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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Troglitazone

Cas:97322-87-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Troglitazone manufacturer/supplier

Cas:97322-87-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Troglitazone 97322-87-7 manufacturers CAS NO.97322-87-7

Cas:97322-87-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Troglitazone

Cas:97322-87-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM -Troglitazone

Cas:97322-87-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 97322-87-7 with competitive price

Cas:97322-87-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to yellow powder Storage:Inert atmosphere,Store in freezer, under -20°C Package:25kg/drum Application:Troglitazone is an an oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Antidi

Troglitazone factory price

Cas:97322-87-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Troglitazone CAS:97322-87-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Troglitazone CAS:97322-87-7

Cas:97322-87-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:97322-87-7

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

CS-045 Troglitazone 97322-87-7

Cas:97322-87-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Troglitazone

Cas:97322-87-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Troglitazone

Cas:97322-87-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Troglitazone

Cas:97322-87-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Troglitazone

Cas:97322-87-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Troglitazone

Cas:97322-87-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Other

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Troglitazone 50mg

Cas:97322-87-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Troglitazone CAS No.97322-87-7

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

TroglitazoneAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

Troglitazone

Cas:97322-87-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Synthetic route

5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzylidene]-2,4-thiazolidinedione

5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzylidene]-2,4-thiazolidinedione

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
With sodium tetrahydroborate; dimethylaminoacetic acid; sodium hydroxide In tetrahydrofuran; water at 20℃;84%
With hydrogen; acetic acid In water; palladium
5-[4-(6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione
199441-78-6

5-[4-(6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
With hydrogenchloride; acetic acid at 70 - 80℃; debenzylation;70%
thiourea
17356-08-0

thiourea

Ethyl 3-<4-<(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>phenyl>-2-chloropropionate
97322-68-4

Ethyl 3-<4-<(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>phenyl>-2-chloropropionate

A

Troglitazone
97322-87-7

Troglitazone

B

5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2-iminothiazolidin-4-one
97323-08-5

5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2-iminothiazolidin-4-one

Conditions
ConditionsYield
With hydrogenchloride; acetic acid 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
Troglitazone glucuronide
127040-01-1

Troglitazone glucuronide

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
enzymatic treatment using glusulase;
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butoxide / dimethylformamide / 8 h / 80 °C
2: AcOH; piperidine / toluene / 4 h / Heating
3: HCl / methanol / 0.25 h
4: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: imidazole / dimethylformamide
2: LAH / 3 h / 20 °C
3: potassium tert-butoxide / dimethylformamide / 8 h / 80 °C
4: AcOH; piperidine / toluene / 4 h / Heating
5: HCl / methanol / 0.25 h
6: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: toluene-4-sulfonic acid / 12 h / Reflux
2: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
6: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
7: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
8: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
(6-t-butyldimethylsilyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzo[1,2-b]pyran-2yl)methanol
228114-44-1

(6-t-butyldimethylsilyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzo[1,2-b]pyran-2yl)methanol

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butoxide / dimethylformamide / 8 h / 80 °C
2: AcOH; piperidine / toluene / 4 h / Heating
3: HCl / methanol / 0.25 h
4: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C
View Scheme
6-tert-butyl(dimethyl)silyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
716320-66-0

6-tert-butyl(dimethyl)silyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: LAH / 3 h / 20 °C
2: potassium tert-butoxide / dimethylformamide / 8 h / 80 °C
3: AcOH; piperidine / toluene / 4 h / Heating
4: HCl / methanol / 0.25 h
5: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C
View Scheme
4-[6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-ylmethoxy]-benzaldehyde
716320-67-1

4-[6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-ylmethoxy]-benzaldehyde

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: AcOH; piperidine / toluene / 4 h / Heating
2: HCl / methanol / 0.25 h
3: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C
View Scheme
5-[1-{4-[6-(tert-Butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-ylmethoxy]-phenyl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

5-[1-{4-[6-(tert-Butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-ylmethoxy]-phenyl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / methanol / 0.25 h
2: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C
View Scheme
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

A

Troglitazone
97322-87-7

Troglitazone

B

PhCO-X

PhCO-X

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: t-BuOK / dimethylformamide / 1 h / 25 °C
1.2: 60 percent / dimethylformamide / 15 h / 25 °C
2.1: benzoic acid; piperidine / toluene / 4 h / 120 °C
3.1: 54 percent / Mg; MeOH / 8 h / 45 °C
4.1: 70 percent / HCl; AcOH / 70 - 80 °C
View Scheme
(6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methanol
171270-07-8

(6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methanol

A

Troglitazone
97322-87-7

Troglitazone

B

PhCO-X

PhCO-X

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: t-BuOK / dimethylformamide / 1 h / 25 °C
1.2: 60 percent / dimethylformamide / 15 h / 25 °C
2.1: benzoic acid; piperidine / toluene / 4 h / 120 °C
3.1: 54 percent / Mg; MeOH / 8 h / 45 °C
4.1: 70 percent / HCl; AcOH / 70 - 80 °C
View Scheme
4-[6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethoxy]benzaldehyde
138564-69-9

4-[6-benzyloxy-2,5,7,8-tetramethylchroman-2-ylmethoxy]benzaldehyde

A

Troglitazone
97322-87-7

Troglitazone

B

PhCO-X

PhCO-X

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: benzoic acid; piperidine / toluene / 4 h / 120 °C
2: 54 percent / Mg; MeOH / 8 h / 45 °C
3: 70 percent / HCl; AcOH / 70 - 80 °C
View Scheme

A

Troglitazone
97322-87-7

Troglitazone

B

PhCO-X

PhCO-X

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 54 percent / Mg; MeOH / 8 h / 45 °C
2: 70 percent / HCl; AcOH / 70 - 80 °C
View Scheme
2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-ol
79907-49-6

2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-ol

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, rt, 1 h, 2.) benzene, rt, 1 h
2: 1.) NaH / 1.) DMSO, benzene, 60 deg C, 20 min, 2.) 60 deg C, 1 h
3: 94 percent / AcOH, 10percent H2SO4 / 0.17 h / 60 °C
4: 94 percent / pyridine / 1.) 10 deg C to rt, 2.) 30 deg C, 1 h
5: 98 percent / H2 / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr
6: 1.) aq. NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, 0 deg C, 2.) 40 to 43 deg C, 30 min
7: 2.) AcOH, conc. HCl / 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h
View Scheme
2-hydroxymethyl-6-methoxymethoxy-2,5,7,8-tetramethylchroman
107188-55-6

2-hydroxymethyl-6-methoxymethoxy-2,5,7,8-tetramethylchroman

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) DMSO, benzene, 60 deg C, 20 min, 2.) 60 deg C, 1 h
2: 94 percent / AcOH, 10percent H2SO4 / 0.17 h / 60 °C
3: 94 percent / pyridine / 1.) 10 deg C to rt, 2.) 30 deg C, 1 h
4: 98 percent / H2 / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr
5: 1.) aq. NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, 0 deg C, 2.) 40 to 43 deg C, 30 min
6: 2.) AcOH, conc. HCl / 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h
View Scheme
6-Hydroxy-2,5,7,8-tetramethyl-2-<(4-nitrophenoxy)methyl>chroman
107188-58-9

6-Hydroxy-2,5,7,8-tetramethyl-2-<(4-nitrophenoxy)methyl>chroman

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / pyridine / 1.) 10 deg C to rt, 2.) 30 deg C, 1 h
2: 98 percent / H2 / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr
3: 1.) aq. NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, 0 deg C, 2.) 40 to 43 deg C, 30 min
4: 2.) AcOH, conc. HCl / 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h
View Scheme
6-acetoxy-2-[(4-aminophenoxy)methyl]-2,5,7,8-tetramethylchromane
107188-37-4

6-acetoxy-2-[(4-aminophenoxy)methyl]-2,5,7,8-tetramethylchromane

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) aq. NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, 0 deg C, 2.) 40 to 43 deg C, 30 min
2: 2.) AcOH, conc. HCl / 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h
View Scheme
2,5,7,8-tetramethyl-6-acetoxy-2-(4-nitrophenyloxy)methylchroman
118070-83-0

2,5,7,8-tetramethyl-6-acetoxy-2-(4-nitrophenyloxy)methylchroman

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / H2 / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr
2: 1.) aq. NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, 0 deg C, 2.) 40 to 43 deg C, 30 min
3: 2.) AcOH, conc. HCl / 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h
View Scheme
6-(Methoxymethoxy)-2,5,7,8-tetramethyl-2-<(4-nitrophenoxy)methyl>chroman
118070-84-1

6-(Methoxymethoxy)-2,5,7,8-tetramethyl-2-<(4-nitrophenoxy)methyl>chroman

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 94 percent / AcOH, 10percent H2SO4 / 0.17 h / 60 °C
2: 94 percent / pyridine / 1.) 10 deg C to rt, 2.) 30 deg C, 1 h
3: 98 percent / H2 / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr
4: 1.) aq. NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, 0 deg C, 2.) 40 to 43 deg C, 30 min
5: 2.) AcOH, conc. HCl / 1.) sulfolane, 115 to 120 deg C, 80 min, 2.) H2O, 85 to 90 deg c, 12 h
View Scheme
(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione
107187-56-4

(+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
In methanol; palladium
2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

Ethyl 3-<4-<(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>phenyl>-2-chloropropionate
97322-68-4

Ethyl 3-<4-<(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>phenyl>-2-chloropropionate

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
With hydrogenchloride; thiourea In sulfolane
carbonic acid tert-butyl ester 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester
1375483-15-0

carbonic acid tert-butyl ester 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
2: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
carbonic acid tert-butyl ester 2-{4-[2,4-dioxothiazolidin-5-ylmethyl]phenoxymethyl}-2,5,7,8-tetramethylchroman-6-yl ester
1375483-24-1

carbonic acid tert-butyl ester 2-{4-[2,4-dioxothiazolidin-5-ylmethyl]phenoxymethyl}-2,5,7,8-tetramethylchroman-6-yl ester

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
With hydrogenchloride; water In acetonitrile for 0.75h; Reflux;
C20H27F3O7S

C20H27F3O7S

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
2: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
3: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
4: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
6-tert-butoxycarbonyloxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid ethyl ester
1375483-09-2

6-tert-butoxycarbonyloxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid ethyl ester

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
4: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
5: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
6: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
carbonic acid tert-butyl ester 2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-yl ester
1375483-11-6

carbonic acid tert-butyl ester 2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-yl ester

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
3: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
4: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
5: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
carbonic acid tert-butyl ester 2-(4-formylphenoxymethyl)-2,5,7,8-tetramethyl-chroman-6-yl ester
1375483-13-8

carbonic acid tert-butyl ester 2-(4-formylphenoxymethyl)-2,5,7,8-tetramethyl-chroman-6-yl ester

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
2: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
3: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
ethyl 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate
53174-07-5

ethyl 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate

Troglitazone
97322-87-7

Troglitazone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
5: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
6: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
7: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
View Scheme
acetic anhydride
108-24-7

acetic anhydride

Troglitazone
97322-87-7

Troglitazone

benzene
71-43-2

benzene

5-<4-<(6-Acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>benzyl>-2,4-thiazolidinedione benzene monoadduct

5-<4-<(6-Acetoxy-2,5,7,8-tetramethylchroman-2-yl)methoxy>benzyl>-2,4-thiazolidinedione benzene monoadduct

Conditions
ConditionsYield
With pyridine for 48h; Ambient temperature;80%
Troglitazone
97322-87-7

Troglitazone

3-PyCO-X

3-PyCO-X

5-[4-(2,5,7,8-tetramethyl-6-nicotinoyloxychroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione
97323-02-9

5-[4-(2,5,7,8-tetramethyl-6-nicotinoyloxychroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione

Conditions
ConditionsYield
75%
succinic acid anhydride
108-30-5

succinic acid anhydride

Troglitazone
97322-87-7

Troglitazone

succinic acid mono-{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxymethyl]-2,5,7,8-tetramethyl-chroman-6-yl} ester

succinic acid mono-{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxymethyl]-2,5,7,8-tetramethyl-chroman-6-yl} ester

Conditions
ConditionsYield
With dmap In dichloromethane for 48h; Reflux;63%
With pyridine at 85℃; for 6h;
With pyridine In cyclohexane
Troglitazone
97322-87-7

Troglitazone

PhCO-X

PhCO-X

5-[4-(6-benzoyloxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione
97323-01-8

5-[4-(6-benzoyloxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione

Conditions
ConditionsYield
62%
Troglitazone
97322-87-7

Troglitazone

PrCO-X

PrCO-X

5-[4-(6-butyryloxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione
97323-00-7

5-[4-(6-butyryloxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]thiazolidine-2,4-dione

Conditions
ConditionsYield
56%
Troglitazone
97322-87-7

Troglitazone

(2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester
7355-18-2

(2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester

methyl 2,3,4-tri-O-acetyl-1-O-<2-<4-<2,4-dioxothiazolidin-5-ylmethyl>phenoxymethyl>-2,5,7,8-tetramethylchroman-6-yl>-β-D-glucopyranuronate
127040-00-0

methyl 2,3,4-tri-O-acetyl-1-O-<2-<4-<2,4-dioxothiazolidin-5-ylmethyl>phenoxymethyl>-2,5,7,8-tetramethylchroman-6-yl>-β-D-glucopyranuronate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In nitrobenzene at 85℃; under 20 Torr; for 4h;23%
Troglitazone
97322-87-7

Troglitazone

Troglitazone glucuronide
127040-01-1

Troglitazone glucuronide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 23 percent / p-toluenesulfonic acid monohydrate / nitrobenzene / 4 h / 85 °C / 20 Torr
2: 100 percent / 2.4percent aq.NaOH / methanol / 1 h / Ambient temperature
View Scheme
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

Troglitazone
97322-87-7

Troglitazone

Di-t-butyl α,α'-{5-[4-(6-t-butoxycarbonylmethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl ]-2,4-dioxothiazolidine-3,5-diyl}diacetate
107187-69-9

Di-t-butyl α,α'-{5-[4-(6-t-butoxycarbonylmethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl ]-2,4-dioxothiazolidine-3,5-diyl}diacetate

Conditions
ConditionsYield
With potassium carbonate In acetone

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