyl (E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methyl-2-propenoate
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium permanganate; ethylene glycol; sodium hydrogencarbonate / water; ethyl acetate / -10 - 0 °C / Large scale 2: triethylamine; sulfuryl dichloride / ethyl acetate / 5 - 25 °C / Large scale 3: potassium fluoride / ethyl acetate / 5 h / Reflux; Large scale 4: hydrogenchloride / water; ethyl acetate / 2 h / 85 - 90 °C / Large scale View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; sulfuryl dichloride / ethyl acetate / 5 - 25 °C / Large scale 2: potassium fluoride / ethyl acetate / 5 h / Reflux; Large scale 3: hydrogenchloride / water; ethyl acetate / 2 h / 85 - 90 °C / Large scale View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
With lithium borohydride In tetrahydrofuran at 0℃; for 6h; Solvent; Concentration; Inert atmosphere; | 94% |
With lithium tri-t-butoxyaluminum hydride In tetrahydrofuran at -20 - 0℃; for 0.5h; Reagent/catalyst; |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
tert-butyldimethylsilyl chloride
Conditions | Yield |
---|---|
With pyridine; 1H-imidazole at 0 - 20℃; for 16h; | 88% |
With pyridine; 1H-imidazole In dichloromethane at 20℃; Cooling with ice; | 63% |
With pyridine; 1H-imidazole In dichloromethane at 20℃; Cooling with ice; | 57.3% |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
benzoyl chloride
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate
Conditions | Yield |
---|---|
With pyridine at 20℃; for 0.333333h; | 87% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; | 86% |
With dmap; triethylamine In acetonitrile at 5 - 20℃; for 2h; Temperature; | 84.2% |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 0.75 h / 0 - 20 °C 2: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate)
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 0.75 h / 0 - 20 °C 2: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere 3: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / -25 - -20 °C / Inert atmosphere View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: pyridine / 0.75 h / 0 - 20 °C 2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / -25 - -20 °C / Inert atmosphere 4.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C 4.2: 50 °C View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
C31H30FN5O5
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: pyridine / 0.75 h / 0 - 20 °C 2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / -25 - -20 °C / Inert atmosphere 4.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C 4.2: 50 °C 5.1: silver nitrate / dichloromethane / 20 °C 5.2: 12 h / 20 °C View Scheme |
(3R,4R,5R)-3‑fluoro‑4‑hydroxy‑5‑(hydroxymethyl)‑3‑methyltetrahydrofuran‑2‑one
C31H29FIN5O4
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: pyridine / 0.75 h / 0 - 20 °C 2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / -25 - -20 °C / Inert atmosphere 4.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C 4.2: 50 °C 5.1: silver nitrate / dichloromethane / 20 °C 5.2: 12 h / 20 °C 6.1: triphenylphosphine; pyridine; iodine / 20 °C View Scheme |
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