742085-16-1

Basic information

• Product Name: 4-CHLORO-4'-PYRROLIDINOMETHYL BENZOPHENONE
• Synonyms: 4-CHLORO-4'-PYRROLIDINOMETHYL BENZOPHENONE
• CAS NO: 742085-16-1
• Molecular Formula: C₁₈H₁₈ClNO
• Molecular Weight: 299.79
• Mol File: 742085-16-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 427.2°C at 760 mmHg
• Flash Point: 212.1°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 1.67E-07mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 4-CHLORO-4'-PYRROLIDINOMETHYL BENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-4'-PYRROLIDINOMETHYL BENZOPHENONE(742085-16-1)
• EPA Substance Registry System: 4-CHLORO-4'-PYRROLIDINOMETHYL BENZOPHENONE(742085-16-1)

Safety Data

• Hazardous Substances Data: 742085-16-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H18ClNO/c19-17-9-7-16(8-10-17)18(21)15-5-3-14(4-6-15)13-20-11-1-2-12-20/h3-10H,1-2,11-13H2

Upstream product

• 123-75-1 pyrrolidine 
• 91457-11-3 4-bromomethyl-4'-chlorobenzophenone 
• 106-38-7 para-bromotoluene 
• 5395-79-9 4'-methyl-4-chlorobenzophenone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 927690-05-9 (+/-)-(4-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]phenylmethanol 
• 927690-16-2 (+/-)-2-(4-chlorophenyl)-2-phenyl-2-{4-[(pyrrolidin-1-yl)methyl]phenyl}acetaldehyde 
• 927690-12-8 (+/-)-2-(4-chlorophenyl)-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-2-phenylethanol 
• 927690-02-6 (+/-)-2-(4-chlorophenyl)-2-phenyl-2-{4-[pyrrolidin-1-ylmethyl]phenyl}acetonitrile 
• 927689-99-4 1-((4-chlorophenyl)(phenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methyl)-1H-imidazole 
• 742085-17-2 (Z)-3-(4-chlorophenyl)-3-[4-(1-pyrrolidinylmethyl)phenyl]-2-propenoic acid hydrochloride 
• 949934-17-2 (4-chlorophenyl)bis[4-(pyrrolidin-1-ylmethyl)phenyl]methanol 
• 949934-18-3 (4-chlorophenyl)(4-fluorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanol 
• 949934-26-3 bis(4-chlorophenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methanol 
• 949934-27-4 (±)-(4-chlorophenyl)(3-methoxyphenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methanol 
• 949934-19-4 (±)-(benzo[d][1,3]dioxol-5-yl)(4-chlorophenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methanol 

Relevant articles and documents

NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS

The present invention relates to clotrimazole/quinoline hybrids useful as active ingredients of anti-malaria drugs. The compounds show a remarkable in vitro biological activity especially against the chloroquine-resistant Plasmodium falciparum strains and

ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE

Antimalarial agents having a novel pharmacophore of formula (I) are herein described. These polycyclic compounds are able to inhibit chloroquine-sensitive and chloroquine-resistant strains ofPlasmodium falciparum (Pf). Furthermore, the synthesis of these compounds involves few steps from commercial products with low cost of production.Λa présente invention concerne des agents antimalariaux comportant un nouveau pharmacophore de formule (I). Ces composés polycycliques sont susceptibles d''inhiber les souches sensibles à la chloroquine et résistantes à la chloroquine de Plasmodium falciparum (Pf). En outre, la synthèse de ces composés est peu onéreuse et implique peu d''étapes à partir des produits commerciaux.

AMINE DERIVATIVE

The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s