Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Tivantinib Manufacturer/High quality/Best price/In stock

Cas:905854-02-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione CAS:905854-02-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trad

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione CAS:905854-02-6

Cas:905854-02-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-

Cas:905854-02-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Tivantinib 905854-02-6

Cas:905854-02-6

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-

Cas:905854-02-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

High Quality Best price Fast Delivery Good Service Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; developm

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

Cas:905854-02-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Tivantinib(ARQ-197)

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

GMP factory Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Api, inhibitor, and fine chemicals for more

Tivantinib cas 905854-02-6

Cas:905854-02-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Tivantinib (ARQ 197) is the first non-ATP-compe

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

Cas:905854-02-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

905854-02-6 CAS No.905854-02-6

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

Hangzhou Fandachem Co.,Ltd

Tivantinib cas 905854-02-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Tivantinib cas 905854-02-6

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

905854-02-6

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:2mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Tivantinib (ARQ 197)

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

Tivantinib

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Tivantinib (ARQ 197)

Cas:905854-02-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and

Tivantinib

Cas:905854-02-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization. Company has strong ability of research and development

Tivantinibwith factory price

Cas:905854-02-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

Tivantinib (ARQ197)

Cas:905854-02-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HuBei Ipure Biotech CO.,ltd

HuBei ipure is a diversified product production and operation enterprise, with API, pharma intermediates, and other fine chemicals as well as R&D and pigments development and sales as one of the large enterprises, with more than 130 acres of pl

Tivantinib Manufacturer/High quality/Best price/In stock

Cas:905854-02-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Synthetic route

(±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

(±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Purification / work up; Resolution of racemate;
With Chiralpak AZ column In methanol; dichloromethane; acetonitrile Resolution of racemate; Multicolumn chromatography;A n/a
B n/a
With CHIRALPAK AD column In methanol; carbon dioxide liquid CO2;
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline
5840-01-7

5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tert-butyl methyl ether / 2.17 h / 15 - 32 °C / Industry scale
1.2: 2 h / Industry scale
2.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 - 32 °C / Industry scale
2.2: 0.5 h / 40 - 50 °C / Industry scale
2.3: 40 °C / pH 8 - 9 / Industry scale
3.1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale
4.1: hydrogenchloride / water; Isopropyl acetate / Industry scale
5.1: Chiralpak AZ column / dichloromethane; acetonitrile; methanol / Resolution of racemate; Multicolumn chromatography
View Scheme
Multi-step reaction with 6 steps
1.1: tert-butyl methyl ether / 2.17 h / 15 - 32 °C / Industry scale
1.2: 2 h / Industry scale
2.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 - 32 °C / Industry scale
2.2: 0.5 h / 40 - 50 °C / Industry scale
2.3: 40 °C / pH 8 - 9 / Industry scale
3.1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale
4.1: hydrogenchloride / water; Isopropyl acetate / Industry scale
5.1: acetonitrile / 50 °C
6.1: hydrogenchloride / 3-methyltetrahydrofuran; water / 50 °C / pH 1.6
View Scheme
Multi-step reaction with 5 steps
1.1: tert-butyl methyl ether / 0.1 h / 20 - 32 °C / Inert atmosphere
1.2: 0.1 h / 25 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 20 - 32 °C / Inert atmosphere
2.2: 0.1 h / 0.4 - 0.5 °C
2.3: 0.01 h / 20 - 32 °C
3.1: potassium tert-butylate; 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 0.45 - 0.5 °C / 3360.34 Torr
4.1: water; methanol / 3 h / 0.55 - 20 °C / Inert atmosphere
5.1: hydrogenchloride / methanol / 0.45 - 0.55 °C
View Scheme
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester
345264-02-0

(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 - 32 °C / Industry scale
1.2: 0.5 h / 40 - 50 °C / Industry scale
1.3: 40 °C / pH 8 - 9 / Industry scale
2.1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale
3.1: hydrogenchloride / water; Isopropyl acetate / Industry scale
4.1: Chiralpak AZ column / dichloromethane; acetonitrile; methanol / Resolution of racemate; Multicolumn chromatography
View Scheme
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 - 32 °C / Industry scale
1.2: 0.5 h / 40 - 50 °C / Industry scale
1.3: 40 °C / pH 8 - 9 / Industry scale
2.1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale
3.1: hydrogenchloride / water; Isopropyl acetate / Industry scale
4.1: acetonitrile / 50 °C
5.1: hydrogenchloride / 3-methyltetrahydrofuran; water / 50 °C / pH 1.6
View Scheme
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 20 - 32 °C / Inert atmosphere
1.2: 0.1 h / 0.4 - 0.5 °C
1.3: 0.01 h / 20 - 32 °C
2.1: potassium tert-butylate; 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 0.45 - 0.5 °C / 3360.34 Torr
3.1: water; methanol / 3 h / 0.55 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / methanol / 0.45 - 0.55 °C
View Scheme
3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion
345261-20-3

3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale
2: hydrogenchloride / water; Isopropyl acetate / Industry scale
3: Chiralpak AZ column / dichloromethane; acetonitrile; methanol / Resolution of racemate; Multicolumn chromatography
View Scheme
Multi-step reaction with 4 steps
1: hydrogen; potassium tert-butylate / 20 % Pd(OH)2/C / tetrahydrofuran / 45 - 55 °C / 3361.55 - 4137.29 Torr / Industry scale
2: hydrogenchloride / water; Isopropyl acetate / Industry scale
3: acetonitrile / 50 °C
4: hydrogenchloride / 3-methyltetrahydrofuran; water / 50 °C / pH 1.6
View Scheme
Multi-step reaction with 3 steps
1: potassium tert-butylate; 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 0.45 - 0.5 °C / 3360.34 Torr
2: water; methanol / 3 h / 0.55 - 20 °C / Inert atmosphere
3: hydrogenchloride / methanol / 0.45 - 0.55 °C
View Scheme
(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / ethanol / 13 h / 65 °C / Industry scale
1.2: 60 °C
2.1: acetonitrile / 50 °C
3.1: hydrogenchloride / 3-methyltetrahydrofuran; water / 50 °C / pH 1.6
View Scheme
(±)-cis-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

(±)-cis-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; Isopropyl acetate / Industry scale
2: Chiralpak AZ column / dichloromethane; acetonitrile; methanol / Resolution of racemate; Multicolumn chromatography
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water; Isopropyl acetate / Industry scale
2: acetonitrile / 50 °C
3: hydrogenchloride / 3-methyltetrahydrofuran; water / 50 °C / pH 1.6
View Scheme
(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex
1313508-66-5

(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione pseudoephedrine complex

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
With hydrogenchloride In 3-methyltetrahydrofuran; water at 50℃; pH=1.6; Product distribution / selectivity;
With hydrogenchloride In methanol at 0.45 - 0.55℃;
1,2,3,4-tetrahydroisoquinoline
635-46-1

1,2,3,4-tetrahydroisoquinoline

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 24.5 h / 20 °C
2.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
3.1: sodium hydroxide; water / ethanol / 2 h / Reflux
4.1: copper chromite / quinoline / 2 h / 185 °C
5.1: diethyl ether / 0 °C
5.2: -78 - 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
7.1: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
8.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 24.5 h / 20 °C
2.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
3.1: sodium hydroxide; water / ethanol / 2 h / Reflux
4.1: copper chromite / quinoline / 2 h / 185 °C
5.1: diethyl ether / 0 °C
5.2: -78 - 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
7.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
8.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 24.5 h / 20 °C
2.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
3.1: sodium hydroxide; water / ethanol / 2 h / Reflux
4.1: copper chromite / quinoline / 2 h / 185 °C
5.1: diethyl ether / 0 °C
5.2: -78 - 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
7.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
8.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
9.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 24.5 h / 20 °C
2.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
3.1: sodium hydroxide; water / ethanol / 2 h / Reflux
4.1: copper chromite / quinoline / 2 h / 185 °C
5.1: diethyl ether / 0 °C
5.2: -78 - 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
7.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
8.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
9.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
3-(3,4-dihydro-2H-quinolin-1-yl)-2-oxopropionic acid ethyl ester
152712-44-2

3-(3,4-dihydro-2H-quinolin-1-yl)-2-oxopropionic acid ethyl ester

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
2.1: sodium hydroxide; water / ethanol / 2 h / Reflux
3.1: copper chromite / quinoline / 2 h / 185 °C
4.1: diethyl ether / 0 °C
4.2: -78 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
6.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
7.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 7 steps
1.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
2.1: sodium hydroxide; water / ethanol / 2 h / Reflux
3.1: copper chromite / quinoline / 2 h / 185 °C
4.1: diethyl ether / 0 °C
4.2: -78 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
6.1: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
7.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 8 steps
1.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
2.1: sodium hydroxide; water / ethanol / 2 h / Reflux
3.1: copper chromite / quinoline / 2 h / 185 °C
4.1: diethyl ether / 0 °C
4.2: -78 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
7.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
8.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 8 steps
1.1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux
2.1: sodium hydroxide; water / ethanol / 2 h / Reflux
3.1: copper chromite / quinoline / 2 h / 185 °C
4.1: diethyl ether / 0 °C
4.2: -78 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
6.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
7.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
8.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester
124730-53-6

5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydroxide; water / ethanol / 2 h / Reflux
2.1: copper chromite / quinoline / 2 h / 185 °C
3.1: diethyl ether / 0 °C
3.2: -78 - 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
5.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
6.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydroxide; water / ethanol / 2 h / Reflux
2.1: copper chromite / quinoline / 2 h / 185 °C
3.1: diethyl ether / 0 °C
3.2: -78 - 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
5.1: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
6.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / ethanol / 2 h / Reflux
2.1: copper chromite / quinoline / 2 h / 185 °C
3.1: diethyl ether / 0 °C
3.2: -78 - 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
6.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
7.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / ethanol / 2 h / Reflux
2.1: copper chromite / quinoline / 2 h / 185 °C
3.1: diethyl ether / 0 °C
3.2: -78 - 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
5.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
6.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
7.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
3-(1-allyl-7-bromo-1H-indol-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

3-(1-allyl-7-bromo-1H-indol-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); 9-bora-bicyclo[3.3.1]nonane
2: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid
124730-56-9

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper chromite / quinoline / 2 h / 185 °C
2.1: diethyl ether / 0 °C
2.2: -78 - 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
4.1: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
5.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 5 steps
1.1: copper chromite / quinoline / 2 h / 185 °C
2.1: diethyl ether / 0 °C
2.2: -78 - 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
4.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
5.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 6 steps
1.1: copper chromite / quinoline / 2 h / 185 °C
2.1: diethyl ether / 0 °C
2.2: -78 - 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
5.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
6.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 6 steps
1.1: copper chromite / quinoline / 2 h / 185 °C
2.1: diethyl ether / 0 °C
2.2: -78 - 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
4.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
5.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
6.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline
5840-01-7

5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diethyl ether / 0 °C
1.2: -78 - 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
3.1: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
4.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 4 steps
1.1: diethyl ether / 0 °C
1.2: -78 - 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
3.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
4.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 5 steps
1.1: diethyl ether / 0 °C
1.2: -78 - 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
4.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
5.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 5 steps
1.1: diethyl ether / 0 °C
1.2: -78 - 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
3.1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
4.1: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
5.1: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester
345264-02-0

(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
2: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
3: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
2: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
3: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 4 steps
1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
3: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
4: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 4 steps
1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 °C
2: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
3: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
4: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion
345261-20-3

3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion

A

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
905854-03-7

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-j]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

B

Tivantinib
905854-02-6

Tivantinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: magnesium; methanol / 0.67 h / Inert atmosphere; Reflux
2: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 2 steps
1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
2: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 3 steps
1: zinc; mercury dichloride; hydrogenchloride / ethanol / Reflux
2: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
3: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
2: potassium tert-butylate / tert-butyl alcohol / 16 h / 50 °C
3: CHIRALPAK® AD column / methanol; carbon dioxide / liquid CO2
View Scheme
Tivantinib
905854-02-6

Tivantinib

A

(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-5-thioxo-pyrrolidin-2-one
1094609-99-0

(3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-5-thioxo-pyrrolidin-2-one

B

(3R,4R)-4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-3-(1H-indol-3-yl)-5-thioxo-pyrrolidin-2-one
1094609-98-9

(3R,4R)-4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-3-(1H-indol-3-yl)-5-thioxo-pyrrolidin-2-one

Conditions
ConditionsYield
With Lawessons reagent In tetrahydrofuran for 17h; Heating / reflux;
Tivantinib
905854-02-6

Tivantinib

1-[(3R,4R)-4-(1H-indol-3-yl)-pyrrolidin-3-yl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline
1094610-07-7

1-[(3R,4R)-4-(1H-indol-3-yl)-pyrrolidin-3-yl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions
ConditionsYield
Stage #1: Tivantinib With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 60℃;
Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0℃; pH=< 2;
Stage #3: With 2-chloro-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone; water In tetrahydrofuran pH=> 9;

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View