Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiry1,2,3,4-Tetrahydroquinoline CAS 635-46-1 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in
Cas:635-46-1
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inquiryhe company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appeara
1,2,3,4-Tetrahydroquinoline CAS NO.:635-46-1 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing &
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for t
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryStock products, own laboratory Appearance:Colorless transparent or light yellow liquid Storage:Room Temperature Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai
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inquiry1,2,3,4-Tetrahydroquinoline Basic information Product Name: 1,2,3,4-Tetrahydroquinoline Synonyms: 1,2,3,4-Tetrahydrochinoline;1,2,3,4-tetrahydro-quinolin;Kusol;Tetrahydroquinoline;AURORA
Cas:635-46-1
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:635-46-1
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName 1,2,3,4-Tetrahydroquinoline Synonyms Quinoline,1,2,3,4-tetrahydro;(1H)-tetrahydroquinoline;1,2,3,4-tetrahydro-quinoline;Kusol;benzopiperidine CAS NO. 635-46-1
Cas:635-46-1
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Cas:635-46-1
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inquiry1,2,3,4-Tetrahydroquinoline CAS:635-46-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:635-46-1
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:635-46-1
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:635-46-1
Min.Order:1 Gram
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:635-46-1
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:635-46-1
Min.Order:4 Kilogram
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inquiryEstablished in 2010, located in Hangzhou Qinglan science park, lingruichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. In our R&D centre, we have a staff of skilled and e
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:635-46-1
Min.Order:100 Gram
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:635-46-1
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:635-46-1
Min.Order:10 Gram
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:635-46-1
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With hydrogen; Wilkinson's catalyst In benzene at 85℃; under 16031.6 Torr; for 60h; | 100% |
With hydrogen; polymer incarcerated palladium In tetrahydrofuran at 20℃; for 24h; | 100% |
With hydrogen; Pd-containing polymer micelles In tetrahydrofuran at 20℃; under 760 Torr; for 24h; | 100% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water | 99% |
With sodium hydroxide In ethanol for 6h; Hydrolysis; Heating; | 93% |
With hydrogenchloride |
1-(4-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With potassium carbonate; thiophenol In acetonitrile for 24h; | 99% |
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; chloro-trimethyl-silane; magnesium In tetrahydrofuran at 50℃; for 24h; | 99% |
Multi-step reaction with 2 steps 1: aminomethyl resin-supported N-propylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 1 h / 20 - 40 °C 2: 86 percent / aminomethyl resin-supported N-propylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 40 °C View Scheme |
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; chloro-trimethyl-silane; magnesium In tetrahydrofuran at 50℃; for 12h; | 99% |
Conditions | Yield |
---|---|
With hydrogen In water at 20℃; for 24h; regioselective reaction; | 97% |
Conditions | Yield |
---|---|
With layered double hydroxide supported NiAl at 20 - 125℃; for 24h; Reagent/catalyst; | 97% |
Conditions | Yield |
---|---|
With [RuCl2(N-heterocyclic carbene)(bis[2-(diphenylphosphino)ethyl]amine)]; hydrogen; caesium carbonate In toluene; butan-1-ol at 120℃; under 22502.3 Torr; for 6h; Catalytic behavior; Solvent; Reagent/catalyst; Schlenk technique; Autoclave; | 96% |
With borane-ammonia complex; boron trifluoride diethyl etherate; tris(pentafluorophenyl)borate In 1,2-dichloro-ethane at 60℃; for 16h; | 90% |
With tetra(n-butyl)ammonium borohydride In dichloromethane for 10h; Heating; | 86% |
3-(2-chlorophenyl)-1-propanamine
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With bis(acetylacetonate)nickel(II); sodium t-butanolate; 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride In 1,4-dioxane at 100℃; for 4h; | 96% |
With sodium hydride; tert-butyl alcohol; 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride; palladium diacetate In 1,4-dioxane for 3h; |
Conditions | Yield |
---|---|
With iridium(IV) oxide tetrahydrate; hydrogen In methanol at 20℃; for 24h; regioselective reaction; | 96% |
1-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With magnesium; lithium tert-butoxide In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents; | 94% |
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; methoxybenzene In dichloromethane at 0℃; desulfonation; | 93% |
1-(mesitylsulfonyl)-1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; chloro-trimethyl-silane; magnesium In tetrahydrofuran at 50℃; for 12h; Inert atmosphere; | 93% |
1-acetyl-1,2,3,4-tetrahydroquinoline
A
1,2,3,4-tetrahydroisoquinoline
B
ethanol
Conditions | Yield |
---|---|
With hydrogen In toluene at 160℃; under 45004.5 Torr; for 15h; Catalytic behavior; Autoclave; | A 93% B 89 %Chromat. |
With {Ru(H)(BH4)(CO)(3-(di-tert-butylphosphino)-N-((1-methyl-1H-imidazol-2-yl)methyl)propylamine)}; hydrogen In isopropyl alcohol at 120℃; under 22502.3 Torr; for 18h; Autoclave; | A 99 %Chromat. B 99 %Chromat. |
With C16H25MnN3O3P(1+)*Br(1-); potassium tert-butylate; hydrogen In cyclohexane at 100℃; under 22502.3 Torr; for 16h; Inert atmosphere; Autoclave; | A 88 %Chromat. B 85 %Chromat. |
quinoline
4-Trifluoromethylbenzaldehyde
A
1,2,3,4-tetrahydroisoquinoline
B
1-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydroquinoline
Conditions | Yield |
---|---|
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (meta-(trifluoromethyl)phenyl)boronic acid In 1,2-dichloro-ethane at 60℃; for 12h; Kinetics; Reagent/catalyst; | A n/a B 93% |
quinoline
A
5,6,7,8-tetrahydroquinoline
B
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With 5% Ru/MgO; hydrogen In tetrahydrofuran at 150℃; under 38002.6 Torr; for 0.7h; Time; Concentration; Pressure; | A 7% B 92% |
With hydrogen; platinum(IV) oxide In trifluoroacetic acid | A 80% B 6% |
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In tetrahydrofuran at 80℃; under 3040.2 Torr; for 48h; Catalytic behavior; Glovebox; | A 58% B 14% |
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With ammonium acetate; 10% Cd/Pd In tetrahydrofuran; water for 0.75h; | 92% |
A
1,2,3,4-tetrahydroisoquinoline
B
1-allyl-1,2,3,4-tetrahydroquinoline
Conditions | Yield |
---|---|
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20 - 40℃; for 1h; | A 92% B n/a |
indan-1-one oxime
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: indan-1-one oxime With diisobutylaluminium hydride In hexane; dichloromethane at 0 - 20℃; Inert atmosphere; Stage #2: With sodium fluoride In hexane; dichloromethane; water at 0℃; for 0.5h; | 92% |
Stage #1: indan-1-one oxime With diisobutylaluminium hydride In hexane; dichloromethane at 0 - 20℃; Inert atmosphere; Stage #2: With water; sodium fluoride In hexane; dichloromethane at 0℃; for 0.5h; Inert atmosphere; regioselective reaction; | 92% |
With dichloroaluminum hydride In cyclopentyl methyl ether at 0 - 20℃; | 69% |
Multi-step reaction with 2 steps 1.1: hydrogenchloride; sodium cyanoborohydride / methanol / 0 - 20 °C 2.1: diisobutylaluminium hydride / hexane; dichloromethane / 3.5 h / 0 °C / Inert atmosphere 2.2: 0.5 h / 0 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Stage #1: Quinoline N-oxide With H2SiEt2; tris(pentafluorophenyl)borate In chloroform at 65℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether at 20℃; for 1h; | 91% |
With ammonium formate; 10percent palladium on carbon In methanol at 20℃; for 16h; | 87% |
With hydrogen In toluene at 120℃; under 15001.5 Torr; for 48h; Autoclave; | 90 %Chromat. |
With hydrogen In water; isopropyl alcohol Heating; High pressure; chemoselective reaction; | 68 %Chromat. |
3-(2-aminophenyl)-1-propanol
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With C36H35IrN2P(1+)*C32H12BF24(1-); potassium tert-butylate In diethylene glycol dimethyl ether at 60℃; for 24h; Inert atmosphere; | 91% |
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium carbonate In toluene at 111℃; for 17h; | 96 % Chromat. |
quinoline
formic acid
A
1,2,3,4-tetrahydroisoquinoline
B
3,4-dihydro-2H-quinoline-1-carbaldehyde
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 130℃; for 0.166667h; Reagent/catalyst; | A 91% B 7% |
With triethylamine In N,N-dimethyl-formamide at 130℃; for 2h; chemoselective reaction; |
1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-quinoline
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With naphthalene; tetraethylammonium bromide In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Electrolysis; | 90% |
With titanium(IV) isopropylate; chloro-trimethyl-silane; magnesium In tetrahydrofuran at 50℃; for 12h; Inert atmosphere; | 79% |
With sodium hydride In N,N-dimethyl acetamide at 60℃; for 8h; Inert atmosphere; | 32% |
1-indanone O-(tert-butyldimethylsilyl)oxime
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With borane-THF at 60℃; Reduction; | 88% |
With dimethylsulfide borane complex; boron trifluoride diethyl etherate at 20℃; |
quinoline
isopropyl alcohol
A
1,2,3,4-tetrahydroisoquinoline
B
1-(1-methylethyl)-1,2,3,4-tetrahydroquinoline
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; zinc at 150℃; for 24h; Autoclave; | A 88% B 11% |
With perchloric acid; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In water for 17h; Heating; | A 69 % Chromat. B n/a |
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; phenylsilane; indium(III) acetate In ethanol at 20℃; for 120h; | A 88% B 8% |
With 2,6-dimethylpyridine; phenylsilane; indium(III) acetate In ethanol at 20℃; for 48h; | A 29% B 48% |
1-(2-nitrobenzyl)-1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrazine In 1,4-dioxane; water for 0.333333h; Inert atmosphere; UV-irradiation; | 88% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; titanium tetrachloride In 1,2-dimethoxyethane for 14h; Ambient temperature; | 87% |
1,3,4,5-tetrahydrobenzo<1,2-c>thiazepine 2,2-dioxide
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
at 650℃; under 0.005 Torr; | 86.9% |
at 650℃; under 0.005 Torr; Mechanism; flash vacuum pyrolyses (flow system); | 86.9% |
Conditions | Yield |
---|---|
100% | |
With benzene |
1,2,3,4-tetrahydroisoquinoline
2-chloropropionyl chloride
1,2,6,7-tetrahydropyrido<3,2,1-i,j>quinolin-3(5H)-one
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline; 2-chloropropionyl chloride In acetone for 1h; Inert atmosphere; Reflux; Stage #2: With aluminum (III) chloride; sodium chloride at 150℃; for 1h; Inert atmosphere; | 100% |
Stage #1: 1,2,3,4-tetrahydroisoquinoline; 2-chloropropionyl chloride In acetone for 1h; Reflux; Stage #2: With aluminum (III) chloride; sodium chloride at 150℃; for 0.5h; | 88% |
With acetone Erhitzen des Reaktionsprodukts mit Aluminiumchlorid; | |
With aluminium trichloride 1.) acetone, reflux, 2 h, 2.) heating; Multistep reaction; |
1,2,3,4-tetrahydroisoquinoline
carbon dioxide
1,2,3,4-tetrahydroquinolin-1-carboxylic acid lithium salt
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline With n-butyllithium In diethyl ether; hexane at -78 - 20℃; for 2h; Stage #2: carbon dioxide In diethyl ether; hexane at -78℃; | 100% |
Stage #1: 1,2,3,4-tetrahydroisoquinoline With n-butyllithium In diethyl ether at -78 - 20℃; Cooling with acetone-dry ice; Inert atmosphere; Stage #2: carbon dioxide In diethyl ether at -78℃; Cooling with ethanol-dry ice; | 100% |
Stage #1: 1,2,3,4-tetrahydroisoquinoline With n-butyllithium In diethyl ether at -78℃; for 17h; Schlenk technique; Inert atmosphere; Stage #2: carbon dioxide In diethyl ether at -78 - 20℃; Schlenk technique; | 100% |
With n-butyllithium 1) THF, hexane, -78 deg C, 2) room temp.; Multistep reaction; | |
Stage #1: 1,2,3,4-tetrahydroisoquinoline With n-butyllithium In hexane; tert-butyl methyl ether at -20 - 20℃; Schlenk technique; Stage #2: carbon dioxide In tetrahydrofuran; diethyl ether; hexane; tert-butyl methyl ether at -78 - 20℃; Schlenk technique; |
1,2,3,4-tetrahydroisoquinoline
trifluoroacetic anhydride
1-(3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone
Conditions | Yield |
---|---|
With triethylamine In diethyl ether at 0 - 20℃; for 5h; | 100% |
With triethylamine In diethyl ether at 20℃; for 5h; | 100% |
With triethylamine In diethyl ether at 0 - 20℃; | 98% |
Conditions | Yield |
---|---|
With sulfuric acid; sodium chloride; sodium nitrite In dichloromethane | 100% |
With sulfuric acid; sodium nitrite In dichloromethane for 1.5h; | 100% |
With sodium nitrite In water; acetic acid; ethyl acetate | 96% |
1,2,3,4-tetrahydroisoquinoline
benzonitrile
phenyl(1,2,3,4-tetrahydroquinolin-8-yl)methanone
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline; benzonitrile With aluminum (III) chloride; water; boron trichloride In dichloromethane; toluene at 110℃; Stage #2: With hydrogenchloride; water In dichloromethane; toluene at 80℃; for 1h; | 100% |
Stage #1: 1,2,3,4-tetrahydroisoquinoline; benzonitrile With aluminum (III) chloride; boron trichloride In dichloromethane; toluene at 0 - 110℃; Stage #2: With hydrogenchloride; water at 80℃; for 1h; | 100% |
With aluminium trichloride; boron trichloride In 1,2-dichloro-ethane Acylation; |
1,2,3,4-tetrahydroisoquinoline
benzenesulfonyl chloride
1-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline
Conditions | Yield |
---|---|
With pyridine at 20℃; for 1h; | 100% |
With pyridine at 50℃; Inert atmosphere; | 97% |
With pyridine at 60 - 80℃; Inert atmosphere; | 87% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; | 100% |
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In tetrachloromethane at 60℃; | 100% |
1,2,3,4-tetrahydroisoquinoline
2-chloroacetylenephosphonic acid dimethyl ester
dimethyl (1,2,3,4-tetrahydroqunolyl)ethynylphosphonate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 2h; Heating; | 100% |
1,2,3,4-tetrahydroisoquinoline
n-butyllithium
carbon dioxide
1,2,3,4-tetrahydroquinolin-1-carboxylic acid lithium salt
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline; n-butyllithium In diethyl ether at -78 - 20℃; for 2h; Cooling with acetone-dry ice; Stage #2: carbon dioxide In diethyl ether at -78 - 20℃; Cooling with acetone-dry ice; | 100% |
1,2,3,4-tetrahydroisoquinoline
4-carbethoxypiperidine
trichloromethyl chloroformate
ethyl 1-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)piperidine-4-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline; trichloromethyl chloroformate With triethylamine In dichloromethane Stage #2: 4-carbethoxypiperidine In dichloromethane | 100% |
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride In 2-methyltetrahydrofuran at 18℃; for 1h; Solvent; Reagent/catalyst; Green chemistry; | 100% |
1,2,3,4-tetrahydroisoquinoline
α-bromopropionyl bromide
2-bromo-1-(3,4-dihydroquinolin-1(2H)-yl)propan-1-one
Conditions | Yield |
---|---|
With pyridine In dichloromethane at -78 - 20℃; for 1.75h; | 100% |
1,2,3,4-tetrahydroisoquinoline
methyl 6-bromohexanoate
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 100℃; for 21h; Inert atmosphere; | 100% |
With potassium carbonate; potassium iodide In acetonitrile for 38h; Inert atmosphere; Reflux; | 91% |
With sodium carbonate; sodium iodide In acetonitrile for 48h; Reflux; Inert atmosphere; | 81% |
With potassium carbonate; potassium iodide In acetonitrile at 100℃; for 30h; Inert atmosphere; | 76% |
With potassium carbonate; potassium iodide In acetonitrile at 100℃; for 30h; Inert atmosphere; | 76% |
Conditions | Yield |
---|---|
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0166667h; | 100% |
1,2,3,4-tetrahydroisoquinoline
isopentyl nitrite
N-nitroso-1,2,3,4-tetrahydroquinoline
Conditions | Yield |
---|---|
With 4-(1,1-dimethylethyl)benzoic acid In dichloromethane at 20℃; for 24h; Inert atmosphere; Schlenk technique; Glovebox; | 100% |
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline In diethyl ether at -78℃; for 0.5h; Schlenk technique; Stage #2: With n-butyllithium In diethyl ether for 2h; Inert atmosphere; Stage #3: carbon dioxide In diethyl ether at -78 - 20℃; | 100% |
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline With n-butyllithium In diethyl ether at -78℃; for 2h; Schlenk technique; Inert atmosphere; Stage #2: carbon dioxide In diethyl ether at -78℃; Schlenk technique; Inert atmosphere; | 100% |
1,2,3,4-tetrahydroisoquinoline
lithium 1,2,3,4-tetrahydroquinolide
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline In diethyl ether at -78℃; for 0.5h; Schlenk technique; Cooling with acetone-dry ice; Stage #2: With n-butyllithium In diethyl ether for 2h; Inert atmosphere; | 100% |
1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 25℃; for 0.5h; | 99.7% |
1,2,3,4-tetrahydroisoquinoline
formic acid
3,4-dihydro-2H-quinoline-1-carbaldehyde
Conditions | Yield |
---|---|
Stage #1: formic acid With acetic anhydride at 70℃; for 1h; Inert atmosphere; Stage #2: 1,2,3,4-tetrahydroisoquinoline at 50℃; Inert atmosphere; | 99% |
With iodine at 70℃; | 96% |
Conditions | Yield |
---|---|
With oxygen In para-xylene at 110℃; for 3.5h; | 99% |
With pyridine at 20℃; for 2h; Catalytic behavior; Reagent/catalyst; Irradiation; | 99% |
With 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; oxygen; nickel dibromide In tert-Amyl alcohol at 95℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; | 99% |
1,2,3,4-tetrahydroisoquinoline
2-[2-(p-tolylsulfanyl)phenyl]acetic acid
1-(3,4-Dihydro-2H-quinolin-1-yl)-2-(2-p-tolylsulfanyl-phenyl)-ethanone
Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide In benzene for 2h; Ambient temperature; | 99% |
Conditions | Yield |
---|---|
With benzoic acid; DavePhos; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In toluene at 50℃; | 99% |
With chlorobis(cyclooctene)rhodium(I) dimer; 1,3-bis-(diphenylphosphino)propane; benzene-1,2-dicarboxylic acid In tetrahydrofuran at 70℃; for 18h; Glovebox; enantioselective reaction; | 99% |
With tetrakis(triphenylphosphine) palladium(0); benzoic acid; CyJohnPhos In water at 100℃; for 24h; Sealed tube; Inert atmosphere; regioselective reaction; | 98% |
1,2,3,4-tetrahydroisoquinoline
methyl chloroformate
3,4-dihydro-2H-quinoline-1-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0 - 50℃; for 6h; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 6h; Cooling with ice; Inert atmosphere; | |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5.16667h; Cooling with ice; |
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