62509-81-3

Basic information

• Product Name: 1-Propanone, 3-methoxy-2-methyl-1-phenyl-
• CAS NO: 62509-81-3
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol File: 62509-81-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-methoxy-2-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-methoxy-2-methyl-1-phenyl-(62509-81-3)
• EPA Substance Registry System: 1-Propanone, 3-methoxy-2-methyl-1-phenyl-(62509-81-3)

Safety Data

• Hazardous Substances Data: 62509-81-3(Hazardous Substances Data)

Upstream product

• 39623-95-5 1-phenylprop-1-enyl acetate 
• 107-30-2 chloromethyl methyl ether 
• 67-56-1 methanol 
• 28640-35-9 4-methyl-3-phenyl-2-isoxazoline 
• 5050-65-7 3-phenyl-5-methyl-Δ²-isoxazoline 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 
• 13057-17-5 bromethyl methyl ether 
• 57051-07-7 erythro-3-methoxy-2-methyl-1-phenyl-1-propanol 
• 50-00-0 formaldehyd 
• 93-55-0 1-phenyl-propan-1-one 
• 66323-99-7 trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 
• 124-41-4 sodium methylate 
• 96569-81-2 1-(methoxymethyloxy)-1-phenylpropene 

Downstream Products

• 57051-07-7 threo-30methoxy-2-methyl-1-phenyl-1-propanol 
• 57051-07-7 erythro-3-methoxy-2-methyl-1-phenyl-1-propanol 
• 611-70-1 phenyl isopropyl ketone 
• 57051-07-7 2-Methoxymethyl-1-phenyl-proponat-⁽¹⁾ 
• 138902-32-6 3-Hydroxy-5-methoxy-4-methyl-3-phenylpentannitril 
• 910618-42-7 3-Hydroxy-5-methoxy-2,2,4-trimethyl-3-phenylpentannitril 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 

Relevant articles and documents

Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol

One-pot synthesis of α-methyl ketones starting from 1,3-diaryl propenols or 1-aryl propenols and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by commercially available Pd(OAc)2 with H2O as the only by-product. Mechanistic studies and deuterium labelling experiments indicate the involvement of isomerization of allyl alcohol followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

Cobalt-Catalyzed α-Methoxymethylation and Aminomethylation of Ketones with Methanol as a C1 Source

Using methanol as a sustainable C1 source, cobalt-catalyzed α-methoxymethylation and α-aminomethylation of ketones have been developed. With cheap CoCl2·6H2O as catalyst and TBHP as oxidant, the methoxymethylated products were obtained within a short reaction time in up to 91% yield. Based on the observed reversibility of methoxy adduct to enone, the α-aminomethylation of ketones was then achieved by a one-pot methylenation/aza-Michael addition sequence. In addition, an easy way to convert α-methoxymethyl ketones to α-aminomethyl ketones has been discovered.

Catalyzed Reactions of Enol Ethers with SN1 Active Groups: A Novel Method for the Preparation of α-Alkylated Ketones

The performance of tert-alkylations, alkoxyalkylations, and aldehyde enolate allylations proceeding with low catalyst loading (0.1 mol % - 5 mol %) is described. The reactions are complete within short times and can even be performed without solvent and under ambient conditions. The mechanism of the reaction was investigated by deuterium labeling and cross-over studies.