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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry, m

2'-Chloro-4'-fluoroacetophenone

Cas:700-35-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2'-Chloro-4'-fluoroacetophenone

Cas:700-35-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 2'-CHLORO-4'-FLUOROACETOPHENONE Synonyms: 2'-Chloro-4'-fluoroacetophenone99%;2'-Chloro-4'-fluoroacetophenone, 98+%;1-(2-Chloro-4-fluorophenyl)ethan-1-one;2-Chloro-4-fluorophenyl methyl ketone;Ethanone,1-

700-35-6 2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Kilogram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2'-CHLORO-4'-FLUOROACETOPHENONE 700-35-6

Cas:700-35-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 700-35-6 with competitive price

Cas:700-35-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 700-35-6 ,2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used to make other chemic

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-chloro-4-fluoroacetophenone

Cas:700-35-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Chloro-4-Fluoroacetophenone CAS No.: 700-35-6 Molecule Formula:C8H6ClFO Molecule Weight:172.58 Purity: 99.0% Package: 200kg/drum Description:Colorless transparent liquid Manufacture Standards:Enterprise Standard T

Lower Price 2-Chloro-4-Fluoroacetophenone in stock

Cas:700-35-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2'-Chloro-4'-fluoroacetophenone

Cas:700-35-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

1-(2-Chloro-4-fluorophenyl)ethanone

Cas:700-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2'-CHLORO-4'-FLUOROACETOPHENONE

Cas:700-35-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Ethanone,1-(2-chloro-4-fluorophenyl)-

Cas:700-35-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2'-Chloro-4'-Fluoroacetophenone cas no. 700-35-6 98%

Cas:700-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-Chloro-4-fluoroacetophenone

Cas:700-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-chloro-4-fluoroacetophenone

Cas:700-35-6

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

2-chloro-4-fluoro-N-methoxy-N-methylbenzamide

2-chloro-4-fluoro-N-methoxy-N-methylbenzamide

methylmagnesium bromide
75-16-1

methylmagnesium bromide

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
In tetrahydrofuran at -78 - 0℃; for 5.5h;98.42%
1-(2-chloro-4-fluorophenyl)ethan-1-ol
112108-68-6

1-(2-chloro-4-fluorophenyl)ethan-1-ol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With bromopentacarbonylmanganese(I); N-methyl-N,N-di(2-pyridylmethyl)amine; acetone; sodium t-butanolate In toluene at 90℃; for 24h; Inert atmosphere; Schlenk technique; Darkness;26%
3-chlorofluorobenzene
625-98-9

3-chlorofluorobenzene

acetyl chloride
75-36-5

acetyl chloride

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With aluminium trichloride In carbon disulfide Heating;
3-chlorofluorobenzene
625-98-9

3-chlorofluorobenzene

acetic anhydride
108-24-7

acetic anhydride

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
With aluminium trichloride In carbon disulfide Heating;
2-choro-4-fluorobenzoic acid
2252-51-9

2-choro-4-fluorobenzoic acid

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 15 °C
2: tetrahydrofuran / 5.5 h / -78 - 0 °C
View Scheme
4-n-butylphenol
1638-22-8

4-n-butylphenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-(4-butylphenoxy)-2-chloroacetophenone

4-(4-butylphenoxy)-2-chloroacetophenone

Conditions
ConditionsYield
Stage #1: 4-n-butylphenol With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 0.5h;
Stage #2: 2'-chloro-4'-fluoroacetophenone In N,N-dimethyl-formamide at 115℃; Inert atmosphere;
100%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(2-chloro-4-fluorophenyl)ethan-1-ol
112108-68-6

1-(2-chloro-4-fluorophenyl)ethan-1-ol

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 0 - 15℃; for 3h;97.81%
With methanol; sodium tetrahydroborate at 0 - 20℃; for 1.16667h;0.4 g
4-Trifluoromethoxyphenol
828-27-3

4-Trifluoromethoxyphenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(2-chloro-4-(4-(trifluoromethoxy)phenoxy)phenyl)ethan-1-one

1-(2-chloro-4-(4-(trifluoromethoxy)phenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 2.5h;91.3%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-chloro-phenol
106-48-9

4-chloro-phenol

1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one
119851-28-4

1-(2-chloro-4-(4-chlorophenoxy)phenyl)-ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 115℃; for 8h;90%
With potassium carbonate In N,N-dimethyl-formamide for 48h; Reflux;
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-chloro-3-fluorophenol
348-60-7

4-chloro-3-fluorophenol

1-(2-chloro-4-(4-chloro-3-fluorophenoxy)phenyl)ethan-1-one

1-(2-chloro-4-(4-chloro-3-fluorophenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h;89.4%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

Ethyl 2-cyano-4-(4-fluorophenyl)-4-oxobutanoate
131952-81-3

Ethyl 2-cyano-4-(4-fluorophenyl)-4-oxobutanoate

Conditions
ConditionsYield
With sodium In ethanol; water88%
4-bromo-phenol
106-41-2

4-bromo-phenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(4-(4-bromophenoxy)-2-chlorophenyl)ethan-1-one

1-(4-(4-bromophenoxy)-2-chlorophenyl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 4-bromo-phenol With potassium carbonate In N,N-dimethyl-formamide at 21℃; for 0.166667h;
Stage #2: 2'-chloro-4'-fluoroacetophenone In N,N-dimethyl-formamide at 120℃; for 3h;
87%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 1.5h;
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

Conditions
ConditionsYield
With isopropyl alcohol for 15h; Schlenk technique; Inert atmosphere; Irradiation; Heating;87%
4-butylthiophenol
4946-15-0

4-butylthiophenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-(4-butylphenylthio)-2-chloroacetophenone

4-(4-butylphenylthio)-2-chloroacetophenone

Conditions
ConditionsYield
Stage #1: 4-butylthiophenol With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 0.5h;
Stage #2: 2'-chloro-4'-fluoroacetophenone In N,N-dimethyl-formamide at 115℃; Inert atmosphere;
85%
3-Bromopyridine
626-55-1

3-Bromopyridine

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(4-fluoro-2-(pyridin-3-yl)phenyl)ethanone

1-(4-fluoro-2-(pyridin-3-yl)phenyl)ethanone

Conditions
ConditionsYield
Stage #1: 3-Bromopyridine With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane In 1,4-dioxane; water at 80℃; Inert atmosphere;
Stage #2: 2'-chloro-4'-fluoroacetophenone With tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate monohydrate; XPhos In 1,4-dioxane; water at 100℃; for 24h; Inert atmosphere; Sealed tube;
84%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

allyl bromide
106-95-6

allyl bromide

2-(2-chloro-4-fluorophenyl)pent-4-en-2-ol

2-(2-chloro-4-fluorophenyl)pent-4-en-2-ol

Conditions
ConditionsYield
With zinc In dimethyl sulfoxide for 2h; Barbier Coupling Reaction; Milling;79%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-bromo-3-fluorophenol
121219-03-2

4-bromo-3-fluorophenol

1-(4-(4-bromo-3-fluorophenoxy)-2-chlorophenyl)ethan-1-one

1-(4-(4-bromo-3-fluorophenoxy)-2-chlorophenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;78.3%
2,4-difluorophenol
367-27-1

2,4-difluorophenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(2-chloro-4-(2,4-difluorophenoxy)phenyl)ethan-1-one
1044060-07-2

1-(2-chloro-4-(2,4-difluorophenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 5.5h;77.3%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 16h;100 g
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

(2-Chloro-4-fluoro-phenyl)-oxo-acetaldehyde
81593-25-1

(2-Chloro-4-fluoro-phenyl)-oxo-acetaldehyde

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane; water for 4h;76%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-cyanophenol
767-00-0

4-cyanophenol

1-(2-chloro-4-(4-cyanophenoxy) phenyl)ethan-1-one
1246382-67-1

1-(2-chloro-4-(4-cyanophenoxy) phenyl)ethan-1-one

Conditions
ConditionsYield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 130℃; for 1h;73.9%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

4-methoxy-phenol
150-76-5

4-methoxy-phenol

1-(2-chloro-4-(4-methoxyphenoxy)phenyl)ethan-1-one

1-(2-chloro-4-(4-methoxyphenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 6h;73.3%
3-mercaptophenol
40248-84-8

3-mercaptophenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

benzyl bromide
100-39-0

benzyl bromide

1-(4-(3-(benzyloxy)phenylthio)-2-chlorophenyl)ethanone
1007165-40-3

1-(4-(3-(benzyloxy)phenylthio)-2-chlorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: 3-mercaptophenol; 2'-chloro-4'-fluoroacetophenone With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 3 - 18h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 60℃; for 3h;
70%
3,4-difluorophenol
2713-33-9

3,4-difluorophenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(2-chloro-4-(3,4-difluorophenoxy)phenyl)ethan-1-one

1-(2-chloro-4-(3,4-difluorophenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 6h;69%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

2,4-dichlorophenol
120-83-2

2,4-dichlorophenol

1-(2-chloro-4-(2,4-dichlorophenoxy)phenyl)ethan-1-one

1-(2-chloro-4-(2,4-dichlorophenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100 - 120℃; for 4.75h;68.3%
6-hydroxyquinoline
580-16-5

6-hydroxyquinoline

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(2-chloro-4-(quinolin-6-yloxy)phenyl)ethan-1-one

1-(2-chloro-4-(quinolin-6-yloxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 3.5h;68.1%
(3-((tert-butyldimethylsilyl)oxy)phenyl)zinc chloride

(3-((tert-butyldimethylsilyl)oxy)phenyl)zinc chloride

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(3'-((tert-butyldimethylsilyl)oxy)-5-fluoro-[1,1'-biphenyl]-2-yl)ethan-1-one

1-(3'-((tert-butyldimethylsilyl)oxy)-5-fluoro-[1,1'-biphenyl]-2-yl)ethan-1-one

Conditions
ConditionsYield
With Li2CoCl4; sodium formate In tetrahydrofuran at 25℃; Negishi Coupling; Inert atmosphere; Schlenk technique;68%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

2-chloro-5-trifluoromethylpyridine
52334-81-3

2-chloro-5-trifluoromethylpyridine

1-(2-Chloro-4-Fluorophenyl)-2-(5-Trifluoromethyl-2-Pyridinyl)Ethanone
372122-68-4

1-(2-Chloro-4-Fluorophenyl)-2-(5-Trifluoromethyl-2-Pyridinyl)Ethanone

Conditions
ConditionsYield
Stage #1: 2'-chloro-4'-fluoroacetophenone; 2-chloro-5-trifluoromethylpyridine With sodium hydride In 1,2-dimethoxyethane at 20 - 45℃; for 1h;
Stage #2: With water In 1,2-dimethoxyethane at 5℃;
67%
2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester
113451-59-5

(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
1186334-88-2

tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;66%
With potassium carbonate In N,N,N,N,N,N-hexamethylphosphoric triamide Inert atmosphere;
formaldehyd
50-00-0

formaldehyd

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

N,N-dimethylammonium chloride
506-59-2

N,N-dimethylammonium chloride

oxalic acid
144-62-7

oxalic acid

1-(2-Chloro-4-fluoro-phenyl)-3-dimethylamino-propan-1-one; compound with oxalic acid
76475-98-4

1-(2-Chloro-4-fluoro-phenyl)-3-dimethylamino-propan-1-one; compound with oxalic acid

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 8h; Heating;65.4%
formaldehyd
50-00-0

formaldehyd

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

piperazine hydrochloride
7542-23-6

piperazine hydrochloride

1-(2-Chloro-4-fluoro-phenyl)-3-{4-[3-(2-chloro-4-fluoro-phenyl)-3-oxo-propyl]-piperazin-1-yl}-propan-1-one; hydrochloride
76476-01-2

1-(2-Chloro-4-fluoro-phenyl)-3-{4-[3-(2-chloro-4-fluoro-phenyl)-3-oxo-propyl]-piperazin-1-yl}-propan-1-one; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 8h; Heating;63%
formaldehyd
50-00-0

formaldehyd

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

1-(2-Chloro-4-fluoro-phenyl)-3-piperidin-1-yl-propan-1-one; hydrochloride
76476-00-1

1-(2-Chloro-4-fluoro-phenyl)-3-piperidin-1-yl-propan-1-one; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 8h; Heating;62.7%
3,4-dichlorophenol
95-77-2

3,4-dichlorophenol

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

1-(2-chloro-4-(3,4-dichlorophenoxy)phenyl)ethan-1-one

1-(2-chloro-4-(3,4-dichlorophenoxy)phenyl)ethan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 6h;62.1%
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

2-chloro-4-fluorobenzoyltrifluoroacetone
38440-20-9

2-chloro-4-fluorobenzoyltrifluoroacetone

Conditions
ConditionsYield
With sodium amide In diethyl ether 0 deg C, 1 h, r.t., overnight then reflux, 4 h;62%
ethyl 5-bromo-3-pyridinecarboxylate
20986-40-7

ethyl 5-bromo-3-pyridinecarboxylate

2'-chloro-4'-fluoroacetophenone
700-35-6

2'-chloro-4'-fluoroacetophenone

ethyl 5-(2-acetyl-5-fluorophenyl)nicotinate

ethyl 5-(2-acetyl-5-fluorophenyl)nicotinate

Conditions
ConditionsYield
Stage #1: ethyl 5-bromo-3-pyridinecarboxylate With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane In 1,4-dioxane; water at 80℃; Inert atmosphere;
Stage #2: 2'-chloro-4'-fluoroacetophenone With tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate monohydrate; XPhos In 1,4-dioxane; water at 100℃; for 24h; Inert atmosphere; Sealed tube;
62%

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