-
Name
DISOPYRAMIDE
- EINECS
- CAS No. 3737-09-5
- Article Data4
- CAS DataBase
- Density 1.059g/cm3
- Solubility 6.17mg/L(22.5 oC)
- Melting Point 94.5-950C
- Formula C21H29 N3 O
- Boiling Point 505.2°Cat760mmHg
- Molecular Weight 339.481
- Flash Point 259.4°C
- Transport Information
- Appearance Crystalline Solid
- Safety Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion: dyspnea, cardiac and pulmonary changes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes 22
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Molecular Structure
-
Hazard Symbols
- Synonyms 2-Pyridineacetamide,a-[2-(diisopropylamino)ethyl]-a-phenyl- (7CI,8CI);(RS)-disopyramide; (?à)-Disopyramide; 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide;Dicorantil; Disopyramide; H 3292; Isorythm; Lispine; Ritmilen; Ritmodan; SC7031; Searle 703; dl-Disopyramide; a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide
- PSA 59.22000
- LogP 4.06220
α-(2-(DIISOPROPYLAMINO)ETHYL)-α-PHENYL-2-PYRIDINEACETAMIDE Chemical Properties
Product Name: α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide (CAS NO.3737-09-5)
Molecular Formula: C21H29N3O
Molecular Weight: 339.47g/mol
Mol File: 3737-09-5.mol
Einecs: 223-110-2
Melting Point: 94.5-95°C
Boiling point: 505.2 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 259.4 °C
Density: 1.059 g/cm3
Surface Tension: 42.3 dyne/cm
Enthalpy of Vaporization: 77.49 kJ/mol
Vapour Pressure: 2.48E-10 mmHg at 25°C
XLogP3-AA: 3.2
H-Bond Donor: 1
H-Bond Acceptor: 3
Product Categories: Intermediates and Fine Chemicals; Pharmaceuticals
α-(2-(DIISOPROPYLAMINO)ETHYL)-α-PHENYL-2-PYRIDINEACETAMIDE Uses
Heart attack class medicine. Anti-arrhythmia, α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide (CAS NO.3737-09-5) applies to supraventricular cardiac ventricular premature beats, atrial fibrillation and other types of tachycardia.
α-(2-(DIISOPROPYLAMINO)ETHYL)-α-PHENYL-2-PYRIDINEACETAMIDE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | LDLo | oral | 46154ug/kg (46.154mg/kg) | BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Medical Journal of Australia. Vol. 2, Pg. 335, 1978. |
| dog | LDLo | intravenous | 36mg/kg (36mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: REGIDITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 114, 1962. |
| guinea pig | LDLo | intravenous | 24900ug/kg (24.9mg/kg) | Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980. | |
| human | TDLo | oral | 4286ug/kg (4.286mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | New England Journal of Medicine. Vol. 302, Pg. 614, 1980. |
| man | LDLo | oral | 11429ug/kg (11.429mg/kg) | Journal of Forensic Sciences. Vol. 32, Pg. 1813, 1987. | |
| mouse | LD50 | intraperitoneal | 114mg/kg (114mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1628, 1971. |
| mouse | LD50 | intravenous | 26mg/kg (26mg/kg) | BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: REGIDITY | United States Patent Document. Vol. #4237139, |
| mouse | LD50 | oral | 352mg/kg (352mg/kg) | Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980. | |
| mouse | LD50 | subcutaneous | 305mg/kg (305mg/kg) | Drugs in Japan Vol. 6, Pg. 319, 1982. | |
| rabbit | LDLo | intravenous | 42200ug/kg (42.2mg/kg) | Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980. | |
| rat | LD50 | intraperitoneal | 170mg/kg (170mg/kg) | Drugs in Japan Vol. 6, Pg. 319, 1982. | |
| rat | LD50 | intravenous | 39100ug/kg (39.1mg/kg) | Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980. | |
| rat | LD50 | oral | 333mg/kg (333mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988. |
| rat | LD50 | subcutaneous | 800mg/kg (800mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 829, 1978. | |
| women | TDLo | oral | 84mg/kg/3W-I (84mg/kg) | SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE BEHAVIORAL: HEADACHE LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | Mayo Clinic Proceedings. Vol. 65, Pg. 1030, 1990. |
| women | TDLo | unreported | 700mg/kg/13W- (700mg/kg) | BEHAVIORAL: COMA ENDOCRINE: HYPOGLYCEMIA | Annales de Medecine Interne. Vol. 146, Pg. 209, 1995. |
α-(2-(DIISOPROPYLAMINO)ETHYL)-α-PHENYL-2-PYRIDINEACETAMIDE Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion: dyspnea, cardiac and pulmonary changes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide (CAS NO.3737-09-5):
Hazard Codes: Xn.gif){kind=small}
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Risk Statements: 22-36/37/38
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 36-26
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
α-(2-(DIISOPROPYLAMINO)ETHYL)-α-PHENYL-2-PYRIDINEACETAMIDE Specification
α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide ,its CAS NO. is 3737-09-5,the synonyms is alpha-[2-[Bis(1-methylethyl)amino]ethyl]-alpha-phenyl-2-pyridine acetamide ; alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide ; Disopyramide ; 2-Pyridineacetamide, alpha-[2-(diisopropylamino)ethyl]-alpha-phenyl- ; 2-Pyridineacetamide, alpha-[2-[bis(1-methylethyl)amino]ethyl]-alpha-phenyl- ; 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide ; 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide ; Alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamid .
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