1-(2-Pyrazinyl)-piperazine

The Pyrazine, 2-(1-piperazinyl)-, with the CAS registry number of 34803-68-4, is also known as 1-(2-Pyrazinyl)-piperazine and (Pyrazin-2-yl)-piperazine. Its EINECS registry number is 252-221-9. This chemical's molecular formula is C₈H₁₂N₄ and molecular weight is 164.21. What's more, its IUPAC name is 2-Piperazin-1-ylpyrazine. In addition, it must be stored in airtight containers and placed in a dry, cool place.

Physical properties about Pyrazine, 2-(1-piperazinyl)- are: (1)ACD/LogP: -0.24; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.43; (4)ACD/LogD (pH 7.4): -0.74; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 5.55; (9)#H bond acceptors: 4; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 32.26 Å²; (13)Index of Refraction: 1.55; (14)Molar Refractivity: 45.98 cm³; (15)Molar Volume: 144.1 cm³; (16)Polarizability: 18.23×10^-24 cm³; (17)Surface Tension: 48.2 dyne/cm; (18)Density: 1.138 g/cm³; (19)Flash Point: 150 °C; (20)Enthalpy of Vaporization: 56.65 kJ/mol; (21)Boiling Point: 324.5 °C at 760 mmHg; (22)Vapour Pressure: 0.000245 mmHg at 25 °C.

Preparation: this chemical is prepared by reaction of Chloro-pyrazine with Piperazine. The reaction can use various solvents. The reaction time is 8 hours with reaction temperature of 169 °C. The yield is about 68 %.

Uses: it is used to produce other chemicals. For example, it is used to produce 7-[3-(2, 3, 5, 6-Tetrahydro-[1, 2']bipyrazinyl-4-yl)-propoxy]-chromen-4-one. This reaction needs reagents Sodium bicarbonate and Sodium iodide. Meanwhile, it needs solvent Dimethylformamide. Other condition of this reaction is reaction time of 10 hours at 85 °C. The yield is about 66 %.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes, respiratory system and skin. In addition, this chemical may cause inflammation to the skin or other mucous membranes. During using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: n1ccncc1N2CCNCC2
(2) InChI: InChI=1/C8H12N4/c1-2-11-8(7-10-1)12-5-3-9-4-6-12/h1-2,7,9H,3-6H2
(3) InChIKey: HCGFLVDMFDHYJD-UHFFFAOYAX