362-54-9

Basic information

• Product Name: Benzenemethanol, 2-fluoro-a-phenyl-
• CAS NO: 362-54-9
• Molecular Formula: C13H11FO
• Molecular Weight: 202.228
• Mol File: 362-54-9.mol
• Article Data: 56

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2-fluoro-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-fluoro-a-phenyl-(362-54-9)
• EPA Substance Registry System: Benzenemethanol, 2-fluoro-a-phenyl-(362-54-9)

Safety Data

• Hazardous Substances Data: 362-54-9(Hazardous Substances Data)

Usage

Main properties

1. Chemical formula: C8H7FO
2. Fluorinated derivative of mandelic acid
3. Intermediate in the synthesis of pharmaceuticals
4. Colorless liquid
5. Mild, floral odor
6. Soluble in water and polar organic solvents
7. Irritating to eyes, skin, and respiratory tract

Specific content

Also known as 2-fluoromandelic acid
Used as an intermediate in the synthesis of antihypertensive and anti-inflammatory drugs

Upstream product

• 424-79-3 1,2-bis-(2-fluoro-phenyl)-1,2-diphenyl-ethane-1,2-diol 
• 103-73-1 Phenetole 
• 342-24-5 o-fluorobenzophenone 
• 446-52-6 2-Fluorobenzaldehyde 
• 3262-89-3 triphenylboroxine 
• 98-80-6 phenylboronic acid 
• 1078-58-6 diphenylzinc 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 100-52-7 benzaldehyde 
• 1124-19-2 phenyltin trichloride 
• 1842-26-8 (2-fluorophenyl)trimethylsilane 
• 3794-15-8 1-benzyl-2-fluorobenzene 
• 1072-85-1 o-fluorobromobenzene 
• 108-86-1 bromobenzene 

Downstream Products

• 362-53-8 (2-fluorophenyl)phenylbromomethane 
• 22278-45-1 2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole 
• 362-54-9 (R)-(+)-(2-fluorophenyl)(phenyl)methanol 
• 362-54-9 (S)-(2-fluorophenyl)(phenyl)methanol 
• 56431-03-9 2-fluoro-α-vinyl-benzhydrol 
• 7007-67-2 3-phenyl-1,2-benzisoxazole 
• 70132-76-2 3-phenyl-1,2-benzoisothiazole 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols

Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates and end products for many industries. Driven by visible light only, this method is based on sequential photochemical dehydrogenation followed by enantioselective thermal hydrogenation. The combination of a heterogeneous dehydrogenation photocatalyst and a chiral molecular hydrogenation catalyst is essential to ensure two distinct pathways for the forward and reverse reactions. These reactions convert a large number of racemic aryl alkyl alcohols into their enantiomerically enriched forms in good yields and enantioselectivities.

Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.