390-75-0Relevant articles and documents
Synthesis of α-fluoro-β-lactones and their thermal conversion to 1-fluoroalkenes
Ocampo, Rogelio,Dolbier Jr., William R.,Zuluaga, Fabio
, p. 1325 - 1334 (2002)
α-Fluoro-β-lactones have been synthesized and isolated for the first time from α-fluoro-β-hydroxy acids by using the couple TsCl/DMAP as lactonization agent. A detailed description of the synthesis and spectroscopic properties of α-fluoro-β-lactones is pr
Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Effect of TESCF3as an Additive
Ye, Yuxuan,Takada, Takashi,Buchwald, Stephen L.
, p. 15559 - 15563 (2016/12/09)
A method for the palladium-catalyzed fluorination of cyclic vinyl triflates has been developed. As with several previous palladium-catalyzed fluorination reactions using fluoride salts, controlling the regioselectivity presented a challenge in developing a practical synthetic procedure. The addition of triethyl(trifluoromethyl)silane (TESCF3) was found to effectively address this problem and resulted in drastically improved regioselectivities in this palladium-catalyzed fluorination reaction. This discovery, along with the use of a new biarylphosphine ligand, allowed for the development of an efficient and highly regioselective protocol for the fluorination of vinyl triflates. This method is compatible with a range of sensitive functional groups and provides access to five-, six-, and seven-membered cyclic vinyl fluorides.
Direct fluorination of styrenes
Shao, Qian,Huang, Yong
supporting information, p. 6584 - 6586 (2015/04/14)
We have developed a practical method to synthesize fluorostyrene compounds. A mild and regioselective mono-fluorination reaction occurred smoothly for various di- and trisubstituted styrenes in the presence of RuCl3 and N-fluorobenzenesulfonimide (NFSI). A tandem alkyne hydroarylation-olefin fluorination reaction was also developed using an Au catalyst.