217792-89-7 Usage
Description
2-HYDROXY-3,17?-O-BIS(METHOXYMETHYL)ESTRADIOL, also known as 2-Hydroxy-3,17β-O-bis(methoxymethyl)estradiol, is a synthetic compound with the CAS number 217792-89-7. It is characterized by its pale yellowish oil appearance and is primarily used in organic synthesis due to its unique chemical structure and properties.
Uses
Used in Organic Synthesis:
2-HYDROXY-3,17?-O-BIS(METHOXYMETHYL)ESTRADIOL is used as an intermediate compound for the synthesis of various organic compounds. Its unique structure allows it to be a versatile building block in the creation of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-HYDROXY-3,17?-O-BIS(METHOXYMETHYL)ESTRADIOL is used as a key component in the development of new drugs, particularly those targeting hormonal imbalances or related conditions. Its chemical properties make it a valuable asset in the design and synthesis of novel therapeutic agents.
Used in Research and Development:
2-HYDROXY-3,17?-O-BIS(METHOXYMETHYL)ESTRADIOL is also utilized in research and development settings, where it serves as a valuable tool for understanding the structure-activity relationships of various biologically active molecules. Its unique chemical properties enable scientists to explore new avenues in drug discovery and development.
Used in Chemical Analysis:
In the field of chemical analysis, 2-HYDROXY-3,17?-O-BIS(METHOXYMETHYL)ESTRADIOL can be employed as a reference compound or standard for the calibration of analytical instruments and methods. Its distinct chemical characteristics make it suitable for validating the performance of various analytical techniques, ensuring accurate and reliable results in chemical measurements.
Check Digit Verification of cas no
The CAS Registry Mumber 217792-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,7,7,9 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 217792-89:
(8*2)+(7*1)+(6*7)+(5*7)+(4*9)+(3*2)+(2*8)+(1*9)=167
167 % 10 = 7
So 217792-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C22H32O5/c1-22-9-8-15-16(18(22)6-7-21(22)27-13-25-3)5-4-14-10-20(26-12-24-2)19(23)11-17(14)15/h10-11,15-16,18,21,23H,4-9,12-13H2,1-3H3/t15-,16+,18-,21-,22-/m0/s1
217792-89-7Relevant articles and documents
An optimized synthesis of 2-methoxyestradiol, a naturally occurring human metabolite with anticancer activity
Wang, Zhiqiang,Cushman, Mark
, p. 4431 - 4437 (1998)
2-Methoxyestradiol, a naturally occurring human metabolite with demonstrated anticancer activity, has been synthesized in three steps and 76% yield from the bis(MOM) ether of 2-formylestradiol.
Synthesis and in vitro evaluation of 2-[11C]methoxyestradiol-3, 17β-O,O-bissulfamate for in vivo studies of angiogenesis
Kang, Choong Mo,Choe, Yearn Seong,Jung, Kyung-Ho,Choi, Joon Young,Lee, Kyung-Han,Kim, Byung-Tae
experimental part, p. 783 - 787 (2012/05/20)
In the present study, 2-methoxyestradiol-3,17β-O,O-bissulfamate (1), a known angiogenesis inhibitor, was prepared in a radiolabeled form by 11C-methylation of 2-hydroxyestradiol-3,17β-O,O-bis(N-trityl) sulfamate (6) followed by detritylation. S
Synthesis of 2-[11C]methoxy-3,17β-estradiol to measure the pharmacokinetics of an antitumor drug candidate, 2-methoxy-3,17β-estradiol
Mun, Jiyoung,Voll, Ronald J.,Goodman, Mark M.
, p. 1117 - 1124 (2007/10/03)
2-Methoxy-3,17β-estradiol, an endogenous estrogen metabolite, showed cytotoxicity in various cancer cell lines and also has antiangiogenic and proapoptotic activities. Clinical I and II trials of 2-methoxy-3,17β- estradiol for multiple myeloma, advanced solid tumors, metastatic breast and prostate cancer are underway. We prepared 2-[11C]methoxy-3,17β- estradiol to measure the pharmacokinetics and organ distribution of 2-methoxy-3,17β-estradiol in clinical trials. 2-[11C]Methoxy-3, 17β-estradiol was synthesized from a precursor, 2-hydroxy-3,17β-O- bis(methoxymethyl)estradiol, in two steps with over 99% radiochemical purity. The overall reaction time was 45 min and the decay-corrected radiochemical yield was 32.9%. The distribution coefficient (logP7.4) of 2-[ 11C]methoxy-3,17β-estradiol at pH 7.4 was measured as 2.95. Copyright
