215257-64-0

Basic information

• Product Name: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-
• CAS NO: 215257-64-0
• Molecular Formula: C16H11Cl2N3
• Molecular Weight: 316.189
• Mol File: 215257-64-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-(215257-64-0)
• EPA Substance Registry System: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-(215257-64-0)

Safety Data

• Hazardous Substances Data: 215257-64-0(Hazardous Substances Data)

Upstream product

• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 
• 113-00-8 guanidine nitrate 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 873-76-7 para-Chlorobenzyl alcohol 
• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 
• 50-01-1 guanidine hydrochloride 
• 506-93-4 guanidine nitrate 
• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 593-85-1 diguanidine carbonate 

Downstream Products

• 1392402-46-8 C₂₃H₁₆Cl₂N₄ 
• 1392402-47-9 C₂₉H₂₀Cl₂N₆O 
• 1392402-48-0 C₂₈H₁₉Cl₂N₇O 

Relevant articles and documents

A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity

A library of benzazolyl pyrimidinyl carbamothioates were prepared by the reaction of benzazolyl carbonothioates with pyrimidinyl-2-amine in the presence of an ionic liquid- 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) under ultrasonication at a frequency of 35?kHz and tested for antimicrobial activity. Chloro- and nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates displayed prominent antibacterial activity against Bacillus subtilis, while nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates showed excellent antifungal activity against Aspergilus niger. Graphic abstract: [Figure not available: see fulltext.].

Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines using nanoTiO2

Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines was carried out by using nano TiO2. The method follows a green route by avoiding the use of toxic organic solvents and tedious experimental conditions. Compared with conventional methods the present strategy offers excellent yield under UV irradiation for a period of 20 min in ethanolic medium. Only a small quantity of nanocatalyst (1 mol%) is sufficient to achieve the completion of the reaction. The nanocatalyst can be reused up to four reaction cycles without much loss in the activity.

Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity

(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et3N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (13c, 13e, 14e: minimum inhibitory concentration?=?6.25?μg/well against Bacillus subtilis; 13e, 14e: minimum inhibitory concentration?=?6.25?μg/well against Aspergillus niger).