531-88-4

Basic information

• Product Name: Nsc25379
• Synonyms: 1(3H)-Isobenzofuranone, 5,6-dimethoxy-;Macconine;Nsc25379;5,6-diMethoxy-1,3-dihydro-2-benzofuran-1-one
• CAS NO: 531-88-4
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 531-88-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 155-157 °C
• Boiling Point: 403 °C at 760 mmHg
• Flash Point: 184.6 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 1.05E-06mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: Nsc25379(CAS DataBase Reference)
• NIST Chemistry Reference: Nsc25379(531-88-4)
• EPA Substance Registry System: Nsc25379(531-88-4)

Safety Data

• Hazardous Substances Data: 531-88-4(Hazardous Substances Data)

Usage

Description

Nsc25379 is a compound with potential applications in various fields, including pharmaceuticals and substance misuse management. It possesses unique properties that make it a promising candidate for specific uses.

Uses

Used in Pharmaceutical Applications:
Nsc25379 is used as a pharmaceutical agent for its potential therapeutic effects. Nsc25379's specific properties and mechanisms of action are yet to be fully explored, but it holds promise in the development of new treatments for various conditions.
Used in Substance Misuse Management:
Nsc25379 is used as an adjunct in the detection of illicit opiate use in the management of substance misuse. Its application in this field aids in the identification and monitoring of opiate abuse, contributing to more effective treatment and rehabilitation strategies for individuals struggling with addiction.
Please note that the provided materials do not give a detailed description of Nsc25379, its production methods, or its specific properties. The information above is based on the general structure of the example provided for Gallotannin. Further research and data would be required to provide a more comprehensive description and list of uses for Nsc25379.

InChI:InChI=1/C10H10O4/c1-12-8-3-6-5-14-10(11)7(6)4-9(8)13-2/h3-4H,5H2,1-2H3

Upstream product

• 76055-91-9 4-(3,4-dimethoxybenzyl)-6,7-dimethoxyisochroman-3-one 
• 7664-93-9 sulfuric acid 
• 53295-41-3 3,9,10-trimethoxy-7,11b-dihydro-indeno[2,1-c]chromen-6a-ol 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 67-68-5 dimethyl sulfoxide 
• 50-00-0 formaldehyd 
• 22792-13-8 4-(3’,4’-dimethoxybenzoyl)morpholine 

Downstream Products

• 577-68-4 m-hemipinic acid 
• 490-63-1 2-formyl-4,5-dimethoxybenzoic acid 
• 22943-99-3 (4,5-dimethoxy-1,2-phenylene)dimethanol 
• 90945-80-5 5,6-dimethoxy-7-nitro-phthalide 
• 22506-55-4 2,3-dimethoxy-anthraquinone 
• 127141-20-2 (Z)?1?benzylidene?5,6?dimethoxy?1,3?dihydroisobenzofuran 
• 91613-77-3 trans-6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-4-hydroxy-2-methyl-3,4-dihydro-1(2H)-isoquinolone 
• 91613-77-3 cis-6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-4-hydroxy-2-methyl-3,4-dihydro-1(2H)-isoquinolone 
• 89968-07-0 2-(2-carboxylato-4,5-dimethoxyphenyl)ethynyltrimethylammonium 
• 116515-65-2 dimethyl 4-hydroxy-6,7-dimethoxy-1-phenylnaphthalene-2,3-dicarboxylate 
• 104756-76-5 dimethyl 4-hydroxy-6,7-dimethoxy-1-(3',4'-dimethoxyphenyl)naphthalene-2,3-dicarboxylate 
• 40125-46-0 3-BROMO-5,6-DIMETHOXY-PHTHALIDE 
• 89736-81-2 6,7-Dimethoxy-2,3-diphenyl-1(2H)-isoquinolinone 
• 206130-71-4 3-(α-hydroxy-4-methoxybenzyl)-5,6-dimethoxyphthalide 

Relevant articles and documents

Synthesis of 3-Unsubstituted Phthalides from Aryl Amides and Paraformaldehyde via Ruthenium(II)-Catalyzed C–H Activation

A straightforward and convenient route has been developed for the synthesis of 3-unsubstituted phthalide derivatives from aryl amides and paraformaldehyde by ruthenium(II)-catalyzed C–H activation. The reaction proceeds through tandem ortho-hydroxymethylation of aryl amide and subsequent intramolecular lactonization.

Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO)6 as carbon monoxide sources

A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and Mo(CO)6 were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. Mo(CO)6 was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1h reaction time.

Electrochemical Oxidation of Aromatic Ethers. Part 9. Proof of the Mode of Aryl-Aryl Coupling in 4-Benzylisochroman-3-ones, and the Oxidative Reactions of 2-and 3-Aralkyl-1,2,3,4-tetrahydroisoquinolines

The influence of the solvent upon the coupling reactions of 4-(3,4-dimethoxybenzyl)-6,7-dimethoxyisochroman-3-one has been studied and it is shown that formation of the product, 7a,8-dihydro-3,10,11-trimethoxy-2H-phenanthrofuran-2,7(5H)-dione, proceeds through a six-membered ring transition state.Anodic oxidation of 2-aralkyl-1,2,3,4-tetrahydroisoquinolines leads to cleavage of the aralkyl substituent, whereas 1,2,3,4-tetrahydro-6,7-dimethoxy-3-(3,4-dimethoxybenzyl)-2-methylisoquinoline cyclises to yield 1,2,3,4-tetrahydro-7,10,11-trimethoxy-3-methyl-2,8a-methanodibenzoazocin-6-one and its 1-hydroxy derivative.