1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one supplier

Name
1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one
EINECS 601-639-3
CAS No. 119851-28-4
Article Data6
CAS DataBase
Density 1.304 g/cm³
Solubility
Melting Point 54-56 ºC
Formula C₁₄H₁₀Cl₂O₂
Boiling Point 369.2 ºC at 760 mmHg
Molecular Weight 281.138
Flash Point 146.5 ºC
Transport Information
Appearance light yellow to dark yellow liquid
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethanone;
PSA 26.30000
LogP 4.98830

Synthetic route

: 700-35-6
2'-chloro-4'-fluoroacetophenone

: 106-48-9
4-chloro-phenol

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 115℃; for 8h;	90%
With potassium carbonate In N,N-dimethyl-formamide for 48h; Reflux;

: 1419873-85-0
1-bromo-2-chloro-4-(4-chlorophenoxy)benzene

: 75-36-5
acetyl chloride

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride; isopropylmagnesium bromide; copper(l) chloride

: 6842-62-2
3,4'-Dichlorobiphenyl ether

: 75-36-5
acetyl chloride

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-ethane at 10 - 50℃;

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 123-11-5
4-methoxy-benzaldehyde

: C22H16Cl2O3

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 906005-51-4
2-bromo-1-(2-chloro-4-(4-chlorophenoxy)phenyl)ethanone

Conditions

Conditions	Yield
With bromine In diethyl ether	95.8%
With 1-butyl-3-methylimidazolium tribromide In neat (no solvent) for 0.2h;	87.8%
With phenyltrimethylammonium tribromide In tetrahydrofuran at 0 - 20℃; for 20h;	75%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 83-38-5
2,6-dichlorobenzaldehyde

: C21H12Cl4O2

Conditions

Conditions	Yield
	92.7%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 6287-38-3
3,4-dichlorobenzaldehyde

: C21H12Cl4O2

Conditions

Conditions	Yield
	91.2%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 100-52-7
benzaldehyde

: 338777-09-6
C21H14Cl2O2

Conditions

Conditions	Yield
	90%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 2181-44-4
trimethylsulfonium methylsulfate

: 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methyloxirane

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water; toluene at 60℃;	86.5%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 874-42-0
2,4-dichlorobenzaldeyhde

: C21H12Cl4O2

Conditions

Conditions	Yield
	85.5%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 104-15-4
toluene-4-sulfonic acid

: 1034188-96-9
C21H16Cl2O5S

Conditions

Conditions	Yield
With Dess-Martin periodane In acetonitrile for 4.5h; Reflux;	84%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 104-88-1
4-chlorobenzaldehyde

: C21H13Cl3O2

Conditions

Conditions	Yield
	81.2%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1-[2-Chloro-4-(4-chloro-phenoxy)-phenyl]-ethylamine

Conditions

Conditions	Yield
With ammonia; hydrogen In tetrahydrofuran at 120℃; for 15h;	79%

: 75-75-2
methanesulfonic acid

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1034188-94-7
2-[2-chloro-4 (4-chlorophenoxy)phenyl]-2-oxo-ethyl methanesulfonate

Conditions

Conditions	Yield
With Dess-Martin periodane In acetonitrile for 4.5h; Reflux;	75%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 104-87-0
4-methyl-benzaldehyde

: C22H16Cl2O2

Conditions

Conditions	Yield
	73.6%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 446-52-6
2-Fluorobenzaldehyde

: C21H13Cl2FO2

Conditions

Conditions	Yield
	58.6%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 95-54-5
1,2-diamino-benzene

: 3-(4-chlorophenoxy)benzo[4,5]thieno[2,3-b]quinoxaline

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; sulfur In dimethyl sulfoxide at 120℃; for 2h;	52%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 2-chloro-1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone

Conditions

Conditions	Yield
With sulfuryl dichloride In methanol; dichloromethane at 20℃; for 64h; Reflux;	49%

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1160554-11-9
C18H19Cl2NO3

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: copper(ll) bromide / ethanol / 6 h / Reflux 2: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C 3: formic acid / 18 h / 180 °C View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: C18H20BrCl2NO4

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper(ll) bromide / ethanol / 6 h / Reflux 2: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1243257-37-5
2-[(2-chloro-4-(4-chlorophenoxy)phenyl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: copper(ll) bromide / ethanol / 6 h / Reflux 2: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C 3: formic acid / 18 h / 180 °C 4: triethylamine / tetrahydrofuran / 6 h / 20 °C View Scheme

: 288-88-0
1,2,4-Triazole

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 136815-80-0
1-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-2-[1,2,4]triazol-1-yl-ethanone

Conditions

Conditions	Yield
Stage #1: 1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one With bromine Stage #2: 1,2,4-Triazole

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

Reaxys ID: 23327348: Reaxys ID: 23327348

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1419875-35-6
2-[2-chloro-4-(4-chlorophenoxy)phenyl]-(1-[1,2,4]triazol-1-yl)pentan-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bromine 2.1: magnesium bromide diethyl etherate / dichloromethane / 1.5 h / 20 °C 2.2: 2 h / 0 - 20 °C View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1419875-41-4
2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-([1,2,4]-triazol-1-yl)pent-3-yn-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bromine 2.1: lanthanium (III) chloride bis(lithium chloride) complex / tetrahydrofuran / 1 h / 20 °C 2.2: 1 h / 20 °C View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1419875-37-8
2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)hexan-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: bromine; acetic acid / tert-butyl methyl ether / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.5 h 2.2: 2.5 h 3.1: magnesium bromide ethyl etherate / dichloromethane / 1 h / 20 °C 3.2: 2 h / 0 °C View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1423010-69-8
1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-hexyl]-1,2,4-triazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: bromine; acetic acid / tert-butyl methyl ether / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.5 h 2.2: 2.5 h 3.1: magnesium bromide ethyl etherate / dichloromethane / 1 h / 20 °C 3.2: 2 h / 0 °C 4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C 4.2: 3 h / 195 °C / Microwave irradiation View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 136815-80-0
1-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-2-[1,2,4]triazol-1-yl-ethanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bromine; acetic acid / tert-butyl methyl ether / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.5 h 2.2: 2.5 h View Scheme
Multi-step reaction with 2 steps 1.1: bromine; acetic acid / tert-butyl methyl ether / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.5 h 2.2: 2.5 h View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1423016-05-0
1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: bromine; acetic acid / tert-butyl methyl ether / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.5 h 2.2: 2.5 h 3.1: magnesiumbromide etherate / dichloromethane / 1 h / 20 °C 3.2: 2 h / -15 °C 4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C 4.2: 10 h / Reflux View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1419875-43-6
2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: bromine; acetic acid / tert-butyl methyl ether / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.5 h 2.2: 2.5 h 3.1: magnesiumbromide etherate / dichloromethane / 1 h / 20 °C 3.2: 2 h / -15 °C View Scheme

: 119851-28-4
1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

: 1159001-34-9
2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 5 - 20 °C 2: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C View Scheme

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one Chemical Properties

Empirical Formula: C₁₄H₁₀Cl₂O₂
Molecular Weight: 281.134g/mol
Structure of 1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one (CAS NO.119851-28-4):

Index of Refraction: 1.588
Molar Refractivity: 72.51 cm³
Molar Volume: 215.4 cm³
Polarizability: 28.74×10^-24cm³
Surface Tension: 44.1 dyne/cm
Density: 1.304 g/cm³
Flash Point: 146.5 °C
Enthalpy of Vaporization: 61.6 kJ/mol
Melting Point: 54-56°C
Boiling Point: 369.2 °C at 760 mmHg
Vapour Pressure: 1.2E-05 mmHg at 25°C
Product Categories: Ketones
Systematic Name: 1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone
SMILES: O=C(c2ccc(Oc1ccc(Cl)cc1)cc2Cl)C
InChI: InChI=1/C14H10Cl2O2/c1-9(17)13-7-6-12(8-14(13)16)18-11-4-2-10(15)3-5-11/h2-8H,1H3
InChIKey: BDTJIVUVQRVLLJ-UHFFFAOYAA

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one Safety Profile

Hazard Codes: Xi
Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
Hazard Note: Irritant

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one Specification

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one , its cas register number is 119851-28-4. It also can be called 1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethanone ; Ethanone, 1-[2-chloro-4-(4-chlorophenoxy)phenyl]- ; 1-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-ethanone ; 1-Acetyl-2-chloro-4-(4-chlorophenoxy)benzene ; 2-Chloro-4-(4-chlorophenoxy)acetophenone . You should avoid 1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one (CAS NO.119851-28-4) contact with skin and eyes.

Product Name

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one

Synthetic route

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one Chemical Properties

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one Safety Profile

1-[2-Chloro-4-(4-chlorophenoxy)phenyl]ethan-1-one Specification

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