351-95-1

Basic information

• Product Name: (4-FLUORO-PHENYLAMINO)-ACETIC ACID
• Synonyms: (4-FLUORO-PHENYLAMINO)-ACETIC ACID;N-(4-fluorophenyl)glycine(SALTDATA: FREE);N-(p-Fluorophenyl)glycine;2-[(4-fluorophenyl)amino]ethanoic acid;2-(4-fluoroanilino)acetic acid
• CAS NO: 351-95-1
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.1530232
• Mol File: 351-95-1.mol
• Article Data: 21

Chemical Properties

• Melting Point: 138°C(lit.)
• Boiling Point: 355.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.361
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.58±0.20(Predicted)
• CAS DataBase Reference: (4-FLUORO-PHENYLAMINO)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-PHENYLAMINO)-ACETIC ACID(351-95-1)
• EPA Substance Registry System: (4-FLUORO-PHENYLAMINO)-ACETIC ACID(351-95-1)

Safety Data

• Hazardous Substances Data: 351-95-1(Hazardous Substances Data)

Usage

General Description

(4-Fluoro-phenylamino)-acetic acid is a synthetic organic compound that falls within the category of amino acids, peptides, and proteins. The chemical formula for this compound is C8H8FNO2. Being a fluorinated compound, it has potential applications in various fields such as pharmaceuticals and agrochemicals, due to its unique reactivity and properties. These characteristics of fluorinated compounds include thermal and oxidative stability, ability to form hydrogen bonds, and a high dipole moment resulting from the bond between fluorine and carbon atoms. As an amino acid, it could also serve as a building block for proteins. However, more specific information about this particular chemical, including its toxicity or safety, potential uses, and handling precautions, is not widely available.

Upstream product

• 79-11-8 chloroacetic acid 
• 371-40-4 4-fluoroaniline 
• 85098-68-6 p-fluorophenylglycine amide 
• 71-36-3 butan-1-ol 
• 459-57-4 4-fluorobenzaldehyde 
• 298-12-4 Glyoxilic acid 
• 2521-99-5 2-(4-fluorophenylamino)acetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 208255-74-7 N-[N-(3,5-difluorophenylacetyl)-L-alaninyl]-2-amino-2-(4-fluorophenyl)acetate ethyl ester 
• 5319-46-0 N-(4-fluoro-phenyl)-N-nitroso-glycine 
• 1092547-39-1 (3aR,6S,6aR)-cis-1-(4-fluoro)phenyl-5-tosyl-6-benzyloctahydropyrrolo[3,4-b]pyrrole 
• 170902-76-8 methyl (R)-amino-(4-fluorophenyl)-acetate 
• 196707-32-1 (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-(4-fluorophenyl)acetic acid 
• 5352-95-4 3-(4-fluorophenyl)-3H-1,2,3-oxadiazol-1-ium-5-olate 
• 1324008-79-8 C₈H₄FIN₂O₂ 
• 370-77-4 N-benzyl-p-fluoroaniline 

Relevant articles and documents

Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ

Cyclic azodicarbonyl derivatives, particularly 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), commonly serve as arenophile, dienophile, enophile and electrophile. Perplexed by its instability in aqueous environment, there are few studies focused on the transient intermediate produced by hydrolysis of PTAD to achieve synthetic significance. Herein, we describe a “photo-click” method that involves nitrile imine (NI) from diarylsydnone to capture the diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD. DFT calculation reveal that H-bonding interactions between PTAD and water are vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit (NBO) analysis. The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z?E photo-switchable linker on target molecules, including peptide and drugs, with excellent anti-fatigue performance. This strategy is showcased to construct highly functionalized carbamoyl formazans in situ for photo-pharmacology and material studies, which also expands the chemistry of PTAD in aqueous media.

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.

Synthesis and evaluation of photo-activatable β-diarylsydnone-L-alanines for fluorogenic photo-click cyclization of peptides

Herein, we design and synthesize a series of photoactivatable β-diarylsydnone-l-alanines (DASAs), which have excellent photo-reactivity with high fluorescence turn-on toward alkenes in a biocompatible environment. The environmental sensing properties of t