• Name

  FLURTAMONE

• EINECS
• CAS No. 96525-23-4
• Article Data3
• CAS DataBase
• Density 1.33 g/cm³
• Solubility
• Melting Point 152.5℃
• Formula C18H14 F3 N O2
• Boiling Point 446.2 °C at 760 mmHg
• Molecular Weight 333.31
• Flash Point 223.6 °C
• Transport Information
• Appearance
• Safety Moderately toxic by ingestion and skin contact routes. Questionable carcinogen with neoplastigenic data reported. When heated to decomposition it emits toxic vapors of NO_x and F⁻.
• Risk Codes 50/53
• Molecular Structure
• Hazard Symbols
• Synonyms 3(2H)-Furanone,5-(methylamino)-2-phenyl-4-[3-(trifluoromethyl)phenyl]-, (?à)-; Bacara; Benchmark;Fluortanone; Flurtamone; RE 40885
• PSA 38.33000
• LogP 4.32490

Synthetic route

96525-22-3

2-phenyl-3-oxo-4-(3-trifluoromethylphenyl)-5-amino-2,3-dihydrofuran

56-37-1

N-benzyl-N,N,N-triethylammonium chloride

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
With sodium hydroxide; dimethyl sulfate In dichloromethane; water

96525-22-3

2-phenyl-3-oxo-4-(3-trifluoromethylphenyl)-5-amino-2,3-dihydrofuran

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
With methylamine In tetrahydrofuran; methanol; water
With hydrogenchloride In methanol; water; methylamine

96525-22-3

2-phenyl-3-oxo-4-(3-trifluoromethylphenyl)-5-amino-2,3-dihydrofuran

77-78-1

dimethyl sulfate

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
With trimethyldodecylammonium chloride; sodium sulfite In water; 1,2-dichloro-ethane at 20℃; for 2.5h; Reagent/catalyst; Large scale;

2338-76-3

3-trifluoromethylphenylacetonitrile

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 16 h / 25 °C / Large scale 2: bromine / methanol / 13 h / 20 °C / Large scale 3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / 1,2-dichloro-ethane; water / 3.5 h / 20 °C / Large scale View Scheme
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 16 h / 25 °C / Large scale 2: bromine / methanol / 13 h / 20 °C / Large scale 3: sodium sulfite; trimethyldodecylammonium chloride / 1,2-dichloro-ethane; water / 2.5 h / 20 °C / Large scale View Scheme

101-97-3

Ethyl 2-phenylethanoate

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 16 h / 25 °C / Large scale 2: bromine / methanol / 13 h / 20 °C / Large scale 3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / 1,2-dichloro-ethane; water / 3.5 h / 20 °C / Large scale View Scheme
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 16 h / 25 °C / Large scale 2: bromine / methanol / 13 h / 20 °C / Large scale 3: sodium sulfite; trimethyldodecylammonium chloride / 1,2-dichloro-ethane; water / 2.5 h / 20 °C / Large scale View Scheme

68084-26-4

(3-trifluoromethylphenyl)benzylcarbonylacetonitrile

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine / methanol / 13 h / 20 °C / Large scale 2: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / 1,2-dichloro-ethane; water / 3.5 h / 20 °C / Large scale View Scheme

96525-22-3

2-phenyl-3-oxo-4-(3-trifluoromethylphenyl)-5-amino-2,3-dihydrofuran

616-38-6

carbonic acid dimethyl ester

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water; 1,2-dichloro-ethane at 20℃; for 3.5h; Reagent/catalyst; Large scale;

96525-23-4

2-Phenyl-3-oxo-4-(-3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Lithium salt of 2-phenyl-3-oxo-4-(3-trifluoromethylphenyl)-5-methylamino-2,3-dihydrofuran

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane

(+-)-5-(Methylamino)-2-phenyl-4-(3-(trifluoromethyl)phenyl)-3(2h)-furanone Chemical Properties

(+-)-5-(Methylamino)-2-phenyl-4-(3-(trifluoromethyl)phenyl)-3(2h)-furanone Toxicity Data With Reference

(+-)-5-(Methylamino)-2-phenyl-4-(3-(trifluoromethyl)phenyl)-3(2h)-furanone Safety Profile