21469-80-7

Basic information

• Product Name: 2-Propenamide, 3-(4-fluorophenyl)-N,N-dimethyl-, (2E)-
• CAS NO: 21469-80-7
• Molecular Formula: C11H12FNO
• Molecular Weight: 193.221
• Mol File: 21469-80-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, 3-(4-fluorophenyl)-N,N-dimethyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, 3-(4-fluorophenyl)-N,N-dimethyl-, (2E)-(21469-80-7)
• EPA Substance Registry System: 2-Propenamide, 3-(4-fluorophenyl)-N,N-dimethyl-, (2E)-(21469-80-7)

Safety Data

• Hazardous Substances Data: 21469-80-7(Hazardous Substances Data)

Upstream product

• 459-32-5 4-fluorocinnamic acid 
• 124-40-3 dimethyl amine 
• 459-56-3 4-fluorobenzylic alcohol 
• 127-19-5 N,N-dimethyl acetamide 
• 2680-03-7 N,N-Dimethylacrylamide 
• 456-22-4 4-Fluorobenzoic acid 
• 137-26-8 Thiram 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 1438559-01-3 (4-fluorophenyl)(quinolin-8-yl)methanone 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Palladium-Catalyzed Decarbonylative Heck Coupling of Aromatic Carboxylic Acids with Terminal Alkenes

A palladium-catalyzed decarbonylative alkenylation of aromatic carboxylic acids was developed. Under the reaction conditions, various benzoic acids including those bearing functional groups coupled to terminal alkenes, producing the corresponding internal alkenes in good to high yields. Cinnamic acids and bioactive benzoic acids such as 3-methylflavone-8-carboxylic acid, probenecid, adapalin, and febuxostat were also applicable to this reaction, demonstrating the potential synthetic value of this new reaction in organic synthesis.

Preparation method of cinnamamide (by machine translation)

The synthesis system disclosed by the invention has the advantages of simple :(1) reaction conditions, wide, reaction conditions, reaction conditions, wide ;(2) substrate range, high yield (1) and wide application range, and the reaction liquid, can be used as an anti-cancer drug, anti-anti-tumor and spice precursor compound in an organic solvent to prepare a corresponding cinnamide compound, product cinnamide . The synthesis system disclosed by the invention has a broad spectrum . The synthesis system disclosed by the invention has a broad spectrum of biological activity, and is suitable for popularization and application, in the following steps, synthesizing cinnamic acid and thiuram disulfide as a raw material, in an organic, solvent, and purifying, parts by mass, separation and purification of the obtained reaction, solution in an organic solvent. (by machine translation)

Oxidative coupling of Michael acceptors with aryl nucleophiles produced through rhodium-catalyzed C-C bond activation

Utilizing rhodium catalysis, aryl nucleophiles generated via carbon-carbon single bond activation successfully undergo oxidative coupling with Michael acceptors. The reaction scope encompasses a broad range of nucleophiles generated from quinolinyl ketones as well as a series of electron deficient terminal alkenes, illustrating the broad potential of intersecting carbon-carbon bond activation with synthetically useful coupling methodologies. The demonstrated oxidative coupling produces a range of cinnamyl derivatives, several of which are challenging to prepare via conventional routes.