140860-79-3Relevant articles and documents
Partially fluorinated heterocycles from 4,4-bis(trifluoromethyl)-hetero-1, 3-dienes via C-F bond activation - Synthesis of 2-fluoro-3-(trifluoromethyl) furans
Burger, Klaus,Helmreich, Brigitte,Hennig, Lothar,Spengler, Jan,Albericio, Fernando,Fuchs, Annett
, p. 227 - 236 (2007)
An efficient synthesis of 2-fluoro-3-(trifluoromethyl)furans was developed. Keystep of the reaction sequence is a [4 + 1] cycloaddition reaction of tin(II)chloride to 4,4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes. At elevated temperatures the tin heterocy
Synthesis of 3-Trifluoromethylfurans from β,β-Bis(trifluoromethyl) α,β-Unsaturated Ketones and Tin(II) Chloride
Burger, Klaus,Helmreich, Brigitte
, p. 348 - 349 (2007/10/02)
A new building block strategy for the syntheisi of 3-trifluoromethyl-substituted furans 9 and 10 is described from β,β-bis(trifluoromethyl) α,β-unsaturated ketones 2 via reductive fluoride elimination and 1,5-electrocyclization with elimination.