24221-86-1

Basic information

• Product Name: D-Ephedrine hydrochloride
• Synonyms: alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,s*))-benzenemethano;alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,s)]-benzenemethano;D-(+)-EPHEDRINE HYDROCHLORIDE;d-alpha-(1-methylaminoethyl)benzyl alcohol;D-ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE;(1S,2R)-(+)-EPHEDRINE HYDROCHLORIDE;(1S,2R)-(+)-ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE;(1S,2R)-2-METHYLAMINO-1-PHENYL-1-PROPANOL HYDROCHLORIDE
• CAS NO: 24221-86-1
• Molecular Formula: C₁₀H₁₅NO*ClH
• Molecular Weight: 201.69
• EINECS: 246-090-7
• Product Categories: Pharmaceutical Raw Materials;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 24221-86-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 218-220 °C(lit.)
• Boiling Point: 255 °C at 760 mmHg
• Flash Point: 9℃
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.00865mmHg at 25°C
• Storage Temp.: Refrigerator
• BRN: 6118541
• CAS DataBase Reference: D-Ephedrine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: D-Ephedrine hydrochloride(24221-86-1)
• EPA Substance Registry System: D-Ephedrine hydrochloride(24221-86-1)

Safety Data

• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 22-25-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: KB1925000
• Hazardous Substances Data: 24221-86-1(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Safety Profile

A poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also EPHEDRINE

Purification Methods

Recrystallise the hydrochloride from EtOH/Et2O. The free base crystallises from *C6H6 with m 40-41o (Skita et al. Chem Ber 66 974 1933]. [Beilstein 13 H 254, 13 II 375, 13 III 1721, 13 IV 1879.]

InChI:InChI=1/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/p+1/t8-,10-/m1/s1

Upstream product

• 90-81-3 ephedrine 

Downstream Products

• 25394-33-6 ((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-methyl-amine 
• 1630-34-8 acetic acid-((1RS,2RS)-2-methylamino-1-phenyl-propylester); hydrochloride 
• 54750-13-9 (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one 
• 54750-12-8 (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 33817-09-3 (R)-2-methylamino-1-phenylpropane 
• 101859-99-8 chlorodeoxypseudoephedrine hydrochloride 
• 27270-80-0 erythro-(1S,2R)-1-chloro-1-phenyl-2-(methylamino)propane hydrochloride 
• 31060-10-3 (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide 
• 623157-95-9 N-((1R,2S)-2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-acrylamide 
• 88762-93-0 (1S,2R)-N-benzylephedrine 
• 112791-04-5 (4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 889100-60-1 (5R,6S)-2-but-3-enyl-2-hydroxy-4,5-dimethyl-6-phenylmorpholin-3-one 
• 889100-62-3 (2S,3R,6S)-3,4-dimethyl-2-phenyl-1-oxa-4-azaspiro[5.5]undec-8-en-5-one 

Relevant articles and documents

Gamma-polymorph of a substituted pyrazoline, its preparation and use as medicaments

The present invention relates to the γ-Polymorph of (R)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide, methods for its preparation, medicaments comprising this compound as well as their use for the preparation of a medicament for the treatment of humans and animals.