(R)-Tetrahydrofuran-3-amine hydrochloride supplier | CasNO.1072015-52-1

Product Name

Name
(R)-Tetrahydrofuran-3-amine hydrochloride
EINECS
CAS No. 1072015-52-1
Density
Solubility
Melting Point
Formula C4H9NO.ClH
Boiling Point
Molecular Weight 123.582
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Josiphos SL-J001-2
PSA 35.25000
LogP 1.23630

Synthetic route

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1-(6-ethyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperidin-4-one

: (R)-1-(6-ethyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydrofuran-3-yl)piperidin-4-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃;	91%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: C19H19FN4O2

: (R)-1-(8-fluoro-4,6-dimethyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydrofuran-3-yl)piperidin-4-amine

Conditions

Conditions	Yield
Stage #1: [(3R)-tetrahydrofuran-3-yl]ammonium chloride; C19H19FN4O2 With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 0.166667h; Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃;	87%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1-(6-ethyl-8-fluoro-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperidin-4-one

: (R)-1-(6-ethyl-8-fluoro-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydrofuran-3-yl)piperidin-4-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃;	77%
Stage #1: [(3R)-tetrahydrofuran-3-yl]ammonium chloride; 1-(6-ethyl-8-fluoro-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperidin-4-one With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 0.166667h; Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 3h;	68%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 3-(5-hydroxy-1H-indazo-1-yl)benzoic acid

: 3-(5-hydroxy-1H-indazol-1-yl)-N-[(3R)-tetrahydrofuran-3-yl]benzamide

Conditions

Conditions	Yield
Stage #1: [(3R)-tetrahydrofuran-3-yl]ammonium chloride; 3-(5-hydroxy-1H-indazo-1-yl)benzoic acid With triethylamine In dichloromethane at 20℃; for 20h; Inert atmosphere; Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 0 - 20℃; for 1h; Inert atmosphere;	73%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperidin-4-one

: (R)-1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydrofuran-3-yl)piperidin-4-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃;	73%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 4,6-dichloro-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl] pyridine-3-carboxamide

: 6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((R)-tetrahydrofuran-3-yl)amino) nicotinamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 120℃; for 12h;	69%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 4-chloro-7,8-dimethoxyquinazoline

: (R)-7,8-dimethoxy-N-(tetrahydrofuran-3-yl)quinazolin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; for 3h;	67%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; for 3h;	67%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 6-amino-4-fluoronicotinonitrile

: (R)-6-amino-4-((tetrahydrofuran-3-yl)amino)nicotinonitrile

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; Inert atmosphere;	66%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 5437-45-6
Benzyl bromoacetate

: (R)-benzyl 2-((tetrahydrofuran-3-yl)amino)acetate

Conditions

Conditions	Yield
Stage #1: [(3R)-tetrahydrofuran-3-yl]ammonium chloride With triethylamine In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: Benzyl bromoacetate With sodium iodide In tetrahydrofuran at 0 - 20℃;	60.6%

: 897030-99-8
4-chloro-5-iodo-6-methyl-pyrimidin-2-ylamine

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1220812-14-5
(R)-5-iodo-6-methyl-N4-(tetrahydrofuran-3-yl)pyrimidine-2,4-diamine

Conditions

Conditions	Yield
With triethylamine In ethanol; water Reflux;	54%

: 1780-36-5
5-methyl-2,4,6-trichloropyrimidine

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: (R)-2,6-dichloro-5-methyl-N-(tetrahydrofuran-3-yl)pyrimidin-4-amine

Conditions

Conditions	Yield
With triethylamine In ethanol at -40 - 20℃; for 14h;	53%
With triethylamine In ethanol at 20℃; for 14h;	53%

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1113050-16-0
C8H5F2IO2

: 1113050-17-1
C12H13FINO3

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 75℃;

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: (3R)-tetrahydro-3-furanamine

Conditions

Conditions	Yield
With N,N,N′,N′-tetramethyl-N″-tert-butylguanidine In N,N-dimethyl-formamide at 20℃; for 0.666667h;

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1231220-84-0
R-6-Chloro-2-methyl-N4-(tetrahydro-furan-3-yl)-pyrimidine-4,5-diamine

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol for 96h; Reflux;

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 19234-66-3
2',3'-isopropylideneadenosine-5'-carboxylic acid

: 1374251-05-4
C17H22N6O5

Conditions

Conditions	Yield
With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;

: 939425-75-9
(S)-4-nitrophenyl 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethylcarbamate

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 939417-75-1
C25H22ClF4N3O2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: C27H18ClF4N3O4

: 1408148-00-4
C25H22ClF4N3O2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1292289-41-8
methyl 4-cyclobutyl-2-(methylsulfonyl)pyrimidine-5-carboxylate

: 1292289-43-0
(R)-methyl 4-cyclobutyl-2-(tetrahydrofuran-3-ylamino)pyrimidine-5-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 16h;

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1432909-99-3
tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylsulfinyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

: 1432910-00-3
C29H32ClN7O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Inert atmosphere;

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1432910-02-5
tert-butyl 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-2-(methylsulfinyl)-8-(pyridin-3-ylmethyl)pyrido[2,3-d]pyrimidin-7(8H)-one

: 1432908-69-4
(R)-6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-(pyridin-3-ylmethyl)-2-((tetrahydrofuran-3-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Inert atmosphere;	45 mg

: 1072015-52-1
[(3R)-tetrahydrofuran-3-yl]ammonium chloride

: 1-(4-(4-fluorophenyl)pyrimidin-5-yl)piperidine-4-carboxylic acid

: 1-(4-(4-fluorophenyl)pyrimidin-5-yl)-N-((3R)-tetrahydrofuran-3-yl)piperidine-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 10 - 35℃; for 4h;	0.34 g
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 10 - 35℃; for 4h;	0.34 g

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