286933-08-2Relevant articles and documents
Evaluation of the tubulin-bound paclitaxel conformation: Synthesis, biology, and SAR studies of C-4 to C-3′ bridged paclitaxel analogues
Ganesh, Thota,Yang, Chao,Norris, Andrew,Glass, Tom,Bane, Susan,Ravindra, Rudravajhala,Banerjee, Abhijit,Metaferia, Belhu,Thomas, Shala L.,Giannakakou, Paraskevi,Alcaraz, Ana A.,Lakdawala, Ami S.,Snyder, James P.,Kingston, David G. I.
, p. 713 - 725 (2007/10/03)
The important anticancer drug paclitaxel binds to the β-subunit of the ββ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of in
Macrocycle formation by ring-closing metathesis. Application to the syntheses of novel macrocyclic taxoids
Ojima, Iwao,Lin, Songnian,Inoue, Tadashi,Miller, Michael L.,Borella, Christopher P.,Geng, Xudong,Walsh, John J.
, p. 5343 - 5353 (2007/10/03)
A series of novel macrocyclic taxoids 6 and 6′ bearing 16-, 17-, and 18-membered rings connecting the substituants at the C-2 and C-3′ positions were designed and synthesized. The syntheses of these macrocycles 6 and 6′ were accomplished using the highly
