Product Name

  • Name

    (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

  • EINECS 601-595-5
  • CAS No. 119302-20-4
  • Article Data5
  • CAS DataBase
  • Density 1.163 g/cm3
  • Solubility
  • Melting Point 161-169 °C
  • Formula C27H46N2O3
  • Boiling Point 565.4 °C at 760 mmHg
  • Molecular Weight 446.674
  • Flash Point 295.7 °C
  • Transport Information
  • Appearance Whitish or yellowish crystalline powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 119302-20-4 ((2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol)
  • Hazard Symbols
  • Synonyms 2b-(4-Morpholinyl)-16b-(1-pyrrolidinyl)-5a-androstane-3a,17b-diol;Androstane-3,17-diol,2-(4-morpholinyl)-16-(1-pyrrolidinyl)-, (2b,3a,5a,16b,17b)-;
  • PSA 56.17000
  • LogP 3.01170

Synthetic route

3α-hydroxy-2β-(4-morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-17-one

3α-hydroxy-2β-(4-morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-17-one

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at -3℃; for 2h;92.7%
morpholine
110-91-8

morpholine

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol
119302-19-1

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
toluene-4-sulfonic acid In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;89.7%
methanesulfonic acid In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
In water for 72h; Product distribution / selectivity; Heating / reflux;
rocuronium bromide

rocuronium bromide

A

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

B

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Product distribution / selectivity; Heating / reflux;A 67.5%
B n/a
pyrrolidine
123-75-1

pyrrolidine

2β-(4-morpholinyl)-3α-ol-16β-bromo-17-one-5α-androstane

2β-(4-morpholinyl)-3α-ol-16β-bromo-17-one-5α-androstane

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
In acetonitrile Reflux;62.1%
rocuronium bromide

rocuronium bromide

A

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

B

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

C

1-[(2β, 3α, 5α, 16β, 17β)-2-(4-morpholinyl)-androstan-16-yl-]-1-(2-propenyl)-pyrrolidinium bromide-3,17-diol
119302-86-2

1-[(2β, 3α, 5α, 16β, 17β)-2-(4-morpholinyl)-androstan-16-yl-]-1-(2-propenyl)-pyrrolidinium bromide-3,17-diol

Conditions
ConditionsYield
In dimethyl acetamide (DMA) for 3h; Product distribution / selectivity; Heating / reflux;
sodium thiophenolate In isopropyl alcohol for 4h; Product distribution / selectivity; Heating / reflux;
In N,N-dimethyl-formamide for 5h; Product distribution / selectivity; Heating / reflux;
...Expand
(2α,3α,5α,16β,17β)2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

(2α,3α,5α,16β,17β)2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
In morpholine; water
morpholine
110-91-8

morpholine

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol
119302-19-1

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

A

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

B

(2β,3α,5α,16α,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3,17-diol

(2β,3α,5α,16α,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3,17-diol

C

2α,3α-epoxy-16α-(pyrrolidin-1-yl)-17β-hydroxy-5α-androstan
930092-98-1

2α,3α-epoxy-16α-(pyrrolidin-1-yl)-17β-hydroxy-5α-androstan

D

C27H46N2O2
144209-33-6

C27H46N2O2

Conditions
ConditionsYield
zinc diacetate In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
...Expand
morpholine
110-91-8

morpholine

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol
119302-19-1

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

A

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

B

2α,3α-epoxy-16α-(pyrrolidin-1-yl)-17β-hydroxy-5α-androstan
930092-98-1

2α,3α-epoxy-16α-(pyrrolidin-1-yl)-17β-hydroxy-5α-androstan

C

C23H39NO3

C23H39NO3

D

C27H46N2O2
144209-33-6

C27H46N2O2

Conditions
ConditionsYield
In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
...Expand
morpholine
110-91-8

morpholine

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol
119302-19-1

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

A

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

B

2α,3α-epoxy-16α-(pyrrolidin-1-yl)-17β-hydroxy-5α-androstan
930092-98-1

2α,3α-epoxy-16α-(pyrrolidin-1-yl)-17β-hydroxy-5α-androstan

C

C23H39NO3

C23H39NO3

Conditions
ConditionsYield
hydrogenchloride In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
toluene-4-sulfonic acid In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
...Expand
morpholine
110-91-8

morpholine

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol
119302-19-1

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

A

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

B

C27H46N2O2
144209-33-6

C27H46N2O2

Conditions
ConditionsYield
sulfuric acid In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
...Expand
morpholine
110-91-8

morpholine

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol
119302-19-1

(2α,3α,5α,16β,17β)-2,3-epoxy-16-(1-pyrrolidinyl)-androstan-17-ol

A

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

B

C23H39NO3

C23H39NO3

C

C27H46N2O2
144209-33-6

C27H46N2O2

Conditions
ConditionsYield
iron(III) chloride In water at 20 - 110℃; for 40h; Product distribution / selectivity; Heating / reflux;
...Expand
5α-androst-2-en-17-one
14639-79-3, 24174-20-7, 82467-84-3, 963-75-7

5α-androst-2-en-17-one

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: dihydrogen peroxide; formic acid / dichloromethane / 5 h / 20 °C
2.1: iron(III) chloride / water / 0.5 h / 20 °C
2.2: 24 h / 130 °C
3.1: copper(ll) bromide / methanol / 30 h / 70 °C / Inert atmosphere
4.1: acetonitrile / 8 h / Inert atmosphere; Reflux
5.1: sodium tetrahydroborate / methanol / 2 h / -3 °C
View Scheme
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 - 5 °C
2: iron(III) chloride / water / Reflux
3: copper(ll) bromide / methanol / Reflux
4: acetonitrile / Reflux
View Scheme
2α,3α-epoxy-5α-androstan-17-one
965-67-3, 7676-05-3, 13094-19-4

2α,3α-epoxy-5α-androstan-17-one

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: iron(III) chloride / water / 0.5 h / 20 °C
1.2: 24 h / 130 °C
2.1: copper(ll) bromide / methanol / 30 h / 70 °C / Inert atmosphere
3.1: acetonitrile / 8 h / Inert atmosphere; Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -3 °C
View Scheme
Multi-step reaction with 3 steps
1: iron(III) chloride / water / Reflux
2: copper(ll) bromide / methanol / Reflux
3: acetonitrile / Reflux
View Scheme
3α-hydroxy-2β-(4-morpholinyl)-5α(H)-androstan-17-one
52-72-2

3α-hydroxy-2β-(4-morpholinyl)-5α(H)-androstan-17-one

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(ll) bromide / methanol / 30 h / 70 °C / Inert atmosphere
2: acetonitrile / 8 h / Inert atmosphere; Reflux
3: sodium tetrahydroborate / methanol / 2 h / -3 °C
View Scheme
Multi-step reaction with 2 steps
1: copper(ll) bromide / methanol / Reflux
2: acetonitrile / Reflux
View Scheme
3α-hydroxy-2β-(4-morpholinyl)-16α-bromo-5α-androstan-17-one

3α-hydroxy-2β-(4-morpholinyl)-16α-bromo-5α-androstan-17-one

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetonitrile / 8 h / Inert atmosphere; Reflux
2: sodium tetrahydroborate / methanol / 2 h / -3 °C
View Scheme
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at 80 - 85℃; regioselective reaction;94.1%
N-Acetylimidazole
2466-76-4

N-Acetylimidazole

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
In dichloromethane at 25℃; for 48h; Product distribution / selectivity;92%
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetic acid
64-19-7

acetic acid

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In acetonitrile for 4.5h; Solvent; Reagent/catalyst; Reflux;91.4%
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetyl chloride
75-36-5

acetyl chloride

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
In dichloromethane at 20 - 25℃;89.7%
In dichloromethane at 35℃; for 4h;
Stage #1: (2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol; acetyl chloride In dichloromethane at 20℃; for 18h;
Stage #2: With sodium carbonate In dichloromethane; water Product distribution / selectivity;
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetic anhydride
108-24-7

acetic anhydride

A

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

B

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane
119302-22-6

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20 - 22℃; for 22h; Product distribution / selectivity;A 68.8%
B n/a
In acetonitrile for 1h; Product distribution / selectivity; Heating / reflux;A 53.4 - 96.1 %Chromat.
B 0.2 - 39.5 %Chromat.
With pyridine In dichloromethane at 20 - 22℃; for 22h; Product distribution / selectivity;
...Expand
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetyl chloride
75-36-5

acetyl chloride

A

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

B

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane
119302-22-6

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane

Conditions
ConditionsYield
In dichloromethane at 0 - 40℃; for 18h; Product distribution / selectivity;A 56.7 - 67.2 %Chromat.
B 6.2 - 21.7 %Chromat.
In dichloromethane at 23℃; for 24h; Product distribution / selectivity;A 94.1 %Chromat.
B 2.1 %Chromat.
With triethylamine In dichloromethane at 20 - 22℃; for 22h; Product distribution / selectivity;
Stage #1: (2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol; acetyl chloride In dichloromethane at 20℃; for 29h;
Stage #2: With sodium carbonate In dichloromethane; water Product distribution / selectivity;
...Expand
diethyl ether-n-hexane

diethyl ether-n-hexane

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetyl chloride
75-36-5

acetyl chloride

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
In dichloromethane
...Expand
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetyl chloride
75-36-5

acetyl chloride

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane
119302-22-6

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane

Conditions
ConditionsYield
In dichloromethane
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetic anhydride
108-24-7

acetic anhydride

A

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

B

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane
119302-22-6

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane

C

2α,3α-epoxy-16β-(1-pyrrolidinyl)-5α-androstane-17-one
159325-45-8

2α,3α-epoxy-16β-(1-pyrrolidinyl)-5α-androstane-17-one

Conditions
ConditionsYield
In dichloromethane; water at 20 - 22℃; for 22h; Product distribution / selectivity;
...Expand
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 0 - 5 °C / Large scale
2: hydrogenchloride / dichloromethane / 20 - 25 °C / Large scale
View Scheme
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

rocuronium bromide

rocuronium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 0 - 5 °C / Large scale
2: hydrogenchloride / dichloromethane / 20 - 25 °C / Large scale
3: dichloromethane / 10 °C / Inert atmosphere; Large scale
View Scheme
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetic anhydride
108-24-7

acetic anhydride

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane
119302-22-6

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3,17-bis(acetyloxyoxy)androstane

Conditions
ConditionsYield
In dichloromethane at 0 - 5℃; Large scale;3.4 kg
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

acetic anhydride
108-24-7

acetic anhydride

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane
119302-24-8

(2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 22h;
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

1-[(2β,3α,5α,16β,17β)-17-acetyloxy-3-hydroxy-2-(4-morpholinyl)-androstan-16-yl]-1-methylpyrrolidinium bromide

1-[(2β,3α,5α,16β,17β)-17-acetyloxy-3-hydroxy-2-(4-morpholinyl)-androstan-16-yl]-1-methylpyrrolidinium bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane
View Scheme
(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
119302-20-4

(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(4-morpholinyl)-androstan-16-yl]-1-(2-propenyl)pyrrolidinium bromide

1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(4-morpholinyl)-androstan-16-yl]-1-(2-propenyl)pyrrolidinium bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane
View Scheme

(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol Chemical Properties

Product Name: (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
Molecular Structure:

Molecular Formula: C27H46N2O3
Molecular Weight: 446.67
Synonyms of (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol (CAS NO.119302-20-4): Androstane-3,17-diol,2-(4-morpholinyl)-16-(1-pyrrolidinyl)-, (2b,3a,5a,16b,17b)- ; 3,17-dihydroxy-2-(4-morpholinyl)-16-(1-pyrroliny)-androstane ; 2,3-Epoxy-1H-cyclopenta[a]phenanthrene,anddrostan-17-ol deriv ; (2β，3ɑ，5ɑ，16ɑ，17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3，17-diol
CAS NO: 119302-20-4
Product Categories: INTERMEDIATESOFROCURONIUMBROMIDE 
Polar Surface Area: 56.17 Å2
Index of Refraction of (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol (CAS NO.119302-20-4): 1.574
Molar Refractivity: 126.67 cm3
Molar Volume: 383.7 cm3
Surface Tension: 49.5 dyne/cm
Density: 1.163 g/cm3
Flash Point: 295.7 °C
Enthalpy of Vaporization: 97.56 kJ/mol
Boiling Point: 565.4 °C at 760 mmHg
Vapour Pressure of (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol (CAS NO.119302-20-4): 3.88E-15 mmHg at 25 °C

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