Product Name

  • Name

    (3S,4E)-3-Hydroxy-7-[(triphenylmethyl)thio]-4-heptenoic acid

  • EINECS
  • CAS No. 180973-24-4
  • Article Data7
  • CAS DataBase
  • Density 1.201
  • Solubility
  • Melting Point
  • Formula C26H26O3S
  • Boiling Point
  • Molecular Weight 418.557
  • Flash Point
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 180973-24-4 ((3S,4E)-3-Hydroxy-7-[(triphenylmethyl)thio]-4-heptenoic acid)
  • Hazard Symbols
  • Synonyms (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid;(3S,E)-3-hydroxy-7-tritylthio-4-heptenoic acid;(E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoic acid;4-Heptenoic acid,3-hydroxy-7-[(triphenylmethyl)thio]-,(3S,4E);
  • PSA 82.83000
  • LogP 5.49360

Synthetic route

(E)-(S)-3-Hydroxy-7-tritylsulfanyl-hept-4-enoic acid benzyl ester
180973-40-4

(E)-(S)-3-Hydroxy-7-tritylsulfanyl-hept-4-enoic acid benzyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
With lithium hydroxide In methanol; water100%
(3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one
663918-95-4

(3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
With lithium hydroxide; water In tetrahydrofuran Cooling with ice;96%
Stage #1: (3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one With water; lithium hydroxide In tetrahydrofuran at 0 - 20℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=2;		86%
With lithium hydroxide monohydrate; water In tetrahydrofuran at 0 - 30℃; for 12h;13 g
(E)-(S)-3-hydroxy-1-[(R)-4-isopropyl-5,5-diphenyl-2-oxo-oxazolidin-3-yl]-7-tritylthio-4-hepten-1-one
878630-47-8

(E)-(S)-3-hydroxy-1-[(R)-4-isopropyl-5,5-diphenyl-2-oxo-oxazolidin-3-yl]-7-tritylthio-4-hepten-1-one

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Stage #1: (E)-(S)-3-hydroxy-1-[(R)-4-isopropyl-5,5-diphenyl-2-oxo-oxazolidin-3-yl]-7-tritylthio-4-hepten-1-one With water; sodium hydroxide In tetrahydrofuran; methanol at 0℃; for 1h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 0℃;		92%
With sodium hydroxide76%
With sodium hydroxide In methanol; water at 0 - 20℃; for 1h;58%
(2E)-5-[(triphenylmethyl)thio]-2-pentenal
180973-22-2

(2E)-5-[(triphenylmethyl)thio]-2-pentenal

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi / tetrahydrofuran / -78 °C
1.2: Cp2ZrCl2 / tetrahydrofuran / -78 - 20 °C
2.1: 76 percent / NaOH
View Scheme
Multi-step reaction with 2 steps
1.1: SmI2 / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / -78 °C
2.1: 76 percent / NaOH
View Scheme
Multi-step reaction with 2 steps
1: 99 percent / Ti(IV) complex with (S)-(-)-binaphthyl amino alcohol
2: 100 percent / LiOH / methanol; H2O
View Scheme
triphenylmethanethiol
3695-77-0

triphenylmethanethiol

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 78 percent / Cs2CO3
2: 91 percent / DIBAL
3: 74 percent / (COCl)2, DMSO, Et3N
4: 99 percent / Ti(IV) complex with (S)-(-)-binaphthyl amino alcohol
5: 100 percent / LiOH / methanol; H2O
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere; Automated synthesizer
2.1: dmap / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere; Automated synthesizer
2.2: 2 h / -20 - 25 °C / Inert atmosphere; Automated synthesizer
2.3: -78 - 0 °C / Inert atmosphere; Automated synthesizer
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere; Automated synthesizer
3.2: 1 h / -78 - -30 °C / Inert atmosphere; Automated synthesizer
3.3: 1 h / -50 - 0 °C / Inert atmosphere; Automated synthesizer
4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C
4.2: 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 20 °C / Flow reactor
2.1: diisobutylaluminium hydride / toluene / -97 °C / Flow reactor
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / Flow reactor
3.2: 0.02 h / -78 °C / Flow reactor
4.1: sodium hydroxide / methanol; water / 1 h / 0 - 20 °C
View Scheme
(E)-5-(tritylthio)-2-penten-1-ol
180973-37-9

(E)-5-(tritylthio)-2-penten-1-ol

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / (COCl)2, DMSO, Et3N
2: 99 percent / Ti(IV) complex with (S)-(-)-binaphthyl amino alcohol
3: 100 percent / LiOH / methanol; H2O
View Scheme
Multi-step reaction with 3 steps
1.1: manganese(IV) oxide / dichloromethane / 8 h / 25 - 45 °C
2.1: titanium tetrachloride / dichloromethane / 0 - 5 °C
2.2: 2 h / -78 °C
2.3: 0.5 h / -78 °C
3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 0 - 30 °C
View Scheme
(E)-5-Tritylsulfanyl-pent-2-enoic acid methyl ester
180973-36-8

(E)-5-Tritylsulfanyl-pent-2-enoic acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 91 percent / DIBAL
2: 74 percent / (COCl)2, DMSO, Et3N
3: 99 percent / Ti(IV) complex with (S)-(-)-binaphthyl amino alcohol
4: 100 percent / LiOH / methanol; H2O
View Scheme
methyl (2E)-penta-2,4-dienoate
2409-87-2

methyl (2E)-penta-2,4-dienoate

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 78 percent / Cs2CO3
2: 91 percent / DIBAL
3: 74 percent / (COCl)2, DMSO, Et3N
4: 99 percent / Ti(IV) complex with (S)-(-)-binaphthyl amino alcohol
5: 100 percent / LiOH / methanol; H2O
View Scheme
S-trityl 3-mercaptopropionaldehyde
150350-28-0

S-trityl 3-mercaptopropionaldehyde

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere; Automated synthesizer
1.2: 2 h / -20 - 25 °C / Inert atmosphere; Automated synthesizer
1.3: -78 - 0 °C / Inert atmosphere; Automated synthesizer
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere; Automated synthesizer
2.2: 1 h / -78 - -30 °C / Inert atmosphere; Automated synthesizer
2.3: 1 h / -50 - 0 °C / Inert atmosphere; Automated synthesizer
3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C
3.2: 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene / -97 °C / Flow reactor
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / Flow reactor
3.2: 0.02 h / -78 °C / Flow reactor
4.1: sodium hydroxide / methanol; water / 1 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene / -97 °C / Flow reactor
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Flow reactor
3.2: 0.02 h / Flow reactor
4.1: sodium hydroxide / methanol; water / 1 h / 0 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triphenylphosphine / toluene; water / 6 h / 25 - 105 °C
1.2: 2 h / 0 - 5 °C
2.1: diisobutylaluminium hydride / toluene / 3 h / 0 - 5 °C / Inert atmosphere
3.1: manganese(IV) oxide / dichloromethane / 8 h / 25 - 45 °C
4.1: titanium tetrachloride / dichloromethane / 0 - 5 °C
4.2: 2 h / -78 °C
4.3: 0.5 h / -78 °C
5.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 0 - 30 °C
View Scheme
ethyl (E)-5-(triphenylmethylthio)-2-pentenoate
1309766-86-6

ethyl (E)-5-(triphenylmethylthio)-2-pentenoate

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / toluene / -97 °C / Flow reactor
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / Flow reactor
2.2: 0.02 h / -78 °C / Flow reactor
3.1: sodium hydroxide / methanol; water / 1 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / toluene / -97 °C / Flow reactor
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Flow reactor
2.2: 0.02 h / Flow reactor
3.1: sodium hydroxide / methanol; water / 1 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / toluene / 3 h / 0 - 5 °C / Inert atmosphere
2.1: manganese(IV) oxide / dichloromethane / 8 h / 25 - 45 °C
3.1: titanium tetrachloride / dichloromethane / 0 - 5 °C
3.2: 2 h / -78 °C
3.3: 0.5 h / -78 °C
4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 0 - 30 °C
View Scheme
trityl chloride
76-83-5

trityl chloride

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: toluene / 6 h / 25 - 30 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 0.17 h / 0 - 5 °C
2.2: 3 h / 0 - 30 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -75 - -70 °C
3.2: 2 h / -75 - 5 °C
4.1: triphenylphosphine / toluene; water / 6 h / 25 - 105 °C
4.2: 2 h / 0 - 5 °C
5.1: diisobutylaluminium hydride / toluene / 3 h / 0 - 5 °C / Inert atmosphere
6.1: manganese(IV) oxide / dichloromethane / 8 h / 25 - 45 °C
7.1: titanium tetrachloride / dichloromethane / 0 - 5 °C
7.2: 2 h / -78 °C
7.3: 0.5 h / -78 °C
8.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 0 - 30 °C
View Scheme
3-(tritylthio) propanoic acid
27144-18-9

3-(tritylthio) propanoic acid

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 0.17 h / 0 - 5 °C
1.2: 3 h / 0 - 30 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -75 - -70 °C
2.2: 2 h / -75 - 5 °C
3.1: triphenylphosphine / toluene; water / 6 h / 25 - 105 °C
3.2: 2 h / 0 - 5 °C
4.1: diisobutylaluminium hydride / toluene / 3 h / 0 - 5 °C / Inert atmosphere
5.1: manganese(IV) oxide / dichloromethane / 8 h / 25 - 45 °C
6.1: titanium tetrachloride / dichloromethane / 0 - 5 °C
6.2: 2 h / -78 °C
6.3: 0.5 h / -78 °C
7.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 0 - 30 °C
View Scheme
3-(tritylthio)propan-1-ol
100360-56-3

3-(tritylthio)propan-1-ol

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -75 - -70 °C
1.2: 2 h / -75 - 5 °C
2.1: triphenylphosphine / toluene; water / 6 h / 25 - 105 °C
2.2: 2 h / 0 - 5 °C
3.1: diisobutylaluminium hydride / toluene / 3 h / 0 - 5 °C / Inert atmosphere
4.1: manganese(IV) oxide / dichloromethane / 8 h / 25 - 45 °C
5.1: titanium tetrachloride / dichloromethane / 0 - 5 °C
5.2: 2 h / -78 °C
5.3: 0.5 h / -78 °C
6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 0 - 30 °C
View Scheme
(S)-2-{(Z)-2-[(S)-2-((R)-2-Amino-3-methyl-butyrylamino)-3-tritylsulfanyl-propionylamino]-but-2-enoylamino}-3-methyl-butyric acid methyl ester
180973-32-4

(S)-2-{(Z)-2-[(S)-2-((R)-2-Amino-3-methyl-butyrylamino)-3-tritylsulfanyl-propionylamino]-but-2-enoylamino}-3-methyl-butyric acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(5E,7S,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate
180973-33-5

(5E,7S,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine95%
C52H49N5O7S
1196992-63-8

C52H49N5O7S

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

C63H63N5O7S2
1196992-65-0

C63H63N5O7S2

Conditions
ConditionsYield
Stage #1: C52H49N5O7S With diethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;		95%
(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196992-16-1

(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(R)-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196992-18-3

(R)-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester With diethylamine In acetonitrile at 20℃; for 1h;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃;		91%
[(1-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-76-3

[(1-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

[(1-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-3-phenyl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-77-4

[(1-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-3-phenyl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: [(1-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester With diethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;		87%
(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-1-methyl-ethylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196992-05-8

(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-1-methyl-ethylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(R)-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-1-methyl-ethylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196992-07-0

(R)-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-1-methyl-ethylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-1-methyl-ethylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester With diethylamine In acetonitrile at 20℃;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃;		85%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate
1043577-31-6

(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane Cooling with ice;80%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 5℃; for 0.916667h;2.5 g
[(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-69-4

[(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

[(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-72-9

[(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: [(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester With diethylamine In dichloromethane; acetonitrile at 20℃; for 1.5h; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 20℃; for 16h; Inert atmosphere;		80%
(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclobutylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196992-35-4

(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclobutylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(R)-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclobutylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196992-37-6

(R)-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclobutylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(methoxycarbonylmethyl-carbamoyl)-cyclobutylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester With diethylamine In acetonitrile at 20℃; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;		75%
(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(1-hydroxy-2-methoxycarbonyl-ethyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester
1196991-91-9

(R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(1-hydroxy-2-methoxycarbonyl-ethyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(R)-4-{(S)-1-[1-(1-hydroxy-2-methoxycarbonyl-ethyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-butyric acid tert-butyl ester
1196991-93-1

(R)-4-{(S)-1-[1-(1-hydroxy-2-methoxycarbonyl-ethyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-4-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-butyric acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{(S)-1-[1-(1-hydroxy-2-methoxycarbonyl-ethyl)-cyclopropylcarbamoyl]-2-tritylsulfanyl-ethylcarbamoyl}-butyric acid tert-butyl ester With diethylamine In dichloromethane; acetonitrile for 1.5h;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h; Inert atmosphere;		72%
(3S,4R)-4-[(S)-2-((R)-2-Amino-propionylamino)-3-tritylsulfanyl-propionylamino]-3-hydroxy-5-methyl-hexanoic acid allyl ester

(3S,4R)-4-[(S)-2-((R)-2-Amino-propionylamino)-3-tritylsulfanyl-propionylamino]-3-hydroxy-5-methyl-hexanoic acid allyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(3S,4R)-3-Hydroxy-4-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-5-methyl-hexanoic acid allyl ester
881845-29-0

(3S,4R)-3-Hydroxy-4-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-5-methyl-hexanoic acid allyl ester

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine65%
[(1-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-pyridin-4-yl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-82-1

[(1-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-pyridin-4-yl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

[(1-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-3-pyridin-4-yl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-84-3

[(1-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-3-pyridin-4-yl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: [(1-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-pyridin-4-yl-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester With diethylamine In acetonitrile at 20℃; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;		61%
C46H44N4O7S
1196992-56-9

C46H44N4O7S

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
1196992-58-1

[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: C46H44N4O7S With diethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 20℃; for 16h; Inert atmosphere;		56%
((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester
1196992-44-5

((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

((R)-2-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester
1196992-46-7

((R)-2-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: ((R)-2-{(S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-3-tritylsulfanyl-propionylamino}-3-methyl-butyrylamino)-acetic acid methyl ester With diethylamine In acetonitrile at 20℃; for 1.25h; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;		51%
[2-((S)-2-{[1-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclopropanecarbonyl]-amino}-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-acetic acid methyl ester

[2-((S)-2-{[1-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclopropanecarbonyl]-amino}-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-acetic acid methyl ester

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

[2-((S)-2-{[1-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-cyclopropanecarbonyl]-amino}-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-acetic acid methyl ester

[2-((S)-2-{[1-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-cyclopropanecarbonyl]-amino}-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: [2-((S)-2-{[1-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclopropanecarbonyl]-amino}-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-acetic acid methyl ester With diethylamine In acetonitrile at 20℃; Inert atmosphere;
Stage #2: (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;		41%
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

spiruchostatin A

spiruchostatin A

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 65 percent / N,N-diisopropylethylamine; benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium PF6(1-)
2: 87 percent / morpholine / Pd(PPh3)4 / methanol
3: 67 percent / MNBA; DMAP / CH2Cl2
4: 100 percent / I2 / methanol; CH2Cl2
View Scheme
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(3S,4R)-3-Hydroxy-4-[((E)-(4S,7R,11S)-11-hydroxy-7-methyl-6,9-dioxo-1,2-dithia-5,8-diaza-cyclopentadec-12-ene-4-carbonyl)-amino]-5-methyl-hexanoic acid

(3S,4R)-3-Hydroxy-4-[((E)-(4S,7R,11S)-11-hydroxy-7-methyl-6,9-dioxo-1,2-dithia-5,8-diaza-cyclopentadec-12-ene-4-carbonyl)-amino]-5-methyl-hexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / N,N-diisopropylethylamine; benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium PF6(1-)
2: 87 percent / morpholine / Pd(PPh3)4 / methanol
3: 100 percent / I2 / methanol; CH2Cl2
View Scheme
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(2S,6R,9S,12R,13S)-13-Hydroxy-12-isopropyl-6-methyl-2-((E)-4-tritylsulfanyl-but-1-enyl)-9-tritylsulfanylmethyl-1-oxa-5,8,11-triaza-cyclopentadecane-4,7,10,15-tetraone
881845-68-7

(2S,6R,9S,12R,13S)-13-Hydroxy-12-isopropyl-6-methyl-2-((E)-4-tritylsulfanyl-but-1-enyl)-9-tritylsulfanylmethyl-1-oxa-5,8,11-triaza-cyclopentadecane-4,7,10,15-tetraone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / N,N-diisopropylethylamine; benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium PF6(1-)
2: 87 percent / morpholine / Pd(PPh3)4 / methanol
3: 67 percent / MNBA; DMAP / CH2Cl2
View Scheme
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(3S,4R)-3-Hydroxy-4-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-5-methyl-hexanoic acid
878630-45-6

(3S,4R)-3-Hydroxy-4-{(S)-2-[(R)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-5-methyl-hexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / N,N-diisopropylethylamine; benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium PF6(1-)
2: 87 percent / morpholine / Pd(PPh3)4 / methanol
View Scheme
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

romidepsin
128517-07-7

romidepsin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA
2: 98 percent / LiOH
3: EDCl, DMAP, TsOH
4: 84 percent / I2 / methanol; H2O
View Scheme
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(3S,9S,12R,16S)-6-eth-(Z)-ylidene-3,12-diisopropyl-16-((E)-4-tritylsulfanyl-but-1-enyl)-9-tritylsulfanylmethyl-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone
180973-35-7

(3S,9S,12R,16S)-6-eth-(Z)-ylidene-3,12-diisopropyl-16-((E)-4-tritylsulfanyl-but-1-enyl)-9-tritylsulfanylmethyl-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA
2: 98 percent / LiOH
3: EDCl, DMAP, TsOH
View Scheme
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

(5E,7S,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid
180973-34-6

(5E,7S,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA
2: 98 percent / LiOH
View Scheme
C51H51ClN3O5PolS

C51H51ClN3O5PolS

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid
180973-24-4

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

C77H75ClN3O7PolS2

C77H75ClN3O7PolS2

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 24h;

(3S,4E)-3-Hydroxy-7-[(triphenylmethyl)thio]-4-heptenoic acid Chemical Properties

Molecular Structure of (3S,4E)-3-Hydroxy-7-[(triphenylmethyl)thio]-4-heptenoic acid (CAS No.180973-24-4):

Molecular Formula: C26H26O3S 
Molecular Weight: 418.5478
CAS No: 180973-24-4
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 11
Polar Surface Area: 82.83 Å2
Index of Refraction: 1.624
Molar Refractivity: 123.08 cm3
Molar Volume: 348.423 cm3
Surface Tension: 52.238 dyne/cm
Density: 1.201 g/cm3
Flash Point: 308.363 °C
Enthalpy of Vaporization: 92.097 kJ/mol
Boiling Point: 586.266 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Systematic Name: (3S,4E)-3-Hydroxy-7-(tritylsulfanyl)hept-4-enoic acid 
InChI: InChI=1/C26H26O3S/c27-24(20-25(28)29)18-10-11-19-30-26(21-12-4-1-5-13-21,22-14-6-2-7-15-22)23-16-8-3-9-17-23/h1-10,12-18,24,27H,11,19-20H2,(H,28,29)/b18-10+/t24-/m1/s1
InChIKey: BGUJCVRJDCZLQS-XMZCUOJSBV
Std. InChI: InChI=1S/C26H26O3S/c27-24(20-25(28)29)18-10-11-19-30-26(21-12-4-1-5-13-21,22-14-6-2-7-15-22)23-16-8-3-9-17-23/h1-10,12-18,24,27H,11,19-20H2,(H,28,29)/b18-10+/t24-/m1/s1
Std. InChIKey: BGUJCVRJDCZLQS-XMZCUOJSSA-N

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