74685-85-1 Usage
Description
1-(1-Naphtyl)cyclohexanol is a chemical compound characterized by a cyclohexane ring attached to a 1-naphtyl group and a hydroxyl group. It is a white solid that exhibits insolubility in water but is soluble in organic solvents. 1-(1-Naphtyl)cyclohexanol is recognized for its role as a precursor in the synthesis of various organic compounds and as a building block in the production of fragrances, pharmaceuticals, and other chemicals. Furthermore, 1-(1-Naphtyl)cyclohexanol has demonstrated potential as a chiral auxiliary in asymmetric synthesis reactions and has been investigated for its pharmacological properties and applications in medicinal chemistry.
Uses
Used in Organic Synthesis:
1-(1-Naphtyl)cyclohexanol is used as a precursor for the synthesis of other organic compounds, leveraging its unique structure to create a diverse range of chemical products.
Used in Fragrance Production:
In the fragrance industry, 1-(1-Naphtyl)cyclohexanol is utilized as a building block to develop complex and distinct scents, capitalizing on its chemical properties to enhance the olfactory profiles of various fragrances.
Used in Pharmaceutical Manufacturing:
1-(1-Naphtyl)cyclohexanol serves as a crucial component in the production of pharmaceuticals, contributing to the development of new drugs and medicines by providing a structural foundation for further chemical modifications.
Used in Asymmetric Synthesis:
As a chiral auxiliary, 1-(1-Naphtyl)cyclohexanol is employed in asymmetric synthesis reactions to facilitate the creation of enantiomerically pure compounds, which are essential in the pharmaceutical industry for their specific biological activities and reduced side effects.
Used in Medicinal Chemistry:
1-(1-Naphtyl)cyclohexanol is studied for its pharmacological properties, with potential applications in the field of medicinal chemistry. Its unique structure and properties make it a promising candidate for the development of novel therapeutic agents and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 74685-85-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,6,8 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 74685-85:
(7*7)+(6*4)+(5*6)+(4*8)+(3*5)+(2*8)+(1*5)=171
171 % 10 = 1
So 74685-85-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H18O/c17-16(11-4-1-5-12-16)15-10-6-8-13-7-2-3-9-14(13)15/h2-3,6-10,17H,1,4-5,11-12H2
74685-85-1Relevant articles and documents
The Barbier-Grignard-Type Arylation of Ketones and Unexpected Cross-Coupling of Phenolic Ketones using Unactivated Aryl Bromides
Wen, Yunming,Chen, Guifang,Huang, Shiqiang,Tang, Yu,Yang, Jun,Zhang, Yuanming
, p. 947 - 957 (2016/04/05)
A novel, highly versatile and efficient method has been developed for the Barbier-Grignard-type arylation of ketones and an unexpected cross-coupling of phenolic ketones was observed using unactivated bromides and magnesium in tetrahydrofuran/toluene at 96°C promoted by multicatalysts of cupric bromide (15 mol%), bismuth chloride (5 mol%) and silver bromide (10 mol%). The substituent and electronic effects on the reaction have been discussed. High yields of arylation and cross-coupling have been attained under mild conditions. A novel reasonable mechanism involving a quinone intermediate is proposed. The high chemical selectivity in the cross-coupling to the hydroxy group of phenolic ketones should help ketones find new applications.
Oxidative fragmentation of 1-aryl-1-cycloalkenes using cerium(IV) ammonium nitrate (CAN): Some novel observations
Nair, Vijay,Panicker, Sreeletha B,Thomas, Siji,Santhi,Mathai, Sindhu
, p. 3229 - 3234 (2007/10/03)
1-Phenyl-1-cycloalkenes undergo oxidative fragmentation in presence of CAN in methanol, affording 1,n-dicarbonyl compounds as the major products along with 1,2-dimethoxycycloalkanes. The reaction under deoxygenated conditions afforded the latter in good yields. In the presence of azide ion, fragmentation leading to the corresponding cyanoketones was observed whereas with sulfinate only the 1-methoxy-2-sulfonyl cycloalkanes were formed.
THE SYNTHESIS OF SOME 1-NAPHTHYLCYCLOALKANOLS AND 1-NAPHTHYLCYCLOALKENES
Guenaydin, Keriman
, p. 925 - 930 (2007/10/03)
1-Naphthylcycloalkanols having 3, 4, 5, 6, 7, 12 and 15 ring carbons were synthesized from corresponding cyclic ketones and 1-naphthylbromide using Grignard reaction. The dehydration products of these naphthylcycloalkanols were obtained. All the products were identified by means of IR- and 1H-NMR spectra.
