6590-94-9Relevant articles and documents
COMPOUNDS WITH COPPER- OR ZINC-ACTIVATED TOXICITY AGAINST MICROBIAL INFECTION
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Paragraph 0087; 0088, (2022/02/05)
Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.
A catalyst-free method for the synthesis of 1,4,2-dithiazoles from isothiocyanates and hydroxylamine triflic acid salts
An, Zhenyu,Liu, Yafeng,Ren, Yi,Wang, Ting,Yan, Rulong
supporting information, p. 6206 - 6209 (2021/07/28)
A catalyst-free method for the preparation of 1,4,2-dithiazoles is developed by reactions of isothiocyanates with hydroxylamine triflic acid salts. This reaction achieves C-S, C-N, and S-N bond formation, and a range of products are obtained in moderate to good yields. The obvious feature is using shelf-stable hydroxylamine triflic acid salts as a N source to synthesize heterocycles under mild conditions.
Pyrazolone amide antifungal drug, and preparation method and application thereof
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Paragraph 0099; 0100; 0102; 0103, (2018/09/12)
The invention discloses a pyrazolone amide antifungal drug or its pharmaceutically acceptable salt. The structure of the compound is represented by general formula I shown in the description. In the general formula I, X is O or S; R1 is hydrogen, or a monosubstituent or a polysubstituent positioned at any position of a phenyl ring; R2 is hydrogen, a substituted or unsubstituted aromatic ring or cycloaliphatic ring, or a lower acyl group; and one of R3 and R4 is an amino group, and the remaining one is carbonyl oxygen. The invention discloses a preparation method of the compound, and an application of the compound in the preparation of an antifungal drug. Results of in-vitro antifungal activity experiments show that most of the compounds represented by general formula show have good antifungal activity characteristics, and have better antifungal activity on fungi comprising Candida albicans, fluconazole-resistant Candida albicans, Cryptococcus neoformans and Candida glabrata than a positive drug fluconazole.