1-(2-Hydroxyphenyl)piperazine

The Phenol,2-(1-piperazinyl)-, with the CAS registry number 1011-17-2, is also known as o-(1-Piperazinyl)phenol. It belongs to the product category of Piperidines, Piperidones, Piperazines. Its EINECS registry number is 213-782-5. This chemical's molecular formula is C₁₀H₁₄N₂O and molecular weight is 178.23. Its IUPAC name is called 2-piperazin-1-ylphenol. This chemical is brown-pink to brown powder and chunks

Physical properties of Phenol,2-(1-piperazinyl)-: (1)ACD/LogP: 0.37; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.33; (4)ACD/LogD (pH 7.4): -0.7; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 3.18; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.576; (13)Molar Refractivity: 51.68 cm³; (14)Molar Volume: 156.1 cm³; (15)Surface Tension: 44.8 dyne/cm; (16)Density: 1.141 g/cm³; (17)Flash Point: 152.3 °C; (18)Enthalpy of Vaporization: 59.32 kJ/mol; (19)Boiling Point: 328.2 °C at 760 mmHg; (20)Vapour Pressure: 0.000101 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(2-methoxy-phenyl)-πperazine. This reaction will need reagent 48 percent aq. HBr. The reaction time is 6 hours with reaction temperature of 140 ℃. The yield is about 54%.

Uses of Phenol,2-(1-piperazinyl)-: it can be used to produce 2-{1-[4-(2-hydroxyphenyl)πperazinyl]}benzoxazole by heating. This reaction will need reagent sodium bicarbonate and solvent propan-2-ol, H₂O with reaction time of 2 hours. The yield is about 83%.

When you are using this chemical, please be cautious about it as the following:
This chemical that at low levels cause damage to health. It also may cause inflammation to the skin or other mucous membranes. In addition, it is toxic if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CN(CCN1)C2=CC=CC=C2O
(2)InChI: InChI=1S/C10H14N2O/c13-10-4-2-1-3-9(10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2
(3)InChIKey: UORNTHBBLYBAJJ-UHFFFAOYSA-N