36188-55-3

Basic information

• Product Name: N-[2-(4-methoxybenzoyl)phenyl]acetamide
• CAS NO: 36188-55-3
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.2952
• Mol File: 36188-55-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 516.2°C at 760 mmHg
• Flash Point: 266°C
• Density: 1.198g/cm³
• Vapor Pressure: 9.19E-11mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: N-[2-(4-methoxybenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-methoxybenzoyl)phenyl]acetamide(36188-55-3)
• EPA Substance Registry System: N-[2-(4-methoxybenzoyl)phenyl]acetamide(36188-55-3)

Safety Data

• Hazardous Substances Data: 36188-55-3(Hazardous Substances Data)

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 552-16-9 ortho-nitrobenzoic acid 
• 73376-03-1 (4-methoxyphenyl)(2-nitrophenyl)methanone 
• 610-14-0 2-nitrobenzyl chloride 
• 7099-91-4 p-methoxybenzoylformic acid 
• 103-84-4 Acetanilid 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-93-8 p-methylanizole 
• 62-53-3 aniline 
• 105-13-5 4-Methoxybenzyl alcohol 
• 36192-61-7 2-amino-4'-methoxybenzophenone 
• 75-36-5 acetyl chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 37118-72-2 4-(p-methoxyphenyl)-2-(1H)-quinolinone 
• 37118-73-3 2-chloro-4-(4-methoxyphenyl)quinoline 
• 120301-15-7 4-(4-Methoxy-phenyl)-2-piperazin-1-yl-quinoline 
• 106015-61-6 2-(4-Ethyl-piperazin-1-yl)-4-(4-methoxy-phenyl)-quinoline 
• 106015-78-5 2-{4-[4-(4-Methoxy-phenyl)-quinolin-2-yl]-piperazin-1-yl}-ethanol 
• 1642628-12-3 (E)-N-(4-(4-methoxyphenyl)quinolin-2(1H)-ylidene)-4-methylbenzenesulfonamide 
• 1642593-30-3 N-(2-(1-hydroxy-1-(4-methoxyphenyl)prop-2-ynyl)phenyl)acetamide 
• 36192-61-7 2-amino-4'-methoxybenzophenone 
• 1581699-73-1 2-bromo-N-(2-(4-methoxybenzoyl)phenyl)acetamide 
• 28586-50-7 N-(2-(hydroxy(4-methoxyphenyl)methyl)phenyl)acetamide 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols

A systematic range of o-hydroxyphenyl ketones were reduced under asymmetric transfer hydrogenation conditions using the C3-tethered catalyst 2. Two directing effects, i.e., an o-hydroxyphenyl coupled to a bulky aromatic on the opposite side of the ketone substrate, combine in a matched manner to deliver reduction products with very high enantiomeric excess.

Dual role of acetanilides: Traceless removal of a directing group through deacetylation/diazotation and palladium-catalyzed C-C-coupling reactions

The acetamide group enables regioselective oxidative ortho-C-H activation reactions, such as Pd-catalyzed acylation. The synthetic utility of these transformations can be significantly enhanced by using the acetamide as a quasi-leaving group in a subsequent conventional Pd-catalyzed coupling or cross-coupling reaction. The concept is illustrated herein for the synthesis of o-alkenyl- and o-arylphenones, which have potential for the synthesis of arylated aromatic heterocycles.

Merging Photoredox with Palladium Catalysis: Decarboxylative ortho-Acylation of Acetanilides with α-Oxocarboxylic Acids under Mild Reaction Conditions

A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y with Pd dual catalytic system. This dual catalytic reaction shows a broad substrate scope and good functional group tolera