(4-Methoxybenzyl)hydrazine supplier

Name
(4-METHOXYBENZYL)HYDRAZINEDIHYDROCHLORIDE
EINECS
CAS No. 140-69-2
Article Data10
CAS DataBase
Density 1.069 g/cm³
Solubility
Melting Point 34-36 °C
Formula C₈H₁₂N₂O
Boiling Point 311.9 °C at 760 mmHg
Molecular Weight 152.196
Flash Point 142.5 °C
Transport Information
Appearance
Safety
Risk Codes Xi:;
Molecular Structure
Hazard Symbols Xi
Synonyms 4-Methoxybenzylhydrazine;p-Methoxybenzylhydrazine;Hydrazine,(p-methoxybenzyl)- (6CI,7CI,8CI);
PSA 47.28000
LogP 3.35370

Synthetic route

: 824-94-2
p-methoxybenzyl chloride

: 140-69-2
4-methoxybenzylhydrazine

Conditions

Conditions	Yield
With potassium carbonate; hydrazine hydrate at 10 - 30℃; Inert atmosphere;	69%
With hydrazine In methanol for 2h; Ambient temperature;	54%
With hydrazine hydrate In methanol at 20℃; for 2h;	52%

: 345928-21-4
2-((4-methoxybenzyl)amino)isoindoline-1,3-dione

A: 1445-69-8
2,3-dihydrophthalazine-1,4-dione

B: 140-69-2
4-methoxybenzylhydrazine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol; water Heating;	A n/a B 65%
With hydrazine hydrate In ethanol; water for 2.5h; Heating;	A n/a B 65%

: 5953-85-5
p-anisaldehyde hydrazone

: 140-69-2
4-methoxybenzylhydrazine

Conditions

Conditions	Yield
With ethanol; acetic acid; platinum Hydrogenation;

: 33708-60-0
4-methoxy-benzaldehyde-(4-methoxy-benzylhydrazone)

: 140-69-2
4-methoxybenzylhydrazine

Conditions

Conditions	Yield
With hydrogenchloride

: 85468-48-0
N-(p-methoxybenzylidene)aminophthalimide

: 140-69-2
4-methoxybenzylhydrazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 79 percent / hydrogen, / 5percent palladium on charcoal / dimethylformamide / 20 h / 2585.7 Torr 2: 65 percent / 64percent NH2NH2*H2O / H2O; ethanol / 2.5 h / Heating View Scheme

: 123-11-5
4-methoxy-benzaldehyde

: 140-69-2
4-methoxybenzylhydrazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / ethanol / 1.) reflux, 2.5 h; 2.) room temp., overnight 2: 79 percent / hydrogen, / 5percent palladium on charcoal / dimethylformamide / 20 h / 2585.7 Torr 3: 65 percent / 64percent NH2NH2*H2O / H2O; ethanol / 2.5 h / Heating View Scheme

: 1226145-00-1
ethyl 4-(3,5-dichlorophenoxy)-3-oxobutanoate

: 140-69-2
4-methoxybenzylhydrazine

: 1412896-04-8
C18H16Cl2N2O3

Conditions

Conditions	Yield
In ethanol at 20℃; for 7h;	97%

: (4-chlorophenyl)(2-isothiocyanatothiophen-3 -yl)methanone

: 140-69-2
4-methoxybenzylhydrazine

: N-(3-(4-chlorobenzoyl)thiophen-2-yl)-1-(4-methoxybenzyl)hydrazine-1-carbothioamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 5h;	80%

: 3-(1,4-Dioxa-spiro[4.4]non-7-yl)-3-oxo-N-(3-trifluoromethyl-phenyl)-thiopropionamide

: 140-69-2
4-methoxybenzylhydrazine

: [5-(1,4-Dioxa-spiro[4.4]non-7-yl)-2-(4-methoxy-benzyl)-2H-pyrazol-3-yl]-(3-trifluoromethyl-phenyl)-amine

Conditions

Conditions	Yield
With acetic acid In ethanol	79%

: 140-69-2
4-methoxybenzylhydrazine

A: 5-Cyclobutyl-2-(4-methoxy-benzyl)-2H-pyrazol-3-ylamine

B: 118431-89-3
β-Cyclobutyl-β-oxopropionitrile

Conditions

Conditions	Yield
In ethanol; ethyl acetate	A 77% B n/a

: tert-butyl ((1-(6-chloro-5-cyanopyrazin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate

: 140-69-2
4-methoxybenzylhydrazine

: tert-butyl ((1-(3-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)methyl)carbamate

Conditions

Conditions	Yield
With triethylamine In ethanol at 90℃; for 12h;	77%

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 140-69-2
4-methoxybenzylhydrazine

: 821016-23-3
ethyl 5-hydroxy-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With potassium carbonate for 3h; Heating;	75%

: 141-97-9
ethyl acetoacetate

: 140-69-2
4-methoxybenzylhydrazine

: 33555-99-6
2-(4-methoxybenzyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

Conditions

Conditions	Yield
at 0℃; for 0.5h;	75%

: 123-54-6
acetylacetone

: 140-69-2
4-methoxybenzylhydrazine

: 1-p-methoxybenzyl-3,5-dimethylpyrazole

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 1h; Heating;	73%

: 17826-12-9
(6-bromo-indol-3-yl)-oxo-acetic acid ethyl ester

: 140-69-2
4-methoxybenzylhydrazine

: 7-bromo-2-[(4-methoxyphenyl)methyl]-2H,4H,5H-pyrazolo[3,4-c]quinolin-4-one

Conditions

Conditions	Yield
With acetic acid In ethanol at 80℃;	68%

: 102-52-3
malonaldehydebis(dimethylacetal)

: 140-69-2
4-methoxybenzylhydrazine

: 145162-51-2
1-(p-methoxyphenyl)methyl-pyrazole

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 1h; Heating;	64%

: 868360-50-3
methyl 2-chloro-6-(2-furyl)-5-pyrimidin-4-ylnicotinate

: 140-69-2
4-methoxybenzylhydrazine

: 868360-65-0
6-(2-furyl)-1-(4-methoxybenzyl)-5-pyrimidin-4-yl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one

Conditions

Conditions	Yield
In ethanol at 65℃;	63%

: 140-69-2
4-methoxybenzylhydrazine

: 94-05-3
ethyl (ethoxymethylene)cyanoacetate

: 384835-92-1
ethyl 5-amino-1-[(4-methoxyphenyl)methyl]pyrazole-4-carboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	63%
In ethanol Reflux;	63%
In ethanol Reflux;	63%

: (4-hydroxyphenyl)carbonohydrazonoyl dicyanide

: 140-69-2
4-methoxybenzylhydrazine

: 1374431-85-2
4-((3,5-diamino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)diazenyl)phenol

Conditions

Conditions	Yield
In methanol at 65℃; for 4h;	62%

: (E)-2-(1-(dimethylamino)-3-oxo-3-phenylprop-1-en-2-yl)isoindoline-1,3-dione

: 140-69-2
4-methoxybenzylhydrazine

: 216854-27-2
2-(3-phenyl-1H-pyrazol-4-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
In ethanol at 20℃; for 15h;	59%

: 140-69-2
4-methoxybenzylhydrazine

: 55557-52-3
2-chloro-3-cyanopyrazine

: 1432112-13-4
1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyrazine-3-amine

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 6h; Reflux;	56%
With potassium carbonate In ethanol for 6h; Reflux;	56%

: 614-16-4
Benzoylacetonitrile

: 140-69-2
4-methoxybenzylhydrazine

: 1-(4-methoxybenzyl)-3-phenyl-1H-pyrazol-5-amine

Conditions

Conditions	Yield
With acetic acid In ethanol at 85℃;	52%
With acetic acid In ethanol at 85℃;	14.4 g

: 141-97-9
ethyl acetoacetate

: 140-69-2
4-methoxybenzylhydrazine

: 326488-07-7
1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-ol

Conditions

Conditions	Yield
In acetic acid at 100℃;	46%

: 5617-74-3
3-oxabicyclo[3.1.0]hexane-2,4-dione

: 140-69-2
4-methoxybenzylhydrazine

: 154186-47-7
(+/-)-3-(4-methoxybenzyl)-3,4-diazabicyclo[4.1.0]heptane-2,5-dione

Conditions

Conditions	Yield
In acetonitrile for 15h; cyclocondensation; Heating;	34%
In acetonitrile Reflux;	25.5%

: 426265-73-8
4-bromo-2-chlorobenzamide

: 534-15-6
1,1-dimethoxyethane

: 140-69-2
4-methoxybenzylhydrazine

: 3-(4-bromo-2-chlorophenyl)-1-(4-methoxybenzyl)-1H-1,2,4-triazole

Conditions

Conditions	Yield
In Petroleum ether	27%

...Expand

: 70515-61-6
(E)-3-(dimethylamino)-2-phenylacrylonitrile

: 140-69-2
4-methoxybenzylhydrazine

A: 1-(4-methoxybenzyl)-4-phenyl-1H-pyrazol-3-amine

B: 5591-70-8
4-phenyl-1H-pyrazol-3-ylamine

Conditions

Conditions	Yield
In ethanol at 20℃; for 12h;	A 12.3% B 21.6%

...Expand

: 140-69-2
4-methoxybenzylhydrazine

: sodium (E)-(4-methoxyphenyl)methanediazoate

Conditions

Conditions	Yield
With n-Butyl nitrite; sodium ethanolate In diethyl ether; ethanol for 16h;

: 131543-46-9
Glyoxal

: 140-69-2
4-methoxybenzylhydrazine

: 2-(4-Methoxy-benzyl)-2H-[1,2,3]triazole 1-oxide

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride; sodium carbonate; copper(II) sulfate 1.) water, methanol, r.t., 0.5 h, 2.) water, methanol, reflux, 0.5 h; Yield given. Multistep reaction;

: 528884-49-3
(2-amino-4-methyl-phenyl)-cyclohexyl-methanone

: 32315-10-9
bis(trichloromethyl) carbonate

: 140-69-2
4-methoxybenzylhydrazine

: C23H29N3O3

Conditions

Conditions	Yield
Stage #1: (2-amino-4-methyl-phenyl)-cyclohexyl-methanone; bis(trichloromethyl) carbonate With triethylamine In dichloromethane at -40℃; for 0.833333h; Stage #2: 4-methoxybenzylhydrazine In dichloromethane at -40 - 20℃; Further stages.;

...Expand

: 463-71-8
thiophosgene

: 551-93-9
2-aminoacetophenone

: 140-69-2
4-methoxybenzylhydrazine

: C17H19N3O2S

Conditions

Conditions	Yield
Stage #1: thiophosgene; 2-aminoacetophenone With triethylamine In dichloromethane at -20 - 20℃; Stage #2: 4-methoxybenzylhydrazine In dichloromethane at 20℃; for 16h; Further stages.;

...Expand

(4-Methoxybenzyl)hydrazine Specification

This chemical is called Hydrazine, [(4-methoxyphenyl)methyl]-, and its systematic name is (4-methoxybenzyl)hydrazine. With the molecular formula of C₈H₁₂N₂O, its molecular weight is 152.09. The CAS registry number of this chemical is 140-69-2.

Other characteristics of the Hydrazine, [(4-methoxyphenyl)methyl]- can be summarised as followings: (1)ACD/LogP: 0.64; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.48; (4)ACD/LogD (pH 7.4): 0.19; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 18.8; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 15.71 Å²; (13)Index of Refraction: 1.545; (14)Molar Refractivity: 44.97 cm³; (15)Molar Volume: 142.2 cm³; (16)Polarizability: 17.83×10^-24cm³; (17)Surface Tension: 40 dyne/cm; (18)Density: 1.069 g/cm³; (19)Flash Point: 142.5 °C; (20)Enthalpy of Vaporization: 55.29 kJ/mol; (21)Boiling Point: 311.9 °C at 760 mmHg; (22)Vapour Pressure: 0.000546 mmHg at 25°C.

You can still convert the following datas into molecular structure:
1.SMILES: O(c1ccc(cc1)CNN)C
2.InChI: InChI=1/C8H12N2O/c1-11-8-4-2-7(3-5-8)6-10-9/h2-5,10H,6,9H2,1H3
3.InChIKey: AQURFXLIZXOCLU-UHFFFAOYAU

Product Name

(4-METHOXYBENZYL)HYDRAZINEDIHYDROCHLORIDE

Synthetic route

(4-Methoxybenzyl)hydrazine Specification

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