1438559-01-3

Basic information

• Product Name: (4-fluorophenyl)(quinolin-8-yl)methanone
• Synonyms: (4-fluorophenyl)(quinolin-8-yl)methanone
• CAS NO: 1438559-01-3
• Molecular Weight: 251.26
• Mol File: 1438559-01-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4-fluorophenyl)(quinolin-8-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluorophenyl)(quinolin-8-yl)methanone(1438559-01-3)
• EPA Substance Registry System: (4-fluorophenyl)(quinolin-8-yl)methanone(1438559-01-3)

Safety Data

• Hazardous Substances Data: 1438559-01-3(Hazardous Substances Data)

Upstream product

• 38707-70-9 8-formylquinoline 
• 1765-93-1 4-fluoroboronic acid 
• 16567-18-3 8-bromoquinoline 
• 459-57-4 4-fluorobenzaldehyde 
• 56234-20-9 1-(quinolin-8-yl)ethan-1-one 
• 1189365-73-8 quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone 
• 40245-26-9 quinoline-8-carboxylic acid methyl ester 
• 86-59-9 8-carboxyquinoline 
• 106-49-0 p-toluidine 
• 25428-06-2 2-amino-5-methyl-acetophenone 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 1438558-75-8 (3,5-dimethylphenyl)(quinolin-8-yl)methanone 
• 10540-44-0 4'-fluoro-3-methyl-1,1'-biphenyl 
• 1438558-67-8 (quinolin-8-yl)(m-tolyl)methanone 
• 1392005-80-9 4-fluoro-3',5'-dimethylbiphenyl 
• 450-39-5 4-(4-fluorophenyl)anisole 
• 1442660-26-5 (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone 
• 1189365-73-8 quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone 
• 1438558-82-7 (3-methoxyphenyl)(quinolin-8-yl)methanone 
• 56234-20-9 1-(quinolin-8-yl)ethan-1-one 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 
• 21469-80-7 trans-3-(4-fluorophenyl)-N,N-dimethylacrylamide 

Relevant articles and documents

Rhodium(III)-Catalyzed Direct Coupling of Quinoline-8-Carbaldehydes with (Het)Arylboronic Acids for the Synthesis of 8-Aryloylquinolines

Herein, we describe a method for the synthesis of aryl-(het)aryl ketones by Rh(III)-catalyzed direct coupling between quinoline-8-carbaldehydes and (het)arylboronic acids. The method has a broad substrate scope, a high functional group tolerance, and uses

Rhodium-Catalyzed Interconversion of Quinolinyl Ketones with Boronic Acids via C-C Bond Activation

A rhodium-catalyzed cross-coupling of aryl and aliphatic quinolinyl ketones with boronic acids has been developed. Proceeding via quinoline-directed carbon-carbon σ bond activation, the transformation demonstrates tolerance of a range of functional groups

Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation

Swapped: Commercially available quinolinone derivatives (1 or 2, see scheme) were reacted with arylboronic acids in the presence of a RhI complex to give aryl(quinolin-8-yl)methanone products 3 in medium to good yields. A mechanism that involves the in situ oxidation of RhI to RhIII by O2 in the presence of CuI was proposed. Copyright