29066-36-2

Basic information

• Product Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate
• CAS NO: 29066-36-2
• Molecular Weight: 212.332
• Mol File: 29066-36-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate(29066-36-2)
• EPA Substance Registry System: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate(29066-36-2)

Safety Data

• Hazardous Substances Data: 29066-36-2(Hazardous Substances Data)

Upstream product

• 105-38-4 vinyl propionate 
• 15356-70-4 menthol 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 2216-51-5 (-)-menthol 
• 89-78-1 menthol 
• 123-62-6 propionic acid anhydride 
• 79-03-8 propionyl chloride 
• 802294-64-0 propionic acid 

Downstream Products

• 119244-66-5 l-menthyl (trimethylsilyl)propanoate 
• 112297-86-6 l-menthyl 2-methyl-2-(trimethylsilyl)-4-phenylbutyrate 
• 112297-82-2 l-menthyl 2-methyl-2-(trimethylsilyl)-4-phenylbutyrate 
• 112297-84-4 l-menthyl 2-methyl-2-(trimethylsilyl)-3-phenylpropionate 
• 112297-80-0 l-menthyl 2-methyl-2-(trimethylsilyl)-3-phenylpropionate 
• 112297-85-5 l-menthyl 2,5-dimethyl-2-(trimethylsilyl)-4-hexanoate 
• 112297-81-1 l-menthyl 2,5-dimethyl-2-(trimethylsilyl)-4-hexanoate 
• 112297-87-7 l-menthyl 2-methyl-2-(trimethylsilyl)heptanoate 
• 112297-83-3 l-menthyl 2-methyl-2-(trimethylsilyl)heptanoate 
• 68326-56-7 (R)-1-[(4-methylphenyl)sulfinyl]butan-2-one 
• 61597-98-6 (1R,2S,5R)-menthyl (S)-(-)-lactate 
• 17162-29-7 (-)-menthyl lactate 
• 107941-59-3 Phosphoric acid diethyl ester (E)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-propenyl ester 

Relevant articles and documents

Preparation method of

The preparation method comprises the following steps 1-11: Wherein. ROH (Formula X) is a chiral alcohol and the like, PG is a hydroxy protecting group, a compound of Formula VI and a compound of Formula V are the chiral auxiliary of the present invention. To the invention, the chiral auxiliary base ROH compound and the chiral alcohol X (Formula VI) are used for preparing the chiral auxiliary base-type compound of formula V IV and the compound of Formula XI, and the compound of formula IV can be prepared through three-step simple operation steps of chiral auxiliary base. Be applicable to industrial production.

Highly Productive and Enantioselective Enzyme Catalysis under Continuous Supported Liquid–Liquid Conditions Using a Hybrid Monolithic Bioreactor

Enzyme-containing ionic liquids (ILs) were immobilized in cellulose-2.5-acetate microbeads particles embedded in a porous monolithic polyurethane matrix. This bioreactor was used under continuous liquid-liquid conditions by dissolving the substrates in a nonpolar organic phase immiscible with the ILs, thereby creating a biphasic system. Lipases (candida antarctica lipase B, CALB, candida rugosa lipase, CRL) were used to catalyze the enantioselective transesterification of racemic (R,S)-1-phenylethanol with vinyl butyrate and vinyl acetate, the esterification of (+/-)-2-isopropyl-5-methylcyclohexanol with propionic anhydride and the amidation of (R,S)-1-phenylethylamine with ethyl methoxyacetate. With this unique setup, very high productivities, that is, turnover numbers (TONs) up to 5.1×106 and space-time yields (STYs) up to 28 g product L?1 h?1, exceeding the corresponding values for batch-type reactions by a factor of 3100 and 40, respectively, were achieved while maintaining or even enhancing enantioselectivity compared to batch reactions via kinetic resolution. To our best knowledge, this is the first continuously operated bioreactor using supported liquid-liquid conditions that shows these features in the synthesis of chiral esters and amides.

Synthesis, antimicrobial evaluation, and QSAR analysis of 2-isopropyl-5-methylcyclohexanol derivatives

A series of 2-isopropyl-5-methylcyclohexanol derivatives were synthesized and evaluated for their antibacterial activity against Gram-positive Staphylococcus aureus and Bacillus subtilis and Gram-negative Escherichia coli and in vitro antifungal activity against Candida albicans and Aspergillus niger. The results of antimicrobial activity demonstrated that the compounds 10, 20, and 21 were the most active ones among the synthesized compounds. The QSAR studies revealed the importance of dipole moment (μ), total energy (Te), and topological parameters (κ1 and κ3) in describing the antimicrobial activity of 2-isopropyl-5-methylcyclohexanol derivatives. Springer Science+Business Media, LLC 2011.