900811-38-3

Basic information

• Product Name: Benzene, 4-[2-(iodoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-, (R)-
• Synonyms: Benzene, 4-[2-(iodoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-, (R)-;(R)-4-(2-(Iodomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene
• CAS NO: 900811-38-3
• Molecular Formula: C₁₇H₂₇IO₃
• Molecular Weight: 406.29895
• Mol File: 900811-38-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzene, 4-[2-(iodoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-[2-(iodoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-, (R)-(900811-38-3)
• EPA Substance Registry System: Benzene, 4-[2-(iodoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-, (R)-(900811-38-3)

Safety Data

• Hazardous Substances Data: 900811-38-3(Hazardous Substances Data)

Usage

General Description

Benzene, 4-[2-(iodomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-, (R)- is a chemical compound with a complex and lengthy name. It appears to be a derivative of benzene, a common aromatic hydrocarbon, with additional functional groups including iodomethyl, methoxy, and propoxy. The (R)- designation indicates that it is a chiral compound with a specific stereochemical configuration. Benzene, 4-[2-(iodomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-, (R)- may have potential applications in organic synthesis, pharmaceuticals, or materials science, but further research and analysis would be necessary to fully understand its properties and potential uses.

Upstream product

• 172900-70-8 (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol 
• 172900-69-5 (R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene 
• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 109-19-3 butyl isovalerate 
• 1027979-11-8 (αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal 
• 1351987-19-3 C₂₁H₃₄O₆ 
• 1351987-20-6 C₂₁H₃₂O₅ 
• 1351987-21-7 methyl-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate 
• 325154-21-0 ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate 
• 1351987-22-8 C₁₈H₃₀O₆S 
• 1351987-18-2 butyl-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate 
• 325154-22-1 2-isopropyl-3-{2-[3-methoxy(propyloxy)]-4-methoxyphenyl}propionic acid 

Downstream Products

• 955020-76-5 (4S)-tert-butyl 4-(3-(3-methoxypropoxy)-4-methoxybenzyl)-2-(diphenylmethyleneamino)-5-methylhexanoate 
• 656241-17-7 (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine 
• 1165874-61-2 C₁₇H₂₇LiO₃ 
• 866030-35-5 tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 
• 1236549-00-0 {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester 
• 1351987-34-2 (S,E)-6-benzyl-1-tert-butyl-3-acetoxy-5-isopropyl-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)hex-2-enedioate 
• 1351987-35-3 (S,E)-3-acetoxy-5-((benzyloxy)carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoicacid 
• 1351987-36-4 (2S,3S,5S)-3-acetoxy-5-(benzyloxycarbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylheptanoic acid 
• 1351987-37-5 (2S,4S,5S,7S)-benzyl-4-acetoxy-5-(benzyloxycarbonylamino)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanoate 
• 1351987-33-1 (5S)-6-benzyl-1-tert-butyl-5-isopropyl-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-3-oxohexanedioate 
• 1351987-32-0 (2R,S)(5S)-6-benzyl 1-ethyl 5-isopropyl-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-3-oxohexanedioate 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 172900-83-3 (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.

Process for Producing Aliskiren

A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.

CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN

Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3_6/su