325154-21-0

Basic information

• Product Name: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate
• Synonyms: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate
• CAS NO: 325154-21-0
• Molecular Weight: 338.444
• Mol File: 325154-21-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate(325154-21-0)
• EPA Substance Registry System: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate(325154-21-0)

Safety Data

• Hazardous Substances Data: 325154-21-0(Hazardous Substances Data)

Upstream product

• 325154-22-1 2-isopropyl-3-{2-[3-methoxy(propyloxy)]-4-methoxyphenyl}propionic acid 
• 1351987-20-6 C₂₁H₃₂O₅ 
• 1351987-19-3 C₂₁H₃₄O₆ 
• 109-19-3 butyl isovalerate 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 1351987-18-2 butyl-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate 
• 64-17-5 ethanol 
• 325154-20-9 ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzylidene)-3-methylbutanoate 

Downstream Products

• 1073553-78-2 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanal 
• 172900-70-8 (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol 
• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 866030-35-5 tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 
• 900811-38-3 (R)--4-(2-(iodomethyl)--3--methylbutyl)--1--methoxy-2--(3--methoxypropoxy)benzene 
• 1027979-11-8 (αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal 
• 1236549-00-0 {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester 
• 1351987-22-8 C₁₈H₃₀O₆S 
• 1351987-29-5 (S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate 
• 1351987-30-8 (5S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methyl-3-oxoheptanoate 
• 1351987-31-9 (S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate 
• 1351987-33-1 (5S)-6-benzyl-1-tert-butyl-5-isopropyl-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-3-oxohexanedioate 
• 1351987-34-2 (S,E)-6-benzyl-1-tert-butyl-3-acetoxy-5-isopropyl-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)hex-2-enedioate 
• 1351987-35-3 (S,E)-3-acetoxy-5-((benzyloxy)carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoicacid 

Relevant articles and documents

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.