21640-35-7

Basic information

• Product Name: 2-BENZYL-ISOQUINOLINE-1,3,4-TRIONE
• Synonyms: 2-BENZYL-ISOQUINOLINE-1,3,4-TRIONE
• CAS NO: 21640-35-7
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.26344
• Mol File: 21640-35-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BENZYL-ISOQUINOLINE-1,3,4-TRIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-ISOQUINOLINE-1,3,4-TRIONE(21640-35-7)
• EPA Substance Registry System: 2-BENZYL-ISOQUINOLINE-1,3,4-TRIONE(21640-35-7)

Safety Data

• Hazardous Substances Data: 21640-35-7(Hazardous Substances Data)

Upstream product

• 6772-61-8 2-(4-benzylphenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 21640-31-3 2-(phenylmethyl)isoquinoline-1,3(2H,4H)-dione 
• 521-73-3 isoquinoline-1,3,4-trione 
• 100-44-7 benzyl chloride 
• 703-59-3 homophthalic anhydride 
• 100-46-9 benzylamine 
• 59168-21-7 2-benzyl-1-(2H)-isoquinoline ketone 
• 23277-04-5 2-benzylisoquinolin-2-ium bromide 
• 100-39-0 benzyl bromide 
• 7460-55-1 2-(2-bromoacetyl)benzoic acid methyl ester 
• 15787-39-0 2-benzylisoquinolin-2-ium iodide 
• 119-65-3 isoquinoline 
• 620-05-3 iodomethylbenzene 

Relevant articles and documents

Iodination/Amidation of the N-Alkyl (Iso)quinolinium Salts

The NaIO4-mediated sequential iodination/amidation reaction of N-alkyl quinolinium iodide salts has been first developed. This cascade process provides an efficient way to rapidly synthesize 3-iodo-N-alkyl quinolinones with high regioselectivity and good functional group tolerance. This protocol was also amenable to the isoquinolinium salts, thus providing a complementary method for preparing the 4-iodo-N-alkyl isoquinolinones.

Metal-Free Air Oxidation in a Convenient Cascade Approach for the Access to Isoquinoline-1,3,4(2H)-triones

Herein we describe a very useful application of the readily available trifunctional aromatic ketone methyl-2-(2-bromoacetyl)benzoate in reactions with primary amines. An unexpected in situ air oxidation that follows a cascade process allowed the access to

Isoquinoline-1,3,4-trione derivative and preparation method thereof

The invention discloses an isoquinoline-1,3,4-trione derivative and a preparation method thereof. The method is characterized in that the isoquinoline-1,3,4-trione derivative is prepared through a reaction of a 3-amino-4-cyano-2-substituted isoquinoline-1-one derivative used as a substrate and an aqueous solution of tert-butyl hydroperoxide at 60-80 DEG C in an organic solvent with copper salt as a catalyst. The method can be used for obtaining multiple isoquinoline-1,3,4-trione derivatives at a high yield, and has the advantages of mild reaction conditions, simplicity in operation and post-treatment, and suitableness for large-scale production.