19955-99-8

Basic information

• Product Name: 3-VINYLBENZALDEHYDE
• Synonyms: 3-VINYLBENZALDEHYDE;3-Formylstyrene;3-Vinylbenzaldehyd;2-vinylbenzaldehyde
• CAS NO: 19955-99-8
• Molecular Formula: C₉H₈O
• Molecular Weight: 132.16
• Product Categories: Aldehydes;C9;Carbonyl Compounds
• Mol File: 19955-99-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 230.2 °C at 760 mmHg
• Flash Point: 210 °F
• Appearance: /
• Density: 1.04 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0668mmHg at 25°C
• Refractive Index: n20/D 1.58(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-VINYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-VINYLBENZALDEHYDE(19955-99-8)
• EPA Substance Registry System: 3-VINYLBENZALDEHYDE(19955-99-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 19955-99-8(Hazardous Substances Data)

Usage

Description

3-VINYLBENZALDEHYDE, also known as 3-VBAL, is an organic compound that features a vinyl group bonded to the aromatic ring of benzaldehyde. It has been utilized in various chemical reactions and material synthesis processes due to its unique structure and reactivity.

Uses

Used in Chemical Synthesis:
3-VINYLBENZALDEHYDE is used as a key intermediate for the synthesis of various complex organic molecules. Its presence in the molecular structure allows for further functionalization and modification, making it a versatile building block in organic chemistry.
Used in Pharmaceutical Industry:
3-VINYLBENZALDEHYDE is used as a starting material for the preparation of pharmaceutical compounds, such as 2-(3-vinylphenyl)-1,3-dioxolane. This application takes advantage of its reactive vinyl group and aromatic ring, which can be further modified to create bioactive molecules with potential therapeutic properties.
Used in Material Science:
3-VINYLBENZALDEHYDE is used as a monomer for the synthesis of polymers, such as poly(3-vinylbenzaldehyde-co-dimethylacrylamide) (PVBA-co-PDMA) copolymers. These copolymers can exhibit unique properties, such as enhanced solubility, stability, or reactivity, which can be tailored for specific applications in material science.
Used in the Synthesis of Imines:
3-VINYLBENZALDEHYDE is used as a precursor for the preparation of various substituted imines. Imines are important intermediates in organic synthesis and can be used to construct a wide range of organic compounds, including pharmaceuticals, agrochemicals, and natural products.
Used in the Synthesis of Monomers with Specific Moieties:
3-VINYLBENZALDEHYDE is used as a building block for the synthesis of monomers bearing a 2,4,5-triphenylimidazole moiety. These monomers can be polymerized to form polymers with specific properties, such as enhanced thermal stability, electrical conductivity, or optical characteristics, which can be applied in various industries, including electronics, sensors, and energy storage.

InChI:InChI=1/C9H8O/c1-2-8-4-3-5-9(6-8)7-10/h2-7H,1H2

Upstream product

• 626-19-7 Isophthalaldehyde 
• 141-82-2 malonic acid 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 3132-99-8 m-bromobenzoic aldehyde 
• 74-85-1 ethene 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 77123-56-9 3-ethynylbenzaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 75927-49-0 pinacol vinylboronate 
• 108-57-6 1,3-divinylbenzene 

Downstream Products

• 28447-20-3 3-vinylbenzoic acid 
• 115104-31-9 2-(3-ethenylphenyl)-1,3-dioxolane 
• 1026688-27-6 cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide 
• 941672-16-8 3-hydroxy-1-(4-methoxy-phenyl)-4-(3-vinyl-phenyl)-azetidin-2-one 
• 930785-83-4 acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester 
• 860782-62-3 3'-dephenyl-3'-(m-vinylphenyl)-4-deacetyl-4-acryloyl-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel 
• 930785-88-9 (3R,4S)-3-Triisopropylsilanyloxy-4-(3-vinyl-phenyl)-azetidin-2-one 
• 286933-08-2 (3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(3-ethenylphenyl)azetidin-2-one 
• 360075-43-0 (3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-(m-vinylphenyl)azetidin-2-one 
• 360075-35-0 C₅₀H₅₃NO₁₄ 
• 860782-65-6 3'-dephenyl-3'-(m-vinylphenyl)-4-deacetyl-4-(pent-4-enoyl)-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel 
• 115104-32-0 2-<3-(2-hydroxyethyl)phenyl>-1,3-dioxolane 

Relevant articles and documents

Copper-Catalyzed Asymmetric Radical 1,2-Carboalkynylation of Alkenes with Alkyl Halides and Terminal Alkynes

A copper-catalyzed intermolecular three-component asymmetric radical 1,2-carboalkynylation of alkenes has been developed, providing straightforward access to diverse chiral alkynes from readily available alkyl halides and terminal alkynes. The utilization of a cinchona alkaloid-derived multidentate N,N,P-ligand is crucial for the efficient radical generation from mildly oxidative precursors by copper and the effective inhibition of the undesired Glaser coupling side reaction. The substrate scope is broad, covering (hetero)aryl-, alkynyl-, and aminocarbonyl-substituted alkenes, (hetero)aryl and alkyl as well as silyl alkynes, and tertiary to primary alkyl radical precursors with excellent functional group compatibility. Facile transformations of the obtained chiral alkynes have also been demonstrated, highlighting the excellent complementarity of this protocol to direct 1,2-dicarbofunctionalization reactions with C(sp2/sp3)-based reagents.

VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

Oxidative trifluoromethylation and fluoroolefination of unactivated olefins

Fluorine-containing organic compounds are gaining increasing importance in medicinal chemistry. Described herein is a mild and efficient method for the radical addition of olefins with TMSCF3 and TMSCF2R (R = COOEt or CF3) to deliver various α-trifluoromethylated ketones and α-fluoroolefinated ketones.