7508-04-5

Basic information

• Product Name: 5-(4-methoxyphenyl)pentanoic acid
• Synonyms: 5-(4-methoxyphenyl)pentanoic acid
• CAS NO: 7508-04-5
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25364
• Mol File: 7508-04-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 371.5°Cat760mmHg
• Flash Point: 142.3°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 3.55E-06mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 5-(4-methoxyphenyl)pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)pentanoic acid(7508-04-5)
• EPA Substance Registry System: 5-(4-methoxyphenyl)pentanoic acid(7508-04-5)

Safety Data

• Hazardous Substances Data: 7508-04-5(Hazardous Substances Data)

Usage

General Description

5-(4-methoxyphenyl)pentanoic acid is a chemical compound that is also known as ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its pain-relieving and anti-inflammatory properties. The compound's chemical structure consists of a pentanoic acid chain with a 4-methoxyphenyl group attached at the 5th carbon position, and it acts by inhibiting the synthesis of prostaglandins, which play a role in inflammation, pain, and fever. Ibuprofen is widely used for the treatment of various conditions such as arthritis, headache, menstrual cramps, and fever, and is available in both prescription and over-the-counter forms for oral and topical administration.

InChI:InChI=1/C12H16O3/c1-15-11-8-6-10(7-9-11)4-2-3-5-12(13)14/h6-9H,2-5H2,1H3,(H,13,14)

Upstream product

• 4609-10-3 5-(4-methoxyphenyl)-5-oxopentanoic acid 
• 301303-19-5 [3-(4-methoxy-phenyl)-propyl]-malonic acid 
• 4654-08-4 5-(4'-hydroxyphenyl)pentanoic acid 
• 77-78-1 dimethyl sulfate 
• 854401-87-9 1,10-bis-(4-methoxy-phenyl)-decane-5,6-diol 
• 546-67-8 lead(IV) tetraacetate 
• 71-43-2 benzene 
• 110146-59-3 1,6-bis-(4-methoxy-phenyl)-hex-1-ene 
• 67-64-1 acetone 
• 108-55-4 glutaric anhydride, 
• 100-66-3 methoxybenzene 
• 5205-39-0 ethyl glutaroyl chloride 
• 47172-89-4 diphenyl glutarate 
• 4648-94-6 5-(4-hydroxy-phenyl)-5-oxo-valeric acid 

Downstream Products

• 4654-08-4 5-(4'-hydroxyphenyl)pentanoic acid 
• 4609-10-3 5-(4-methoxyphenyl)-5-oxopentanoic acid 
• 79023-06-6 5-(4-methoxyphenyl)pentanoic acid ethyl ester 
• 61875-52-3 5-(4-methoxy-phenyl)-valeryl chloride 
• 34665-81-1 5-hydroxy-5-(4-methoxyphenyl)valeric acid δ lactone 
• 14374-54-0 5-(4-methoxyphenyl)pentan-1-ol 
• 127047-17-0 5-(4-methoxyphenyl)pentan-1-al 
• 104489-49-8 1-[5-(4-Hydroxy-phenyl)-pentyl]-1,3-dihydro-imidazole-2-thione 
• 104489-46-5 1-[5-(4-Methoxy-phenyl)-pentyl]-1,3-dihydro-imidazole-2-thione 
• 14469-84-2 1-(para-anisyl)-5-bromopentane 
• 4626-83-9 5-(2,4-dinitro-phenylhydrazono)-5-(4-methoxy-phenyl)-valeric acid 
• 4280-60-8 1,10-bis(4-methoxyphenyl)decane 
• 854401-87-9 1,10-bis-(4-methoxy-phenyl)-decane-5,6-diol 

Relevant articles and documents

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2

A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlorides with CO2 at atmospheric pressure is described. This protocol represents the first intermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowledge in the cross-coupling arena.

Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2

A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2 at atmospheric pressure is described. The method is characterized by its mild conditions and remarkably wide scope without the need for air- or moisture-sensitive reagents, which make it a user-friendly and operationally simple protocol en route to carboxylic acids.